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Nuria Maria Pastor-Soler, MD, PhD
Associate Professor of Medicine
Assistant Dean For Research Mentoring
IRD 2020 Zonal Ave Off Campus Los Angeles


Dr. Pastor-Soler's research interests include regulation acid-base homeostasis by the kidney and the study of the vacuolar proton ATPase (V-ATPase) in the kidney and the male reproductive tract. Other research projects in her laboratory study the regulation of sodium transport in the collecting duct by bicarbonate-regulated sAC, and renal salt transport regulation by WNK kinases, to name a few. She is currently studying the molecular and cellular mechanisms by which metabolic pathways in the kidney are affected by acidosis, a known predictor of CKD progression. She is also studying renal cell carcinomas with the aim to confirm a novel biomarker that could be used clinically to assess the presence and severity of this disease.

Dr. Pastor-Soler earned her medical degree from Jefferson Medical College. She then went on to complete her PhD in Biochemistry and Molecular Biology at Jefferson. Dr. Pastor-Soler completed her Nephrology Fellowship at the Brigham and Women's/Massachusetts General Hospital program. She is currently Associate Professor of Medicine in the Division of Nephrology and Hypertension and Assistant Dean for Research Mentoring at Keck School of Medicine of USC. She is also the Director of the Required Scholarly Project Program.


Armand Hammer United World College: Full Scholarship, 1984-1986

American Physiological Society: Career Enhancement Award, 2011

American Society of Nephrology: Fellow, 2005

Thomas Jefferson University: Gibbon Scholar, 1989-1996

Bryn Mawr College: Full Scholarship, 1986-1989

Claflin: Distinguished Scholar Award, 2005

Abigail Van Buren Scholarship

American Society for Clinical Investigation: Member, 2012

American Society of Nephrology: Carl W. Gottschalk Research Scholar Grant, 2009

P. and E. Brown Foerderer Foundation: Fellowship, 1990-1991

Dorothy Nepper Marshall Teacher Apprenticeship: Scholar, 1988-1989

Department of Medicine, University of Pittsburgh: Junior Scholar Award, 2012-2014

Haverford College: Pew Summer Research Foundation Fellowship, 1988

Telluride Epithelial Physiology Workshop: Research Recognition Award, 2012

Council for the Kidney in Cardiovascular Disease, American Heart Association: Elected to Vice-Chair, 2014

American Physiological Society: Renal Section, Young Investigator Award, 2012

American Physiological Society: Renal Section, New Investigator Award, 2009

Council for the Kidney in Cardiovascular Disease, American Heart Association: Chair, 2016

Council for the Kidney in Cardiovascular Disease, American Heart Association: Elected to Vice-Chair, 2014-2016

Massachusetts General Hospital: Claflin Distinguished Scholar Award, 2005

Women in Nephrology: President, 2016


Mo D, Costa SA, Ihrke G, Youker RT, Pastor-Soler N, Hughey RP, Weisz OA. Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9-dependent mechanism. Mol Biol Cell. 2012 Sep; 23(18):3636-46. View in: PubMed

Rondanino C, Poland PA, Kinlough CL, Li H, Rbaibi Y, Myerburg MM, Al-bataineh MM, Kashlan OB, Pastor-Soler NM, Hallows KR, Weisz OA, Apodaca G, Hughey RP. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011 Sep; 301(3):F622-33. View in: PubMed

Estilo G, Liu W, Pastor-Soler N, Mitchell P, Carattino MD, Kleyman TR, Satlin LM. Effect of aldosterone on BK channel expression in mammalian cortical collecting duct. Am J Physiol Renal Physiol. 2008 Sep; 295(3):F780-8. View in: PubMed

Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, Brown D, Pastor-Soler N, Ameen N, Laprade R, Ramesh V, Breton S. Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9. J Biol Chem. 2008 Feb 1; 283(5):2986-96. View in: PubMed

Pastor-Soler N, Piétrement C, Breton S. Role of acid/base transporters in the male reproductive tract and potential consequences of their malfunction. Physiology (Bethesda). 2005 Dec; 20:417-28. View in: PubMed

Bouley R, Pastor-Soler N, Cohen O, McLaughlin M, Breton S, Brown D. Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra). Am J Physiol Renal Physiol. 2005 Jun; 288(6):F1103-12. View in: PubMed

Beaulieu V, Da Silva N, Pastor-Soler N, Brown CR, Smith PJ, Brown D, Breton S. Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling. J Biol Chem. 2005 Mar 4; 280(9):8452-63. View in: PubMed

Silberstein C, Bouley R, Huang Y, Fang P, Pastor-Soler N, Brown D, Van Hoek AN. Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells. Am J Physiol Renal Physiol. 2004 Sep; 287(3):F501-11. View in: PubMed

Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S. Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem. 2003 Dec 5; 278(49):49523-9. View in: PubMed

van Balkom BW, van Raak M, Breton S, Pastor-Soler N, Bouley R, van der Sluijs P, Brown D, Deen PM. Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells. J Biol Chem. 2003 Jan 10; 278(2):1101-7. View in: PubMed

Fisher JS, Pastor-Soler N, Sharpe RM, Breton S. Modulation of the onset of postnatal development of H(+)-ATPase-rich cells by steroid hormones in rat epididymis. Biol Reprod. 2002 Oct; 67(4):1106-14. View in: PubMed

Pastor-Soler N, Isnard-Bagnis C, Herak-Kramberger C, Sabolic I, Van Hoek A, Brown D, Breton S. Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens. Biol Reprod. 2002 Jun; 66(6):1716-22. View in: PubMed

Emlet DR, Pastor-Soler N, Marciszyn A, Wen X, Gomez H, Humphries WH, Morrisroe S, Volpe JK, Kellum JA. Insulin-Like Growth Factor Binding Protein 7 and Tissue Inhibitor of Metalloproteinases-2: Differential Expression and Secretion in Human Kidney Tubule Cells. Am J Physiol Renal Physiol. 2016 Dec 21; ajprenal. 00271. 2016. View in: PubMed

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