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Ebrahim Zandi, PhD

Associate Professor of Molecular Microbiology & Immunology

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Phone +1 323 865 0644
Email zandi@usc.edu
CTSI Profile

Publications

  • High precision and cost-effective multiplex quantification of amyloid-ß40, amyloid-ß42, p181Tau, p217Tau, neurofilament light chain, and glial fibrillary acidic protein from plasma and serum J Alzheimers Dis. 2025 May 13; 13872877251340999. . View in PubMed
  • Second Generation DNA Methylation Age Predicts Cognitive Change in Midlife: The Moderating Role of Childhood Socioeconomic Status Res Sq. 2024 Dec 24. . View in PubMed
  • Epigenome-wide association study of loneliness in a sample of US. middle-aged twins. Epigenetics. 2024 Dec; 19(1):2427999. . View in PubMed
  • Midlife Study of the Louisville Twins: Connecting Cognitive Development to Biological and Cognitive Aging Behav Genet. 2020 03; 50(2):73-83. . View in PubMed
  • Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-ß signaling Proc Natl Acad Sci U S A. 2018 05 01; 115(18):E4245-E4254. . View in PubMed
  • A perillyl alcohol-conjugated analog of 3-bromopyruvate without cellular uptake dependency on monocarboxylate transporter 1 and with activity in 3-BP-resistant tumor cells Cancer Lett. 2017 08 01; 400:161-174. . View in PubMed
  • Multidimensional Separation Using HILIC and SCX Pre-fractionation for RP LC-MS/MS Platform with Automated Exclusion List-based MS Data Acquisition with Increased Protein Quantification J Proteomics Bioinform. 2015 Nov; 8(11):260-265. . View in PubMed
  • Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis Immunity. 2015 Aug 18; 43(2):251-63. . View in PubMed
  • An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction PLoS Pathog. 2015 Jul; 11(7):e1005060. . View in PubMed
  • Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production Mol Cell. 2015 Apr 02; 58(1):134-46. . View in PubMed
  • Activation of a novel c-Myc-miR27-prohibitin 1 circuitry in cholestatic liver injury inhibits glutathione synthesis in mice Antioxid Redox Signal. 2015 Jan 20; 22(3):259-74. . View in PubMed
  • Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression PLoS One. 2015; 10(2):e0117758. . View in PubMed
  • Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca(2+) channel sulfhydration Cell Stem Cell. 2014 Jul 03; 15(1):66-78. . View in PubMed
  • CAF-secreted annexin A1 induces prostate cancer cells to gain stem cell-like features Mol Cancer Res. 2014 Apr; 12(4):607-21. . View in PubMed
  • Site-specific modification of adeno-associated viruses via a genetically engineered aldehyde tag Small. 2013 Feb 11; 9(3):421-9. . View in PubMed
  • Novel Phosphorylations of IKK? /NEMO. mBio. 2012 Nov 06; 3(6):e00411-12.. View in PubMed
  • Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16348-53. . View in PubMed
  • Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation Cell Host Microbe. 2012 Mar 15; 11(3):264-76. . View in PubMed
  • Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs) J Med Chem. 2011 Apr 28; 54(8):2902-14. . View in PubMed
  • Novel function and intracellular localization of methionine adenosyltransferase 2beta splicing variants J Biol Chem. 2010 Jun 25; 285(26):20015-21. . View in PubMed
  • DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis DNA Repair (Amst). 2010 Apr 04; 9(4):429-37. . View in PubMed
  • Regulation of I(kappa)B kinase complex by phosphorylation of (gamma)-binding domain of I(kappa)B kinase (beta) by Polo-like kinase 1 J Biol Chem. 2008 Dec 19; 283(51):35354-67. . View in PubMed
  • Identification of galectin-3-binding protein as a factor secreted by tumor cells that stimulates interleukin-6 expression in the bone marrow stroma J Biol Chem. 2008 Jul 04; 283(27):18573-81. . View in PubMed
  • A simple and inexpensive on-column frit fabrication method for fused-silica capillaries for increased capacity and versatility in LC-MS/MS applications Proteomics. 2008 May; 8(9):1758-61. . View in PubMed
  • A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity J Biol Chem. 2007 Jul 20; 282(29):21487-96. . View in PubMed
  • DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5′ or 3′ overhangs J Biol Chem. 2006 Nov 10; 281(45):33900-9. . View in PubMed
  • Regulation of IkappaB kinase (IKK) complex by IKKgamma-dependent phosphorylation of the T-loop and C terminus of IKKbeta J Biol Chem. 2006 Jun 02; 281(22):15268-76. . View in PubMed
  • TNFalpha induces chromosomal abnormalities independent of ROS through IKK, JNK, p38 and caspase pathways Cytokine. 2006 Apr; 34(1-2):39-50. . View in PubMed
  • Identification of post-translational modifications by blind search of mass spectra Nat Biotechnol. 2005 Dec; 23(12):1562-7. . View in PubMed
  • InsPecT: identification of posttranslationally modified peptides from tandem mass spectra Anal Chem. 2005 Jul 15; 77(14):4626-39. . View in PubMed
  • Tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells mediated through IKK J Biol Chem. 2005 Mar 04; 280(9):7634-44. . View in PubMed
  • Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation J Biol Chem. 2005 Jan 28; 280(4):2912-23. . View in PubMed
  • Identification of post-translational modifications via blind search of mass-spectra Proc IEEE Comput Syst Bioinform Conf. 2005; 157-66. . View in PubMed
  • Signaling role of intracellular iron in NF-kappaB activation J Biol Chem. 2003 May 16; 278(20):17646-54. . View in PubMed
  • Iron activates NF-kappaB in Kupffer cells Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3):G719-26. . View in PubMed
  • Complete reconstitution of human IkappaB kinase (IKK) complex in yeastAssessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation. J Biol Chem. 2001 Sep 28; 276(39):36320-6. . View in PubMed
  • Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B J Biol Chem. 2001 Aug 10; 276(32):30188-98. . View in PubMed
  • Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex Mol Cell Biol. 1999 Jul; 19(7):4547-51. . View in PubMed
  • Fluid shear stress activation of IkappaB kinase is integrin-dependent J Biol Chem. 1998 Nov 13; 273(46):30544-9. . View in PubMed
  • IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex Nature. 1998 Sep 17; 395(6699):297-300. . View in PubMed
  • Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate Science. 1998 Aug 28; 281(5381):1360-3. . View in PubMed
  • NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation J Biol Chem. 1998 Aug 14; 273(33):21132-6. . View in PubMed
  • The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation Cell. 1997 Oct 17; 91(2):243-52. . View in PubMed
  • A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB Nature. 1997 Aug 07; 388(6642):548-54. . View in PubMed
  • Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity Mol Cell Biol. 1997 Aug; 17(8):4687-95. . View in PubMed
  • Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions Mol Cell Biol. 1997 Jun; 17(6):3094-102. . View in PubMed
  • Nuclear entry, oligomerization, and DNA binding of the Drosophila heat shock transcription factor are regulated by a unique nuclear localization sequence Genes Dev. 1997 May 15; 11(10):1299-314. . View in PubMed
  • AP-1 function and regulation Curr Opin Cell Biol. 1997 Apr; 9(2):240-6. . View in PubMed
  • The yeast and mammalian Ras pathways control transcription of heat shock genes independently of heat shock transcription factor Mol Cell Biol. 1994 Jul; 14(7):4929-37. . View in PubMed
  • Zinc finger mutations that alter domain interactions in the glucocorticoid receptor J Mol Biol. 1993 Mar 05; 230(1):124-36. . View in PubMed

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