Faculty

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Neil Kaplowitz, MD
Professor of Medicine
Usc Associates/Thomas H. Brem Chair in Medicine
Chief, Division of Gastroenterology and Liver Diseases
Medicine
HMR 101 Health Sciences Campus Los Angeles
+1 323 442 5576

Overview

Dr. Kaplowtiz's research interests include drug toxicity, signal transduction, oxidative stress, glutathione metabolism, pathogenesis of alcoholic liver disease, endoplasmic reticulum (ER) stress, and mitochondrial biogenesis.

Dr. Kaplowitz earned his medical degree from New York University School of Medicine. He then went on to complete a Gastroenterology Fellowship at Cornell University Medical College.

Awards

American Liver Foundation: Distinguished Scientific Achievement Award, 2008

Western Society of Clinical Investigation: Mayo Soley Award, 2007

American Association for the Study of Liver Diseases: Distinguished Achievement Award, 2006

Wadworth VA Alumni Association: William H. Oldendorf Lifetime Achievement Award, 2006

American Gastroenterological Association: Foundation Research Mentor Award Honoree, 2005

American Liver Foundation: Greater Los Angeles Medical Honoree, 2000

New York University School of Medicine: Solomon A. Berson Medical Alumni Achievement Award in Clinical Science, 1994

Department of Veterans Affairs : William S. Middleton Award, 1993

NIH: Merit Award, 1992

Association of American Physicians: Member, 1988

Western Gastroenterology : Research Prize, 1986

Publications

Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proc Natl Acad Sci U S A. 2017 Mar 22. View in: PubMed

Protective role of p53 in acetaminophen hepatotoxicity. Free Radic Biol Med. 2017 Feb 11; 106:111-117. View in: PubMed

Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments. PLoS Comput Biol. 2016 Dec; 12(12):e1005253. View in: PubMed

Mitochondrial remodeling in the liver following chronic alcohol feeding to rats. Free Radic Biol Med. 2016 Nov 17. View in: PubMed

A murder mystery in the liver: who done it and how? J Clin Invest. A murder mystery in the liver: who done it and how? J Clin Invest. 2016 Nov 1; 126(11):4068-4071. View in: PubMed

The many faces of RIPK3: What about NASH? Hepatology. The many faces of RIPK3: What about NASH? Hepatology. 2016 Nov; 64(5):1411-1413. View in: PubMed

Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-?B. Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-? B. J Immunol. 2016 Oct 15; 197(8):3120-3129. View in: PubMed

Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria. Antioxid Redox Signal. 2016 Oct 11. View in: PubMed

Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury. J Hepatol. 2016 Sep; 65(3):532-42. View in: PubMed

Reply. Hepatology. 2016 Jul; 64(1):312-3. View in: PubMed

Reply. Hepatology. 2016 Jul; 64(1):308-9. View in: PubMed

Is Sensitivity the Key Measure to Predict Acute Liver Failure in Drug-Induced Liver Injury Patients? Clin Gastroenterol Hepatol. Is Sensitivity the Key Measure to Predict Acute Liver Failure in Drug-Induced Liver Injury Patients? Clin Gastroenterol Hepatol. 2016 Jun; 14(6):918. View in: PubMed

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. Hepatology. 2016 Jun; 63(6):1987-2003. View in: PubMed

HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer. Clin Cancer Res. 2016 Mar 15; 22(6):1371-7. View in: PubMed

Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications. Liver Int. 2016 Feb; 36(2):158-65. View in: PubMed

Questions and controversies: the role of necroptosis in liver disease. Cell Death Discov. 2016; 2:16089. View in: PubMed

Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology. 2015 Dec; 62(6):1847-57. View in: PubMed

Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database. Drug Saf. 2015 Nov; 38(11):1103-13. View in: PubMed

Inhibition of immune tolerance unmasks drug-induced allergic hepatitis. Hepatology. 2015 Aug; 62(2):346-8. View in: PubMed

Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: a systematic review and meta-analysis of clinical trials in advanced cancer patients. Eur J Cancer. 2015 Jul; 51(10):1293-302. View in: PubMed

Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity. J Hepatol. 2015 Jul; 63(1):5-7. View in: PubMed

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. J Hepatol. 2015 Jun; 62(6):1367-74. View in: PubMed

Reply. Gastroenterology. 2015 Feb; 148(2):452-3. View in: PubMed

Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways. J Hepatol. 2015 Jan; 62(1):219-33. View in: PubMed

Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy. Sci Rep. 2015; 5:18017. View in: PubMed

In vitro assays of mitochondrial function/dysfunction. Clin Pharmacol Ther. 2014 Dec; 96(6):665-8. View in: PubMed

Reply. Gastroenterology. 2014 Dec; 147(6):1442. View in: PubMed

The clinical liver safety assessment best practices workshop: rationale, goals, accomplishments and the future. Drug Saf. 2014 Nov; 37 Suppl 1:1-7. View in: PubMed

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. J Hepatol. 2014 Nov; 61(5):1126-34. View in: PubMed

Liver safety assessment in special populations (hepatitis B, C, and oncology trials). Drug Saf. 2014 Nov; 37 Suppl 1:57-62. View in: PubMed

Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology. 2014 Oct; 147(4):765-783. e4. View in: PubMed

Use of Hy's Law and a New Composite Algorithm to Predict Acute Liver Failure in Patients With Drug-Induced Liver Injury. Gastroenterology. 2014 Jul; 147(1):109-118. e5. View in: PubMed

Respiratory Substrates Regulate S-Nitrosylation of Mitochondrial Proteins through a Thiol-Dependent Pathway. Chem Res Toxicol. 2014 May 19; 27(5):794-804. View in: PubMed

JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death. Cell Death Dis. 2014; 5:e989. View in: PubMed

Mechanisms of drug-induced liver injury. Clin Liver Dis. 2013 Nov; 17(4):507-18, vii. View in: PubMed

ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. J Hepatol. 2013 Oct; 59(4):805-13. View in: PubMed

Role of Mitochondria in Alcoholic Liver Disease. Curr Pathobiol Rep. 2013 Sep 1; 1(3):159-168. View in: PubMed

Avoiding idiosyncratic DILI: two is better than one. Hepatology. 2013 Jul; 58(1):15-7. View in: PubMed

Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta. 2013 May; 1830(5):3317-28. View in: PubMed

Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. View in: PubMed

Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem. 2012 Dec 7; 287(50):42165-79. View in: PubMed

Current challenges and controversies in drug-induced liver injury. Drug Saf. 2012 Dec 1; 35(12):1099-117. View in: PubMed

Investigation of chronic alcohol consumption in rodents via ultra-high-performance liquid chromatography-mass spectrometry based metabolite profiling. J Chromatogr A. 2012 Oct 12; 1259:128-37. View in: PubMed

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J Hepatol. 2012 Oct; 57(4):852-9. View in: PubMed

Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology. 2012 Jul; 56(1):130-9. View in: PubMed

Dealing with stress. Hepatology. 2012 Jan; 55(1):3-13. View in: PubMed

c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J Biol Chem. 2011 Oct 7; 286(40):35071-8. View in: PubMed

Recurrent drug-induced liver injury (DILI) with different drugs in the Spanish Registry: the dilemma of the relationship to autoimmune hepatitis. J Hepatol. 2011 Oct; 55(4):820-7. View in: PubMed

Differential effect of gender on hepatic fat. Pediatr Radiol. 2011 Sep; 41(9):1146-53. View in: PubMed

Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice. Hepatology. 2011 Jul; 54(1):229-39. View in: PubMed

Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab. Pharmacogenet Genomics. 2011 Jul; 21(7):365-74. View in: PubMed

Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem. 2011 Jun 24; 286(25):22047-54. View in: PubMed

Case definition and phenotype standardization in drug-induced liver injury. Clin Pharmacol Ther. 2011 Jun; 89(6):806-15. View in: PubMed

The contribution of endoplasmic reticulum stress to liver diseases. Hepatology. 2011 May; 53(5):1752-63. View in: PubMed

Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis. J Proteome Res. 2011 Feb 4; 10(2):705-13. View in: PubMed

Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates. J Biol Chem. 2010 Dec 17; 285(51):39646-54. View in: PubMed

Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria. Mol Interv. 2010 Apr; 10(2):98-111. View in: PubMed

Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem. 2010 Mar 12; 285(11):8244-55. View in: PubMed

Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats. Hepatology. 2010 Mar; 51(3):796-805. View in: PubMed

Signal transduction pathways involved in drug-induced liver injury. Handb Exp Pharmacol. 2010; (196):267-310. View in: PubMed

Diagnosis, management and prevention of drug-induced liver injury. Gut. 2009 Nov; 58(11):1555-64. View in: PubMed

Redox regulation of tumor necrosis factor signaling. Antioxid Redox Signal. 2009 Sep; 11(9):2245-63. View in: PubMed

Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex. Hepatology. 2009 Jun; 49(6):2001-9. View in: PubMed

Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease. Am J Respir Crit Care Med. 2009 May 1; 179(9):835-42. View in: PubMed

Glutathione in liver diseases and hepatotoxicity. Mol Aspects Med. 2009 Feb-Apr; 30(1-2):29-41. View in: PubMed

How to protect against acetaminophen: don't ask for JUNK. Gastroenterology. 2008 Oct; 135(4):1047-51. View in: PubMed

Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates. Gastroenterology. 2008 Oct; 135(4):1168-75. View in: PubMed

Clinical risk factors for portopulmonary hypertension. Hepatology. 2008 Jul; 48(1):196-203. View in: PubMed

Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C50-63. View in: PubMed

Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver. Alcohol Clin Exp Res. 2008 Jun; 32(6):1049-58. View in: PubMed

Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem. 2008 May 16; 283(20):13565-77. View in: PubMed

Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes. Hepatology. 2007 Nov; 46(5):1586-96. View in: PubMed

Endoplasmic reticulum stress and liver injury. Semin Liver Dis. 2007 Nov; 27(4):367-77. View in: PubMed

Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms. J Biol Chem. 2007 Oct 5; 282(40):29470-81. View in: PubMed

Mechanisms of drug-induced liver disease. Clin Liver Dis. 2007 Aug; 11(3):459-75, v. View in: PubMed

Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am J Clin Nutr. 2007 Jul; 86(1):14-24. View in: PubMed

Drug-induced liver injury. Drug Saf. 2007; 30(4):277-94. View in: PubMed

Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry. Hepatology. 2006 Dec; 44(6):1581-8. View in: PubMed

Current concepts and controversies in the treatment of alcoholic hepatitis. World J Gastroenterol. 2006 Nov 21; 12(43):6909-21. View in: PubMed

Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model. J Hepatol. 2006 Nov; 45(5):717-24. View in: PubMed

Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum. J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S7-9. View in: PubMed

Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis. Free Radic Biol Med. 2006 Aug 15; 41(4):627-39. View in: PubMed

Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol. 2006 Aug; 2(4):493-503. View in: PubMed

ER stress: can the liver cope? J Hepatol. ER stress: can the liver cope? J Hepatol. 2006 Aug; 45(2):321-33. View in: PubMed

Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA. 2006 Jul 5; 296(1):87-93. View in: PubMed

Mechanisms of liver injury. III. Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 291(1):G1-7. View in: PubMed

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology. 2006 Jul; 131(1):165-78. View in: PubMed

Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology. 2006 Jun; 43(6):1220-30. View in: PubMed

Drug hepatotoxicity. Clin Liver Dis. 2006 May; 10(2):207-17, vii. View in: PubMed

Rules and laws of drug hepatotoxicity. Pharmacoepidemiol Drug Saf. 2006 Apr; 15(4):231-3. View in: PubMed

Liver biology and pathobiology. Hepatology. 2006 Feb; 43(2 Suppl 1):S235-8. View in: PubMed

Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding. Alcohol Clin Exp Res. 2005 Aug; 29(8):1496-503. View in: PubMed

Idiosyncratic drug hepatotoxicity. Nat Rev Drug Discov. 2005 Jun; 4(6):489-99. View in: PubMed

Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicol Appl Pharmacol. 2005 May 1; 204(3):263-73. View in: PubMed

Serum alanine aminotransferase in skeletal muscle diseases. Hepatology. 2005 Feb; 41(2):380-2. View in: PubMed

Marked elevation in serum transaminases: an atypical presentation of choledocholithiasis. Am J Gastroenterol. 2005 Feb; 100(2):295-8. View in: PubMed

Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology. 2004 Dec; 127(6):1760-74. View in: PubMed

Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid. J Hepatol. 2004 Dec; 41(6):1062-4. View in: PubMed

Statin-induced hepatotoxicity. Gastroenterology. 2004 Oct; 127(4):1278; author reply 1278-9. View in: PubMed

Liver injury associated with the beta-interferons for MS. Neurology. 2004 Sep 28; 63(6):1142-3; author reply 1142-3. View in: PubMed

Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. Hepatology. 2004 Aug; 40(2):442-51. View in: PubMed

Acetaminophen hepatoxicity: what do we know, what don't we know, and what do we do next? Hepatology. Acetaminophen hepatoxicity: what do we know, what don't we know, and what do we do next? Hepatology. 2004 Jul; 40(1):23-6. View in: PubMed

Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury. World J Gastroenterol. 2004 Jun 15; 10(12):1699-708. View in: PubMed

Clinical perspectives on xenobiotic-induced hepatotoxicity. Drug Metab Rev. 2004 May; 36(2):301-12. View in: PubMed

Drug-induced liver injury. Clin Infect Dis. 2004 Mar 1; 38 Suppl 2:S44-8. View in: PubMed

Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress. Biochem Pharmacol. 2004 Feb 1; 67(3):439-51. View in: PubMed

Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells. Am J Physiol Gastrointest Liver Physiol. 2003 Dec; 285(6):G1335-44. View in: PubMed

Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria. Mol Pharmacol. 2003 Nov; 64(5):1136-44. View in: PubMed

Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion. Hepatology. 2003 Sep; 38(3):692-702. View in: PubMed

Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes. Hepatology. 2003 Jun; 37(6):1425-34. View in: PubMed

Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology. 2003 May; 124(5):1488-99. View in: PubMed

Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology. 2003 Mar; 124(3):708-24. View in: PubMed

Did this drug cause my patient's hepatitis? Ann Intern Med. 2003 Jan 21; 138(2):159-60; author reply 159-60. View in: PubMed

Hepatic reactions during treatment of multiple sclerosis with interferon-beta-1a: incidence and clinical significance. Drug Saf. 2003; 26(11):815-27. View in: PubMed

Immune-mediated drug-induced liver disease. Clin Liver Dis. 2002 Aug; 6(3):755-74. View in: PubMed

Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes. Hepatology. 2002 Jul; 36(1):55-64. View in: PubMed

Mechanism of staurosporine-induced apoptosis in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2002 May; 282(5):G825-34. View in: PubMed

The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane. Mol Pharmacol. 2002 Feb; 61(2):425-35. View in: PubMed

Biochemical and cellular mechanisms of toxic liver injury. Semin Liver Dis. 2002; 22(2):137-44. View in: PubMed

Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione. Hepatology. 2001 Nov; 34(5):964-71. View in: PubMed

How is the liver primed or sensitized for alcoholic liver disease? Alcohol Clin Exp Res. How is the liver primed or sensitized for alcoholic liver disease? Alcohol Clin Exp Res. 2001 May; 25(5 Suppl ISBRA):171S-181S. View in: PubMed

Regulation of GSH in alphaA-expressing human lens epithelial cell lines and in alphaA knockout mouse lenses. Invest Ophthalmol Vis Sci. 2001 Feb; 42(2):409-16. View in: PubMed

Causality assessment versus guilt-by-association in drug hepatotoxicity. Hepatology. 2001 Jan; 33(1):308-10. View in: PubMed

Drug-induced liver disorders: implications for drug development and regulation. Drug Saf. 2001; 24(7):483-90. View in: PubMed

Radiation inactivation studies of hepatic sinusoidal reduced glutathione transport system. Biochim Biophys Acta. 2000 Apr 5; 1464(2):207-18. View in: PubMed

Colchicine protects mice from the lethal effect of an agonistic anti-Fas antibody. J Clin Invest. 2000 Feb; 105(3):329-39. View in: PubMed

Cell death at the millennium. Implications for liver diseases. Clin Liver Dis. 2000 Feb; 4(1):1-23, v. View in: PubMed

GSH transport in human cerebrovascular endothelial cells and human astrocytes: evidence for luminal localization of Na+-dependent GSH transport in HCEC. Brain Res. 2000 Jan 10; 852(2):374-82. View in: PubMed

Mechanisms of liver cell injury. J Hepatol. 2000; 32(1 Suppl):39-47. View in: PubMed

Avoiding hepatic injury from drugs. Gastroenterology. 1999 Oct; 117(4):759. View in: PubMed

GSH transport in immortalized mouse brain endothelial cells: evidence for apical localization of a sodium-dependent GSH transporter. J Neurochem. 1999 Jul; 73(1):390-9. View in: PubMed

Hepatotoxicity of psychotropic drugs. Hepatology. 1999 May; 29(5):1347-51. View in: PubMed

Protection from oxidant injury by sodium-dependent GSH uptake in retinal Müller cells. Exp Eye Res. 1999 May; 68(5):609-16. View in: PubMed

Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology. 1998 Dec; 115(6):1541-51. View in: PubMed

Glutathione transport in immortalized HLE cells and expression of transport in HLE cell poly(A)+ RNA-injected Xenopus laevis oocytes. Invest Ophthalmol Vis Sci. 1998 Jul; 39(8):1379-86. View in: PubMed

Novel properties of hepatic canalicular reduced glutathione transport revealed by radiation inactivation. Am J Physiol. 1998 May; 274(5 Pt 1):G923-30. View in: PubMed

Role of the liver in interorgan homeostasis of glutathione and cyst(e)ine. Semin Liver Dis. 1998; 18(4):313-29. View in: PubMed

Changes in glutathione homeostasis during liver regeneration in the rat. Hepatology. 1998 Jan; 27(1):147-53. View in: PubMed

Mitochondrial glutathione: importance and transport. Semin Liver Dis. 1998; 18(4):389-401. View in: PubMed

Hepatotoxicity of herbal remedies: insights into the intricacies of plant-animal warfare and cell death. Gastroenterology. 1997 Oct; 113(4):1408-12. View in: PubMed

Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-L-methionine. Hepatology. 1997 Sep; 26(3):699-708. View in: PubMed

GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect. Am J Physiol. 1997 Jul; 273(1 Pt 1):G7-17. View in: PubMed

Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains. Biochem Pharmacol. 1997 May 9; 53(9):1339-45. View in: PubMed

Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epithelium. Exp Eye Res. 1997 Apr; 64(4):615-26. View in: PubMed

Progressive defect in biliary GSH secretion in streptozotocin-induced diabetic rats. Am J Physiol. 1997 Feb; 272(2 Pt 1):G374-82. View in: PubMed

Oxidative stress and alcoholic liver disease. Alcohol Health Res World. 1997; 21(4):321-4. View in: PubMed

Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium. Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2269-75. View in: PubMed

Alterations in glutathione homeostasis in mutant Eisai hyperbilirubinemic rats. Hepatology. 1996 Jul; 24(1):253-8. View in: PubMed

Inhibition of rat sinusoidal GSH transporter by thioethers: specificity, sidedness, and kinetics. Am J Physiol. 1996 Jun; 270(6 Pt 1):G969-75. View in: PubMed

Evidence that interference with binding to hepatic cytosol binders can inhibit bile acid excretion in rats. Hepatology. 1996 Jun; 23(6):1642-9. View in: PubMed

GSH transporters: molecular characterization and role in GSH homeostasis. Biol Chem Hoppe Seyler. 1996 May; 377(5):267-73. View in: PubMed

Plasma membrane and mitochondrial transport of hepatic reduced glutathione. Semin Liver Dis. 1996 May; 16(2):147-58. View in: PubMed

Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. Expression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. J Biol Chem. 1996 Apr 19; 271(16):9754-8. View in: PubMed

Role of two recently cloned rat liver GSH transporters in the ubiquitous transport of GSH in mammalian cells. J Clin Invest. 1996 Mar 15; 97(6):1488-96. View in: PubMed

Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease. Hepatology. 1996 Mar; 23(3):589-99. View in: PubMed

Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: physiologic importance and manipulations. Exp Eye Res. 1996 Jan; 62(1):29-37. View in: PubMed

Oxidative stress and liver disease. Prog Liver Dis. 1996; 14:131-59. View in: PubMed

Mechanisms of drug-induced liver disease. Gastroenterol Clin North Am. 1995 Dec; 24(4):787-810. View in: PubMed

Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes. Mol Pharmacol. 1995 Nov; 48(5):825-34. View in: PubMed

Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters. Toxicol Appl Pharmacol. 1995 Oct; 134(2):264-72. View in: PubMed

Molecular characterization of a reduced glutathione transporter in the lens. Invest Ophthalmol Vis Sci. 1995 Aug; 36(9):1785-92. View in: PubMed

Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathione. Expression studies in Xenopus laevis oocytes. J Biol Chem. 1995 Jul 7; 270(27):15946-9. View in: PubMed

Expression cloning of the cDNA for a polypeptide associated with rat hepatic sinusoidal reduced glutathione transport: characteristics and comparison with the canalicular transporter. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1495-9. View in: PubMed

Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes. Hepatology. 1995 Jan; 21(1):207-14. View in: PubMed

Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye. Exp Eye Res. 1994 Oct; 59(4):487-96. View in: PubMed

Specificity and directionality of thiol effects on sinusoidal glutathione transport in rat liver. Mol Pharmacol. 1994 Sep; 46(3):578-85. View in: PubMed

Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. J Clin Invest. 1994 Jul; 94(1):193-201. View in: PubMed

Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain. Biochem Biophys Res Commun. 1994 May 30; 201(1):402-8. View in: PubMed

Role of BSP/bilirubin binding protein and bilitranslocase in glutathione uptake in rat basolateral liver plasma membrane vesicles. Biochem Biophys Res Commun. 1994 Apr 29; 200(2):1079-85. View in: PubMed

Expression cloning of a rat hepatic reduced glutathione transporter with canalicular characteristics. J Clin Invest. 1994 Apr; 93(4):1841-5. View in: PubMed

Distribution of 3 alpha-hydroxysteroid dehydrogenase (bile acid binder) in rat small intestine: comparison with glutathione S-transferase subunits. J Gastroenterol. 1994 Apr; 29(2):115-9. View in: PubMed

Bidirectional membrane transport of intact glutathione in Hep G2 cells. Am J Physiol. 1993 Dec; 265(6 Pt 1):G1128-34. View in: PubMed

Mitochondrial glutathione depletion in alcoholic liver disease. Alcohol. 1993 Nov-Dec; 10(6):469-75. View in: PubMed

Identification and purification of a human liver cytosolic tocopherol binding protein. Protein Expr Purif. 1993 Oct; 4(5):382-9. View in: PubMed

Thiol-disulfide effects on hepatic glutathione transport. Studies in cultured rat hepatocytes and perfused livers. J Clin Invest. 1993 Sep; 92(3):1188-97. View in: PubMed

Selective induction by phenobarbital of the electrogenic transport of glutathione and organic anions in rat liver canalicular membrane vesicles. J Biol Chem. 1993 May 25; 268(15):10836-41. View in: PubMed

Expression of rat liver reduced glutathione transport in Xenopus laevis oocytes. J Biol Chem. 1993 Feb 5; 268(4):2324-8. View in: PubMed

Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology. 1992 Dec; 16(6):1423-7. View in: PubMed

Transport of glutathione at blood-brain barrier of the rat: inhibition by glutathione analogs and age-dependence. J Pharmacol Exp Ther. 1992 Dec; 263(3):964-70. View in: PubMed

Bidirectional mechanism of plasma membrane transport of reduced glutathione in intact rat hepatocytes and membrane vesicles. J Biol Chem. 1992 Nov 5; 267(31):22256-64. View in: PubMed

Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat. Studies in cultured hepatocytes and in vivo. J Clin Invest. 1992 Aug; 90(2):524-32. View in: PubMed

The relationship between biliary secretion of bilirubin and glutathione in the rat. Gastroenterol Jpn. 1992 Jun; 27(3):369-73. View in: PubMed

Neutrophil accumulation in ischemic reperfused rat liver: evidence for a role for superoxide free radicals. Am J Physiol. 1992 Apr; 262(4 Pt 1):G669-76. View in: PubMed

Identification, purification, and immunochemical characterization of a tocopherol-binding protein in rat liver cytosol. J Lipid Res. 1992 Mar; 33(3):343-50. View in: PubMed

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Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat. J Clin Invest. 1990 Jun; 85(6):2009-13. View in: PubMed

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Oxidation and reduction of bile acid precursors by rat hepatic 3 alpha-hydroxysteroid dehydrogenase and inhibition by bile acids and indomethacin. Biochim Biophys Acta. 1990 Apr 2; 1043(2):153-6. View in: PubMed

Relationship between the newly identified bile acid binder and bile acid oxidoreductases in human liver. J Biol Chem. 1990 Feb 5; 265(4):2132-6. View in: PubMed

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The role of cytoplasmic proteins in hepatic bile acid transport. Annu Rev Physiol. 1989; 51:161-76. View in: PubMed

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Inhibition of glutathione efflux in the perfused rat liver and isolated hepatocytes by organic anions and bilirubin. Kinetics, sidedness, and molecular forms. J Clin Invest. 1988 Aug; 82(2):608-16. View in: PubMed

Comparison of the effects of bile acids and GSH on the fluorescence of bound 1-anilino-8-naphthalene sulfonate and the enzymatic activity of cationic and neutral human hepatic GSH S-transferases. Biochim Biophys Acta. 1988 Apr 28; 954(1):37-43. View in: PubMed

Comparison of the binding sites of GSH S-transferases of the Ya- and Yb-subunit classes: effect of glutathione on the binding of bile acids. J Lipid Res. 1988 Mar; 29(3):279-86. View in: PubMed

Effect of age on the sinusoidal release of hepatic glutathione from the perfused rat liver. Biochem Pharmacol. 1987 Nov 15; 36(22):4015-7. View in: PubMed

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Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by 3 alpha-hydroxysteroid dehydrogenase. II. Studies in the prograde and retrograde single-pass, perfused rat liver and inhibition by indomethacin. J Clin Invest. 1987 Sep; 80(3):861-6. View in: PubMed

Effect of chronic ethanol feeding on rat hepatocytic glutathione. Compartmentation, efflux, and response to incubation with ethanol. J Clin Invest. 1987 Jul; 80(1):57-62. View in: PubMed

A serologic follow-up of the 1942 epidemic of post-vaccination hepatitis in the United States Army. N Engl J Med. 1987 Apr 16; 316(16):965-70. View in: PubMed

Trans-stimulation and driving forces for GSH transport in sinusoidal membrane vesicles from rat liver. Biochem Biophys Res Commun. 1987 Feb 27; 143(1):377-82. View in: PubMed

3 alpha-hydroxysteroid dehydrogenase activity of the Y' bile acid binders in rat liver cytosol. Identification, kinetics, and physiologic significance. J Clin Invest. 1987 Feb; 79(2):427-34. View in: PubMed

Subunit heterogeneity of cationic human hepatic glutathione S-transferases. Pharmacology. 1987; 35(2):65-78. View in: PubMed

Binding of bile acids, oleic acid, and organic anions by rat and human hepatic Z protein. Arch Biochem Biophys. 1986 Nov 15; 251(1):385-92. View in: PubMed

Purification of a 32. 5 kDa monomeric sulfotransferase from rat liver with activity for bile acids and phenolic steroids. FEBS Lett. 1986 Oct 27; 207(2):193-7. View in: PubMed

Mechanism of inhibition of glutathione efflux by methionine from isolated rat hepatocytes. Am J Physiol. 1986 Sep; 251(3 Pt 1):G354-61. View in: PubMed

Binding of bile acids by glutathione S-transferases from rat liver. J Lipid Res. 1986 Sep; 27(9):955-66. View in: PubMed

Comparison of the affinities of newly identified human bile acid binder and cationic glutathione S-transferase for bile acids. J Lipid Res. 1986 Jun; 27(6):652-7. View in: PubMed

Drug-induced hepatotoxicity. Ann Intern Med. 1986 Jun; 104(6):826-39. View in: PubMed

Cytosolic bile acid binding protein in rat liver: radioimmunoassay, molecular forms, developmental characteristics and organ distribution. Hepatology. 1986 May-Jun; 6(3):433-9. View in: PubMed

Kinetics of glutathione efflux from isolated rat hepatocytes. Am J Physiol. 1986 Feb; 250(2 Pt 1):G236-43. View in: PubMed

Organic anion-binding by human hepatic GSH S-transferases. Biochem Pharmacol. 1986 Jan 15; 35(2):354-6. View in: PubMed

Gamma-glutamylcysteine: a substrate for glutathione S-transferases. Biochem Pharmacol. 1985 Oct 15; 34(20):3643-7. View in: PubMed

Modulating effect of thiol-disulfide status on [14C]aminopyrine accumulation in the isolated parietal cell. J Biol Chem. 1985 Jul 5; 260(13):8020-5. View in: PubMed

Acetaldehyde-dependent oxidation of glutathione catalyzed by rat liver cytosol. Biochem Biophys Res Commun. 1985 Jun 28; 129(3):949-57. View in: PubMed

Disease-specific amino acid infusion (F080) in hepatic encephalopathy: a prospective, randomized, double-blind, controlled trial. JPEN J Parenter Enteral Nutr. 1985 May-Jun; 9(3):288-95. View in: PubMed

The regulation of hepatic glutathione. Annu Rev Pharmacol Toxicol. 1985; 25:715-44. View in: PubMed

Sinusoidal efflux of glutathione in the perfused rat liver. Evidence for a carrier-mediated process. J Clin Invest. 1985 Jan; 75(1):258-65. View in: PubMed

Identification and partial purification of a unique phenolic steroid sulphotransferase in rat liver cytosol. Biochem J. 1984 Dec 15; 224(3):947-53. View in: PubMed

Identification and purification of a 36 kDa bile acid binder in human hepatic cytosol. FEBS Lett. 1984 Nov 5; 177(1):31-5. View in: PubMed

Evidence for a common high affinity binding site on glutathione S-transferase B for lithocholic acid and bilirubin. J Lipid Res. 1984 Nov; 25(11):1177-83. View in: PubMed

Comparison of the binding affinities of five forms of rat glutathione S-transferases for bilirubin, sulfobromophthalein and hematin. Biochem Pharmacol. 1984 Nov 1; 33(21):3511-3. View in: PubMed

Comparison of binding of thyroid hormone analogues to hepatic organic anion binding proteins. Biochim Biophys Acta. 1984 Sep 28; 801(2):184-8. View in: PubMed

Role of glutathione in gastric mucosal cytoprotection. Am J Physiol. 1984 Sep; 247(3 Pt 1):G296-304. View in: PubMed

Inhibition of glutathione efflux from isolated rat hepatocytes by methionine. J Biol Chem. 1984 Aug 10; 259(15):9355-8. View in: PubMed

Quantitation and characterization of a newly described organic anion binder by radioimmunoassay. Biochim Biophys Acta. 1984 Jul 30; 800(2):171-7. View in: PubMed

Binding of glutathione by rat liver cytosol. Pharmacology. 1984; 28(2):61-6. View in: PubMed

Newly identified bile acid binders in rat liver cytosol. Purification and comparison with glutathione S-transferases. J Biol Chem. 1983 Mar 25; 258(6):3602-7. View in: PubMed

Factors influencing the efflux of hepatic glutathione into bile in rats. J Pharmacol Exp Ther. 1983 Jan; 224(1):141-7. View in: PubMed

Newly identified organic anion-binding proteins in rat liver cytosol. Biochim Biophys Acta. 1982 Dec 20; 709(2):342-52. View in: PubMed

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Identification of hepatic Z-protein in a marine elasmobranch, Platyrhinoides triseriata. Biochem J. 1982 May 1; 203(2):377-81. View in: PubMed

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The importance and regulation of hepatic glutathione. Yale J Biol Med. 1981 Nov-Dec; 54(6):497-502. View in: PubMed

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Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology. 1981 Sep-Oct; 1(5):431-5. View in: PubMed

The hepatocellular uptake and biliary excretion of endotoxin in the rat. Hepatology. 1981 Sep-Oct; 1(5):401-7. View in: PubMed

Halothane-induced hepatic disease. Semin Liver Dis. 1981 May; 1(2):134-42. View in: PubMed

Rapid oxidation in vitro of endogenous and exogenous glutathione in bile of rats. J Biol Chem. 1981 Mar 10; 256(5):2115-7. View in: PubMed

Direct protection against acetaminophen hepatotoxicity by propylthiouracil. In vivo and in vitro studies in rats and mice. J Clin Invest. 1981 Mar; 67(3):688-95. View in: PubMed

Glutathione-dependent thyroxine 5'-monodeiodination modulates growth hormone production by cultured nonthyrotropic rat pituitary cells. Endocrinology. 1981 Mar; 108(3):970-6. View in: PubMed

Extrahepatic obstruction in chronic alcoholic pancreatitis. Alcohol Clin Exp Res. 1981 Jan; 5(1):110-8. View in: PubMed

Liver histopathology in chronic common bile duct stenosis due to chronic alcoholic pancreatitis. Hepatology. 1981 Jan-Feb; 1(1):65-72. View in: PubMed

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Effect of pyridoxine deficiency on serum and liver transaminases in experimental liver injury in the rat. Gastroenterology. 1980 Sep; 79(3):545-9. View in: PubMed

Estimation of glutathione in rat liver by reversed-phase high-performance liquid chromatography: separation from cysteine and gamma-glutamylcysteine. J Chromatogr. 1980 Jun 27; 194(3):424-8. View in: PubMed

Bile acid tolerance tests: rationale. Gastroenterology. 1980 Jun; 78(6):1654-5. View in: PubMed

Inhibition of hepatic metabolism of azathioprine by furosemide in human liver in vitro. Biochem Pharmacol. 1980 May 15; 29(10):1439-41. View in: PubMed

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Binding of ethacrynic acid to hepatic glutathione S-transferases in vivo in the rat. Biochem Pharmacol. 1980 Apr 15; 29(8):1205-8. View in: PubMed

Effect of salicylates and phenobarbital on hepatic glutathione in the rat. J Pharmacol Exp Ther. 1980 Feb; 212(2):240-5. View in: PubMed

Common bile duct stenosis from chronic pancreatitis: a clinical and pathologic spectrum. Medicine (Baltimore). 1979 Nov; 58(6):385-412. View in: PubMed

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Significance of microscopic cholangitis in alcoholic liver disease. Gastroenterology. 1978 Dec; 75(6):1045-50. View in: PubMed

Aplastic anemia associated with type B viral hepatitis. Arch Intern Med. 1978 Oct; 138(10):1557-8. View in: PubMed

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The effect of phenobarbital, probenecid and diethyl maleate on the pharmaco-kinetics and biliary excretion of ethacrynic acid in the rat. J Pharmacol Exp Ther. 1978 May; 205(2):471-9. View in: PubMed

Glutathione S-transferase in human lymphoid cell lines and fractionated peripheral leucocytes. Biochem J. 1978 Mar 1; 169(3):465-70. View in: PubMed

Inhibition of hepatic metabolism of azathioprine in vivo. Gastroenterology. 1978 Jan; 74(1):90-2. View in: PubMed

Effect of dietary phenobarbital, 3,4-benzo(alpha)pyrene and 3-methylcholanthrene on hepatic, intestinal and renal glutathione s-transferase activities in the rat. Biochem Pharmacol. 1978; 27(8):1284-7. View in: PubMed

Endocrine and metabolic alterations with food and water deprivation. Am J Clin Nutr. 1977 Dec; 30(12):1953-62. View in: PubMed

Interaction of azathioprine and glutathione in the liver of the rat. J Pharmacol Exp Ther. 1977 Mar; 200(3):479-86. View in: PubMed

The glutathione S-transferases of the small intestine in the rat. Cancer Res. 1977 Mar; 37(3):788-91. View in: PubMed

Metabolic clearance of furosemide in the rat. J Pharmacol Exp Ther. 1977 Jan; 200(1):52-7. View in: PubMed

Enzymatic thiolysis of azathioprine in vitro. Biochem Pharmacol. 1976 Nov 1; 25(21):2421-6. View in: PubMed

Comparison of renal and hepatic glutathione S-transferases in the rat. Biochem J. 1976 Aug 15; 158(2):243-8. View in: PubMed

Drug induction and sex differences of renal glutathione S-transferases in the rat. Biochem J. 1975 Aug; 150(2):259-62. View in: PubMed

Hepatic glutathione S-transferases: identification by gel filtration and in vitro inhibition by organic anions. Proc Soc Exp Biol Med. 1975 May; 149(1):234-7. View in: PubMed

Drug induction of hepatic glutathione S-transferases in male and female rats*. Biochem J. 1975 Feb; 146(2):351-6. View in: PubMed

Malabsorption secondary to mesenteric ischemia. Am J Roentgenol Radium Ther Nucl Med. 1973 Oct; 119(2):352-8. View in: PubMed

Role of hepatic anion-binding protein in bromsulphthalein conjugation. J Exp Med. 1973 Aug 1; 138(2):483-7. View in: PubMed

Postprandial serum bile acid for the detection of hepatobiliary disease. JAMA. 1973 Jul 16; 225(3):292-3. View in: PubMed

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Isolation of erythrocytes with normal protoporphyrin levels in erythropoietic protoporphyria. N Engl J Med. 1968 May 16; 278(20):1077-81. View in: PubMed

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