Keck School Faculty

Abhay Sagare, PhD
Abhay Sagare, PhD
Assistant Professor of Research Physiology & Neuroscience
Zilkha Neurogenetic Institute
ZNI 301, 1501 San Pablo Street Health Sciences Campus Los Angeles

Prion Protein Antagonists Rescue Alzheimer's Amyloid-ß-Related Cognitive Deficits Trends Mol Med. 2019 Jan 17. . View in PubMed

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice J Exp Med. 2019 Jan 15. . View in PubMed

Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction Nat Med. 2019 Jan 14. . View in PubMed

Vascular dysfunction-The disregarded partner of Alzheimer's disease Alzheimers Dement. 2019 Jan; 15(1):158-167. . View in PubMed

Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders Nat Rev Neurol. 2018 Mar; 14(3):133-150. . View in PubMed

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system Nat Med. 2018 Mar; 24(3):326-337. . View in PubMed

Neuropharmacology. 2018 05 15; 134(Pt B):293-301. . View in PubMed

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-ß42 by LRP1-dependent apolipoprotein E isoform-specific mechanism Mol Neurodegener. 2018 10 19; 13(1):57. . View in PubMed

Neuropharmacology. 2017 Sep 18. . View in PubMed

Role of clusterin in the brain vascular clearance of amyloid-ß Proc Natl Acad Sci U S A. 2017 Aug 15; 114(33):8681-8682. . View in PubMed

Role of clusterin in the brain vascular clearance of amyloid-ß Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8681-8682. . View in PubMed

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease Biochim Biophys Acta. 2016 May; 1862(5):887-900. . View in PubMed

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease Biochim Biophys Acta. 2016 05; 1862(5):887-900. . View in PubMed

Shedding of soluble platelet-derived growth factor receptor-ß from human brain pericytes Neurosci Lett. 2015 Oct 21; 607:97-101. . View in PubMed

Central role for PICALM in amyloid-ß blood-brain barrier transcytosis and clearance Nat Neurosci. 2015 Jul; 18(7):978-87. . View in PubMed

Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease J Cereb Blood Flow Metab. 2015 Jul; 35(7):1055-68. . View in PubMed

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration Nat Neurosci. 2015 Apr; 18(4):521-530. . View in PubMed

Blood-brain barrier breakdown in the aging human hippocampus Neuron. 2015 Jan 21; 85(2):296-302. . View in PubMed

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1 Front Aging Neurosci. 2015; 7:136. . View in PubMed

The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathol. 2014 Jul; 24(4):371-86.. View in PubMed

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. . View in PubMed

Low levels of copper disrupt brain amyloid-ß homeostasis by altering its production and clearance Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):14771-6. . View in PubMed

Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown JAMA Neurol. 2013 Sep 01; 70(9):1198-200. . View in PubMed

A lipoprotein receptor cluster IV mutant preferentially binds amyloid-ß and regulates its clearance from the mouse brain J Biol Chem. 2013 May 24; 288(21):15154-66. . View in PubMed

Neurovascular defects and faulty amyloid-ß vascular clearance in Alzheimer's disease J Alzheimers Dis. 2013; 33 Suppl 1:S87-100. . View in PubMed

Pericyte loss influences Alzheimer-like neurodegeneration in mice Nat Commun. 2013; 4:2932. . View in PubMed

Neurovascular dysfunction and faulty amyloid ß-peptide clearance in Alzheimer disease Cold Spring Harb Perspect Med. 2012 Oct 01; 2(10). . View in PubMed

Low-density lipoprotein receptor-related protein 1: a physiological Aß homeostatic mechanism with multiple therapeutic opportunities Pharmacol Ther. 2012 Oct; 136(1):94-105. . View in PubMed

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A Nature. 2012 May 16; 485(7399):512-6. . View in PubMed

A multimodal RAGE-specific inhibitor reduces amyloid ß-mediated brain disorder in a mouse model of Alzheimer disease J Clin Invest. 2012 Apr; 122(4):1377-92. . View in PubMed

From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-ß levels J Neurosci Res. 2011 Jul; 89(7):967-8. . View in PubMed

Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-ß is an early biomarker for mild cognitive impairment preceding Alzheimer's disease J Alzheimers Dis. 2011; 24(1):25-34. . View in PubMed

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid ß-peptide elimination from the brain J Neurochem. 2010 Dec; 115(5):1077-89. . View in PubMed

Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region J Neurosci. 2010 Nov 17; 30(46):15521-34. . View in PubMed

Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging Neuron. 2010 Nov 04; 68(3):409-27. . View in PubMed

Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor Blood. 2010 Jun 10; 115(23):4963-72. . View in PubMed

Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice Brain Res. 2010 Mar 04; 1317:218-26. . View in PubMed

Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease CNS Neurol Disord Drug Targets. 2009 Mar; 8(1):16-30. . View in PubMed

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells Nat Cell Biol. 2009 Feb; 11(2):143-53. . View in PubMed

Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier J Cereb Blood Flow Metab. 2009 Jan; 29(1):25-33. . View in PubMed

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain J Clin Invest. 2008 Dec; 118(12):4002-13. . View in PubMed

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration Nat Neurosci. 2008 Apr; 11(4):420-2. . View in PubMed

The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease Curr Pharm Des. 2008; 14(16):1601-5. . View in PubMed

Clearance of amyloid-beta by circulating lipoprotein receptors Nat Med. 2007 Sep; 13(9):1029-31. . View in PubMed

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system J Cereb Blood Flow Metab. 2007 May; 27(5):909-18. . View in PubMed

IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor J Neurosci. 2005 Dec 14; 25(50):11495-503. . View in PubMed

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model J Clin Invest. 2005 Nov; 115(11):3285-90. . View in PubMed

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease Nat Med. 2005 Sep; 11(9):959-65. . View in PubMed

Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice J Neurosci Methods. 2004 Sep 30; 138(1-2):233-42. . View in PubMed

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms Neuron. 2004 Aug 05; 43(3):333-44. . View in PubMed

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