Arnold Sipos, MD, PhD

Research Assistant Professor of Pathology (Part-Time)

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Dr. Sipos earned his medical degree from Semmelweis University School of Medicine. He then completed his PhD in Pathophysiology. Prior to joining the Division of Pulmonary, Critical Care and Sleep Medicine as an Assistant Professor, Dr. Sipos served as a Postdoctoral Research Associate for the Department of Medicine.


  • Amgen: Postdoctoral Excellence in Renal Research Award, 2008
  • American Heart Association: Postdoctoral Fellowship, 2007-2009
  • Experimental Biology Travel Grant, 2007
  • Semmelweis University Research Council: Scientific Merit, 2004
  • European Physiological Societies : Travel Grant, 2003
  • Hungary: National Scientific Award for Medical Students, 2003
  • Semmelweis University Research Council: Research Grant, 2003
  • Semmelweis University: Scientific Award for Medical Students, 2003
  • Semmelweis University: Scientific Award for Medical Students, 2002
  • Semmelweis University: Scientific Award for Medical Students, 2001


  • Real-Time Autophagic Flux Measurements in Live Cells Using a Novel Fluorescent Marker DAPRed Bio Protoc. 2024 Mar 05; 14(5):e4949. . View in PubMed
  • Kinetics of autophagic activity in nanoparticle-exposed lung adenocarcinoma (A549) cells Autophagy Rep. 2023; 2(1). . View in PubMed
  • Biokinetic modeling of nanoparticle interactions with lung alveolar epithelial cells: uptake, intracellular processing, and egress Am J Physiol Regul Integr Comp Physiol. 2021 01 01; 320(1):R36-R43. . View in PubMed
  • Evidence for Nanoparticle-Induced Lysosomal Dysfunction in Lung Adenocarcinoma (A549) Cells Int J Mol Sci. 2019 Oct 23; 20(21). . View in PubMed
  • Alveolar epithelial cell processing of nanoparticles activates autophagy and lysosomal exocytosis Am J Physiol Lung Cell Mol Physiol. 2018 08 01; 315(2):L286-L300. . View in PubMed
  • The macula densa prorenin receptor is essential in renin release and blood pressure control Am J Physiol Renal Physiol. 2018 09 01; 315(3):F521-F534. . View in PubMed
  • Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. . View in PubMed
  • Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms Nanomedicine. 2013 Aug; 9(6):786-94. . View in PubMed
  • Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation Proc Natl Acad Sci U S A. 2013 Mar 12; 110(11):4410-5. . View in PubMed
  • A novel dual-color reporter for identifying insulin-producing beta-cells and classifying heterogeneity of insulinoma cell lines PLoS One. 2012; 7(4):e35521. . View in PubMed
  • Nanomaterial interactions with and trafficking across the lung alveolar epithelial barrier: implications for health effects of air-pollution particles Air Qual Atmos Health. 2011 Mar 01; 4(1):65-78. . View in PubMed
  • Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers Int J Nanomedicine. 2011; 6:2849-57. . View in PubMed
  • A high-powered view of the filtration barrier J Am Soc Nephrol. 2010 Nov; 21(11):1835-41. . View in PubMed
  • Direct demonstration of tubular fluid flow sensing by macula densa cells Am J Physiol Renal Physiol. 2010 Nov; 299(5):F1087-93. . View in PubMed
  • Loss of renal microvascular integrity in postnatal Crim1 hypomorphic transgenic mice Kidney Int. 2009 Dec; 76(11):1161-71. . View in PubMed
  • Connexin 30 deficiency impairs renal tubular ATP release and pressure natriuresis J Am Soc Nephrol. 2009 Aug; 20(8):1724-32. . View in PubMed
  • Multiphoton imaging of renal regulatory mechanisms Physiology (Bethesda). 2009 Apr; 24:88-96. . View in PubMed
  • Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure Am J Physiol Regul Integr Comp Physiol. 2008 Aug; 295(2):R371-80. . View in PubMed
  • Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney J Clin Invest. 2008 Jul; 118(7):2526-34. . View in PubMed
  • The collecting duct is the major source of prorenin in diabetes Hypertension. 2008 Jun; 51(6):1597-604. . View in PubMed
  • From in vitro to in vivo: imaging from the single cell to the whole organismCurr Protoc Cytom. 2008 Apr; Chapter 12:Unit 12. 12. . View in PubMed
  • Evidence for restriction of fluid and solute movement across the glomerular capillary wall by the subpodocyte space Am J Physiol Renal Physiol. 2007 Dec; 293(6):F1777-86. . View in PubMed
  • Advances in renal (patho)physiology using multiphoton microscopy Kidney Int. 2007 Nov; 72(10):1188-91. . View in PubMed
  • Fluid flow in the juxtaglomerular interstitium visualized in vivo Am J Physiol Renal Physiol. 2006 Dec; 291(6):F1241-7. . View in PubMed
  • Imaging the renin-angiotensin system: an important target of anti-hypertensive therapy Adv Drug Deliv Rev. 2006 Sep 15; 58(7):824-33. . View in PubMed
  • Quantitative imaging of basic functions in renal (patho)physiology Am J Physiol Renal Physiol. 2006 Aug; 291(2):F495-502. . View in PubMed