Keck School Faculty

Arthur W. Toga
Arthur W. Toga
Provost Professor of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, Radiology and Engineering;Ghada Irani Chair in Neuroscience, Director, USC Mark and Mary Stevens Neuroimaging and Informatics Institute
USC Institute for Neuroimaging and Informatics
SHN 2025 Zonal Avenue Health Sciences Campus Los Angeles
Dr. Toga is interested in the development of new algorithms and the computer science aspects important to neuroimaging. New visualization techniques and statistical measurement are employed in the study of morphometric variability in humans, subhuman primates and rodents.\n\nHis laboratory (Laboratory of Neuro Imaging) has been working on the creation of three dimensional digital neuroanatomic and functional neuroanatomic atlases for stereotactic localization and multisubject comparison. Specific programs include the development of local deformation techniques to equate brain data sets from different modalities and different subjects and the development of electronic data bases for the archival, interaction and distribution of brain data.

A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid Alzheimers Dement. 2020 06; 16(6):821-830. . View in PubMed

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline Nature. 2020 05; 581(7806):71-76. . View in PubMed

Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint Alzheimers Dement. 2020 01; 16(1):11-21. . View in PubMed

7-Tesla MRI of the brain in a research subject with bilateral, total knee replacement implants: Case report and proposed safety guidelines Magn Reson Imaging. 2019 04; 57:313-316. . View in PubMed

Age-Related Differences in Brain Morphology and the Modifiers in Middle-Aged and Older Adults Cereb Cortex. 2019 09 13; 29(10):4169-4193. . View in PubMed

A probabilistic atlas of human brainstem pathways based on connectome imaging data Neuroimage. 2018 04 01; 169:227-239. . View in PubMed

Assessment of Follow-up Care After Emergency Department Presentation for Mild Traumatic Brain Injury and Concussion: Results From the TRACK-TBI Study JAMA Netw Open. 2018 05 18; 1(1):e180210. . View in PubMed

Analytic Tools for Post-traumatic Epileptogenesis Biomarker Search in Multimodal Dataset of an Animal Model and Human Patients Front Neuroinform. 2018; 12:86. . View in PubMed

Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease BMC Med Genomics. 2017 05 24; 10(Suppl 1):29. . View in PubMed

Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis JAMA Neurol. 2017 10 01; 74(10):1178-1189. . View in PubMed

2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception Alzheimers Dement. 2015 Jun; 11(6):e1-120. . View in PubMed

Abnormal hippocampal morphology in dissociative identity disorder and post-traumatic stress disorder correlates with childhood trauma and dissociative symptoms Hum Brain Mapp. 2015 May; 36(5):1692-704. . View in PubMed

A commonly carried genetic variant in the delta opioid receptor gene, OPRD1, is associated with smaller regional brain volumes: replication in elderly and young populations Hum Brain Mapp. 2014 Apr; 35(4):1226-36. . View in PubMed

Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility Mol Psychiatry. 2014 Apr; 19(4):452-61. . View in PubMed

Association of cerebrospinal fluid ß-amyloid 1-42, T-tau, P-tau181, and a-synuclein levels with clinical features of drug-naive patients with early Parkinson disease JAMA Neurol. 2013 Oct; 70(10):1277-87. . View in PubMed

Angular versus spatial resolution trade-offs for diffusion imaging under time constraints Hum Brain Mapp. 2013 Oct; 34(10):2688-706. . View in PubMed

Applying tensor-based morphometry to parametric surfaces can improve MRI-based disease diagnosis Neuroimage. 2013 Jul 01; 74:209-30. . View in PubMed

A Dynamical Clustering Model of Brain Connectivity Inspired by the N -Body Problem Multimodal Brain Image Anal (2013). 2013; 8159:129-137. . View in PubMed

Alzheimer's Disease Disrupts Rich Club Organization in Brain Connectivity Networks Proc IEEE Int Symp Biomed Imaging. 2013; 266-269. . View in PubMed

A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):E2230-9. . View in PubMed

Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins Twin Res Hum Genet. 2012 Jun; 15(3):286-95. . View in PubMed

Applications of the pipeline environment for visual informatics and genomics computations BMC Bioinformatics. 2011 Jul 26; 12:304. . View in PubMed

Accurate measurement of brain changes in longitudinal MRI scans using tensor-based morphometry Neuroimage. 2011 Jul 01; 57(1):5-14. . View in PubMed

A web-based brain atlas of the vervet monkey, Chlorocebus aethiops Neuroimage. 2011 Feb 01; 54(3):1872-80. . View in PubMed

Abnormal structural correlates of response perseveration in individuals with psychopathy J Neuropsychiatry Clin Neurosci. 2011; 23(1):107-10. . View in PubMed

An MRI-based atlas and database of the developing mouse brain Neuroimage. 2011 Jan 01; 54(1):80-9. . View in PubMed

Altered structural brain connectivity in healthy carriers of the autism risk gene, CNTNAP2 Brain Connect. 2011; 1(6):447-59. . View in PubMed

Amygdala reactivity in healthy adults is correlated with prefrontal cortical thickness J Neurosci. 2010 Dec 08; 30(49):16673-8. . View in PubMed

Anatomical global spatial normalization Neuroinformatics. 2010 Oct; 8(3):171-82. . View in PubMed

3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects Neurobiol Aging. 2010 Aug; 31(8):1284-303. . View in PubMed

3D maps localize caudate nucleus atrophy in 400 Alzheimer's disease, mild cognitive impairment, and healthy elderly subjects Neurobiol Aging. 2010 Aug; 31(8):1312-25. . View in PubMed

3D mapping of brain differences in native signing congenitally and prelingually deaf subjects Hum Brain Mapp. 2010 Jul; 31(7):970-8. . View in PubMed

A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8404-9. . View in PubMed

3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI Hum Brain Mapp. 2010 May; 31(5):786-97. . View in PubMed

A GENETIC ANALYSIS OF CORTICAL THICKNESS IN 372 TWINS Proc IEEE Int Symp Biomed Imaging. 2010 Apr; 2010:101-104. . View in PubMed

Alzheimer's Disease Neuroimaging Initiative (ADNI): clinical characterization Neurology. 2010 Jan 19; 74(3):201-9. . View in PubMed

Alterations in functional activation in euthymic bipolar disorder and schizophrenia during a working memory task Hum Brain Mapp. 2009 Dec; 30(12):3958-69. . View in PubMed

Active fibers: matching deformable tract templates to diffusion tensor images Neuroimage. 2009 Aug; 47 Suppl 2:T82-9. . View in PubMed

Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 05; 150B(5):683-92. . View in PubMed

Abnormal temporal and prefrontal cortical gray matter thinning in psychopaths Mol Psychiatry. 2009 Jun; 14(6):561-2555. . View in PubMed

A LAGRANGIAN FORMULATION FOR STATISTICAL FLUID REGISTRATION Proc IEEE Int Symp Biomed Imaging. 2009 Jun-Jul; 2009:975-978. . View in PubMed

Alzheimer's disease neuroimaging initiative: a one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition Neuroimage. 2009 Apr 15; 45(3):645-55. . View in PubMed

A diffusion tensor imaging tractography algorithm based on Navier-Stokes fluid mechanics IEEE Trans Med Imaging. 2009 Mar; 28(3):348-60. . View in PubMed

A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale PLoS Comput Biol. 2009 Mar; 5(3):e1000334. . View in PubMed

A framework for brain registration via simultaneous surface and volume flow Inf Process Med Imaging. 2009; 21:576-88. . View in PubMed

A novel measure of fractional anisotropy based on the tensor distribution function Med Image Comput Comput Assist Interv. 2009; 12(Pt 1):845-52. . View in PubMed

Anisotropic Laplace-Beltrami Eigenmaps: Bridging Reeb Graphs and Skeletons Proc IEEE Comput Soc Conf Comput Vis Pattern Recognit. 2008 Jul 15; 2008:1-7. . View in PubMed

Amygdala volume and psychopathology in childhood complex partial seizures Epilepsy Behav. 2008 Jul; 13(1):212-7. . View in PubMed

3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry Neuroimage. 2008 May 15; 41(1):19-34. . View in PubMed


Age effects on hippocampal structural changes in old men: the HAAS Neuroimage. 2008 Apr 15; 40(3):1003-15. . View in PubMed

Abnormal cortical thickness and brain-behavior correlation patterns in individuals with heavy prenatal alcohol exposure Cereb Cortex. 2008 Jan; 18(1):136-44. . View in PubMed

3D mapping of language networks in clinical and pre-clinical Alzheimer's disease Brain Lang. 2008 Jan; 104(1):33-41. . View in PubMed

A tensor-based morphometry study of genetic influences on brain structure using a new fluid registration method Med Image Comput Comput Assist Interv. 2008; 11(Pt 2):914-21. . View in PubMed

Acceleration of cerebral ventricular expansion in the Cardiovascular Health Study Neurobiol Aging. 2007 Sep; 28(9):1316-21. . View in PubMed

A genome-scale map of expression for a mouse brain section obtained using voxelation Physiol Genomics. 2007 Aug 20; 30(3):313-21. . View in PubMed

3D pattern of brain abnormalities in Williams syndrome visualized using tensor-based morphometry Neuroimage. 2007 Jul 15; 36(4):1096-109. . View in PubMed

3D pattern of brain abnormalities in Fragile X syndrome visualized using tensor-based morphometry Neuroimage. 2007 Feb 01; 34(3):924-38. . View in PubMed

3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometry Neuroimage. 2007 Jan 01; 34(1):44-60. . View in PubMed

A high-resolution anatomical framework of the neonatal mouse brain for managing gene expression data Front Neuroinform. 2007; 1:6. . View in PubMed

3-D analysis of cortical morphometry in differential diagnosis of Parkinson's plus syndromes: mapping frontal lobe cortical atrophy in progressive supranuclear palsy patients Med Image Comput Comput Assist Interv. 2007; 10(Pt 2):891-9. . View in PubMed

3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease Brain. 2006 Nov; 129(Pt 11):2867-73. . View in PubMed

3D mapping of mini-mental state examination performance in clinical and preclinical Alzheimer disease Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4):224-31. . View in PubMed

Adaptive reproducing kernel particle method for extraction of the cortical surface IEEE Trans Med Imaging. 2006 Jun; 25(6):755-67. . View in PubMed

3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDS Neuroimage. 2006 May 15; 31(1):12-23. . View in PubMed

A curvature-based approach to estimate local gyrification on the cortical surface Neuroimage. 2006 Feb 15; 29(4):1224-30. . View in PubMed

A learning based algorithm for automatic extraction of the cortical sulci Med Image Comput Comput Assist Interv. 2006; 9(Pt 1):695-703. . View in PubMed

Age-related morphology trends of cortical sulci Hum Brain Mapp. 2005 Nov; 26(3):210-20. . View in PubMed

Antidepressant exposure may protect against decrement in frontal gray matter volumes in geriatric depression J Clin Psychiatry. 2005 Aug; 66(8):964-7. . View in PubMed

Abnormal development of the anterior cingulate in childhood-onset schizophrenia: a preliminary quantitative MRI study Psychiatry Res. 2005 Apr 30; 138(3):221-33. . View in PubMed

Abnormal cortical complexity and thickness profiles mapped in Williams syndrome J Neurosci. 2005 Apr 20; 25(16):4146-58. . View in PubMed

A wavelet-based statistical analysis of FMRI data: Imotivation and data distribution modeling. Neuroinformatics. 2005; 3(4):319-42. . View in PubMed

Applications of morphometric and diffusion tensor magnetic resonance imaging to the study of brain abnormalities in the alcoholism spectrum Alcohol Clin Exp Res. 2005 Jan; 29(1):159-166. . View in PubMed

A meta-algorithm for brain extraction in MRI Neuroimage. 2004 Oct; 23(2):625-37. . View in PubMed

Anatomical methods for voxelation of the mammalian brain Neurochem Res. 2004 Jun; 29(6):1299-306. . View in PubMed

Abnormal gyral complexity in first-episode schizophrenia Biol Psychiatry. 2004 Apr 15; 55(8):859-67. . View in PubMed

1H MRSI evidence of metabolic abnormalities in childhood-onset schizophrenia Neuroimage. 2004 Apr; 21(4):1781-9. . View in PubMed

A multimodal, multidimensional atlas of the C57BL/6J mouse brain J Anat. 2004 Feb; 204(2):93-102. . View in PubMed

An adaptive level set segmentation on a triangulated mesh IEEE Trans Med Imaging. 2004 Feb; 23(2):191-201. . View in PubMed

A myelo-architectonic method for the structural classification of cortical areas Neuroimage. 2004 Jan; 21(1):15-26. . View in PubMed

Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex Am J Psychiatry. 2004 Jan; 161(1):99-108. . View in PubMed

Applications and limitations of perfusion-dependent functional brain mapping for neurosurgical guidance Neurosurg Focus. 2003 Jul 15; 15(1):E2. . View in PubMed

A twin study of genetic contributions to hippocampal morphology in schizophrenia Neurobiol Dis. 2002 Oct; 11(1):83-95. . View in PubMed

An optimized individual target brain in the Talairach coordinate system Neuroimage. 2002 Oct; 17(2):922-7. . View in PubMed

Adaptive elastic segmentation of brain MRI via shape-model-guided evolutionary programming IEEE Trans Med Imaging. 2002 Aug; 21(8):910-23. . View in PubMed

A four-dimensional probabilistic atlas of the human brain J Am Med Inform Assoc. 2001 Sep-Oct; 8(5):401-30. . View in PubMed

A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM) Philos Trans R Soc Lond B Biol Sci. 2001 Aug 29; 356(1412):1293-322. . View in PubMed

Analyzing functional brain images in a probabilistic atlas: a validation of subvolume thresholding J Comput Assist Tomogr. 2000 Jan-Feb; 24(1):128-38. . View in PubMed

Arrangement of vestibular nerve fibers in the semicircular canal crista of the chinchilla Audiol Neurootol. 1997 Jul-Aug; 2(4):213-22. . View in PubMed

A three-dimensional multimodality brain map of the nemestrina monkey Brain Res Bull. 1997; 43(2):141-8. . View in PubMed

A 3D medical image database management system Comput Med Imaging Graph. 1996 Jul-Aug; 20(4):269-84. . View in PubMed

A surface-based technique for warping three-dimensional images of the brain IEEE Trans Med Imaging. 1996; 15(4):402-17. . View in PubMed

A probabilistic atlas of the human brain: theory and rationale for its developmentThe International Consortium for Brain Mapping (ICBM). Neuroimage. 1995 Jun; 2(2):89-101. . View in PubMed

A graphic digital database of Drosophila embryogenesis Trends Genet. 1995 Feb; 11(2):51-8. . View in PubMed

3D spatial relationships of histochemical activity in the rat superior colliculus Eur J Morphol. 1995 Jan; 33(1):71-9. . View in PubMed

A 3D digital map of rat brain Brain Res Bull. 1995; 38(1):77-85. . View in PubMed

Animated visualization of a high resolution color three dimensional digital computer model of the whole human head Int J Biomed Comput. 1993 Jan; 32(1):7-17. . View in PubMed

A digital three-dimensional atlas of structure/function relationships J Chem Neuroanat. 1991 Sep-Oct; 4(5):313-8. . View in PubMed

Animating the 3D structure and function of brain Comput Med Imaging Graph. 1991 Sep-Oct; 15(5):285-91. . View in PubMed

A mathematical model and image analysis technique for calculating regional cerebral blood flow Comput Methods Programs Biomed. 1989 May; 29(1):59-69. . View in PubMed

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