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Anat Erdreich-Epstein, MD, PhD

Associate Professor of Pediatrics

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Phone +1 323 361 4613
Email epstein@usc.edu
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Publications

  • Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG. Oncogene. 2025 Oct; 44(39):3694-3712.. View in PubMed
  • Rhabdoid tumors in patients conceived following ART: is there an association? Hum Reprod. 2023 10 03; 38(10):2028-2038.. View in PubMed
  • Editorial: Developmental therapeutics in pediatric neuro-oncology. Front Oncol. 2023; 13:1134168.. View in PubMed
  • Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation. J Immunother Cancer. 2023 01; 11(1).. View in PubMed
  • Maximizing the potential of aggressive mouse tumor models in preclinical drug testing. Sci Rep. 2021 06 02; 11(1):11580.. View in PubMed
  • Clinical utility of comprehensive genomic profiling in central nervous system tumors of children and young adults. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab037.. View in PubMed
  • SMARCB1 loss induces druggable cyclin D1 deficiency via upregulation of MIR17HG in atypical teratoid rhabdoid tumors. J Pathol. 2020 09; 252(1):77-87.. View in PubMed
  • Reciprocal Induction of MDM2 and MYCN in Neural and Neuroendocrine Cancers. Front Oncol. 2020; 10:563156.. View in PubMed
  • GRK2 promotes growth of medulloblastoma cells and protects them from chemotherapy-induced apoptosis. Sci Rep. 2019 09 25; 9(1):13902.. View in PubMed
  • Rare Pediatric Invasive Gliofibroma Has BRAFV600E Mutation and Transiently Responds to Targeted Therapy Before Progressive Clonal Evolution. JCO Precis Oncol. 2019; 3.. View in PubMed
  • Continuous and bolus intraventricular topotecan prolong survival in a mouse model of leptomeningeal medulloblastoma. PLoS One. 2019; 14(1):e0206394.. View in PubMed
  • Association of high microvessel αvβ3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126. Oncotarget. 2017 Aug 08; 8(32):52193-52210.. View in PubMed
  • PID1 increases chemotherapy-induced apoptosis in medulloblastoma and glioblastoma cells in a manner that involves NFκB. Sci Rep. 2017 04 11; 7(1):835.. View in PubMed
  • CXCR4 increases in-vivo glioma perivascular invasion, and reduces radiation induced apoptosis: A genetic knockdown study. Oncotarget. 2016 12 13; 7(50):83701-83719.. View in PubMed
  • Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors. Cancer Cell. 2016 Dec 12; 30(6):891-908.. View in PubMed
  • Association of high microvessel avß3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126. Oncotarget. 2016 Nov 16.. View in PubMed
  • Re-irradiation of Recurrent Pineal Germ Cell Tumors with Radiosurgery: Report of Two Cases and Review of Literature. Cureus. 2016 Apr 25; 8(4):e585.. View in PubMed
  • BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma. PLoS One. 2016; 11(6):e0156907.. View in PubMed
  • Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy. Neuro Oncol. 2016 Jan; 18(1):126-31.. View in PubMed
  • Wnt pathway in atypical teratoid rhabdoid tumors. Neuro Oncol. 2015 Apr; 17(4):526-35.. View in PubMed
  • Tumor-associated macrophages in SHH subgroup of medulloblastomas. Clin Cancer Res. 2015 Mar 15; 21(6):1457-65.. View in PubMed
  • Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target. Oncotarget. 2015 Feb 20; 6(5):3165-77.. View in PubMed
  • Pediatric brain tumor cell lines. J Cell Biochem. 2015 Feb; 116(2):218-24.. View in PubMed
  • The chromatin-modifying protein HMGA2 promotes atypical teratoid/rhabdoid cell tumorigenicity. J Neuropathol Exp Neurol. 2015 Feb; 74(2):177-85.. View in PubMed
  • Disseminated Medulloblastoma in a Child with Germline BRCA2 6174delT Mutation and without Fanconi Anemia. Front Oncol. 2015; 5:191.. View in PubMed
  • Novel paracrine modulation of Notch-DLL4 signaling by fibulin-3 promotes angiogenesis in high-grade gliomas. Cancer Res. 2014 Oct 01; 74(19):5435-5448.. View in PubMed
  • A retrospective analysis of recurrent intracranial ependymoma. Pediatr Blood Cancer. 2014 Jul; 61(7):1195-201.. View in PubMed
  • PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas. Clin Cancer Res. 2014 Feb 15; 20(4):827-36.. View in PubMed
  • A novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1. Neuro Oncol. 2014 Jan; 16(2):191-203.. View in PubMed
  • Choroid plexus tumors; management, outcome, and association with the Li-Fraumeni syndrome: the Children’s Hospital Los Angeles (CHLA) experience, 1991-2010. Pediatr Blood Cancer. 2012 Jun; 58(6):905-9.. View in PubMed
  • Heparanase-induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells. Mol Cancer Res. 2012 Jun; 10(6):689-702.. View in PubMed
  • Novel cell lines established from pediatric brain tumors. J Neurooncol. 2012 Apr; 107(2):269-80.. View in PubMed
  • Microdeletion del(22)(q12.2) encompassing the facial development-associated gene, MN1 (meningioma 1) in a child with Pierre-Robin sequence (including cleft palate) and neurofibromatosis 2 (NF2): a case report and review of the literature. BMC Med Genet. 2012 Mar 22; 13:19.. View in PubMed
  • c-Abl is an upstream regulator of acid sphingomyelinase in apoptosis induced by inhibition of integrins αvβ3 and αvβ5. PLoS One. 2012; 7(8):e42291.. View in PubMed
  • Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro. J Neuroinflammation. 2011 Nov 23; 8:162.. View in PubMed
  • Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen. J Neurooncol. 2011 Jul; 103(3):673-80.. View in PubMed
  • Novel cancer vaccine based on genes of Salmonella pathogenicity island 2. Int J Cancer. 2010 Jun 01; 126(11):2622-34.. View in PubMed
  • c-Abl mediates endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 and by disruption of actin. Blood. 2010 Apr 01; 115(13):2709-18.. View in PubMed
  • Nuclear factor IA is expressed in astrocytomas and is associated with improved survival. Neuro Oncol. 2010 Feb; 12(2):122-32.. View in PubMed
  • High-dose chemotherapy and autologous hematopoietic progenitor cell rescue in children with recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors: the impact of prior radiotherapy on outcome. Cancer. 2009 Jul 01; 115(13):2956-63.. View in PubMed
  • Metabolism of orthotopic mouse brain tumor models. Mol Imaging. 2009 Jul-Aug; 8(4):199-208.. View in PubMed
  • Inducing a mode of NK-resistance to suppression by stress and surgery: a potential approach based on low dose of poly I-C to reduce postoperative cancer metastasis. Brain Behav Immun. 2007 May; 21(4):395-408.. View in PubMed
  • Progress in the treatment of childhood brain tumors: no room for complacency. Pediatr Hematol Oncol. 2007 Jan-Feb; 24(1):79-84.. View in PubMed
  • Androgen inducibility of Fgf8 in Shionogi carcinoma 115 cells correlates with an adjacent t(5;19) translocation. Genes Chromosomes Cancer. 2006 Feb; 45(2):169-81.. View in PubMed
  • Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathways. Blood. 2005 Jun 01; 105(11):4353-61.. View in PubMed
  • Bone marrow mesenchymal stem cells provide an alternate pathway of osteoclast activation and bone destruction by cancer cells. Cancer Res. 2005 Feb 15; 65(4):1129-35.. View in PubMed
  • Approaches to treatment for extraocular retinoblastoma: Children’s Hospital Los Angeles experience. J Pediatr Hematol Oncol. 2004 Jan; 26(1):31-4.. View in PubMed
  • Induction of intercellular adhesion molecule-1 on human brain endothelial cells by HIV-1 gp120: role of CD4 and chemokine coreceptors. Lab Invest. 2003 Dec; 83(12):1787-98.. View in PubMed
  • Placenta growth factor activates monocytes and correlates with sickle cell disease severity. Blood. 2003 Aug 15; 102(4):1506-14.. View in PubMed
  • Ceramide signaling in fenretinide-induced endothelial cell apoptosis. J Biol Chem. 2002 Dec 20; 277(51):49531-7.. View in PubMed
  • Successful multimodality therapy of recurrent multifocal juvenile granulosa cell tumor of the ovary. J Pediatr Hematol Oncol. 2002 Mar-Apr; 24(3):229-33.. View in PubMed
  • Plasminogen activator inhibitor-1 promotes angiogenesis by stimulating endothelial cell migration toward fibronectin. Cancer Res. 2001 Jul 15; 61(14):5587-94.. View in PubMed
  • Integrins alpha(v)beta3 and alpha(v)beta5 are expressed by endothelium of high-risk neuroblastoma and their inhibition is associated with increased endogenous ceramide. Cancer Res. 2000 Feb 01; 60(3):712-21.. View in PubMed
  • High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase. J Immunol. 1999 Dec 01; 163(11):6023-34.. View in PubMed
  • Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages. J Leukoc Biol. 1999 Apr; 65(4):523-34.. View in PubMed
  • Characterization of Cbl-Nck and Nck-Pak1 interactions in myeloid FcgammaRII signaling. Exp Cell Res. 1998 Dec 15; 245(2):330-42.. View in PubMed
  • Differential expression of Wnt genes in normal and flat variants of PC12 cells, a cell line responsive to ectopic Wnt1 expression. Growth Factors. 1998; 15(2):149-58.. View in PubMed
  • Protein tyrosine phosphatase inhibitors in Fc gamma RI-induced myeloid oxidant signaling. Exp Cell Res. 1997 Dec 15; 237(2):288-95.. View in PubMed
  • Prolonged clinical response to vincristine treatment in two patients with idiopathic hypereosinophilic syndrome. Am J Pediatr Hematol Oncol. 1992 Nov; 14(4):348-51.. View in PubMed

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