Benjamin Yixing Xu, MD, PhD

Associate Professor of Ophthalmology (Clinical Scholar)

Chief, Glaucoma Service

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Overview

Dr. Xu attended Yale University where he graduated cum laude with a bachelor of science in biomedical engineering. He received his MD and PhD degrees from Columbia University where he was part of the NIH-sponsored Medical Scientist Training Program. He completed a well-received thesis studying how the brain uses eye position signals to coordinate accurate eye movements. Dr. Xu completed his residency in ophthalmology at the LAC+USC Medical Center and USC Roski Eye Institute, where he served as Chief Resident and was recognized for his academic and teaching achievements. He completed his glaucoma fellowship with Dr. Robert Weinreb at the UCSD Shiley Eye Institute and Hamilton Glaucoma Center.

Dr. Xu’s current research focus is developing novel interventions to enhance glaucoma care and prevent glaucoma-related vision loss. Dr. Xu’s research combines non-invasive ocular imaging and artificial intelligence to develop precise and convenient tools to detect and evaluate patients with or at risk for glaucoma. Dr. Xu studies the impact of glaucoma on diverse populations in the United States, using big data to identify and elucidate disparities in glaucoma care. He also uses data from NIH-funded population-based epidemiological studies, including the Chinese American Eye Study (CHES) and Los Angeles Latino Eye Study (LALES), to study the prevalence and impact of glaucoma in the United States. Dr. Xu has a particular interest in studying primary angle closure glaucoma (PACG), a visually devastating form of glaucoma.

Awards

  • Columbia University: NIH Medical Scientist Training Program Training Grant, 2004
     – 2008
  • Columbia University: Columbia University Vision Sciences NEI Training Grant, 2008
     – 2009
  • Columbia University: Dr. Alfred P. Steiner Dean’s Day Reseach Award, 2011
  • University of Southern California: USC Ophthalmology Resident Teaching Award, 2016
  • University of Southern California: USC Ophthalmology Attending Teaching Award, 2019
  • Newsweek Magazine: America’s Best Eye Doctors, 2021
     – 2023

Education and Training

  • Yale University — BS — 20024 — Biomedical Engineering
  • Columbia University — MD, PhD — 2012 — Neuroscience
  • University of Southern California Roski Eye Institute — Residency — 2016 — Ophthalmology
  • University of California San Diego Shiley Eye Institute — Fellowship — 2017 — Glaucoma

Research Funding

  • Clinical Evaluation and Risk Stratification of Angle Closure Disease Using Quantitative OCT
    NIH · R01EY035677 · Feb 1, 2024 – Jan 31, 2029 · Role: Principal Investigator
  • Development and Validation of Quantitative Anterior Segment OCT-based Methods to Evaluate Patients with Primary Angle Closure Disease
    NIH · K23EY029763 · Feb 1, 2019 – Jan 31, 2024 · Role: Principal Investigator

Publications

  • Incidence patterns and genetic validation of primary glaucoma subtypes among 1 million adults in China and the UK. Br J Ophthalmol. 2026 Sep 17.. View in PubMed
  • Novel Wnt potentiators induce iPSC-derived cardiomyocyte proliferation and increase embryonic zebrafish heart size. J Mol Cell Cardiol. 2026 Oct; 219:52-57.. View in PubMed
  • Large Language Models Approximate Inter-Expert Agreement in Glaucoma Suspect and Glaucoma Classification from Multimodal Data. Ophthalmol Sci. 2026 Oct; 6(10):101352.. View in PubMed
  • Quantitative Ciliary Body Imaging Using Image-Registered Swept-Source AS-OCT and Ultrasound Biomicroscopy. Transl Vis Sci Technol. 2026 Aug 03; 15(8):4.. View in PubMed
  • Agreement of Anterior Segment Biometrics Measured Using Image-Registered Swept-Source OCT and High-Frequency Ultrasound Biomicroscopy. J Glaucoma. 2026 Jul 28.. View in PubMed
  • Incidence and Predictors of IOP-Lowering Treatment Following Detection of Referable Glaucoma in a Teleretinal Screening Program. medRxiv. 2026 Jun 04.. View in PubMed
  • Risk-Stratified Monitoring of Open Angle Glaucoma Suspects Based on Diagnostic Conversion Risk. Am J Ophthalmol. 2026 Sep; 289:313-324.. View in PubMed
  • Increased Risk of Intraocular Pressure-Lowering Treatment in Patients with End-Stage Renal Disease Undergoing Hemodialysis. Ophthalmol Glaucoma. 2026 May 12.. View in PubMed
  • Ocular Biometric Determinants of Intraocular Pressure and Risk Factors for Ocular Hypertension: The Chinese American Eye Study. J Glaucoma. 2026 Jun 01; 35(6):362-368.. View in PubMed
  • Ultrasound elastography system for quantifying Age-Related biomechanical changes in ocular tissues. Ultrasonics. 2026 Sep; 165:108059.. View in PubMed