Arthur W. Toga, PhD

Provost Professor of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, Radiology, Biomedical Engineering and Electrical Engineering

Ghada Irani Chair in Neuroscience, Director, USC Mark and Mary Stevens Neuroimaging and Informatics Institute

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Overview

Dr. Toga is interested in the development of new algorithms and the computer science aspects important to neuroimaging. New visualization techniques and statistical measurement are employed in the study of morphometric variability in humans, subhuman primates and rodents.

His laboratory (Laboratory of Neuro Imaging) has been working on the creation of three dimensional digital neuroanatomic and functional neuroanatomic atlases for stereotactic localization and multisubject comparison. Specific programs include the development of local deformation techniques to equate brain data sets from different modalities and different subjects and the development of electronic data bases for the archival, interaction and distribution of brain data.

Research Funding

  • The Health & Aging Brain Study – Health Disparities (HABS-HD)
    NIH · U19AG078109 · Sep 30, 2022 – Aug 31, 2027 · Role: Co-Principal Investigator
  • Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium
    NIH · U24AG074855 · Sep 30, 2021 – Aug 31, 2026 · Role: Co-Principal Investigator
  • Neurocognitive Aging & Analytics Research Education (NAARE)
    NIH · R25AG069711 · Jun 1, 2021 – May 31, 2026 · Role: Co-Principal Investigator
  • Alzheimer's Disease Research Centers
    NIH · P30AG066530 · Sep 1, 2020 – Mar 31, 2030 · Role: Co-Principal Investigator
  • Health and Aging Brain among Latino Elders (HABLE-AT(N)) Study
    NIH · R01AG058533 · Aug 1, 2020 – Apr 30, 2026 · Role: Co-Principal Investigator
  • Amyloid Burden among Mexican Americans
    NIH · R56AG058533 · Sep 30, 2018 – Jul 31, 2020 · Role: Co-Principal Investigator
  • Data Archive for the Brain Initiative (DABI)
    NIH · R24MH114796 · Sep 5, 2018 – May 31, 2024 · Role: Principal Investigator
  • Training in the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer?s Disease
    NIH · T32AG058507 · May 1, 2018 – Apr 30, 2028 · Role: Principal Investigator
  • Seattle Longitudinal Study: Archiving, Harmonizing and Augmenting Alzheimer's Disease Relevant Data Sets
    NIH · R01AG055653 · Sep 30, 2017 – May 31, 2021 · Role: Co-Principal Investigator
  • Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican Americans
    NIH · R01AG054073 · Sep 1, 2017 – May 31, 2022 · Role: Co-Principal Investigator
  • The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx)
    NIH · U54NS100064 · Jan 15, 2017 – Nov 30, 2021 · Role: Principal Investigator
  • Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's Disease
    NIH · P01AG052350 · Sep 30, 2016 – Mar 31, 2028 · Role: Co-Principal Investigator
  • Neurodegeneration in Aging Down Syndrome (NiAD): A Longitudinal Study of Cognition and Biomarkers of Alzheimer's Disease
    NIH · U01AG051406 · Sep 30, 2015 – Apr 30, 2021 · Role: Co-Principal Investigator
  • Big Data for Discovery Science
    NIH · U54EB020406 · Sep 29, 2014 – Sep 30, 2020 · Role: Principal Investigator
  • Genetic Influences on Human Neuroanatomical Shapes
    NIH · R01MH094343 · Jul 1, 2012 – Mar 31, 2019 · Role: Principal Investigator
  • High Capacity Storage System for Computational Biology
    NIH · S10OD011939 · Apr 2, 2012 – Mar 31, 2014 · Role: Principal Investigator
  • Distributed Supercomputing for Brain Mapping
    NIH · S10RR019901 · May 7, 2009 – May 6, 2010 · Role: Principal Investigator
  • Optimizing a Pipelined HPCC Processing Environment for Computational Neuroscience
    NIH · S10RR025523 · Dec 15, 2008 – Dec 14, 2010 · Role: Principal Investigator
  • Mouse BIRN
    NIH · U24RR021760 · May 1, 2005 – Apr 30, 2011 · Role: Principal Investigator
  • Collaborative Brain Mapping: Tools for Sharing
    NIH · R01MH071940 · Sep 28, 2004 – Jul 31, 2010 · Role: Principal Investigator
  • Center for Computational Biology (CCB)(RMI)
    NIH · U54RR021813 · Sep 24, 2004 – Jan 31, 2012 · Role: Principal Investigator
  • Computional Brain Biology from Genotype to Phenotype
    NIH · P20MH065166 · Feb 4, 2002 – Jan 31, 2005 · Role: Principal Investigator
  • DISTRIBUTED GRAPHICS SUPERCOMPUTING FOR NEUROINFORMATICS
    NIH · S10RR015788 · Apr 1, 2001 – Mar 31, 2002 · Role: Principal Investigator
  • AN INFORMATICS FACILITY FOR NEUROIMAGING
    NIH · C06RR015431 · Sep 1, 2000 – Jun 30, 2005 · Role: Principal Investigator
  • A MULTIMODAL MULTIDIMENSIONAL MAP OF THE MOUSE BRAIN
    NIH · R01EB002172 · Sep 30, 1999 – May 31, 2005 · Role: Principal Investigator
  • A MULTIMODAL MULTIDIMENSIONAL MAP OF THE MOUSE BRAIN
    NIH · R01MH061223 · Sep 30, 1999 – May 31, 2004 · Role: Principal Investigator
  • Laboratory of Neuro Imaging Resource (LONIR)
    NIH · P41EB015922 · Sep 30, 1998 – Feb 29, 2024 · Role: Principal Investigator
  • Computational Anatomy and Multidimensional Modeling
    NIH · P41RR013642 · Sep 30, 1998 – Sep 6, 2012 · Role: Principal Investigator
  • CONFERENCE ON BRAIN MAPPING ADDICTION NEUROBIOLOGY
    NIH · R13DA012145 · Aug 1, 1998 – Jul 31, 1999 · Role: Principal Investigator
  • SHARED INSTRUMENTATION FOR COMPUTIONAL NEUROANATOMY
    NIH · S10RR012036 · Jun 1, 1997 – May 31, 1998 · Role: Principal Investigator
  • TRAINING PROGRAM IN NEUROIMAGING
    NIH · T32MH019950 · Jul 1, 1996 – Jun 30, 2005 · Role: Principal Investigator
  • Characteristics of perfusion related cortical signals
    NIH · R01MH052083 · Sep 30, 1995 – Feb 28, 2009 · Role: Principal Investigator
  • A Multidimensional Alzheimer's Disease Brain Atlas
    NIH · R01LM005639 · May 1, 1995 – Jan 31, 2008 · Role: Principal Investigator
  • MODELING BRAIN MORPHOLOGY IN 4D
    NIH · R01NS038753 · Sep 30, 1990 – Aug 31, 2002 · Role: Principal Investigator
  • QUANTITATIVE TRANSFORMATIONS OF DIGITAL BRAIN
    NIH · R01RR005956 · Sep 30, 1990 – Sep 29, 1999 · Role: Principal Investigator

Publications

  • Clinical-biological Alzheimer’s disease stage concordance: insights from cohorts and autopsy data. Brain. 2026 Aug 03; 149(8):2803-2815.. View in PubMed
  • Depression and hippocampal subfield volume in older adults. Transl Psychiatry. 2026 Jul 14.. View in PubMed
  • Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis. JAMA. 2026 Jul 13.. View in PubMed
  • Genetic architecture of the limbic white matter microstructure in aging and Alzheimer’s Disease. Alzheimers Dement. 2026 Jul; 22(7):e71630.. View in PubMed
  • Relationships of CSF biomarkers to cortical atrophy in early-onset Alzheimer’s disease. Alzheimers Dement. 2026 Jul; 22(7):e71479.. View in PubMed
  • Contributions of the Alzheimer’s Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications. Alzheimers Dement. 2026 Jun; 22(6):e71566.. View in PubMed
  • Association of cognitive impairment and APOE ε4 with Centiloids in Hispanic and non-Hispanic White cohorts. Alzheimers Dement. 2026 Jun; 22(6):e71586.. View in PubMed
  • Brain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention: The POINTER Imaging Ancillary Study. JAMA Neurol. 2026 Jun 01; 83(6):521-529.. View in PubMed
  • Predicting Autopsy-Confirmed Neuropathology across Clinical, Neuroimaging, and CSF Biomarkers using Machine Learning. bioRxiv. 2026 May 23.. View in PubMed
  • Eligibility for anti-amyloid treatment in a multiethnic community-based study. Alzheimers Dement (Amst). 2026 Apr-Jun; 18(2):e70314.. View in PubMed