April Shu, PhD

Assistant Professor of Population and Public Health Sciences, Pediatrics, and Quantitative and Computational Biology

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Overview

Chang Shu, also known as April Shu, is an Assistant Professor in the Center for Genetic Epidemiology and the Department of Population and Public Health Sciences at Keck School of Medicine of USC. Dr. Shu specializes in psychiatric genetics and epidemiology. Her work focuses on autism genetics, substance use epigenetics, and single-cell transcriptomics. She utilizes advanced statistical and machine learning techniques to uncover novel genetic and epigenetic factors in mental and behavioral disorders. Dr. Shu received her Ph.D. in Mental Health focusing on psychiatric genetics and a concurrent master’s degree in Biostatistics from Johns Hopkins Bloomberg School of Public Health. She also holds an additional master’s degree in Epidemiology from Harvard School of Public Health. Her current lab website is: https://www.aprilshulab.com/.

Awards

  • College on Problems of Drug Dependence: Early Career Investigators Awards, 2020
  • the DREAM challenge: Winner of single-cell transcriptome prediction, 2018
  • Phi Beta Kappa Honor Society: Phi Beta Kappa, 2018
  • Johns Hopkins Bloomberg School of Public Health: Lucy Shum Memorial Scholarship for excellence in public health research, 2016

Education and Training

  • Columbia University, New York, NY — Associate Research Scientist — 2023 — Psychiatric Genetics
  • Yale University, New Haven, CT — Postdoc — 2020 — Psychiatric Genetics and Epigenetics
  • Johns Hopkins University, Baltimore, MD — PhD — 2018 — Mental Health
  • Johns Hopkins University, Baltimore, MD — MHS — 2018 — Biostatistics
  • Harvard University, Boston, MA — MS — 2014 — Epidemiology
  • Tsinghua University, Beijing, China — BS — 2012 — Chemistry

Research Keywords

  • Psychiatric genetics
  • Epigenetics
  • Autism spectrum disorder
  • Substance use
  • Machine learning

Publications

  • Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer’s Disease. Aging Cell. 2025 10; 24(10):e70189.. View in PubMed
  • Return of genetic research results in 21,532 individuals with autism. Genet Med. 2024 10; 26(10):101202.. View in PubMed
  • A review of single-cell transcriptomics and epigenomics studies in maternal and child health. Epigenomics. 2024; 16(10):775-793.. View in PubMed
  • Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes. Nat Genet. 2022 09; 54(9):1305-1319.. View in PubMed
  • Sex Difference and Interaction of SIRT1 and FOXO3 Candidate Longevity Genes on Life Expectancy: A 10-Year Prospective Longitudinal Cohort Study. J Gerontol A Biol Sci Med Sci. 2022 08 12; 77(8):1557-1563.. View in PubMed
  • Epigenome-wide association analyses of active injection drug use. Drug Alcohol Depend. 2022 06 01; 235:109431.. View in PubMed
  • Differential expression of NPAS4 in the dorsolateral prefrontal cortex following opioid overdose. Drug Alcohol Depend Rep. 2022 Jun; 3:100040.. View in PubMed
  • Imputing cognitive impairment in SPARK, a large autism cohort. Autism Res. 2022 01; 15(1):156-170.. View in PubMed
  • Interaction of greenness and polygenic risk score of Alzheimer’s disease on risk of cognitive impairment. Sci Total Environ. 2021 Nov 20; 796:148767.. View in PubMed
  • Epigenome-wide study of brain DNA methylation following acute opioid intoxication. Drug Alcohol Depend. 2021 04 01; 221:108658.. View in PubMed