Axel Schonthal, PhD

Associate Professor of Immunology and Immune Therapeutics

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Overview

The Schönthal lab performs preclinical cancer research and pursues anticancer drug development. The main focus is on brain malignancies, which include primary brain cancers (such as glioblastoma) and secondary brain cancers (such as melanoma or breast cancer that has spread to the brain). The work is done in collaboration with Dr. Thomas Chen, a neurosurgeon and Director of the USC Brain Tumor Group. This joint approach supports interdisciplinary efforts that translate laboratory findings to patient applications.

Education and Training

  • University of Karlsruhe, Germany — PhD — Molecular Biology
  • UC San Diego, San Diego, CA — Postdoc — Cancer Biology

Publications

  • Protocol for a pilot-randomized trial in newly diagnosed glioblastoma: standard care with or without daily intranasal perillyl alcohol. Future Oncol. 2026 May; 22(11):1263-1271.. View in PubMed
  • Safety and functional evaluation of a synthetic lamina cover that replaces lost autologous spinal bone after laminectomy, in a sheep and human study. N Am Spine Soc J. 2025 Dec; 24:100795.. View in PubMed
  • International guidelines on the diagnosis and treatment of NUT carcinoma. Innovation (Camb). 2026 Jan 05; 7(1):101068.. View in PubMed
  • Potent Therapeutic Activity of NEO212 in Preclinical Models of Human and Canine Leukaemia and Lymphoma. Vet Comp Oncol. 2025 Sep; 23(3):412-423.. View in PubMed
  • Patient with recurrent grade 4 astrocytoma responding favorably to intranasal delivery of NEO100, highly pure perillyl alcohol: illustrative case. J Neurosurg Case Lessons. 2025 Mar 17; 9(11).. View in PubMed
  • Bringing intranasal drug delivery for malignancies in the brain to market. Expert Opin Drug Deliv. 2025 Mar; 22(3):311-314.. View in PubMed
  • In Reply: Application and Safety of Externally Controlled Metronomic Drug Delivery to the Brain by an Implantable Smart Pump in a Sheep Model. Neurosurgery. 2025 Feb 01; 96(2):e34.. View in PubMed
  • Characterization of cerebrospinal fluid markers as indicators of spinal cord ischemia following an endovascular aortic aneurysm repair procedure. J Neurosurg. 2025 04 01; 142(4):993-1002.. View in PubMed
  • Application and Safety of Externally Controlled Metronomic Drug Delivery to the Brain by an Implantable Smart Pump in a Sheep Model. Neurosurgery. 2025 Feb 01; 96(2):471-478.. View in PubMed
  • Discovery of Cell Number-Interstitial Fluid Volume (CIF) Ratio Reveals Secretory Autophagy Pathway to Supply eHsp90α for Wound Healing. Cells. 2024 07 30; 13(15).. View in PubMed