Faculty

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Shuping Zhong, PhD
Associate Professor of Research Biochemistry & Molecular Biology
Medicine
HMR 604 2011 Zonal Avenue Health Sciences Campus Los Angeles
+1 323 442 1141

Overview

Shuping Zhong, Ph.D. received his master degree at Fudan University, Shanghai Medical College (Shanghai Medical University) and his Ph.D. at Hunan Medical University (Xiang-Ya Medical College), and finished his postdoctoral training at University of Minnesota. He joined USC in 2001 and became a faculty member in 2006 in Department of Biochemistry and Molecular Biologyof USC. His studies focus on the molecular mechanism of alcohol-associated breast cancer and hepatocellular carcinoma, which includes signal transduction, histone modifications and regulation of RNA Pol III genes on cancers. His lab discovered for the first time that alcohol-activated JNK1 upregulates Pol III gene transcription to promoted tumor formation in alcohol-fed mice. His studies were the first to demonstrate a role of histone H3 phosophorylation in deregulation of Brf1 and Pol III genes and to establish that alcohol- increased ERa activity enhanced expression of these genes, resulting in cell transformation. His lab is currently exploring the synergistic inhibitory effects of chemicals and kinase inhibitors on alcohol-associated cancers.

Publications

Characterization and bioactivity of novel calcium antagonists - N-methoxy-benzyl haloperidol quaternary ammonium salt. Oncotarget. 2015 Dec 22; 6(41):43759-69. View in: PubMed

The significance of Brf1 overexpression in human hepatocellular carcinoma. Oncotarget. 2015 Dec 18. View in: PubMed

N-n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy. Oncotarget. 2015 Sep 22; 6(28):24709-21. View in: PubMed

Alteration of BRCA1 expression affects alcohol-induced transcription of RNA Pol III-dependent genes. Gene. 2015 Feb 1; 556(1):74-9. View in: PubMed

Effect of N-n-butyl haloperidol iodide on ROS/JNK/Egr-1 signaling in H9c2 cells after hypoxia/reoxygenation. Sci Rep. 2015; 5:11809. View in: PubMed

Transcription of the Human Microsomal Epoxide Hydrolase Gene (EPHX1) Is Regulated by PARP-1 and Histone H1. 2. Association with Sodium-Dependent Bile Acid Transport. PLoS One. 2015; 10(5):e0125318. View in: PubMed

Tamoxifen represses alcohol-induced transcription of RNA polymerase III-dependent genes in breast cancer cells. Oncotarget. 2014 Dec 15; 5(23):12410-7. View in: PubMed

Activated pregnane X receptor inhibits cervical cancer cell proliferation and tumorigenicity by inducing G2/M cell-cycle arrest. Cancer Lett. 2014 May 28; 347(1):88-97. View in: PubMed

N-n-butyl haloperidol iodide inhibits H2O2-induced Na+/Ca2+-exchanger activation via the Na+/H+ exchanger in rat ventricular myocytes. Drug Des Devel Ther. 2014; 8:1257-67. View in: PubMed

Anti-Inflammatory Activity of N-Butanol Extract from Ipomoea stolonifera In Vivo and In Vitro. PLoS One. 2014; 9(4):e95931. View in: PubMed

Self-assembled nanoparticles of glycyrrhetic Acid-modified pullulan as a novel carrier of curcumin. Molecules. 2014; 19(9):13305-18. View in: PubMed

Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation. Carcinogenesis. 2013 Nov; 34(11):2460-9. View in: PubMed

Transcription of the human microsomal epoxide hydrolase gene (EPHX1) is regulated by an HNF-4a/CAR/RXR/PSF complex. Biochim Biophys Acta. 2013 Oct; 1829(10):1000-9. View in: PubMed

Elk1 and AP-1 sites in the TBP promoter mediate alcohol-induced deregulation of Pol III-dependent genes. Gene. 2013 Aug 15; 526(1):54-60. View in: PubMed

ERa mediates alcohol-induced deregulation of Pol III genes in breast cancer cells. Carcinogenesis. 2013 Jan; 34(1):28-37. View in: PubMed

Antioxidant, Antibacterial and Antischistosomal Activities of Extracts from Grateloupia livida (Harv). Yamada. PLoS One. 2013; 8(11):e80413. View in: PubMed

N-n-Butyl Haloperidol Iodide Ameliorates Cardiomyocytes Hypoxia/Reoxygenation Injury by Extracellular Calcium-Dependent and -Independent Mechanisms. Oxid Med Cell Longev. 2013; 2013:912310. View in: PubMed

Caveosomal Oxidative Stress Causes Src-p21ras Activation and Lysine 63 TRAF6 Protein Polyubiquitination in Iron-induced M1 Hepatic Macrophage Activation. J Biol Chem. 2012 Sep 14; 287(38):32078-84. View in: PubMed

Phosphorylation of histone H3 serine 28 modulates RNA polymerase III-dependent transcription. Oncogene. 2011 Sep 15; 30(37):3943-52. View in: PubMed

Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression. J Biol Chem. 2011 Jan 28; 286(4):2393-401. View in: PubMed

The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits. Proc Natl Acad Sci U S A. 2009 Aug 4; 106(31):12682-7. View in: PubMed

PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex. Mol Cell Biol. 2008 Jun; 28(12):4204-14. View in: PubMed

TBP is differentially regulated by c-Jun N-terminal kinase 1 (JNK1) and JNK2 through Elk-1, controlling c-Jun expression and cell proliferation. Mol Cell Biol. 2007 Jan; 27(1):54-64. View in: PubMed

PNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription. J Mol Signal. 2007; 2:5. View in: PubMed

Epidermal growth factor enhances cellular TATA binding protein levels and induces RNA polymerase I- and III-dependent gene activity. Mol Cell Biol. 2004 Jun; 24(12):5119-29. View in: PubMed

Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A. Oncogene. 2003 Aug 14; 22(34):5291-7. View in: PubMed

Detection of human papillomavirus in esophageal carcinoma. J Med Virol. 2002 Nov; 68(3):412-6. View in: PubMed

Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation. J Biol Chem. 2002 Jul 5; 277(27):24039-48. View in: PubMed

Ultraviolet B-induced phosphorylation of histone H3 at serine 28 is mediated by MSK1. J Biol Chem. 2001 Aug 31; 276(35):33213-9. View in: PubMed

Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation. J Biol Chem. 2001 Jul 6; 276(27):25558-67. View in: PubMed

Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation. J Biol Chem. 2001 Jun 15; 276(24):20913-23. View in: PubMed

Organ-specific activation of activator protein-1 in transgenic mice by 12-o-tetradecanoylphorbol-13-acetate with different administration methods. Cancer Res. 2001 May 15; 61(10):4084-91. View in: PubMed

UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways. J Biol Chem. 2001 May 4; 276(18):14572-80. View in: PubMed

MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28. J Biol Chem. 2001 Apr 20; 276(16):12932-7. View in: PubMed

Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis. J Biol Chem. 2001 Apr 13; 276(15):11775-82. View in: PubMed

Organ-specific distribution of AP-1 in AP-1 luciferase transgenic mice during the maturation process. Am J Physiol Regul Integr Comp Physiol. 2001 Feb; 280(2):R376-81. View in: PubMed

ERKs and p38 kinases mediate ultraviolet B-induced phosphorylation of histone H3 at serine 10. J Biol Chem. 2000 Jul 14; 275(28):20980-4. View in: PubMed

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