Faculty 2016-07-07T13:39:32+00:00

Faculty

Roksana Karim, MD, PhD

Assistant Professor of Clinical Preventive Medicine

Preventive Medicine
SSB 2001 N. Soto Street
Health Sciences Campus
Los Angeles

+1 323 226 5068
rkarim@usc.edu


Overview

Dr. Karim joined the MCA family as an Assistant Professor of Research in 2007; soon after receiving her Doctoral degree in Epidemiology at USC. She received her medical degree from Dhaka Medical College, Bangladesh, in 1996. Her primary research interest is HIV-associated endocrine and cardiovascular complications in women and children and also menopause-related cardiovascular outcomes in women. Dr. Karim has recently received the Zumberge Individual Research Award for her study evaluating the immunopathogenesis of atherosclerosis in HIV-infected children in MCA. She is actively involved in the Women's Interagency HIV Study (WIHS) and has initiated several research projects involving body fat redistribution, sex hormones, and menopause in HIV-infected women. Dr. Karim co-authored a number of publications examining the factors associated with HIV/AIDS disease progression and survival in HIV-infected women. She has authored several research papers looking at hormone therapy, sex hormones and atherosclerosis in postmenopausal women, which are published in well respected peer reviewed journals.

Publications

Lipoprotein(a) and HIV: Allele-Specific Apolipoprotein(a) Levels Predict Carotid Intima-Media Thickness in HIV-Infected Young Women in the Women's Interagency HIV Study. Arterioscler Thromb Vasc Biol. 2017 Mar 23. View in: PubMed

Effect of Reproductive History and Exogenous Hormone Use on Cognitive Function in Mid- and Late Life. J Am Geriatr Soc. 2016 Dec; 64(12):2448-2456. View in: PubMed

Trends of and factors associated with live-birth and abortion rates among HIV-positive and HIV-negative women. Am J Obstet Gynecol. 2016 Sep 15. View in: PubMed

Association of bilateral oophorectomy with cognitive function in healthy, postmenopausal women. Fertil Steril. 2016 Sep 1; 106(3):749-756. e2. View in: PubMed

Use of antimüllerian hormone to predict the menopausal transition in HIV-infected women. Am J Obstet Gynecol. 2016 Jul 26. View in: PubMed

Association of Hepatitis C Virus Infection With CD4/CD8 Ratio in HIV-Positive Women. J Acquir Immune Defic Syndr. 2016 Jun 1; 72(2):162-70. View in: PubMed

Enhanced liver fibrosis marker as a noninvasive predictor of mortality in HIV/hepatitis C virus-coinfected women from a multicenter study of women with or at risk for HIV. AIDS. 2016 Mar 13; 30(5):723-9. View in: PubMed

Systemic Immune Activation and HIV Shedding in the Female Genital Tract. J Acquir Immune Defic Syndr. 2016 Feb 1; 71(2):155-62. View in: PubMed

Menstrual cycle phase and single tablet antiretroviral medication adherence in women with HIV. AIDS Care. 2016 Jan; 28(1):11-21. View in: PubMed

Impact of CD4+ Lymphocytes and HIV Infection on Anti-Müllerian Hormone Levels in a Large Cohort of HIV-infected and HIV-uninfected Women. Am J Reprod Immunol. 2015 Mar; 73(3):273-84. View in: PubMed

Association of endogenous sex hormones with adipokines and ghrelin in postmenopausal women. J Clin Endocrinol Metab. 2015 Feb; 100(2):508-15. View in: PubMed

The Effects of Viral Load Burden on Pregnancy Loss among HIV-Infected Women in the United States. Infect Dis Obstet Gynecol. 2015; 2015:362357. View in: PubMed

T-Cell Activation, Both Pre- and Post-HAART Levels, Correlates With Carotid Artery Stiffness Over 6. 5 Years Among HIV-Infected Women in the WIHS. J Acquir Immune Defic Syndr. 2014 Nov 1; 67(3):349-56. View in: PubMed

Investigating the effects of metabolic dysregulation on hair follicles: a comparison of HIV-infected women with and without central lipohypertrophy. Int J Dermatol. 2014 Oct; 53(10):e443-8. View in: PubMed

Antiretroviral therapy modifies the genetic effect of known type 2 diabetes-associated risk variants in HIV-infected women. AIDS. 2014 Jul 31; 28(12):1815-23. View in: PubMed

Macrophage inflammatory markers are associated with subclinical carotid artery disease in women with human immunodeficiency virus or hepatitis C virus infection. Arterioscler Thromb Vasc Biol. 2014 May; 34(5):1085-92. View in: PubMed

RYR3 gene variants in subclinical atherosclerosis among HIV-infected women in the Women's Interagency HIV Study (WIHS). Atherosclerosis. 2014 Apr; 233(2):666-72. View in: PubMed

Cognition, mood, and physiological concentrations of sex hormones in the early and late postmenopause. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20290-5. View in: PubMed

The association of self-perception of body fat changes and quality of life in the Women's Interagency HIV Study. AIDS Care. 2013 Dec; 25(12):1544-50. View in: PubMed

Association of HIV clinical disease progression with profiles of early immune activation: results from a cluster analysis approach. AIDS. 2013 Jun 1; 27(9):1473-81. View in: PubMed

Gonadotropin and sex steroid levels in HIV-infected premenopausal women and their association with subclinical atherosclerosis in HIV-infected and -uninfected women in the women's interagency HIV study (WIHS). J Clin Endocrinol Metab. 2013 Apr; 98(4):E610-8. View in: PubMed

Effects of highly active antiretroviral therapy and its adherence on herpes zoster incidence: a longitudinal cohort study. AIDS Res Ther. 2013; 10(1):34. View in: PubMed

Association of HIV infection with incident diabetes mellitus: impact of using hemoglobin A1C as a criterion for diabetes. J Acquir Immune Defic Syndr. 2012 Nov 1; 61(3):334-40. View in: PubMed

Circulating vitamin D correlates with serum antimüllerian hormone levels in late-reproductive-aged women: Women's Interagency HIV Study. Fertil Steril. 2012 Jul; 98(1):228-34. View in: PubMed

Permissive and protective factors associated with presence, level, and longitudinal pattern of cervicovaginal HIV shedding. J Acquir Immune Defic Syndr. 2012 May 1; 60(1):99-110. View in: PubMed

Hip fracture in postmenopausal women after cessation of hormone therapy: results from a prospective study in a large health management organization. Menopause. 2011 Nov; 18(11):1172-7. View in: PubMed

Relative time to pregnancy among HIV-infected and uninfected women in the Women's Interagency HIV Study, 2002-2009. AIDS. 2011 Mar 13; 25(5):707-11. View in: PubMed

T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women. J Infect Dis. 2011 Feb 15; 203(4):452-63. View in: PubMed

Pre-existing albuminuria predicts AIDS and non-AIDS mortality in women initiating antiretroviral therapy. Antivir Ther. 2011; 16(4):591-6. View in: PubMed

HIV, HAART, and lipoprotein particle concentrations in the Women's Interagency HIV Study. AIDS. 2010 Nov 27; 24(18):2809-17. View in: PubMed

Microalbuminuria is associated with all-cause and AIDS mortality in women with HIV infection. J Acquir Immune Defic Syndr. 2010 Sep; 55(1):73-7. View in: PubMed

Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women. Menopause. 2010 Jul; 17(4):785-90. View in: PubMed

Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus. J Infect Dis. 2010 Mar 15; 201(6):823-34. View in: PubMed

Pediatric endurance and limb strengthening (PEDALS) for children with cerebral palsy using stationary cycling: a randomized controlled trial. Phys Ther. 2010 Mar; 90(3):367-81. View in: PubMed

Prevalence and correlates of elevated body mass index among HIV-positive and HIV-negative women in the Women's Interagency HIV Study. AIDS Patient Care STDS. 2009 Dec; 23(12):1009-16. View in: PubMed

Influence of age and obesity on serum estradiol, estrone, and sex hormone binding globulin concentrations following oral estrogen administration in postmenopausal women. J Clin Endocrinol Metab. 2009 Nov; 94(11):4136-43. View in: PubMed

Variations in serum müllerian inhibiting substance between white, black, and Hispanic women. Fertil Steril. 2009 Nov; 92(5):1674-8. View in: PubMed

Correlates of perinatal depression in HIV-infected women. AIDS Patient Care STDS. 2009 Feb; 23(2):101-8. View in: PubMed

Relation of Framingham risk score to subclinical atherosclerosis evaluated across three arterial sites. Am J Cardiol. 2008 Oct 1; 102(7):825-30. View in: PubMed

Longitudinal anthropometric patterns among HIV-infected and HIV-uninfected women. J Acquir Immune Defic Syndr. 2008 Mar 1; 47(3):312-9. View in: PubMed

Relationship between serum levels of sex hormones and progression of subclinical atherosclerosis in postmenopausal women. J Clin Endocrinol Metab. 2008 Jan; 93(1):131-8. View in: PubMed

Correlates of prevalent hypertension in a large cohort of HIV-infected women: Women's Interagency HIV Study. AIDS. 2007 Nov 30; 21(18):2539-41. View in: PubMed

Outcomes of a mind-body treatment program for chronic back pain with no distinct structural pathology--a case series of patients diagnosed and treated as tension myositis syndrome. Altern Ther Health Med. 2007 Sep-Oct; 13(5):26-35. View in: PubMed

Hepatitis C virus quasispecies in HIV-infected women: role of injecting drug use and highly active antiretroviral therapy (HAART). Hepatology. 2007 Aug; 46(2):359-70. View in: PubMed

Correlates of CD4+ and CD8+ lymphocyte counts in high-risk immunodeficiency virus (HIV)-seronegative women enrolled in the women's interagency HIV study (WIHS). Hum Immunol. 2007 May; 68(5):342-9. View in: PubMed

Neutropenia in human immunodeficiency virus infection: data from the women's interagency HIV study. Arch Intern Med. 2006 Feb 27; 166(4):405-10. View in: PubMed

Prognostic factors in HIV-related diffuse large-cell lymphoma: before versus after highly active antiretroviral therapy. J Clin Oncol. 2005 Nov 20; 23(33):8477-82. View in: PubMed

Determinants of the effect of estrogen on the progression of subclinical atherosclerosis: Estrogen in the Prevention of Atherosclerosis Trial. Menopause. 2005 Jul-Aug; 12(4):366-73. View in: PubMed

AIDS-related Burkitt's lymphoma versus diffuse large-cell lymphoma in the pre-highly active antiretroviral therapy (HAART) and HAART eras: significant differences in survival with standard chemotherapy. J Clin Oncol. 2005 Jul 1; 23(19):4430-8. View in: PubMed

The association of smoking and subclinical atherosclerosis in Type 2 diabetes: modification by duration of diabetes. Diabet Med. 2005 Jan; 22(1):81-7. View in: PubMed

Impact of highly active antiretroviral therapy on anemia and relationship between anemia and survival in a large cohort of HIV-infected women: Women's Interagency HIV Study. J Acquir Immune Defic Syndr. 2004 Oct 1; 37(2):1245-52. View in: PubMed