Keck School Faculty

Development of human alveolar epithelial cell models to study distal lung biology and disease iScience. 2022 Feb 18; 25(2):103780. . View in PubMed

FOXO1 Couples KGF and PI-3K/AKT Signaling to NKX21-Regulated Differentiation of Alveolar Epithelial Cells. Cells. 2022 03 26; 11(7). . View in PubMed

Wnt5a Promotes AT1 and Represses AT2 Lineage-Specific Gene Expression in a Cell-Context-Dependent Manner Stem Cells. 2022 07 27; 40(7):691-703. . View in PubMed

Endoplasmic reticulum chaperone GRP78/BiP is critical for mutant Kras-driven lung tumorigenesis Oncogene. 2021 05; 40(20):3624-3632. . View in PubMed

Fibrinolytic niche is required for alveolar type 2 cell-mediated alveologenesis via a uPA-A6-CD44+-ENaC signal cascade Signal Transduct Target Ther. 2021 02 27; 6(1):97. . View in PubMed

TENET 20: Identification of key transcriptional regulators and enhancers in lung adenocarcinoma. PLoS Genet. 2020 09; 16(9):e1009023. . View in PubMed

WNT5a-ROR Signaling Is Essential for Alveologenesis Cells. 2020 02 07; 9(2). . View in PubMed

Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker Cells. 2020 11 11; 9(11). . View in PubMed

Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis Am J Respir Crit Care Med. 2020 01 15; 201(2):198-211. . View in PubMed

Genome-wide integration of microRNA and transcriptomic profiles of differentiating human alveolar epithelial cells Am J Physiol Lung Cell Mol Physiol. 2020 07 01; 319(1):L173-L184. . View in PubMed

LINC00261 Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Cancer Res. 2019 Jun 15; 79(12):3050-3062. . View in PubMed

Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes Epigenomics. 2018 09; 10(9):1167-1187. . View in PubMed

Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis J Clin Invest. 2018 03 01; 128(3):970-984. . View in PubMed

CLDN181 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018 12 15; 143(12):3169-3180. . View in PubMed

Region-specific role for Pten in maintenance of epithelial phenotype and integrity Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L131-L142. . View in PubMed

Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation Sci Rep. 2017 06 14; 7(1):3473. . View in PubMed

p300/ß-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC) J Biol Chem. 2016 Mar 18; 291(12):6569-82. . View in PubMed

Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15; 310(2):L114-20. . View in PubMed

Pleiotropic Analysis of Lung Cancer and Blood Triglycerides J Natl Cancer Inst. 2016 12; 108(12). . View in PubMed

The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development Am J Respir Cell Mol Biol. 2016 07; 55(1):135-49. . View in PubMed

The importance of detailed epigenomic profiling of different cell types within organs Epigenomics. 2016 06; 8(6):817-29. . View in PubMed

Transforming Growth Factor-ß1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E Sci Rep. 2015 Dec 18; 5:18233. . View in PubMed

Transcriptomic Profiling of Primary Alveolar Epithelial Cell Differentiation in Human and Rat Genom Data. 2014 Dec 01; 2:105-109. . View in PubMed

TRIM72 is required for effective repair of alveolar epithelial cell wounding Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6):L449-59. . View in PubMed

Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. . View in PubMed

Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue Nat Commun. 2014 Feb 27; 5:3365. . View in PubMed

Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation PLoS Genet. 2013 Jun; 9(6):e1003513. . View in PubMed

Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2 PLoS One. 2013; 8(1):e53342. . View in PubMed

GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling J Cell Physiol. 2012 Dec; 227(12):3803-11. . View in PubMed

Interactions between ß-catenin and transforming growth factor-ß signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP) J Biol Chem. 2012 Mar 02; 287(10):7026-38. . View in PubMed

Ligand-independent transforming growth factor-ß type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition J Pathol. 2012 Mar; 226(4):633-44. . View in PubMed

Troglitazone attenuates TGF-ß1-induced EMT in alveolar epithelial cells via a PPAR? -independent mechanism. PLoS One. 2012; 7(6):e38827.. View in PubMed

Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein Am J Respir Cell Mol Biol. 2011 Sep; 45(3):498-509. . View in PubMed

Epithelium-specific deletion of TGF-ß receptor type II protects mice from bleomycin-induced pulmonary fibrosis J Clin Invest. 2011 Jan; 121(1):277-87. . View in PubMed

Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14309-14. . View in PubMed

Directed expression of Cre in alveolar epithelial type 1 cells Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. . View in PubMed

Rat aquaporin-5 43-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C111-20. . View in PubMed

Foxp2 inhibits Nkx21-mediated transcription of SP-C via interactions with the Nkx2. 1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. . View in PubMed

Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. . View in PubMed

Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1280-90. . View in PubMed

Transcriptional regulation by targeted expression of architectural transcription factor high mobility group A2 in salivary glands of transgenic mice Eur J Oral Sci. 2007 Feb; 115(1):30-9. . View in PubMed

Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2 J Histochem Cytochem. 2004 Jun; 52(6):759-67. . View in PubMed

Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer Hum Gene Ther. 2004 May; 15(5):457-68. . View in PubMed

Identification of three genes of known function expressed by alveolar epithelial type I cells Am J Respir Cell Mol Biol. 2003 Jul; 29(1):98-105. . View in PubMed

Na transport proteins are expressed by rat alveolar epithelial type I cells Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L599-608. . View in PubMed

Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells J Appl Physiol (1985). 2005 Jan; 98(1):322-8. . View in PubMed