Faculty

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Meredith N. Braskie, PhD
Assistant Professor of Research Neurology
Neurology
ISI, 4676 Admiralty Way, Ste. 200 Health Sciences Campus Marina Del Rey
+1 323 442 7246

Overview

My research focus is to evaluate how genetic and environmental risk factors for Alzheimer's disease (AD) relate to brain structure, function, and connectivity throughout adulthood, with an emphasis on cognitively intact adults and those with early mild cognitive impairment. We also seek to understand the biological mechanisms and signaling pathways that may contribute to or protect against AD-related changes, using relevant blood and cerebrospinal fluid measures, and multimodal imaging (structural and functional MRI, diffusion tensor imaging, and PET). When possible, we engage in collaborative research with laboratories investigating similar concepts in a wet lab environment.

Awards

Turken Award for Alzheimer’s Disease Research

Ruth L. Kirschstein National Research Service Award

Achievement Rewards for College Scientists (ARCS) fellowship

Ruth L Kirschstein National Research Service Award

Publications

Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E e4 Carriers: A Review. JAMA Neurol. 2017 Mar 01; 74(3):339-347. View in: PubMed

Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans. J Neurosci. 2017 Feb 15; 37(7):1696-1707. View in: PubMed

Relationship of a common OXTR gene variant to brain structure and default mode network function in healthy humans. Neuroimage. 2017 Feb 15; 147:500-506. View in: PubMed

Independent value added by diffusion MRI for prediction of cognitive function in older adults. Neuroimage Clin. 2017; 14:166-173. View in: PubMed

Cerebral amyloid is associated with greater white-matter hyperintensity accrual in cognitively normal older adults. Neurobiol Aging. 2016 Dec; 48:48-52. View in: PubMed

Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. Neurobiol Aging. 2016 Nov; 47:201-209. View in: PubMed

Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly. Front Aging Neurosci. 2015; 7:221. View in: PubMed

Obesity gene NEGR1 associated with white matter integrity in healthy young adults. Neuroimage. 2014 Nov 15; 102 Pt 2:548-57. View in: PubMed

Physical activity, inflammation, and volume of the aging brain. Neuroscience. 2014 Jul 25; 273:199-209. View in: PubMed

A focus on structural brain imaging in the Alzheimer's disease neuroimaging initiative. Biol Psychiatry. 2014 Apr 01; 75(7):527-33. View in: PubMed

Memory performance and fMRI signal in presymptomatic familial Alzheimer's disease. Hum Brain Mapp. 2013 Dec; 34(12):3308-19. View in: PubMed

Relation between variants in the neurotrophin receptor gene, NTRK3, and white matter integrity in healthy young adults. Neuroimage. 2013 Nov 15; 82:146-53. View in: PubMed

Understanding cognitive deficits in Alzheimer's disease based on neuroimaging findings. Trends Cogn Sci. 2013 Oct; 17(10):510-6. View in: PubMed

Regional brain volume differences in symptomatic and presymptomatic carriers of familial Alzheimer's disease mutations. J Neurol Neurosurg Psychiatry. 2013 Feb; 84(2):154-62. View in: PubMed

Recent advances in imaging Alzheimer's disease. J Alzheimers Dis. 2013; 33 Suppl 1:S313-27. View in: PubMed

How a common variant in the growth factor receptor gene, NTRK1, affects white matter. Bioarchitecture. 2012 Sep-Oct; 2(5):181-4. View in: PubMed

Predicting white matter integrity from multiple common genetic variants. Neuropsychopharmacology. 2012 Aug; 37(9):2012-9. View in: PubMed

Prediction of cognitive decline based on hemispheric cortical surface maps of FDDNP PET. Neuroimage. 2012 Jul 16; 61(4):749-60. View in: PubMed

Relationship of a variant in the NTRK1 gene to white matter microstructure in young adults. J Neurosci. 2012 Apr 25; 32(17):5964-72. View in: PubMed

Dopamine and frontostriatal networks in cognitive aging. Neurobiol Aging. 2012 Mar; 33(3):623. e15-24. View in: PubMed

Increased fMRI signal with age in familial Alzheimer's disease mutation carriers. Neurobiol Aging. 2012 Feb; 33(2):424. e11-21. View in: PubMed

Correlations of striatal dopamine synthesis with default network deactivations during working memory in younger adults. Hum Brain Mapp. 2011 Jun; 32(6):947-61. View in: PubMed

Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci. 2011 May 04; 31(18):6764-70. View in: PubMed

Effects of risk genes on BOLD activation in presymptomatic carriers of familial Alzheimer's disease mutations during a novelty encoding task. Cereb Cortex. 2011 Apr; 21(4):877-83. View in: PubMed

Neuroimaging measures as endophenotypes in Alzheimer's disease. Int J Alzheimers Dis. 2011 Mar 31; 2011:490140. View in: PubMed

Cortical and hippocampal atrophy in patients with autosomal dominant familial Alzheimer's disease. Dement Geriatr Cogn Disord. 2011; 32(2):118-25. View in: PubMed

Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease. Neurobiol Aging. 2010 Oct; 31(10):1669-78. View in: PubMed

Vascular health risks and fMRI activation during a memory task in older adults. Neurobiol Aging. 2010 Sep; 31(9):1532-42. View in: PubMed

Overeating Behavior and Striatal Dopamine with 6-[F]-Fluoro-L-m-Tyrosine PET. J Obes. 2010; 2010. View in: PubMed

FDDNP binding using MR derived cortical surface maps. Neuroimage. 2010 Jan 01; 49(1):240-8. View in: PubMed

Entorhinal cortex structure and functional MRI response during an associative verbal memory task. Hum Brain Mapp. 2009 Dec; 30(12):3981-92. View in: PubMed

Relationship of striatal dopamine synthesis capacity to age and cognition. J Neurosci. 2008 Dec 24; 28(52):14320-8. View in: PubMed

Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers. Neuroimage. 2008 Jul 15; 41(4):1177-83. View in: PubMed

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