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Uttam Kumar Sinha, MD

Professor of Otolaryngology--Head and Neck Surgery

Medical Director of Head and Neck Surgery

Watt Family Endowed Chair for Head and Neck Cancers

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Phone +1 323 442 5790
Email sinha@usc.edu
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Overview

Dr. Uttam K. Sinha graduated with distinction from the Calcutta University, India in 1985. He was invited by the House Ear Institute and University of Southern California where he started his research career in molecular biology of neuroscience and cancer. He then finished residency in Otolaryngology-Head and Neck Surgery at USC. He continued to peruse academic career and completed a clinical fellowship in Microvascular and Plastic and Reconstructive Surgery in Mount Sinai Hospital, New York. He then went to Leon, France to complete a clinical fellowship in laryngology. Subsequently, he joined the faculty of the Department of Otolaryngology-Head and Neck Surgery at USC. Because of his academic achievements, leadership, teaching and research, he became Chief and Residency Program Director for the department. His major areas of research are head and neck cancer, thyroid cancer, plastic and reconstructive surgery, trauma, and speech and swallowing. By using nanotechnology, Dr. Sinha and his team are able to detect cancer cell in the saliva and serum. He is also studying the mechanism of metastasis. Dysphagia (difficulty in swallowing) is a common symptom following head and neck cancer therapy. Dr. Sinha and his team introduced a novel treatment called neuromuscular electrical stimulation (NMES) for rehabilitation of swallowing using a new “platform” technology called BION. He received multiple federal and foundation grants. His dedication to patient care and research made him world authority in head and neck diseases. To further the research endeavors, Dr. Sinha has established collaboration with multiple national and international institutes from England, France, India, China and Mexico. Three years ago Dr. Sinha launched a Patient Survivorship Program (http://hncsupport.org). The Support Group is actively involved in patient education and promoting awareness about head and neck cancer.

USC Caruso Department of Otolaryngology – Head & Neck Surgery

Awards

  • Alpha Omega Alpha (Gamma Chapter) as an Outstanding Resident, 1992
  • House Ear Institute: Rupley Fellowship, 1986
  • Calcutta University: Gold Medal for highest marks in General Surgery, 1977
  • Calcutta University: Annual Scholarship for Academic Merit, 1977
  • Government of India: National Scholarship for Academic Merit, 1973

Publications

  • Nat Commun. 2024 Mar 20; 15(1):2484. . View in PubMed
  • Activation of Epstein-Barr Virus’ Lytic Cycle in Nasopharyngeal Carcinoma Cells by NEO212, a Conjugate of Perillyl Alcohol and Temozolomide Cancers (Basel). 2024 Feb 26; 16(5). . View in PubMed
  • Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma Cell Death Dis. 2024 Feb 19; 15(2):152. . View in PubMed
  • Free Flap Outcomes for Head and Neck Surgery in Patients with COVID-19 Laryngoscope. 2023 Nov 08. . View in PubMed
  • Comparison of Free Flap Outcomes at a University Hospital versus County Hospital Setting for Head and Neck Reconstruction Int Arch Otorhinolaryngol. 2023 Apr; 27(2):e183-e190. . View in PubMed
  • Opioid Sparing Multimodal Analgesia for Transoral Robotic Surgery: Improved Analgesia and Narcotic Use Reduction OTO Open. 2023 Jan-Mar; 7(1):e17. . View in PubMed
  • Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation Genome Biol. 2023 08 24; 24(1):193. . View in PubMed
  • A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy Theranostics. 2023; 13(6):1823-1825. . View in PubMed
  • Human papillomavirus detection in oral rinses and history of tonsillectomy in US. adults. Am J Otolaryngol. 2022 Nov-Dec; 43(6):103558. . View in PubMed
  • Variation in compensatory strategies as a function of target constriction degree in post-glossectomy speech JASA Express Lett. 2022 Apr; 2(4):045205. . View in PubMed
  • Single-cell genomics identifies immune response to neoadjuvant chemoradiotherapy EBioMedicine. 2022 12; 86:104389. . View in PubMed
  • An Exploration of Online Support Community Participation Among Patients With Vestibular Disorders Laryngoscope. 2022 09; 132(9):1835-1842. . View in PubMed
  • Investigation of early neoplastic transformation and premalignant biology using genetically engineered organoid models Comput Struct Biotechnol J. 2022; 20:5309-5315. . View in PubMed
  • Improved Swallow Outcomes with Early Intervention using Combined Swallow Therapy in Advanced Oropharyngeal Carcinoma J Laryngol Otol. 2021 Oct 27; 1-22. . View in PubMed
  • Outcomes of Combined Antegrade-Retrograde Dilations for Radiation-Induced Esophageal Strictures in Head and Neck Cancer Patients Dysphagia. 2021 12; 36(6):1040-1047. . View in PubMed
  • Complexity of vocal tract shaping in glossectomy patients and typical speakers: A principal component analysis J Acoust Soc Am. 2021 06; 149(6):4437. . View in PubMed
  • ERAS for Head and Neck Tissue Transfer Reduces Opioid Usage, Peak Pain Scores, and Blood Utilization Laryngoscope. 2021 03; 131(3):E792-E799. . View in PubMed
  • Evidence for AJUBA-catenin-CDH4-linked differentiation resistance of mesenchymal stem cells implies tumorigenesis and progression of head and neck squamous cell carcinoma: a single-cell transcriptome approach Blood Genom. 2021; 5(1):29-39. . View in PubMed
  • Prevalence of oral human papillomavirus infections by race in the United States: An association with sexual behavior Oral Dis. 2020 Jul; 26(5):930-940. . View in PubMed
  • Enhanced Recovery After Surgery-Based Perioperative Protocol for Head and Neck Free Flap Reconstruction OTO Open. 2020 Apr-Jun; 4(2):2473974X20931037. . View in PubMed
  • Association of insurance type with time course of care in head and neck cancer management Laryngoscope. 2020 11; 130(11):E587-E592. . View in PubMed
  • Evaluation of lymph node ratio and lymph node yield as prognosticators of locoregional recurrence in p16-associated oropharyngeal squamous cell carcinoma Head Neck. 2020 10; 42(10):2811-2820. . View in PubMed
  • A Practical Mathematic Method to Predict and Manage Hypocalcemia After Parathyroidectomy and Thyroidectomy Ann Otol Rhinol Laryngol. 2020 Jan; 129(1):70-77. . View in PubMed
  • Association of Race/Ethnicity, Stage, and Survival in Oral Cavity Squamous Cell Carcinoma: A SEER Study OTO Open. 2019 Oct-Dec; 3(4):2473974X19891126. . View in PubMed
  • Outcomes of Self-Esophageal Dilation for Head and Neck Cancer Patients Am J Speech Lang Pathol. 2019 08 09; 28(3):1060-1066. . View in PubMed
  • Outcomes of reconstruction after temporal bone resection for malignancy J Craniomaxillofac Surg. 2018 Oct; 46(10):1856-1861. . View in PubMed
  • The molecular mechanisms of increased radiosensitivity of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC): an extensive review J Otolaryngol Head Neck Surg. 2018 Sep 21; 47(1):59. . View in PubMed
  • Interdisciplinary Telemedicine in the Management of Dysphagia in Head and Neck Dysphagia. 2018 Aug; 33(4):474-480. . View in PubMed
  • Clin Med Insights Ear Nose Throat. 2018; 11:1179550618792248. . View in PubMed
  • Effects of Resonance Voice Therapy on Hormone-Related Vocal Disorders in Professional Singers: A Pilot Study Clin Med Insights Ear Nose Throat. 2018; 11:1179550618786934. . View in PubMed
  • Rapidly Enlarging Parapharyngeal Mass JAMA Otolaryngol Head Neck Surg. 2018 12 01; 144(12):1178-1179. . View in PubMed
  • Transoral surgery vs intensity-modulated radiotherapy for early supraglottic cancer: a systematic review Curr Opin Otolaryngol Head Neck Surg. 2017 Apr; 25(2):133-141. . View in PubMed
  • Management of Chyle Leak after Head and Neck Surgery: Review of Current Treatment Strategies Int J Otolaryngol. 2017; 2017:8362874. . View in PubMed
  • J Surg Oncol. 2016 Jul; 114(1):27-31. . View in PubMed
  • Device Life of Two Generations of Provox Voice Prostheses Ann Otol Rhinol Laryngol. 2016 Jun; 125(6):501-7. . View in PubMed
  • The Role of HPV in Head and Neck Cancer Stem Cell Formation and Tumorigenesis Cancers (Basel). 2016 Feb 19; 8(2). . View in PubMed
  • Overcoming radioresistance in head and neck squamous cell carcinoma Oral Oncol. 2016 12; 63:44-51. . View in PubMed
  • Erratum to “The effect of human papillomavirus on DNA repair in head and neck squamous cell carcinoma” [Oral Oncol61 (2016) 27-30]. Oral Oncol. 2016 11; 62:e5. . View in PubMed
  • The effect of human papillomavirus on DNA repair in head and neck squamous cell carcinoma Oral Oncol. 2016 10; 61:27-30. . View in PubMed
  • ABCLOVE: Voice therapy outcomes for patients with head and neck cancer Head Neck. 2016 04; 38 Suppl 1:E1810-3. . View in PubMed
  • Use of Octreotide for the Management of Chyle Fistula Following Neck Dissection JAMA Otolaryngol Head Neck Surg. 2015 Aug; 141(8):723-7. . View in PubMed
  • Rationale for combined blockade of PD-1 and CTLA-4 in advanced head and neck squamous cell cancer—review of current data Oral Oncol. 2015 Jan; 51(1):12-5. . View in PubMed
  • Defining the localization and molecular characteristic of minor salivary gland label-retaining cells Stem Cells. 2014 Aug; 32(8):2267-77. . View in PubMed
  • Diagnosis and management of merkel cell carcinoma of the head and neck: current trends and controversies Cancers (Basel). 2014 Jun 27; 6(3):1256-66. . View in PubMed
  • Bacterial biofilms and increased bacterial counts are associated with airway stenosis Otolaryngol Head Neck Surg. 2014 May; 150(5):834-40. . View in PubMed
  • Use of the supraclavicular artery island flap for reconstruction of cervicofacial defects Otolaryngol Head Neck Surg. 2014 Feb; 150(2):222-8. . View in PubMed
  • Evaluation of swallow function after tongue cancer treatment using real-time magnetic resonance imaging: a pilot study JAMA Otolaryngol Head Neck Surg. 2013 Dec; 139(12):1312-9. . View in PubMed
  • The supraclavicular artery island flap in head and neck reconstruction: applications and limitations JAMA Otolaryngol Head Neck Surg. 2013 Nov; 139(11):1247-55. . View in PubMed
  • A novel orthotopic mouse model of head and neck cancer and lymph node metastasis Oncogenesis. 2013 Sep 09; 2:e68. . View in PubMed
  • Transoral robotic resection of oropharyngeal synovial sarcoma in a pediatric patient Int J Pediatr Otorhinolaryngol. 2013 Jun; 77(6):1042-4. . View in PubMed
  • DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays Oral Oncol. 2013 Feb; 49(2):93-101. . View in PubMed
  • Solitary fibrous tumor of the postcricoid region: a case report and literature review Case Rep Otolaryngol. 2013; 2013:908327. . View in PubMed
  • Uncommon cutaneous neoplasms of the head and neck Facial Plast Surg Clin North Am. 2012 Nov; 20(4):483-91. . View in PubMed
  • a-Catulin marks the invasion front of squamous cell carcinoma and is important for tumor cell metastasis Mol Cancer Res. 2012 Jul; 10(7):892-903. . View in PubMed
  • Predictive value of bedside clinical signs and symptoms in early diagnosis of deep vein thrombosis in acutely ill medical patients with special reference to deep vein thrombosis prophylaxis J Indian Med Assoc. 2012 Apr; 110(4):218-23. . View in PubMed
  • Prevalidation of salivary biomarkers for oral cancer detection Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):664-72. . View in PubMed
  • Gold nanorod-sphingosine kinase siRNA nanocomplexes: a novel therapeutic tool for potent radiosensitization of head and neck cancer Integr Biol (Camb). 2012 Feb; 4(2):132-41. . View in PubMed
  • Recent advances in biomarkers and potential targeted therapies in head and neck squamous cell carcinoma ISRN Surg. 2012; 2012:715743. . View in PubMed
  • USC-HN2, a new model cell line for recurrent oral cavity squamous cell carcinoma with immunosuppressive characteristics Oral Oncol. 2011 Sep; 47(9):810-7. . View in PubMed
  • Osteoradionecrosis Oral Maxillofac Surg Clin North Am. 2011 Aug; 23(3):455-64. . View in PubMed
  • The role of salivary cytokine biomarkers in tongue cancer invasion and mortality Oral Oncol. 2011 Apr; 47(4):282-7. . View in PubMed
  • Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition Head Neck. 2011 Feb; 33(2):178-88. . View in PubMed
  • Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations J Cell Biochem. 2010 Mar 01; 109(4):818-27. . View in PubMed
  • Establishment and characterization of a novel head and neck squamous cell carcinoma cell line USC-HN1 Head Neck Oncol. 2010 Feb 22; 2:5. . View in PubMed
  • Invasion characteristics of oral tongue cancer: frequency of reporting and effect on survival in a population-based study Cancer. 2009 Sep 01; 115(17):4010-20. . View in PubMed
  • Use of an oral sensory feedback device in the management of jaw-opening dystonia Otolaryngol Head Neck Surg. 2009 Jul; 141(1):142-3. . View in PubMed
  • The significance of EphB4 and EphrinB2 expression and survival in head and neck squamous cell carcinoma Arch Otolaryngol Head Neck Surg. 2008 Sep; 134(9):985-91. . View in PubMed
  • Efficient multilevel brain tumor segmentation with integrated bayesian model classification IEEE Trans Med Imaging. 2008 May; 27(5):629-40. . View in PubMed
  • Provider perceptions of patient psychosocial needs after orofacial injury J Oral Maxillofac Surg. 2007 Aug; 65(8):1584-9. . View in PubMed
  • The association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma Arch Otolaryngol Head Neck Surg. 2006 Oct; 132(10):1053-9. . View in PubMed
  • EphB4 provides survival advantage to squamous cell carcinoma of the head and neck Int J Cancer. 2006 Sep 15; 119(6):1236-48. . View in PubMed
  • Circles of prominence: a new theory on facial aesthetics Arch Facial Plast Surg. 2006 Jul-Aug; 8(4):263-7. . View in PubMed
  • Serum circulating human mRNA profiling and its utility for oral cancer detection J Clin Oncol. 2006 Apr 10; 24(11):1754-60. . View in PubMed
  • p53 apoptotic response to DNA damage dependent on bcl2 but not bax in head and neck squamous cell carcinoma lines Head Neck. 2006 Jan; 28(1):15-23. . View in PubMed
  • Analysis of the brain-stem white-matter tracts with diffusion tensor imaging Neuroradiology. 2005 Dec; 47(12):895-902. . View in PubMed
  • Sperm protein 17 expression defines 2 subsets of primary esthesioneuroblastoma Hum Pathol. 2005 Dec; 36(12):1289-93. . View in PubMed
  • Salivary transcriptome diagnostics for oral cancer detection Clin Cancer Res. 2004 Dec 15; 10(24):8442-50. . View in PubMed
  • Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma Arch Otolaryngol Head Neck Surg. 2004 Aug; 130(8):929-35. . View in PubMed
  • Relationships between stem cells and cancer stem cells Histol Histopathol. 2004 04; 19(2):505-9. . View in PubMed
  • Functional outcomes following palatal reconstruction with a folded radial forearm free flap Ear Nose Throat J. 2004 Jan; 83(1):45-8. . View in PubMed
  • Quantitative assessment of parallel acquisition techniques in diffusion tensor imaging at 30 Tesla. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:1072-5. . View in PubMed
  • Expression of EphB4 in head and neck squamous cell carcinoma Ear Nose Throat J. 2003 Nov; 82(11):866869-70887. . View in PubMed
  • Pressure-Specifying Sensory Device: quantitative sensory measurement in the oral cavity and oropharynx of normal adults Ear Nose Throat J. 2003 Sep; 82(9):682-4687-90. . View in PubMed
  • Overexpression of cell cycle regulatory proteins correlates with advanced tumor stage in head and neck squamous cell carcinomas Int J Oncol. 2003 Jun; 22(6):1285-90. . View in PubMed
  • Effects of steel scalpel, ultrasonic scalpel, CO2 laser, and monopolar and bipolar electrosurgery on wound healing in guinea pig oral mucosa Laryngoscope. 2003 Feb; 113(2):228-36. . View in PubMed
  • Use of AlloDerm implant to prevent frey syndrome after parotidectomy Arch Facial Plast Surg. 2003 Jan-Feb; 5(1):109-12. . View in PubMed
  • Three-layer reconstruction for large defects of the anterior skull base Laryngoscope. 2002 Mar; 112(3):424-7. . View in PubMed
  • Use of AlloDerm for coverage of radial forearm free flap donor site Laryngoscope. 2002 Feb; 112(2):230-4. . View in PubMed
  • Molecular pathology of head and neck cancer Histol Histopathol. 2002; 17(3):909-14. . View in PubMed
  • Reconstruction of pharyngeal defects using AlloDerm and sternocleidomastoid muscle flap Laryngoscope. 2001 Nov; 111(11 Pt 1):1910-6. . View in PubMed
  • Frontotemporal reconstruction with hydroxyapatite cement and the radial forearm free flap Arch Facial Plast Surg. 2001 Oct-Dec; 3(4):271-6. . View in PubMed
  • Image content extraction: application to MR images of the brain Radiographics. 2001 Mar-Apr; 21(2):535-47. . View in PubMed
  • Relationships between choline magnetic resonance spectroscopy, apparent diffusion coefficient and quantitative histopathology in human glioma J Neurooncol. 2000 Dec; 50(3):215-26. . View in PubMed
  • Interactive software for generation and visualization of structured findings in radiology reports AJR Am J Roentgenol. 2000 Sep; 175(3):609-12. . View in PubMed
  • Teleradiology as a foundation for an enterprise-wide health care delivery system Radiographics. 2000 Jul-Aug; 20(4):1137-50. . View in PubMed
  • Improving the quality of care through routine teleradiology consultation Acad Radiol. 2000 Mar; 7(3):149-55. . View in PubMed
  • Evaluation of SNOMED35 in representing concepts in chest radiology reports: integration of a SNOMED mapper with a radiology reporting workstation. Proc AMIA Symp. 2000; 799-803. . View in PubMed
  • Endoscopic surgical management of sphenoid sinus disease Laryngoscope. 1999 Oct; 109(10):1601-6. . View in PubMed
  • Surgery of the salivary glands Otolaryngol Clin North Am. 1999 Oct; 32(5):887-906. . View in PubMed
  • Case-based explanation of non-case-based learning methods Proc AMIA Symp. 1999; 212-5. . View in PubMed
  • Initial experiences with building a health care infrastructure based on Java and object-oriented database technology Proc AMIA Symp. 1999; 515-9. . View in PubMed
  • Process models for telehealth: an industrial approach to quality management of distant medical practice Proc AMIA Symp. 1999; 545-9. . View in PubMed
  • Inverse correlation between choline magnetic resonance spectroscopy signal intensity and the apparent diffusion coefficient in human glioma Magn Reson Med. 1999 Jan; 41(1):2-7. . View in PubMed
  • Oromandibular reconstruction using microvascular composite flaps: report of 210 cases Arch Otolaryngol Head Neck Surg. 1998 Jan; 124(1):46-55. . View in PubMed
  • Intraoperative mapping of sensate flapsElectrophysiologic techniques and neurosomal boundaries. Arch Otolaryngol Head Neck Surg. 1997 Aug; 123(8):823-9. . View in PubMed
  • Use of a mechanical microvascular anastomotic device in head and neck free tissue transfer Arch Otolaryngol Head Neck Surg. 1996 May; 122(5):529-32. . View in PubMed
  • Temporal bone findings in Alzheimer’s disease Laryngoscope. 1996 Jan; 106(1 Pt 1):1-5. . View in PubMed
  • Sensory recovery in noninnervated free flaps for head and neck reconstruction Laryngoscope. 1995 Dec; 105(12 Pt 1):1290-3. . View in PubMed
  • Safety of thyroidectomy in residency: a review of 186 consecutive cases Laryngoscope. 1995 Nov; 105(11):1173-5. . View in PubMed
  • Dynamic properties of the posterior cricoarytenoid muscle Ann Otol Rhinol Laryngol. 1994 Dec; 103(12):937-44. . View in PubMed
  • MR imaging signal response to sustained stimulation in human visual cortex J Magn Reson Imaging. 1994 Jul-Aug; 4(4):537-43. . View in PubMed
  • Abnormal neuritic architecture identified by Di-I in Pick’s disease J Neuropathol Exp Neurol. 1993 Jul; 52(4):411-8. . View in PubMed
  • Auditory system degeneration in Alzheimer’s disease Neurology. 1993 Apr; 43(4):779-85. . View in PubMed
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  • Radionecrosis secondary to interstitial brachytherapy: correlation of magnetic resonance imaging and histopathology Neurosurgery. 1992 Aug; 31(2):336-43. . View in PubMed
  • A PACS-based interactive teaching module for radiologic sciences AJR Am J Roentgenol. 1992 Jul; 159(1):199-205. . View in PubMed
  • Anatomical relationships of the cochlear nuclei and the pontobulbar body: possible significance for neuroprosthesis placement Laryngoscope. 1987 Sep; 97(9):1009-11. . View in PubMed
  • Computer-aided three-dimensional reconstruction of the cochlear nerve root Arch Otolaryngol Head Neck Surg. 1987 Jun; 113(6):651-5. . View in PubMed
  • Fractures of the upper-third of the tibial shaft Int Surg. 1983 Jul-Sep; 68(3):267-70. . View in PubMed
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