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Frances Chow, MD

Assistant Professor of Clinical Neurological Surgery and Neurology

Neuro-Oncology Disease Affinity Group Leader, USC Norris Comprehensive Cancer Center

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Email chow@usc.edu
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Awards

  • Society for Neuro-Oncology (SNO): Scholar, Editorial Scholars Program, 2025
  • Division of Medical Oncology, Keck School of Medicine of USC: Faculty Teaching & Mentorship Award, 2025
  • Society for Neuro-Oncology (SNO): Scholar, Future Leaders Development Program, 2024
  • Society for Immunotherapy of Cancer (SITC): Scholar, Women in Cancer Immunotherapy Network (WIN) Leadership Institute, 2024
  • Keck School of Medicine of USC: Service Excellence Award, 2023-2024
  • Los Angeles Magazine: Top Doctor Award, 2022-2025
  • Pasadena Magazine: Top Doctor Award, 2022-2025
  • Super Doctors: Rising Stars Award, 2020-2024
  • Keck School of Medicine of USC: Outstanding Teaching Award, 2018

Publications

  • Tumor cells upregulate neurotransmitter GABA in the choroid plexus through STAT6-Bestrophin1 signaling, promoting leptomeningeal dissemination. Neuro Oncol. 2025 Jul 30; 27(6):1476-1490.. View in PubMed
  • Resolving spatial subclonal genomic heterogeneity of loss of heterozygosity and extrachromosomal DNA in gliomas. Nat Commun. 2025 Jun 13; 16(1):5290.. View in PubMed
  • Treatment practices and survival outcomes for IDH-wildtype glioblastoma patients according to MGMT promoter methylation status: insights from the U.S. National Cancer Database. J Neurooncol. 2025 May; 172(3):655-665.. View in PubMed
  • Incidence of brain metastasis according to patient race and primary cancer origin: a systematic review. J Neurooncol. 2024 Sep; 169(3):457-467.. View in PubMed
  • Targeting MDSC-HTR2B to Improve Immune Checkpoint Inhibitors in Breast to Brain Metastasis. bioRxiv. 2024 Jun 25.. View in PubMed
  • Editorial: Developing next-generation therapeutics to defeat mutation-driven cancer. Front Immunol. 2024; 15:1487952.. View in PubMed
  • Profiling the molecular and clinical landscape of glioblastoma utilizing the Oncology Research Information Exchange Network brain cancer database. Neurooncol Adv. 2024 Jan-Dec; 6(1):vdae046.. View in PubMed
  • Multi-omic profiling reveals discrepant immunogenic properties and a unique tumor microenvironment among melanoma brain metastases. NPJ Precis Oncol. 2023 Nov 14; 7(1):120.. View in PubMed
  • Increased time to surgery and worse perioperative outcome in benign brain tumor patients with COVID-19. J Clin Neurosci. 2023 Nov; 117:20-26.. View in PubMed
  • Comparison of preoperative versus postoperative treatment dosimetry plans of single-fraction stereotactic radiosurgery for surgically resected brain metastases. Neurosurg Focus. 2023 08; 55(2):E9.. View in PubMed
  • Cancer stem cell assay-guided chemotherapy improves survival of patients with recurrent glioblastoma in a randomized trial. Cell Rep Med. 2023 05 16; 4(5):101025.. View in PubMed
  • A cross-sectional study to test equivalence of low- versus intermediate-flip angle dynamic susceptibility contrast MRI measures of relative cerebral blood volume in patients with high-grade gliomas at 1.5 Tesla field strength. Front Oncol. 2023; 13:1156843.. View in PubMed
  • Distinct molecular features and potential therapeutic strategies for spinal cord gliomas. American Society of Clinical Oncology. 2023.
  • Identification of sub-clonal loss of heterozygosity (LOH) in glioblastomas analyzed with spatial transcriptomics. Cancer Res. 2023; 7_Supp(83):3124.
  • A Phase 1 and Randomized Phase 2 Clinical Trial of Selinexor and Temozolomide in Recurrent Glioblastoma Among Adults: The Product of a Successful Team Science Approach. Journal of Clinical and Translational Science. 2023.
  • Cancer stem cell assay-guided chemotherapy promotes survival benefit for patients with recurrent high-grade glioma in a randomized clinical trial. Cell Rep. 2023.
  • Breast to Brain Metastasis: From Microenvironment to Plasticity. Curr Breast Can Rep. 2023.
  • Neurofibromatosis–Diagnosis and Treatments. Immunotherapy Strategies for NF2 Associated Tumors. 2023.
  • Coronavirus disease-19 is associated with decreased treatment access and worsened outcomes in malignant brain tumor patients. Surg Neurol Int. 2023; 14:292.. View in PubMed
  • MR multitasking-based dynamic imaging for cerebrovascular evaluation (MT-DICE): Simultaneous quantification of permeability and leakage-insensitive perfusion by dynamic T1/T2* mapping. Magn Reson Med. 2023 Jan; 89(1):161-176.. View in PubMed
  • Test-retest repeatability of high-resolution whole-brain DCE-MRI in high-grade glioma patients. International Society for Magnetic Resonance in Medicine Annual Meeting. 2022.
  • Clinical features and molecular characterization of leptomeningeal disease in patients with high grade glioma. Neuro-Oncol. 2022; 24(s7):vii154–vii155.
  • Breast to brain metastasis is exacerbated with chemotherapy through blood-cerebral spinal fluid-barrier and induces alzheimer’s-like pathology. Neuro-Oncol. 2022; 24(s7):vii21–vii22.
  • Modulating glioblastoma chemotherapy response: Evaluating long non-coding RNA effects on DNA damage response, glioma stem cell function, and hypoxic processes. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac119.. View in PubMed
  • Interplay between B cell and GABA metabolism (GABAm) and association with immune evasion in breast carcinoma (BC). Journal of Clinical Oncology. 2022; 16(40):1097.
  • Anaplastic Pleomorphic Xanthoastrocytoma with Extracranial Bone Metastasis: A Case Report and Literature Review. Neurology. 2022; 18(98):1251.
  • Two Rare Cases of Glioma in Total Spine with Metastases to Brain. Neurology. 2022; 18(98):3885.
  • Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma. Nat Commun. 2021 11 26; 12(1):6938.. View in PubMed
  • Complementary and Alternative Medicine for the Treatment of Gliomas: Scoping Review of Clinical Studies, Patient Outcomes, and Toxicity Profiles. World Neurosurg. 2021 07; 151:e682-e692.. View in PubMed
  • Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1. Nat Commun. 2021 06 29; 12(1):4031.. View in PubMed
  • Comorbid depression in surgical cancer patients associated with non-routine discharge and readmission. Surg Oncol. 2021 Jun; 37:101533.. View in PubMed
  • Utilization of Discarded Surgical Tissue from Ultrasonic Aspirators to Establish Patient-Derived Metastatic Brain Tumor Cells: A Guide from the Operating Room to the Research Laboratory. Curr Protoc. 2021 Jun; 1(6):e140.. View in PubMed
  • Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank. Neuro Oncol. 2021 03 25; 23(3):356-375.. View in PubMed
  • Phase I trial of intranasal NEO100, highly purified perillyl alcohol, in adult patients with recurrent glioblastoma. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab005.. View in PubMed
  • A phase 1 with dose expansion/phase 2 study of selinexor in combination with standard of care therapy for newly diagnosed or recurrent glioblastoma. Neuro-Oncology. 2021; 6(23):vi62-63.
  • Targeted next-generation sequencing of 565 neuro-oncology patients at UCLA: A single-institution experience. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa009.. View in PubMed
  • Single-cell RNAseq of tumor infiltrating immune cells from neoadjuvant anti-PD1 treated GBM patients reveals global transcriptional changes and immunosuppressive adaptive responses by myeloid cells. Neuro-Oncology. 2020; 2(22):ii108-ii109.
  • Neoadjuvant PD-1 antibody blockade remodels the immune microenvironment of metastatic brain tumors. Neuro-Oncology. 2020; 2(22):ii212-ii213.
  • Validation of response to neoadjuvant anti-PD-1 immunotherapy in recurrent glioblastoma. Neuro-Oncology. 2020; 21(6):vi4-vi5.
  • Patterns of long-term survivorship following bevacizumab treatment for recurrent glioma: a case series. CNS Oncol. 2019 06 01; 8(2):CNS35.. View in PubMed
  • Myeloid populations and the effect of neoadjuvant PD-1 inhibition in the glioblastoma microenvironment: a surfaceomic and transcriptomic dissection at the single-cell level. Neuro-Oncology. 2019; 21(6):vi248.
  • Neoantigens arising from alternative splicing events may be targeted by tumor infiltrating lymphocytes in glioblastomas. Neuro-Oncology. 2019; 21(6):vi118-vi119.
  • Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer’s Disease. Front Neurol. 2019; 10:1140.. View in PubMed
  • Treatment at Safety-Net Hospitals Is Associated with Delays in Coil Embolization in Patients with Subarachnoid Hemorrhage. World Neurosurg. 2018 Dec; 120:e434-e439.. View in PubMed
  • The challenge of distinguishing POEMS from chronic inflammatory demyelinating polyneuropathy. US Neurology. 2018; 2(14):94-7.
  • Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer’s Disease. Neural Plast. 2017; 2017:3270725.. View in PubMed
  • The Potential Role of Insulin on the Shank-Postsynaptic Platform in Neurodegenerative Diseases Involving Cognition. Am J Alzheimers Dis Other Demen. 2014 Jun; 29(4):303-10.. View in PubMed
  • Molecular characteristics and pathways of Avastin for the treatment of glioblastoma multiforme. Neurosurg Clin N Am. 2012 Jul; 23(3):417-27.. View in PubMed
  • Temozolomide and other potential agents for the treatment of glioblastoma multiforme. Neurosurg Clin N Am. 2012 Apr; 23(2):307-22, ix.. View in PubMed

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