USC.edu
Are you a Patient?

Adam de Smith, PhD

Assistant Professor of Population and Public Health Sciences

Image of Adam de Smith, PhD
Is this your profile? Click to edit
Email desmith@usc.edu
CTSI Profile

Overview

Adam de Smith is an Assistant Professor in the USC Center for Genetic Epidemiology in the Department of Population and Public Health Sciences, and is a member of the USC Norris Comprehensive Cancer Center. He is a genetic epidemiologist with a research focus on identifying the causes of acute lymphoblastic leukemia (ALL), the most common childhood cancer. Dr. de Smith leads studies investigating the role of common and rare genetic variants in ALL etiology, with a particular interest in elucidating the increased ALL risk in Latinos. He also leads a study of leukemia in children with Down syndrome, the International Study of Down Syndrome Acute Leukemia (IS-DSAL), investigating genetic and epigenetic variation associated with risk of DS-ALL. In addition, Dr. de Smith utilizes whole genome sequencing of tumors to examine potential causative agents, i.e. DNA mutational signatures as molecular footprints of environmental exposures.

Publications

  • A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children Cell Genom. 2024 Mar 22; 100526. . View in PubMed
  • Backtracking to the future: unraveling the origins of childhood leukemia Leukemia. 2024 02; 38(2):416-419. . View in PubMed
  • Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men Hum Mol Genet. 2023 01 13; 32(3):489-495. . View in PubMed
  • Associations between early-life and in utero infections and cytomegalovirus-positive acute lymphoblastic leukemia in children Int J Cancer. 2023 03 01; 152(5):845-853. . View in PubMed
  • Genetic Risk of Second Primary Cancer in Breast Cancer Survivors: The Multiethnic Cohort Study Cancer Res. 2022 Sep 16; 82(18):3201-3208. . View in PubMed
  • Variant to function mapping at single-cell resolution through network propagation bioRxiv. 2022 Jan 24. . View in PubMed
  • Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice Nat Biotechnol. 2022 12; 40(12):1834-1844. . View in PubMed
  • Variant to function mapping at single-cell resolution through network propagation Nat Biotechnol. 2022 11; 40(11):1644-1653. . View in PubMed
  • Localized variation in ancestral admixture identifies pilocytic astrocytoma risk loci among Latino children PLoS Genet. 2022 09; 18(9):e1010388. . View in PubMed
  • Accelerated epigenetic aging in newborns with Down syndrome Aging Cell. 2022 07; 21(7):e13652. . View in PubMed
  • Development of a Droplet Digital™ PCR DNA methylation detection and quantification assay of prenatal tobacco exposure Biotechniques. 2022 04; 72(4):121-133. . View in PubMed
  • Genome-wide trans-ethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia Leukemia. 2022 03; 36(3):865-868. . View in PubMed
  • Exploring the genetic and epigenetic origins of juvenile myelomonocytic leukemia using newborn screening samples Leukemia. 2022 01; 36(1):279-282. . View in PubMed
  • Epigenome-wide association study of acute lymphoblastic leukemia in children with Down syndrome Blood Adv. 2022 07 26; 6(14):4132-4136. . View in PubMed
  • Mitochondrial 1555 G>A variant as a potential risk factor for childhood glioblastoma Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac045. . View in PubMed
  • Clinical characteristics of cytomegalovirus-positive pediatric acute lymphoblastic leukemia at diagnosis Am J Hematol. 2022 06 01; 97(6):E198-E201. . View in PubMed
  • Periconceptional folate intake influences DNA methylation at birth based on dietary source in an analysis of pediatric acute lymphoblastic leukemia cases and controls Am J Clin Nutr. 2022 12 19; 116(6):1553-1564. . View in PubMed
  • Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children Haematologica. 2022 09 01; 107(9):2266-2270. . View in PubMed
  • Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL Blood Adv. 2022 06 28; 6(12):3756-3766. . View in PubMed
  • Investigating DNA methylation as a mediator of genetic risk in childhood acute lymphoblastic leukemia Hum Mol Genet. 2022 10 28; 31(21):3741-3756. . View in PubMed
  • Epigenetic Biomarkers of Prenatal Tobacco Smoke Exposure Are Associated with Gene Deletions in Childhood Acute Lymphoblastic Leukemia Cancer Epidemiol Biomarkers Prev. 2021 08; 30(8):1517-1525. . View in PubMed
  • Cancer health disparities in racial/ethnic minorities in the United States Br J Cancer. 2021 01; 124(2):315-332. . View in PubMed
  • Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia Am J Hum Genet. 2021 10 07; 108(10):1823-1835. . View in PubMed
  • Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites Elife. 2021 06 22; 10. . View in PubMed
  • In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system Clin Sci (Lond). 2021 04 30; 135(8):1053-1063. . View in PubMed
  • Trends in Acute Lymphoblastic Leukemia Incidence in the United States by Race/Ethnicity From 2000 to 2016 Am J Epidemiol. 2021 04 06; 190(4):519-527. . View in PubMed
  • The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis Nat Commun. 2021 02 05; 12(1):821. . View in PubMed
  • Common genetic variation and risk of osteosarcoma in a multi-ethnic pediatric and adolescent population Bone. 2020 01; 130:115070. . View in PubMed
  • Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma Acta Neuropathol Commun. 2020 10 28; 8(1):173. . View in PubMed
  • European genetic ancestry associated with risk of childhood ependymoma Neuro Oncol. 2020 11 26; 22(11):1637-1646. . View in PubMed
  • History of Early Childhood Infections and Acute Lymphoblastic Leukemia Risk Among Children in a US Integrated Health-Care System Am J Epidemiol. 2020 10 01; 189(10):1076-1085. . View in PubMed
  • Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia Blood Adv. 2020 02 25; 4(4):672-675. . View in PubMed
  • Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa089. . View in PubMed
  • Germline cancer predisposition variants and pediatric glioma: a population-based study in California Neuro Oncol. 2020 06 09; 22(6):864-874. . View in PubMed
  • Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome Leukemia. 2019 11; 33(11):2746-2751. . View in PubMed
  • Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology Haematologica. 2019 11; 104(11):e514-e516. . View in PubMed
  • Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children Genes Chromosomes Cancer. 2019 10; 58(10):723-730. . View in PubMed
  • Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome Blood. 2019 10 10; 134(15):1227-1237. . View in PubMed
  • Germline genetic landscape of pediatric central nervous system tumors Neuro Oncol. 2019 11 04; 21(11):1376-1388. . View in PubMed
  • Two HLA Class II Gene Variants Are Independently Associated with Pediatric Osteosarcoma Risk Cancer Epidemiol Biomarkers Prev. 2018 10; 27(10):1151-1158. . View in PubMed
  • A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology Haematologica. 2018 01; 103(1):e29-e31. . View in PubMed
  • Genetic determinants of childhood and adult height associated with osteosarcoma risk Cancer. 2018 09 15; 124(18):3742-3752. . View in PubMed
  • GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q2421. Nat Commun. 2018 01 18; 9(1):286. . View in PubMed
  • Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers Environ Health. 2018 05 02; 17(1):43. . View in PubMed
  • BMI1 enhancer polymorphism underlies chromosome 10p1231 association with childhood acute lymphoblastic leukemia. Int J Cancer. 2018 12 01; 143(11):2647-2658. . View in PubMed
  • To ERV Is Human: A Phenotype-Wide Scan Linking Polymorphic Human Endogenous Retrovirus-K Insertions to Complex Phenotypes Front Genet. 2018; 9:298. . View in PubMed
  • Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma J Neurooncol. 2017 Nov; 135(2):237-244. . View in PubMed
  • Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia Cancer Res. 2017 04 01; 77(7):1674-1683. . View in PubMed
  • In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia Blood. 2017 03 23; 129(12):1680-1684. . View in PubMed
  • Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia Oncotarget. 2016 Nov 08; 7(45):72733-72745. . View in PubMed
  • Tobacco Smoke and Ras Mutations Among Latino and Non-Latino Children with Acute Lymphoblastic Leukemia Arch Med Res. 2016 11; 47(8):677-683. . View in PubMed
  • Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates Epigenetics. 2016 09; 11(9):664-673. . View in PubMed
  • Cortical Lewy bodies and Aß burden are associated with prevalence and timing of dementia in Lewy body diseases Neuropathol Appl Neurobiol. 2016 08; 42(5):436-50. . View in PubMed
  • Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia Cancer Epidemiol Biomarkers Prev. 2016 07; 25(7):1043-9. . View in PubMed
  • Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers Carcinogenesis. 2016 06; 37(6):576-582. . View in PubMed
  • A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros Leukemia. 2016 05; 30(5):1194-7. . View in PubMed
  • A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution Cancer Res. 2015 Nov 15; 75(22):4884-94. . View in PubMed
  • PDGFRa demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium Nat Commun. 2015 May 18; 6:6930. . View in PubMed
  • Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures Nucleic Acids Res. 2015 Mar 11; 43(5):2590-602. . View in PubMed
  • Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes Epigenetics. 2015; 10(12):1166-76. . View in PubMed
  • Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA PLoS One. 2015; 10(11):e0143343. . View in PubMed
  • PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia Int J Cancer. 2014 Sep 01; 135(5):1101-9. . View in PubMed
  • Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B-cell acute lymphoblastic leukemia Am J Hematol. 2014 Jul; 89(7):721-5. . View in PubMed
  • Imprinted expression of UBE3A in non-neuronal cells from a Prader-Willi syndrome patient with an atypical deletion Hum Mol Genet. 2014 May 01; 23(9):2364-73. . View in PubMed
  • The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia Blood. 2014 Apr 17; 123(16):2497-503. . View in PubMed
  • Associations between genome-wide Native American ancestry, known risk alleles and B-cell ALL risk in Hispanic children Leukemia. 2013 Dec; 27(12):2416-9. . View in PubMed
  • GATA3 risk alleles are associated with ancestral components in Hispanic children with ALL Blood. 2013 Nov 07; 122(19):3385-7. . View in PubMed
  • Novel childhood ALL susceptibility locus BMI1-PIP4K2A is specifically associated with the hyperdiploid subtype Blood. 2013 Jun 06; 121(23):4808-9. . View in PubMed
  • Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity PLoS One. 2013; 8(3):e58048. . View in PubMed
  • A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network Nucleic Acids Res. 2012 Dec; 40(22):11339-51. . View in PubMed
  • Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity Hum Mol Genet. 2012 Aug 15; 21(16):3727-38. . View in PubMed
  • Accurate single-nucleotide polymorphism allele assignment in trisomic or duplicated regions by using a single base-extension assay with MALDI-TOF mass spectrometry Clin Chem. 2011 Aug; 57(8):1188-95. . View in PubMed
  • Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly Nat Biotechnol. 2011 Jul 24; 29(8):723-30. . View in PubMed
  • Chromosome 19p133 deletion in a patient with macrocephaly, obesity, mental retardation, and behavior problems. Am J Med Genet A. 2011 May; 155A(5):1192-5. . View in PubMed
  • Investigation of the HIN200 locus in UK SLE families identifies novel copy number variants Ann Hum Genet. 2011 May; 75(3):383-97. . View in PubMed
  • Implications of copy number variation in people with chromosomal abnormalities: potential for greater variation in copy number state may contribute to variability of phenotype Hugo J. 2010 Dec; 4(1-4):1-9. . View in PubMed
  • cnvHap: an integrative population and haplotype-based multiplatform model of SNPs and CNVs Nat Methods. 2010 Jul; 7(7):541-6. . View in PubMed
  • A new highly penetrant form of obesity due to deletions on chromosome 16p112. Nature. 2010 Feb 04; 463(7281):671-5. . View in PubMed
  • A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism Hum Mol Genet. 2009 Sep 01; 18(17):3257-65. . View in PubMed
  • Small deletion variants have stable breakpoints commonly associated with alu elements PLoS One. 2008 Aug 29; 3(8):e3104. . View in PubMed
  • Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease Cytogenet Genome Res. 2008; 123(1-4):17-26. . View in PubMed
  • Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases Hum Mol Genet. 2007 Dec 01; 16(23):2783-94. . View in PubMed
  • FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity Nat Genet. 2007 Jun; 39(6):721-3. . View in PubMed

Similar People