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Alessandro Altoe, PhD

Instructor Of Research Otolaryngology-Head and Neck Surgery

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Email altoe@usc.edu
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Overview

Dr. Altoè is an Electrical Engineer and Acoustician. Since 2018 he has been a member of the Auditory Physics Group, where he studies cochlear mechanics. His research has a keen focus on identifying the signal processing strategies within the cochlea that enable healthy ears outperform man-made technology.

Publications

  • Intracochlear overdrive: Characterizing nonlinear wave amplification in the mouse apex. J Acoust Soc Am. 2023 11 01; 154(5):3414-3428.. View in PubMed
  • Otoacoustic emissions reveal the micromechanical role of organ-of-Corti cytoarchitecture in cochlear amplification. Proc Natl Acad Sci U S A. 2023 10 10; 120(41):e2305921120.. View in PubMed
  • Estimating cochlear impulse responses using frequency sweeps. J Acoust Soc Am. 2023 04 01; 153(4):2251.. View in PubMed
  • The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea. J Assoc Res Otolaryngol. 2023 04; 24(2):129-145.. View in PubMed
  • The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell. J Assoc Res Otolaryngol. 2023 04; 24(2):117-127.. View in PubMed
  • Crucial 3-D viscous hydrodynamic contributions to the theoretical modeling of the cochlear response. J Acoust Soc Am. 2023 01; 153(1):77.. View in PubMed
  • Overturning the mechanisms of cochlear amplification via area deformations of the organ of Corti. J Acoust Soc Am. 2022 10; 152(4):2227.. View in PubMed
  • The Elusive Cochlear Filter: Wave Origin of Cochlear Cross-Frequency Masking. J Assoc Res Otolaryngol. 2021 12; 22(6):623-640.. View in PubMed
  • Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo. Proc Natl Acad Sci U S A. 2021 10 26; 118(43).. View in PubMed
  • The cochlear ear horn: geometric origin of tonotopic variations in auditory signal processing. Sci Rep. 2020 11 25; 10(1):20528.. View in PubMed
  • Optimized Tuning of Auditory Inner Hair Cells to Encode Complex Sound through Synergistic Activity of Six Independent K+ Current Entities. Cell Rep. 2020 07 07; 32(1):107869.. View in PubMed
  • Asymmetry and Microstructure of Temporal-Suppression Patterns in Basilar-Membrane Responses to Clicks: Relation to Tonal Suppression and Traveling-Wave Dispersion. J Assoc Res Otolaryngol. 2020 04; 21(2):151-170.. View in PubMed
  • Nonlinear cochlear mechanics without direct vibration-amplification feedback. Phys Rev Res. 2020 Feb-Apr; 2(1).. View in PubMed
  • Constraints imposed by zero-crossing invariance on cochlear models with two mechanical degrees of freedom. J Acoust Soc Am. 2019 09; 146(3):1685.. View in PubMed
  • The effects of the activation of the inner-hair-cell basolateral K+ channels on auditory nerve responses. Hear Res. 2018 07; 364:68-80.. View in PubMed
  • Computational modeling of the human auditory periphery: Auditory-nerve responses, evoked potentials and hearing loss. Hear Res. 2018 03; 360:55-75.. View in PubMed
  • Dynamics of cochlear nonlinearity: Automatic gain control or instantaneous damping? J Acoust Soc Am. 2017 12; 142(6):3510.. View in PubMed
  • Model-based estimation of the frequency tuning of the inner-hair-cell stereocilia from neural tuning curves. J Acoust Soc Am. 2017 06; 141(6):4438.. View in PubMed
  • Integrated processing of spatial cues in human auditory cortex. Hear Res. 2015 Sep; 327:143-52.. View in PubMed
  • Decoupling the level dependence of the basilar membrane gain and phase in nonlinear cochlea models. J Acoust Soc Am. 2015 Aug; 138(2):EL155-60.. View in PubMed
  • Human cortical sensitivity to interaural time difference in high-frequency sounds. Hear Res. 2015 May; 323:99-106.. View in PubMed
  • Transmission line cochlear models: improved accuracy and efficiency. J Acoust Soc Am. 2014 Oct; 136(4):EL302-8.. View in PubMed

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