Keck School Faculty

Beiyun Zhou, PhD
Beiyun Zhou, PhD
Associate Professor of Medicine
Medicine
HMR 911 Health Sciences Campus Los Angeles
Dr. Zhou’s research focuses on the delineation of mechanisms regulating alveolar epithelial cell (AEC) function, differentiation and plasticity in the context of lung injury and repair. A major focus has been to elucidate pathways (e.g., Hippo/YAP, Wnt/B-catenin, TGF-B/Smad, Forkhead box (Fox) and GATA6) as well as transcriptomic and epigenomic regulations that control differentiation of the alveolar epithelium (including pulmonary stem/progenitor cell proliferation/differentiation) in order to understand how they are altered in disease and injury. Her current studies engaged in to investigate the role of endoplasmic reticulum (ER) stress and the ER master regulator GRP78 in AEC abnormalities in chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) using AEC-specific Grp78 knockout mice model. Her goal is to examine signaling pathways that modulate aberrant epithelial-mesenchymal interactions underlying ER stress-mediated fibrosis and identify new therapeutic approaches for pulmonary fibrosis.

American Thoracic Society International Conference: Award for Best Scientific Abstract, 2015

Epithelial-Mesenchymal Transition International Association: Travel Bursary, 2013

SuperArray Bioscience Corporation: SuperArray Travel Grant Award, 2008

Phi Kappa Phi: Elected Member, 2008

Chinese Academy of Sciences: Visiting Scholar Fellowship, 1998-1999

Grp78 Loss in Epithelial Progenitors Reveals an Age-Linked Role for ER Stress in Pulmonary Fibrosis Am J Respir Crit Care Med. 2019 Nov 18. . View in PubMed

LINC00261 Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Cancer Res. 2019 Jun 15; 79(12):3050-3062. . View in PubMed

Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes Epigenomics. 2018 09; 10(9):1167-1187. . View in PubMed

CLDN181 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018 12 15; 143(12):3169-3180. . View in PubMed

Region-specific role for Pten in maintenance of epithelial phenotype and integrity Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L131-L142. . View in PubMed

Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation Sci Rep. 2017 06 14; 7(1):3473. . View in PubMed

p300/ß-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC) J Biol Chem. 2016 Mar 18; 291(12):6569-82. . View in PubMed

Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15; 310(2):L114-20. . View in PubMed

Pleiotropic Analysis of Lung Cancer and Blood Triglycerides J Natl Cancer Inst. 2016 12; 108(12). . View in PubMed

The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development Am J Respir Cell Mol Biol. 2016 07; 55(1):135-49. . View in PubMed

The importance of detailed epigenomic profiling of different cell types within organs Epigenomics. 2016 06; 8(6):817-29. . View in PubMed

Transforming Growth Factor-ß1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E Sci Rep. 2015 Dec 18; 5:18233. . View in PubMed

Transcriptomic Profiling of Primary Alveolar Epithelial Cell Differentiation in Human and Rat Genom Data. 2014 Dec 01; 2:105-109. . View in PubMed

TRIM72 is required for effective repair of alveolar epithelial cell wounding Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6):L449-59. . View in PubMed

Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. . View in PubMed

Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue Nat Commun. 2014 Feb 27; 5:3365. . View in PubMed

Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation PLoS Genet. 2013 Jun; 9(6):e1003513. . View in PubMed

Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2 PLoS One. 2013; 8(1):e53342. . View in PubMed

GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling J Cell Physiol. 2012 Dec; 227(12):3803-11. . View in PubMed

Interactions between ß-catenin and transforming growth factor-ß signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP) J Biol Chem. 2012 Mar 02; 287(10):7026-38. . View in PubMed

Ligand-independent transforming growth factor-ß type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition J Pathol. 2012 Mar; 226(4):633-44. . View in PubMed

Troglitazone attenuates TGF-ß1-induced EMT in alveolar epithelial cells via a PPAR? -independent mechanism. PLoS One. 2012; 7(6):e38827.. View in PubMed

Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein Am J Respir Cell Mol Biol. 2011 Sep; 45(3):498-509. . View in PubMed

Epithelium-specific deletion of TGF-ß receptor type II protects mice from bleomycin-induced pulmonary fibrosis J Clin Invest. 2011 Jan; 121(1):277-87. . View in PubMed

Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14309-14. . View in PubMed

Directed expression of Cre in alveolar epithelial type 1 cells Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. . View in PubMed

Rat aquaporin-5 43-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C111-20. . View in PubMed

Foxp2 inhibits Nkx21-mediated transcription of SP-C via interactions with the Nkx2. 1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. . View in PubMed

Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. . View in PubMed

Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1280-90. . View in PubMed

Transcriptional regulation by targeted expression of architectural transcription factor high mobility group A2 in salivary glands of transgenic mice Eur J Oral Sci. 2007 Feb; 115(1):30-9. . View in PubMed

Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2 J Histochem Cytochem. 2004 Jun; 52(6):759-67. . View in PubMed

Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer Hum Gene Ther. 2004 May; 15(5):457-68. . View in PubMed

Identification of three genes of known function expressed by alveolar epithelial type I cells Am J Respir Cell Mol Biol. 2003 Jul; 29(1):98-105. . View in PubMed

Na transport proteins are expressed by rat alveolar epithelial type I cells Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L599-608. . View in PubMed

Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells J Appl Physiol (1985). 2005 Jan; 98(1):322-8. . View in PubMed

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