Leslie Ann Saxon, 2017-04-24T04:45:21+00:00


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Leslie Ann Saxon, MD
Professor of Medicine (Clinical Scholar)
Executive Director, Center For Body Computing (Cbc)
HCC 300N Health Sciences Campus Los Angeles
+1 323 442 6130


Leslie Saxon, M.D., is a Professor of Clinical Medicine at the Keck School of Medicine of USC, specializing in the diagnosis and treatment of arrhythmias in patients with congestive heart failure. After serving as the director of the electrophysiology laboratory and implantable device services at UC San Francisco, Dr. Saxon was recruited to serve as the Chief of Cardiovascular Medicine at USC.

In addition to using state-of-the-art resynchronization devices in patients with arrhythmias, such as modified pacemakers and implantable defribrillators, Dr. Saxon also collaborates with medical device companies to evaluate the latest, most innovative interventional gadgets for patients with difficult-to-treat heart failure.

Dr. Saxon has completed over 75 publications in various medical journals and is an active member of a multitude of organizations, including the American College of Cardiology, the Heart Rhythm Society, The American Heart Association, and the Heart Failure Society of America.

In 2002, Dr. Saxon co-chaired the first Heart Rhythm Society Conference in Cardiac Resynchronization. On October 26, 2007, Dr. Saxon was proud to host the First Annual USC Body Computing Conference, which brought together leading authors and futurists as well as leaders from the fields of medicine, design, entertainment, the FDA, investment banking, and pharmaceuticals for a day of intense discussions about the nascent but exciting field of wireless physiologic monitoring.


American College of Cardiology: Fellow


Kalscheur MM, Saxon LA, Lee BK, Steinberg JS, Mei C, Buhr KA, DeMets DL, Bristow MR, Singh SN. Outcomes of Cardiac Resynchronization Therapy in Patients with Intermittent Atrial Fibrillation or Atrial Flutter in the COMPANION Trial. Heart Rhythm. 2017 Mar 17. View in: PubMed

Saxon LA. Athletic Performance Monitoring, Pseudo Science and Metaphysics Meet Ethics. Am J Bioeth. 2017 Jan; 17(1):61-62. View in: PubMed

Shinbane JS, Saxon LA. Digital monitoring and care: Virtual medicine. Trends Cardiovasc Med. 2016 Nov; 26(8):722-730. View in: PubMed

Chang PM, Powell BD, Jones PW, Carter N, Hayes DL, Saxon LA. Implantable Cardioverter Defibrillator Programming Characteristics, Shocked Rhythms, and Survival Among Patients Under Thirty Years of Age. J Cardiovasc Electrophysiol. 2016 Oct; 27(10):1183-1190. View in: PubMed

Bristow MR, Saxon LA, Feldman AM, Mei C, Anderson SA, DeMets DL. Lessons Learned and Insights Gained in the Design, Analysis, and Outcomes of the COMPANION Trial. JACC Heart Fail. 2016 Jul; 4(7):521-35. View in: PubMed

Saxon LA. Mobile Health Application Solutions. Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e002477. View in: PubMed

Konecny T, Saxon LA. Integration of Smartphone Based Monitoring: No Modality is an Island, Entire of Itself. J Cardiovasc Electrophysiol. 2016 Jan; 27(1):58-9. View in: PubMed

Akar JG, Bao H, Jones PW, Wang Y, Varosy PD, Masoudi FA, Stein KM, Saxon LA, Normand SL, Curtis JP. Use of Remote Monitoring Is Associated With Lower Risk of Adverse Outcomes Among Patients With Implanted Cardiac Defibrillators. Circ Arrhythm Electrophysiol. 2015 Oct; 8(5):1173-80. View in: PubMed

Hsu JC, Saxon LA, Jones PW, Wehrenberg S, Marcus GM. Utilization trends and clinical outcomes in patients implanted with a single- vs a dual-coil implantable cardioverter-defibrillator lead: Insights from the ALTITUDE Study. Heart Rhythm. 2015 Aug; 12(8):1770-5. View in: PubMed

Freeman JV, Saxon L. Remote Monitoring and Outcomes in Pacemaker and Defibrillator Patients: Big Data Saving Lives? J Am Coll Cardiol. 2015 Jun 23; 65(24):2611-3. View in: PubMed

Maurer MS, Adamson PB, Costanzo MR, Eigler N, Gilbert J, Gold MR, Klapholz M, Saxon LA, Singh JP, Troughton R, Abraham WT. Rationale and Design of the Left Atrial Pressure Monitoring to Optimize Heart Failure Therapy Study (LAPTOP-HF). J Card Fail. 2015 Jun; 21(6):479-88. View in: PubMed

Haberman ZC, Jahn RT, Bose R, Tun H, Shinbane JS, Doshi RN, Chang PM, Saxon LA. Wireless Smartphone ECG Enables Large-Scale Screening in Diverse Populations. J Cardiovasc Electrophysiol. 2015 May; 26(5):520-6. View in: PubMed

Mahajan D, Dong Y, Saxon LA, Cha YM, Gilliam FR, Asirvatham SJ, Cesario DA, Jones PW, Seth M, Powell BD. Performance of an Automatic Arrhythmia Classification Algorithm: Comparison to the ALTITUDE Electrophysiologist Panel Adjudications. Pacing Clin Electrophysiol. 2014 Jul; 37(7):889-99. View in: PubMed

Chang PM, Doshi R, Saxon LA. Subcutaneous implantable cardioverter-defibrillator. Circulation. 2014 Jun 10; 129(23):e644-6. View in: PubMed

Merchant FM, Jones P, Wehrenberg S, Lloyd MS, Saxon LA. Incidence of defibrillator shocks after elective generator exchange following uneventful first battery life. J Am Heart Assoc. 2014; 3(6). View in: PubMed

Akar JG, Bao H, Jones P, Wang Y, Chaudhry SI, Varosy P, Masoudi FA, Stein K, Saxon LA, Curtis JP. Use of Remote Monitoring of Newly Implanted Cardioverter-Defibrillators: Insights From the Patient Related Determinants of ICD Remote Monitoring (PREDICT RM) Study. Circulation. 2013 Nov 26; 128(22):2372-83. View in: PubMed

Powell BD, Saxon LA, Boehmer JP, Day JD, Gilliam FR, Heidenreich PA, Jones PW, Rousseau MJ, Hayes DL. Survival after shock therapy in implantable cardioverter-defibrillator and cardiac resynchronization therapy-defibrillator recipients according to rhythm shocked. The ALTITUDE survival by rhythm study. J Am Coll Cardiol. 2013 Oct 29; 62(18):1674-9. View in: PubMed

Saxon LA. The subcutaneous implantable defibrillator: a new technology that raises an existential question for the implantable cardioverter-defibrillator. Circulation. 2013 Aug 27; 128(9):938-40. View in: PubMed

Cha YM, Hayes DL, Asirvatham SJ, Powell BD, Cesario DA, Cao M, Gilliam FR, Jones PW, Jiang S, Saxon LA. Impact of shock energy and ventricular rhythm on the success of first shock therapy: the ALTITUDE first shock study. Heart Rhythm. 2013 May; 10(5):702-8. View in: PubMed

Saxon LA. Ubiquitous wireless ECG recording: a powerful tool physicians should embrace. J Cardiovasc Electrophysiol. 2013 Apr; 24(4):480-3. View in: PubMed

Saxon LA, Wilkoff BL. CRT or CRT-D devices? The case for 'high energy' devices. Heart Fail Rev. 2012 Nov; 17(6):777-9. View in: PubMed

2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management: A registered branch of the European Society of Cardiology (ESC), and the Heart Rhythm Society; and in collaboration with the Heart Failure Society of America (HFSA), the American Society of Echocardiography (ASE), the American Heart Association (AHA), the European Association of Echocardiography (EAE) of the ESC and the Heart Failure Association of the ESC (HFA). * Endorsed by the governing bodies of AHA, ASE, EAE, HFSA, HFA, EHRA, and HRS. Europace. 2012 Sep; 14(9):1236-86. View in: PubMed

Daubert JC, Saxon L, Adamson PB, Auricchio A, Berger RD, Beshai JF, Breithard O, Brignole M, Cleland J, Delurgio DB, Dickstein K, Exner DV, Gold M, Grimm RA, Hayes DL, Israel C, Leclercq C, Linde C, Lindenfeld J, Merkely B, Mont L, Murgatroyd F, Prinzen F, Saba SF, Shinbane JS, Singh J, Tang AS, Vardas PE, Wilkoff BL, Zamorano JL. 2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management. Heart Rhythm. 2012 Sep; 9(9):1524-76. View in: PubMed

Somma KA, Bhatt DL, Fonarow GC, Cannon CP, Cox M, Laskey W, Peacock WF, Hernandez AF, Peterson ED, Schwamm L, Saxon LA. Guideline Adherence After ST-Segment Elevation Versus Non-ST Segment Elevation Myocardial Infarction. Circ Cardiovasc Qual Outcomes. 2012 Sep 1; 5(5):654-61. View in: PubMed

Powell BD, Asirvatham SJ, Perschbacher DL, Jones PW, Cha YM, Cesario DA, Cao M, Gilliam Iii FR, Saxon LA. Noise, Artifact, and Oversensing Related Inappropriate ICD Shock Evaluation: ALTITUDE NOISE Study. Pacing Clin Electrophysiol. 2012 Jul; 35(7):863-9. View in: PubMed

Cao M, Saxon LA. Spinal cord stimulation: a triple threat therapy? J Cardiovasc Electrophysiol. 2012 May; 23(5):541-2. View in: PubMed

Shinbane JS, Shriki J, Hindoyan A, Ghosh B, Chang P, Farvid A, Saxon LA, Cao M, Cesario D, Takahashi M, Colletti PM, Wilcox A, Baker C, Starnes V. Unoperated congenitally corrected transposition of the great arteries, nonrestrictive ventricular septal defect, and pulmonary stenosis in middle adulthood: do multiple wrongs make a right? World J Pediatr Congenit Heart Surg. 2012 Jan 1; 3(1):123-9. View in: PubMed

Saxon LA. Left ventricular versus biventricular for cardiac resynchronization therapy: comparable but not equal. Circulation. 2011 Dec 20; 124(25):2803-4. View in: PubMed

Gilliam FR, Hayes DL, Boehmer JP, Day J, Heidenreich PA, Seth M, Jones PW, Stein KM, Saxon LA. Real world evaluation of dual-zone ICD and CRT-D programming compared to single-zone programming: the ALTITUDE REDUCES study. J Cardiovasc Electrophysiol. 2011 Sep; 22(9):1023-9. View in: PubMed

Hayes DL, Boehmer JP, Day JD, Gilliam FR, Heidenreich PA, Seth M, Jones PW, Saxon LA. Cardiac resynchronization therapy and the relationship of percent biventricular pacing to symptoms and survival. Heart Rhythm. 2011 Sep; 8(9):1469-75. View in: PubMed

Powell BD, Cha YM, Asirvatham SJ, Cesario DA, Cao M, Jones PW, Seth M, Saxon LA, Gilliam FR. Implantable cardioverter defibrillator electrogram adjudication for device registries: methodology and observations from ALTITUDE. Pacing Clin Electrophysiol. 2011 Aug; 34(8):1003-12. View in: PubMed

Hindoyan A, Cao M, Cesario DA, Shinbane JS, Saxon LA. Impact of relaxation training on patient-perceived measures of anxiety, pain, and outcomes after interventional electrophysiology procedures. Pacing Clin Electrophysiol. 2011 Jul; 34(7):821-6. View in: PubMed

Fong MW, Grazette L, Cesario D, Cao M, Saxon L. Treatment of ventricular tachycardia in patients with heart failure. Curr Cardiol Rep. 2011 Jun; 13(3):203-9. View in: PubMed

Cesario DA, Saxon LA, Cao MK, Bowdish M, Cunningham M. Ventricular tachycardia in the era of ventricular assist devices. J Cardiovasc Electrophysiol. 2011 Mar; 22(3):359-63. View in: PubMed

Saxon LA. Cardiovascular care and research in the networked era. J Cardiovasc Transl Res. 2011 Feb; 4(1):1-2. View in: PubMed

Troughton RW, Ritzema J, Eigler NL, Melton IC, Krum H, Adamson PB, Kar S, Shah PK, Whiting JS, Heywood JT, Rosero S, Singh JP, Saxon L, Matthews R, Crozier IG, Abraham WT. Direct left atrial pressure monitoring in severe heart failure: long-term sensor performance. J Cardiovasc Transl Res. 2011 Feb; 4(1):3-13. View in: PubMed

Huang G, Pashmforoush M, Chung B, Saxon LA. The role of cardiac electrophysiology in myocardial regenerative stem cell therapy. J Cardiovasc Transl Res. 2011 Feb; 4(1):61-5. View in: PubMed

Saxon LA, Hayes DL, Gilliam FR, Heidenreich PA, Day J, Seth M, Meyer TE, Jones PW, Boehmer JP. Long-term outcome after ICD and CRT implantation and influence of remote device follow-up: the ALTITUDE survival study. Circulation. 2010 Dec 7; 122(23):2359-67. View in: PubMed

Saxon L. Implant wizard. Interview by Gary Baldwin. Health Data Manag. 2010 Jan; 18(1):40. View in: PubMed

Bar-Cohen Y, Takao CM, Wells WJ, Saxon LA, Cesario DA, Silka MJ. Novel use of a vascular plug to anchor an azygous vein ICD lead. J Cardiovasc Electrophysiol. 2010 Jan; 21(1):99-102. View in: PubMed

Cao MK, Saxon LA. Complete heart block and preserved LV function: does right ventricular pacing site matter? J Cardiovasc Electrophysiol. 2009 Aug; 20(8):906-7. View in: PubMed

Sumner AD, Boehmer JP, Saxon LA, Carson P, Feldman AM, Galle E, Bristow MR. Statin use is associated with improved survival in patients with advanced heart failure receiving resynchronization therapy. Congest Heart Fail. 2009 Jul-Aug; 15(4):159-64. View in: PubMed

Saxon LA, Olshansky B, Volosin K, Steinberg JS, Lee BK, Tomassoni G, Guarnieri T, Rao A, Yong P, Galle E, Leigh J, Ecklund F, Bristow MR. Influence of left ventricular lead location on outcomes in the COMPANION study. J Cardiovasc Electrophysiol. 2009 Jul; 20(7):764-8. View in: PubMed

Saxon LA, Rao AK, Klarich KW. Shortage of female cardiologists: exploring the issues. Mayo Clin Proc. 2008 Sep; 83(9):1022-5. View in: PubMed

De Marco T, Wolfel E, Feldman AM, Lowes B, Higginbotham MB, Ghali JK, Wagoner L, Kirlin PC, Kennett JD, Goel S, Saxon LA, Boehmer JP, Mann D, Galle E, Ecklund F, Yong P, Bristow MR. Impact of cardiac resynchronization therapy on exercise performance, functional capacity, and quality of life in systolic heart failure with QRS prolongation: COMPANION trial sub-study. J Card Fail. 2008 Feb; 14(1):9-18. View in: PubMed

Saxon LA. Survival after tachyarrhythmic arrest--what are we waiting for? N Engl J Med. 2008 Jan 3; 358(1):77-9. View in: PubMed

Saxon LA, Rao AK. Body computing: how networked medical devices can solve problems facing health care today. J Cardiovasc Electrophysiol. 2007 Dec; 18(12):1345-7. View in: PubMed

Ghali JK, Boehmer J, Feldman AM, Saxon LA, Demarco T, Carson P, Yong P, Galle EG, Leigh J, Ecklund FL, Bristow MR. Influence of diabetes on cardiac resynchronization therapy with or without defibrillator in patients with advanced heart failure. J Card Fail. 2007 Nov; 13(9):769-73. View in: PubMed

Friedewald VE, Boehmer JP, Kowal RC, Saxon L, Yancy CW, Roberts WC. The editor's roundtable: Cardiac resynchronization therapy. Am J Cardiol. 2007 Oct 1; 100(7):1145-52. View in: PubMed

Saxon LA. Defining response and defining how we measure response to CRT. J Cardiovasc Electrophysiol. 2007 Sep; 18(10):1020-1. View in: PubMed

Cao M, Shinbane JS, Gillberg JM, Saxon LA, Swerdlow CD. Taser-induced rapid ventricular myocardial capture demonstrated by pacemaker intracardiac electrograms. J Cardiovasc Electrophysiol. 2007 Aug; 18(8):876-9. View in: PubMed

Saxon LA, Boehmer JP, Neuman S, Mullin CM. Remote Active Monitoring in Patients with Heart Failure (RAPID-RF): design and rationale. J Card Fail. 2007 May; 13(4):241-6. View in: PubMed

Saxon LA. Does cardiac resynchronization therapy reduce the incidence of atrial fibrillation, and does atrial fibrillation compromise the cardiac resynchronization therapy effect? Heart Rhythm. 2007 Mar; 4(3 Suppl):S31-3. View in: PubMed

Lindenfeld J, Feldman AM, Saxon L, Boehmer J, Carson P, Ghali JK, Anand I, Singh S, Steinberg JS, Jaski B, DeMarco T, Mann D, Yong P, Galle E, Ecklund F, Bristow M. Effects of cardiac resynchronization therapy with or without a defibrillator on survival and hospitalizations in patients with New York Heart Association class IV heart failure. Circulation. 2007 Jan 16; 115(2):204-12. View in: PubMed

Saxon LA, Bristow MR, Boehmer J, Krueger S, Kass DA, De Marco T, Carson P, DiCarlo L, Feldman AM, Galle E, Ecklund F. Predictors of sudden cardiac death and appropriate shock in the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Trial. Circulation. 2006 Dec 19; 114(25):2766-72. View in: PubMed

Cao M, Saxon LA. Selection of patients for CRT--prevention or reversal of remodeling as a therapeutic endpoint for CRT. J Cardiovasc Electrophysiol. 2006 Dec; 17(12):1293-4. View in: PubMed

Carlson MD, Wilkoff BL, Maisel WH, Carlson MD, Ellenbogen KA, Saxon LA, Prystowsky EN, Alpert JS, Cain ME, Ching EA, Curtis AB, Davies DW, Hammill SC, Hauser RG, Lampert R, Zipes DP. Recommendations from the Heart Rhythm Society Task Force on Device Performance Policies and Guidelines Endorsed by the American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA) and the International Coalition of Pacing and Electrophysiology Organizations (COPE). Heart Rhythm. 2006 Oct; 3(10):1250-73. View in: PubMed

Saxon LA. More is better with cardiac resynchronization therapy--but is it enough? Eur Heart J. 2006 Aug; 27(16):1891-2. View in: PubMed

Saxon LA. Patient selection for primary prevention ICDs--are eps shocking patients into consent? J Card Fail. 2006 Aug; 12(6):413-5. View in: PubMed

Saxon LA, Greenfield RA, Crandall BG, Nydegger CC, Orlov M, VAN Genderen R. Results of the multicenter RENEWAL 3 AVT clinical study of cardiac resynchronization defibrillator therapy in patients with paroxysmal atrial fibrillation. J Cardiovasc Electrophysiol. 2006 May; 17(5):520-5. View in: PubMed

Marcus GM, Rose E, Viloria EM, Schafer J, De Marco T, Saxon LA, Foster E. Septal to posterior wall motion delay fails to predict reverse remodeling or clinical improvement in patients undergoing cardiac resynchronization therapy. J Am Coll Cardiol. 2005 Dec 20; 46(12):2208-14. View in: PubMed

Feldman AM, de Lissovoy G, Bristow MR, Saxon LA, De Marco T, Kass DA, Boehmer J, Singh S, Whellan DJ, Carson P, Boscoe A, Baker TM, Gunderman MR. Cost effectiveness of cardiac resynchronization therapy in the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) trial. J Am Coll Cardiol. 2005 Dec 20; 46(12):2311-21. View in: PubMed

Saxon L. Delayed defibrillation testing after CRT-D implant-weighing competing risks. J Cardiovasc Electrophysiol. 2005 Dec; 16(12):1284-5. View in: PubMed

De Lurgio DB, Foster E, Higginbotham MB, Larntz K, Saxon LA. A comparison of cardiac resynchronization by sequential biventricular pacing and left ventricular pacing to simultaneous biventricular pacing: rationale and design of the DECREASE-HF clinical trial. J Card Fail. 2005 Apr; 11(3):233-9. View in: PubMed

Saxon LA. Sudden cardiac death: epidemiology and temporal trends. Rev Cardiovasc Med. 2005; 6 Suppl 2:S12-20. View in: PubMed

Horwich T, Foster E, De Marco T, Tseng Z, Saxon L. Effects of resynchronization therapy on cardiac function in pacemaker patients "upgraded" to biventricular devices. J Cardiovasc Electrophysiol. 2004 Nov; 15(11):1284-9. View in: PubMed

Saxon LA. Improvement in heart rate turbulence as a measure of response to beta-blocker therapy for heart failure. J Cardiovasc Electrophysiol. 2004 Jul; 15(7):757-8. View in: PubMed

Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, De Marco T, Carson P, DiCarlo L, DeMets D, White BG, DeVries DW, Feldman AM. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med. 2004 May 20; 350(21):2140-50. View in: PubMed

Steinberg JS, Maniar PB, Higgins SL, Whiting SL, Meyer DB, Dubner S, Shah AH, Huang DT, Saxon LA. Noninvasive assessment of the biventricular pacing system. Ann Noninvasive Electrocardiol. 2004 Jan; 9(1):58-70. View in: PubMed

Higgins SL, Hummel JD, Niazi IK, Giudici MC, Worley SJ, Saxon LA, Boehmer JP, Higginbotham MB, De Marco T, Foster E, Yong PG. Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias. J Am Coll Cardiol. 2003 Oct 15; 42(8):1454-9. View in: PubMed

Horwich T, Lee SJ, Saxon L. Usefulness of QRS prolongation in predicting risk of inducible monomorphic ventricular tachycardia in patients referred for electrophysiologic studies. Am J Cardiol. 2003 Oct 1; 92(7):804-9. View in: PubMed

Saxon LA, Ellenbogen KA. Resynchronization therapy for the treatment of heart failure. Circulation. 2003 Sep 2; 108(9):1044-8. View in: PubMed

Hayes DL, Naccarelli GV, Furman S, Parsonnet V, Reynolds D, Goldschlager N, Gillette P, Maloney JD, Saxon L, Leon A, Daoud E. NASPE training requirements for cardiac implantable electronic devices: selection, implantation, and follow-up. Pacing Clin Electrophysiol. 2003 Jul; 26(7 Pt 1):1556-62. View in: PubMed

Lee SJ, McCulloch C, Mangat I, Foster E, De Marco T, Saxon LA. Isolated bundle branch block and left ventricular dysfunction. J Card Fail. 2003 Apr; 9(2):87-92. View in: PubMed

Kumar UN, Saxon LA. Ventricular resynchronization: a promising therapy for heart failure. Am J Geriatr Cardiol. 2003 Jan-Feb; 12(1):41-8. View in: PubMed

Saxon LA. The MIRACLE trial: an electrophysiologist's perspective. J Card Fail. 2002 Aug; 8(4):202-3. View in: PubMed

Saxon LA. Heart failure and Implantable Cardioverter Defibrillator (ICD) therapy: Update and perspective on current primary prevention trials. J Card Fail. 2002 Jun; 8(3):161-6. View in: PubMed

Saxon LA, De Marco T, Schafer J, Chatterjee K, Kumar UN, Foster E. Effects of long-term biventricular stimulation for resynchronization on echocardiographic measures of remodeling. Circulation. 2002 Mar 19; 105(11):1304-10. View in: PubMed

Saxon LA, De Marco T. Arrhythmias associated with dilated cardiomyopathy. Card Electrophysiol Rev. 2002 Feb; 6(1-2):18-25. View in: PubMed

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