Keck School Faculty

Arthur W. Toga, PhD
Arthur W. Toga, PhD
Provost Professor of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, Radiology and Engineering;Ghada Irani Chair in Neuroscience, Director, USC Mark and Mary Stevens Neuroimaging and Informatics Institute
USC Institute for Neuroimaging and Informatics
SHN 2025 Zonal Avenue Health Sciences Campus Los Angeles
Dr. Toga is interested in the development of new algorithms and the computer science aspects important to neuroimaging. New visualization techniques and statistical measurement are employed in the study of morphometric variability in humans, subhuman primates and rodents.

His laboratory (Laboratory of Neuro Imaging) has been working on the creation of three dimensional digital neuroanatomic and functional neuroanatomic atlases for stereotactic localization and multisubject comparison. Specific programs include the development of local deformation techniques to equate brain data sets from different modalities and different subjects and the development of electronic data bases for the archival, interaction and distribution of brain data.

7-Tesla MRI of the brain in a research subject with bilateral, total knee replacement implants: Case report and proposed safety guidelines Magn Reson Imaging. 2019 Apr; 57:313-316. . View in PubMed

Age-Related Differences in Brain Morphology and the Modifiers in Middle-Aged and Older Adults Cereb Cortex. 2018 Dec 07. . View in PubMed

7-Tesla MRI of the brain in a research subject with bilateral, total knee replacement implants: Case report and proposed safety guidelines Magn Reson Imaging. 2018 Nov 26. . View in PubMed

Big data sharing and analysis to advance research in post-traumatic epilepsy Neurobiol Dis. 2018 Jun 01. . View in PubMed

Big data sharing and analysis to advance research in post-traumatic epilepsy Neurobiol Dis. 2018 Jun 01. . View in PubMed

Assessment of Follow-up Care After Emergency Department Presentation for Mild Traumatic Brain Injury and Concussion: Results From the TRACK-TBI Study JAMA Netw Open. 2018 May 18; 1(1):e180210. . View in PubMed

A probabilistic atlas of human brainstem pathways based on connectome imaging data Neuroimage. 2018 Apr 01; 169:227-239. . View in PubMed

A probabilistic atlas of human brainstem pathways based on connectome imaging data Neuroimage. 2018 04 01; 169:227-239. . View in PubMed

Analytic Tools for Post-traumatic Epileptogenesis Biomarker Search in Multimodal Dataset of an Animal Model and Human Patients Front Neuroinform. 2018; 12:86. . View in PubMed

Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis JAMA Neurol. 2017 Oct 01; 74(10):1178-1189. . View in PubMed

Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease BMC Med Genomics. 2017 May 24; 10(Suppl 1):29. . View in PubMed

Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease BMC Med Genomics. 2017 05 24; 10(Suppl 1):29. . View in PubMed

Automated retinofugal visual pathway reconstruction with multi-shell HARDI and FOD-based analysis Neuroimage. 2016 Jan 15; 125:767-779. . View in PubMed

Big biomedical data as the key resource for discovery science J Am Med Inform Assoc. 2015 Nov; 22(6):1126-31. . View in PubMed

2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception Alzheimers Dement. 2015 Jun; 11(6):e1-120. . View in PubMed

Abnormal hippocampal morphology in dissociative identity disorder and post-traumatic stress disorder correlates with childhood trauma and dissociative symptoms Hum Brain Mapp. 2015 May; 36(5):1692-704. . View in PubMed

Automatic clustering of white matter fibers in brain diffusion MRI with an application to genetics Neuroimage. 2014 Oct 15; 100:75-90. . View in PubMed

Automatic clustering and population analysis of white matter tracts using maximum density paths Neuroimage. 2014 Aug 15; 97:284-95. . View in PubMed

A commonly carried genetic variant in the delta opioid receptor gene, OPRD1, is associated with smaller regional brain volumes: replication in elderly and young populations Hum Brain Mapp. 2014 Apr; 35(4):1226-36. . View in PubMed

Angular versus spatial resolution trade-offs for diffusion imaging under time constraints Hum Brain Mapp. 2013 Oct; 34(10):2688-706. . View in PubMed

Association of cerebrospinal fluid ß-amyloid 1-42, T-tau, P-tau181, and a-synuclein levels with clinical features of drug-naive patients with early Parkinson disease JAMA Neurol. 2013 Oct; 70(10):1277-87. . View in PubMed

Applying tensor-based morphometry to parametric surfaces can improve MRI-based disease diagnosis Neuroimage. 2013 Jul 01; 74:209-30. . View in PubMed

A Dynamical Clustering Model of Brain Connectivity Inspired by the N -Body Problem Multimodal Brain Image Anal (2013). 2013; 8159:129-137. . View in PubMed

Alzheimer's Disease Disrupts Rich Club Organization in Brain Connectivity Networks Proc IEEE Int Symp Biomed Imaging. 2013; 266-269. . View in PubMed

A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):E2230-9. . View in PubMed

Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins Twin Res Hum Genet. 2012 Jun; 15(3):286-95. . View in PubMed

Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3985-90. . View in PubMed

Applications of the pipeline environment for visual informatics and genomics computations BMC Bioinformatics. 2011 Jul 26; 12:304. . View in PubMed

Accurate measurement of brain changes in longitudinal MRI scans using tensor-based morphometry Neuroimage. 2011 Jul 01; 57(1):5-14. . View in PubMed

Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment Neuroimage. 2011 May 01; 56(1):212-9. . View in PubMed

ATLAS-BASED FIBER CLUSTERING FOR MULTI-SUBJECT ANALYSIS OF HIGH ANGULAR RESOLUTION DIFFUSION IMAGING TRACTOGRAPHY Proc IEEE Int Symp Biomed Imaging. 2011 Apr; 2011:276-280. . View in PubMed

BDNF gene effects on brain circuitry replicated in 455 twins Neuroimage. 2011 Mar 15; 55(2):448-54. . View in PubMed

A web-based brain atlas of the vervet monkey, Chlorocebus aethiops Neuroimage. 2011 Feb 01; 54(3):1872-80. . View in PubMed

An MRI-based atlas and database of the developing mouse brain Neuroimage. 2011 Jan 01; 54(1):80-9. . View in PubMed

Altered structural brain connectivity in healthy carriers of the autism risk gene, CNTNAP2 Brain Connect. 2011; 1(6):447-59. . View in PubMed

Abnormal structural correlates of response perseveration in individuals with psychopathy J Neuropsychiatry Clin Neurosci. 2011; 23(1):107-10. . View in PubMed

Amygdala reactivity in healthy adults is correlated with prefrontal cortical thickness J Neurosci. 2010 Dec 08; 30(49):16673-8. . View in PubMed

Biomarkers to predict antidepressant response Curr Psychiatry Rep. 2010 Dec; 12(6):553-62. . View in PubMed

Anatomical global spatial normalization Neuroinformatics. 2010 Oct; 8(3):171-82. . View in PubMed

Atlas-guided tract reconstruction for automated and comprehensive examination of the white matter anatomy Neuroimage. 2010 Oct 01; 52(4):1289-301. . View in PubMed

3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects Neurobiol Aging. 2010 Aug; 31(8):1284-303. . View in PubMed

3D mapping of brain differences in native signing congenitally and prelingually deaf subjects Hum Brain Mapp. 2010 Jul; 31(7):970-8. . View in PubMed

Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjects Neuroimage. 2010 May 15; 51(1):488-99. . View in PubMed

A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8404-9. . View in PubMed

3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI Hum Brain Mapp. 2010 May; 31(5):786-97. . View in PubMed

Automated sulci identification via intrinsic modeling of cortical anatomy Med Image Comput Comput Assist Interv. 2010; 13(Pt 3):49-56. . View in PubMed

Alterations in functional activation in euthymic bipolar disorder and schizophrenia during a working memory task Hum Brain Mapp. 2009 Dec; 30(12):3958-69. . View in PubMed

Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls Hum Brain Mapp. 2009 Sep; 30(9):2766-88. . View in PubMed

Active fibers: matching deformable tract templates to diffusion tensor images Neuroimage. 2009 Aug; 47 Suppl 2:T82-9. . View in PubMed

Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 05; 150B(5):683-92. . View in PubMed

Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer's disease participants Neuroimage. 2009 Jun; 46(2):486-99. . View in PubMed

A LAGRANGIAN FORMULATION FOR STATISTICAL FLUID REGISTRATION Proc IEEE Int Symp Biomed Imaging. 2009 Jun-Jul; 2009:975-978. . View in PubMed

Alzheimer's disease neuroimaging initiative: a one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition Neuroimage. 2009 Apr 15; 45(3):645-55. . View in PubMed

A diffusion tensor imaging tractography algorithm based on Navier-Stokes fluid mechanics IEEE Trans Med Imaging. 2009 Mar; 28(3):348-60. . View in PubMed

Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls Neuroimage. 2009 Mar; 45(1 Suppl):S3-15. . View in PubMed

A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale PLoS Comput Biol. 2009 Mar; 5(3):e1000334. . View in PubMed

A framework for brain registration via simultaneous surface and volume flow Inf Process Med Imaging. 2009; 21:576-88. . View in PubMed

A novel measure of fractional anisotropy based on the tensor distribution function Med Image Comput Comput Assist Interv. 2009; 12(Pt 1):845-52. . View in PubMed

Anisotropic Laplace-Beltrami Eigenmaps: Bridging Reeb Graphs and Skeletons Proc IEEE Comput Soc Conf Comput Vis Pattern Recognit. 2008 Jul 15; 2008:1-7. . View in PubMed

Amygdala volume and psychopathology in childhood complex partial seizures Epilepsy Behav. 2008 Jul; 13(1):212-7. . View in PubMed

3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry Neuroimage. 2008 May 15; 41(1):19-34. . View in PubMed

BEST INDIVIDUAL TEMPLATE SELECTION FROM DEFORMATION TENSOR MINIMIZATION Proc IEEE Int Symp Biomed Imaging. 2008 May; 2008:460-463. . View in PubMed

A NEW REGISTRATION METHOD BASED ON LOG-EUCLIDEAN TENSOR METRICS AND ITS APPLICATION TO GENETIC STUDIES Proc IEEE Int Symp Biomed Imaging. 2008 May; 2008:1115-1118. . View in PubMed

Age effects on hippocampal structural changes in old men: the HAAS Neuroimage. 2008 Apr 15; 40(3):1003-15. . View in PubMed

Automated ventricular mapping with multi-atlas fluid image alignment reveals genetic effects in Alzheimer's disease Neuroimage. 2008 Apr 01; 40(2):615-630. . View in PubMed

Automatic independent component labeling for artifact removal in fMRI Neuroimage. 2008 Feb 01; 39(3):1227-45. . View in PubMed

Abnormal cortical thickness and brain-behavior correlation patterns in individuals with heavy prenatal alcohol exposure Cereb Cortex. 2008 Jan; 18(1):136-44. . View in PubMed

Automatic localization of anatomical point landmarks for brain image processing algorithms Neuroinformatics. 2008; 6(2):135-48. . View in PubMed

A tensor-based morphometry study of genetic influences on brain structure using a new fluid registration method Med Image Comput Comput Assist Interv. 2008; 11(Pt 2):914-21. . View in PubMed

3D mapping of language networks in clinical and pre-clinical Alzheimer's disease Brain Lang. 2008 Jan; 104(1):33-41. . View in PubMed

Automatic subcortical segmentation using a contextual model Med Image Comput Comput Assist Interv. 2008; 11(Pt 1):194-201. . View in PubMed

Asymmetries of cortical thickness: effects of handedness, sex, and schizophrenia Neuroreport. 2007 Sep 17; 18(14):1427-31. . View in PubMed

A genome-scale map of expression for a mouse brain section obtained using voxelation Physiol Genomics. 2007 Aug 20; 30(3):313-21. . View in PubMed

3D pattern of brain abnormalities in Williams syndrome visualized using tensor-based morphometry Neuroimage. 2007 Jul 15; 36(4):1096-109. . View in PubMed

Automated extraction of the cortical sulci based on a supervised learning approach IEEE Trans Med Imaging. 2007 Apr; 26(4):541-52. . View in PubMed

Asymmetries of cortical shape: Effects of handedness, sex and schizophrenia Neuroimage. 2007 Feb 01; 34(3):939-48. . View in PubMed

3D pattern of brain abnormalities in Fragile X syndrome visualized using tensor-based morphometry Neuroimage. 2007 Feb 01; 34(3):924-38. . View in PubMed

A high-resolution anatomical framework of the neonatal mouse brain for managing gene expression data Front Neuroinform. 2007; 1:6. . View in PubMed

3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometry Neuroimage. 2007 Jan 01; 34(1):44-60. . View in PubMed

3-D analysis of cortical morphometry in differential diagnosis of Parkinson's plus syndromes: mapping frontal lobe cortical atrophy in progressive supranuclear palsy patients Med Image Comput Comput Assist Interv. 2007; 10(Pt 2):891-9. . View in PubMed

3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease Brain. 2006 Nov; 129(Pt 11):2867-73. . View in PubMed

3D mapping of mini-mental state examination performance in clinical and preclinical Alzheimer disease Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4):224-31. . View in PubMed

Adaptive reproducing kernel particle method for extraction of the cortical surface IEEE Trans Med Imaging. 2006 Jun; 25(6):755-67. . View in PubMed

3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDS Neuroimage. 2006 May 15; 31(1):12-23. . View in PubMed

A learning based algorithm for automatic extraction of the cortical sulci Med Image Comput Comput Assist Interv. 2006; 9(Pt 1):695-703. . View in PubMed

Age-related morphology trends of cortical sulci Hum Brain Mapp. 2005 Nov; 26(3):210-20. . View in PubMed

Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory Arch Gen Psychiatry. 2005 Nov; 62(11):1205-13. . View in PubMed

Antidepressant exposure may protect against decrement in frontal gray matter volumes in geriatric depression J Clin Psychiatry. 2005 Aug; 66(8):964-7. . View in PubMed

Automated brain tissue assessment in the elderly and demented population: construction and validation of a sub-volume probabilistic brain atlas Neuroimage. 2005 Jul 15; 26(4):1009-18. . View in PubMed

Abnormal development of the anterior cingulate in childhood-onset schizophrenia: a preliminary quantitative MRI study Psychiatry Res. 2005 Apr 30; 138(3):221-33. . View in PubMed

Abnormal cortical complexity and thickness profiles mapped in Williams syndrome J Neurosci. 2005 Apr 20; 25(16):4146-58. . View in PubMed

Applications of morphometric and diffusion tensor magnetic resonance imaging to the study of brain abnormalities in the alcoholism spectrum Alcohol Clin Exp Res. 2005 Jan; 29(1):159-166. . View in PubMed

A wavelet-based statistical analysis of FMRI data: Imotivation and data distribution modeling. Neuroinformatics. 2005; 3(4):319-42. . View in PubMed

A meta-algorithm for brain extraction in MRI Neuroimage. 2004 Oct; 23(2):625-37. . View in PubMed

Anatomical methods for voxelation of the mammalian brain Neurochem Res. 2004 Jun; 29(6):1299-306. . View in PubMed

Abnormal gyral complexity in first-episode schizophrenia Biol Psychiatry. 2004 Apr 15; 55(8):859-67. . View in PubMed

1H MRSI evidence of metabolic abnormalities in childhood-onset schizophrenia Neuroimage. 2004 Apr; 21(4):1781-9. . View in PubMed

An adaptive level set segmentation on a triangulated mesh IEEE Trans Med Imaging. 2004 Feb; 23(2):191-201. . View in PubMed

A multimodal, multidimensional atlas of the C57BL/6J mouse brain J Anat. 2004 Feb; 204(2):93-102. . View in PubMed

Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex Am J Psychiatry. 2004 Jan; 161(1):99-108. . View in PubMed

Applications and limitations of perfusion-dependent functional brain mapping for neurosurgical guidance Neurosurg Focus. 2003 Jul 15; 15(1):E2. . View in PubMed

Asymmetry of the brain surface from deformation field analysis Hum Brain Mapp. 2003 Jun; 19(2):79-89. . View in PubMed

A twin study of genetic contributions to hippocampal morphology in schizophrenia Neurobiol Dis. 2002 Oct; 11(1):83-95. . View in PubMed

Adaptive elastic segmentation of brain MRI via shape-model-guided evolutionary programming IEEE Trans Med Imaging. 2002 Aug; 21(8):910-23. . View in PubMed

Powered by SC CTSI
Go to Top