Zhengzheng Xu, PhD

Dr. Zhengzheng Xu is an Assistant Professor of Clinical Radiation Oncology-Medical Physics at USC Norris Cancer Hospital and USC + Los Angeles County Medical Center. Dr. Xu joined USC in February 2021. Dr. Xu graduated from Zhejiang University in Zhejiang, China with a Bachelor of Science degree in Biomedical Engineering. He received his master’s degree in medical physics from Duke University and the doctorate degree in Medical Physics from University at Buffalo. Dr. Xu completed his residency in medical physics at University Hospitals Seidman Cancer Center in 2018. After completing the residency, Dr. Xu became a clinical staff at UH Seidman Cancer Center specializing in medical physics. He was focused and dedicated in image guided radiotherapy (IGRT) for GI cancer, advanced HDR brachytherapy for GYN cancer. Dr. Xu has presented and published in multiple areas including HDR brachytherapy, stereotactic body radiation therapy (SBRT)/stereotactic radiosurgery (SRS), and FMEA for Radiation Oncology. His research interests include image guided adaptive brachytherapy, SBRT/SRS and spatially fractionated radiation therapy (SFRT).

• AAPM Penn-Ohio Chapter: AAPM Annual Meeting Travel Award of Penn-Ohio Chapter Meeting, 2018
• AAPM Upstate New York Chapter: Young Investigator Competition -2nd, 2016
• Duke University: Master Thesis Project Scholarship, 2011
• Zhejiang University: First-Class of National Scholarship Award, 2009-2010
• Zhejiang University: Top Student Dissertation Award, 2009

• toxicity. Journal of Oncology Research. 1(3):109.
• Stereotactic core ablative radiation therapy for small hypoxic tumors: impact of dosimetric approaches and consequent optimization strategy in the context of spatially fractionated radiation therapy. Front Oncol. 2025; 15:1568959.. View in PubMed
• Dosimetric characterization for GRID collimator-based spatially fractionated radiation therapy: Dosimetric parameter acquisition and machine interchangeability investigation. J Appl Clin Med Phys. 2024 Aug; 25(8):e14410.. View in PubMed
• Dosimetric characterization for GRID collimator-based spatially fractionated radiation therapy: Dosimetric parameter acquisition and machine interchangeability investigation. Journal of Applied Clinical Medical Physics. 2024; 25(8):1-11.
• Hippocampal sparing radiation therapy for brain metastases: treatment techniques and clinical implementation. Chin Clin Oncol. 2023 Oct; 12(5):56.. View in PubMed
• Effect of applicator removal from target volume for cervical cancer patients treated with Venezia high-dose-rate brachytherapy applicator. J Contemp Brachytherapy. 2022 Apr; 14(2):176-182.. View in PubMed
• Automatic segmentation of high-risk clinical target volume for tandem-and-ovoids brachytherapy patients using an asymmetric dual-path convolutional neural network. Med Phys. 2022 Mar; 49(3):1712-1722.. View in PubMed
• Dose uncertainty due to needle-tip localization error in prostate seed implantation. Journal of Contemporary Brachytherapy. 2022; 6(14):582-589.
• Feasibility of improving patient’s safety with in vivo dose tracking in intracavitary and interstitial HDR brachytherapy. Brachytherapy. 2021 Mar-Apr; 20(2):353-360.. View in PubMed
• Permanent Interstitial Cesium-131 Brachytherapy in Treating High-Risk Recurrent Head and Neck Cancer: A Prospective Pilot Study. Front Oncol. 2021; 11:639480.. View in PubMed
• Appropriate Methodology for EBRT and HDR Intracavitary/Interstitial Brachytherapy Dose Composite and Clinical Plan Evaluation for Patients With Cervical Cancer. Pract Radiat Oncol. 2019 Nov; 9(6):e559-e571.. View in PubMed
• Evaluating radiotherapy treatment delay using Failure Mode and Effects Analysis (FMEA). Radiother Oncol. 2019 08; 137:102-109.. View in PubMed
• Assessment of beam-matched linacs quality/accuracy for interchanging SBRT or SRT patient using VMAT without replanning. J Appl Clin Med Phys. 2019 Jan; 20(1):68-75.. View in PubMed
• Effects of collimator angle, couch angle, and starting phase on motion-tracking dynamic conformal arc therapy (4D DCAT). J Appl Clin Med Phys. 2017 Sep; 18(5):54-63.. View in PubMed
• Evaluation of dosimetric effect caused by slowing with multi-leaf collimator (MLC) leaves for volumetric modulated arc therapy (VMAT). Radiol Oncol. 2016 Feb 16; 50(1):121-128.. View in PubMed
• Evaluation of fluence-based dose delivery incorporating the spatial variation of dosimetric leaf gap (DLG). J Appl Clin Med Phys. 2016 01 08; 17(1):12-21.. View in PubMed
• Spatial Variation of Dosimetric Leaf Gap and its Impact on Dose Delivery. Medical Physics. 2014; 11(41):111711.

• Matsuo, Koji
• Chang, Eric
• Olch, Arthur
• Zhang, Hualin