Keck School Faculty

Abhay Sagare

Abhay Sagare

Assistant Professor of Research Physiology & Neuroscience
Assistant Director, Biomarkers Assay Core
Zilkha Neurogenetic Institute
ZNI 301, 1501 San Pablo Street Health Sciences Campus Los Angeles

Brain barriers and their potential role in migraine pathophysiology J Headache Pain. 2022 Jan 26; 23(1):16. . View in PubMed

Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C J Exp Med. 2022 01 03; 219(1). . View in PubMed

APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-ß Nat Aging. 2021 Jun; 1(6):506-520. . View in PubMed

Evidence that blood-CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen Headache. 2021 Mar; 61(3):536-545. . View in PubMed

Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults Brain Behav Immun. 2021 05; 94:299-307. . View in PubMed

MarkVCID cerebral small vessel consortium: IEnrollment, clinical, fluid protocols. Alzheimers Dement. 2021 04; 17(4):704-715. . View in PubMed

On the intersection between systemic infection, brain vascular dysfunction and dementia Brain. 2021 07 28; 144(6):1629-1631. . View in PubMed

Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A J Exp Med. 2021 04 05; 218(4). . View in PubMed

Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial EBioMedicine. 2020 Sep; 59:102883. . View in PubMed

A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid Alzheimers Dement. 2020 06; 16(6):821-830. . View in PubMed

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline Nature. 2020 05; 581(7806):71-76. . View in PubMed

Functional connectivity among brain regions affected in Alzheimer's disease is associated with CSF TNF-a in APOE4 carriers Neurobiol Aging. 2020 02; 86:112-122. . View in PubMed

Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline PLoS One. 2020; 15(5):e0232785. . View in PubMed

Correction: Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline PLoS One. 2020; 15(7):e0236379. . View in PubMed

Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid J Neurosci. 2020 10 28; 40(44):8573-8586. . View in PubMed

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss Nat Neurosci. 2019 07; 22(7):1089-1098. . View in PubMed

Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction Nat Med. 2019 02; 25(2):270-276. . View in PubMed

Prion Protein Antagonists Rescue Alzheimer's Amyloid-ß-Related Cognitive Deficits Trends Mol Med. 2019 02; 25(2):74-76. . View in PubMed

Vascular dysfunction-The disregarded partner of Alzheimer's disease Alzheimers Dement. 2019 01; 15(1):158-167. . View in PubMed

Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons JCI Insight. 2019 07 16; 5. . View in PubMed

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice J Exp Med. 2019 02 04; 216(2):279-293. . View in PubMed

Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders Nat Rev Neurol. 2018 03; 14(3):133-150. . View in PubMed

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system Nat Med. 2018 03; 24(3):326-337. . View in PubMed

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-ß42 by LRP1-dependent apolipoprotein E isoform-specific mechanism Mol Neurodegener. 2018 10 19; 13(1):57. . View in PubMed

Neuropharmacology. 2018 05 15; 134(Pt B):293-301. . View in PubMed

Role of clusterin in the brain vascular clearance of amyloid-ß Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8681-8682. . View in PubMed

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease Biochim Biophys Acta. 2016 05; 1862(5):887-900. . View in PubMed

Shedding of soluble platelet-derived growth factor receptor-ß from human brain pericytes Neurosci Lett. 2015 Oct 21; 607:97-101. . View in PubMed

Central role for PICALM in amyloid-ß blood-brain barrier transcytosis and clearance Nat Neurosci. 2015 Jul; 18(7):978-87. . View in PubMed

Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease J Cereb Blood Flow Metab. 2015 Jul; 35(7):1055-68. . View in PubMed

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration Nat Neurosci. 2015 Apr; 18(4):521-530. . View in PubMed

Blood-brain barrier breakdown in the aging human hippocampus Neuron. 2015 Jan 21; 85(2):296-302. . View in PubMed

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1 Front Aging Neurosci. 2015; 7:136. . View in PubMed

The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathol. 2014 Jul; 24(4):371-86.. View in PubMed

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. . View in PubMed

Low levels of copper disrupt brain amyloid-ß homeostasis by altering its production and clearance Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):14771-6. . View in PubMed

Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown JAMA Neurol. 2013 Sep 01; 70(9):1198-200. . View in PubMed

A lipoprotein receptor cluster IV mutant preferentially binds amyloid-ß and regulates its clearance from the mouse brain J Biol Chem. 2013 May 24; 288(21):15154-66. . View in PubMed

Pericyte loss influences Alzheimer-like neurodegeneration in mice Nat Commun. 2013; 4:2932. . View in PubMed

Neurovascular defects and faulty amyloid-ß vascular clearance in Alzheimer's disease J Alzheimers Dis. 2013; 33 Suppl 1:S87-100. . View in PubMed

Neurovascular dysfunction and faulty amyloid ß-peptide clearance in Alzheimer disease Cold Spring Harb Perspect Med. 2012 Oct 01; 2(10). . View in PubMed

Low-density lipoprotein receptor-related protein 1: a physiological Aß homeostatic mechanism with multiple therapeutic opportunities Pharmacol Ther. 2012 Oct; 136(1):94-105. . View in PubMed

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A Nature. 2012 May 16; 485(7399):512-6. . View in PubMed

A multimodal RAGE-specific inhibitor reduces amyloid ß-mediated brain disorder in a mouse model of Alzheimer disease J Clin Invest. 2012 Apr; 122(4):1377-92. . View in PubMed

From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-ß levels J Neurosci Res. 2011 Jul; 89(7):967-8. . View in PubMed

Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-ß is an early biomarker for mild cognitive impairment preceding Alzheimer's disease J Alzheimers Dis. 2011; 24(1):25-34. . View in PubMed

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid ß-peptide elimination from the brain J Neurochem. 2010 Dec; 115(5):1077-89. . View in PubMed

Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region J Neurosci. 2010 Nov 17; 30(46):15521-34. . View in PubMed

Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging Neuron. 2010 Nov 04; 68(3):409-27. . View in PubMed

Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor Blood. 2010 Jun 10; 115(23):4963-72. . View in PubMed

Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice Brain Res. 2010 Mar 04; 1317:218-26. . View in PubMed

Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease CNS Neurol Disord Drug Targets. 2009 Mar; 8(1):16-30. . View in PubMed

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells Nat Cell Biol. 2009 Feb; 11(2):143-53. . View in PubMed

Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier J Cereb Blood Flow Metab. 2009 Jan; 29(1):25-33. . View in PubMed

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain J Clin Invest. 2008 Dec; 118(12):4002-13. . View in PubMed

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration Nat Neurosci. 2008 Apr; 11(4):420-2. . View in PubMed

The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease Curr Pharm Des. 2008; 14(16):1601-5. . View in PubMed

Clearance of amyloid-beta by circulating lipoprotein receptors Nat Med. 2007 Sep; 13(9):1029-31. . View in PubMed

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system J Cereb Blood Flow Metab. 2007 May; 27(5):909-18. . View in PubMed

IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor J Neurosci. 2005 Dec 14; 25(50):11495-503. . View in PubMed

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model J Clin Invest. 2005 Nov; 115(11):3285-90. . View in PubMed

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease Nat Med. 2005 Sep; 11(9):959-65. . View in PubMed

Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice J Neurosci Methods. 2004 Sep 30; 138(1-2):233-42. . View in PubMed

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms Neuron. 2004 Aug 05; 43(3):333-44. . View in PubMed

Formation of protoberberine-type alkaloids by the tubers of somatic embryo-derived plants of Corydalis yanhusuo Planta Med. 2001 Dec; 67(9):839-42. . View in PubMed

De novo regeneration of Scrophularia yoshimurae Yamazaki (Scrophulariaceae) and quantitative analysis of harpagoside, an iridoid glucoside, formed in aerial and underground parts of in vitro propagated and wild plants by HPLC Biol Pharm Bull. 2001 Nov; 24(11):1311-5. . View in PubMed

Quantitative determination of secoiridoid glucosides in in vitro propagated plants of Gentiana davidii varformosana by high performance liquid chromatography. Planta Med. 2001 Feb; 67(1):70-3. . View in PubMed

Cytokinin-induced somatic embryogenesis and plant regeneration in Corydalis yanhusuo (Fumariaceae) - a medicinal plant Plant Sci. 2000 Dec 07; 160(1):139-147. . View in PubMed

Agrobacterium mediated transformation of chickpea (Cicer arietinum L) embryo axes. Plant Cell Rep. 2000 Jan; 19(3):235-240. . View in PubMed

Plant regeneration via somatic embryogenesis in chick pea (Cicer arietinum L). Plant Cell Rep. 1993 Sep; 12(11):652-5. . View in PubMed

sc ctsi logoPowered by SC CTSI