Zlokovic’s more recent research interests are focused on genes that influence the risk for Alzheimer’s disease, particularly how APOE4, PICALM, and CLU affect the cerebrovascular system. In these studies, he uses different transgenic animal models, and human inducible pluripotent stem cell-derived neuronal and blood-brain barrier in vitro models of neurological disorders. He and his research team have also developed novel neuroimaging methods in the living human brain and animal models and novel molecular biomarkers of the neurovascular unit to evaluate how blood-brain barrier and cerebral blood flow functions influence neuronal function, neurodegeneration and cognition. He also remains interested in developing advanced approaches with activated protein C therapy for stroke and other neurological disorders.
Zlokovic is recognized internationally as a leader in the fields of Alzheimer’s disease and stroke. Thomson Reuters listed Zlokovic as one of “The World’s Most Influential Scientific Minds” in 2002-2012, and 2012-2017 for ranking in one percent of the most-cited authors in the field of neurosciences and behavioral sciences. He is the recipient of many awards, including the MetLife Award for Medical Research for “significant contributions to our understanding of Alzheimer’s disease and for bringing us closer to a cure”, the Potamkin Prize from the American Academy of Neurology " in recognition of outstanding achievements in research on Alzheimer’s and related neurodegenerative diseases”, the Javits Award from the National Institute on Neurological Disorders and Stroke "in recognition of distinguished record of substantial contributions in a field of neurological sciences”, and the MERIT Award from the National Institute on Aging "in recognition of sustained contribution to aging and leadership and commitment to the field”. He is a fellow of the American Association for Advancement of Science (AAAS) and a member of The Dana Alliance for Brain Initiative, the Serbian Academy of Sciences and Arts and The European Academy of Sciences (Academia Europeae) - the Life Sciences Class. In 2016 and 2107, he was asked by the Nobel Assembly at Karolinska Institutet, The Nobel Committee to nominate one or more candidates for the Nobel Prize in Physiology and Medicine 2017 and 2018.
Zlokovic is an active entrepreneur and inventor. He co-founded ZZ Biotech, a biotechnology company that is dedicated to developing new treatments for stroke and neurological disorders.
i-10 index: 228; h-index: 91; >350 publications; 34,063 citations (Google Scholar, Sep 2018); complete list in Google Scholar: https://goo.gl/2Npcj2
Selected Publications representing interests of the Zlokovic laboratory.
Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV (2018) Pericyte degeneration causes white matter dysfunction in the mouse CNS. Nature Medicine 24(3), 326-337.
Sweeney MD, Sagare AP, Zlokovic BV (2018) Blood-brain barrier breakdown in Alzheimer’s disease and other neurodegenerative disorders. Nature Reviews Neurology 14(3), 133-150.
Kisler K, Lazic D, Sweeney M, Plunkett S, Khatib ME, Vinogradov SA, Boas DA, Sakadzic S, Zlokovic BV (2018) Diverse protocols for in vivo measurements of cerebrovascular hemodynamic responses and tissue oxygen levels and delivery in the mouse brain. Nature Protocols 13(6), 1377-1402.
Sweeney MD, Zlokovic BV (2018) A lymphatic waste-disposal system implicated in Alzheimer’s disease. Nature 560 (7717) 172-174.
Kisler K, Nelson A, Montagne A, Zlokovic BV (2017) Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer’s disease. Nature Reviews Neuroscience 18, 419-434.
Kisler K, Nelson AR, Rege SV, Ramanathan A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, Boas DA, Sakadžic S, Zlokovic BV (2017) Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nature Neuroscience 20, 406-416.
Wang Y, Zhao Z, Rege S, Griffin JH, Goldman SA, Zlokovic BV (2016) 3K3A-APC stimulates post-ischemic neuronal repair by human neural progenitor cells in mice. Nature Medicine 22 (9): 1050-1055.
Sweeney MD, Ayyadurai S, Zlokovic BV (2016) Pericytes of the neurovascular unit: key functions and signaling pathways. Nature Neuroscience 19 (6): 771-783.
Zhao Z, Nelson A, Betsholtz C, Zlokovic BV (2015) Establishment and dysfunction of blood-brain barrier. Cell 163, Nov 19;163(5):1064-78.
Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NQ, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV (2015) Central role for PICALM in amyloid-? blood-brain barrier transcytosis and clearance. Nature Neuroscience 18, 978-987.
Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wendy RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV (2015) GLUT1 reductions exacerbate Alzheimer’s disease vasculo-neuronal dysfunction and degeneration. Nature Neuroscience 18, 521-530.
Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV (2015) Blood-brain barrier breakdown in the aging human hippocampus. Neuron 85, 296-302.
Griffin JH, Zlokovic BV, Mosnier LO (2015) Activated Protein C: Biased for Translation. Blood 125 (19), 2898-2907.
Zhao Z and Zlokovic BV (2014) Blood-Brain Barrier: A Dual Life of MFSD2A? Neuron 82, 728–730.
Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong G, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV (2014) Blood-spinal cord barrier disruption contributes to early motor neuron degeneration in ALS model mice. Proceedings of the National Academy of Sciences USA 111(11), E1035-42.
Bell RD, Winkler E, Sagare A, Singh I, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk B, Zlokovic BV (2012) Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 485, 512-516.
Deane R, Singh I, Sagare A, Bell R, Ross NT, Larue B, Love R, Perry S, Deane RJ, Thiyagarajan M, Zarcone T, Friedman A, Miller BL, Zlokovic BV (2012) A novel multi-modal RAGE-specific inhibitor controls amyloid-beta-mediated brain disorder in mice. Journal of Clinical Investigation 122 (4), 1377-1392.
Winkler E, Bell R, Zlokovic BV (2011) Functions of CNS pericytes in health and disease. Nature Neuroscience 14, 1398-1405.
Zlokovic BV (2011) Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders. Nature Reviews Neuroscience 12, 723-738.
Winkler EA, Bell RD, Zlokovic BV (2011) Lack of Smad and Notch Leads to a Fatal Game of Brain Pericyte Hopscotch. Developmental Cell (Cell) 20 (3), 279-281.
Zlokovic BV, Griffin JH (2011) Activated protein C cytoprotective pathways and implications for stroke and neurological disorders. Trends in Neurosciences 34 (4), 1198-2009.
Zlokovic BV (2010) Neurodegeneration and the neurovascular unit. Nature Medicine 16(12), 1370-71.
Bell RD, Winkler EA, Sagare A, Singh I, LaRue B, Deane R, Zlokovic BV (2010) Pericytes control key neurovascular functions and the neuronal phenotype in the adult brain and during brain aging. Neuron 68, 409-427.
Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV (2010) Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood 115, 4963-4972.
Bell RD , Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JP, Zlokovic BV (2009) SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nature Cell Biology 11(2), 143-153.
Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino F, Stojanovic K, Cleveland DW, Zlokovic BV (2009) Activated protein C slows ALS-like disease by transcrptionally inhibiting SOD1 in motor neurons and microglial cells. Journal of Clinical Investigation 119(11), 3437-3440.
Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV (2008) Apolipoprotein E isoform-specific disruption of Alzheimer’s amyloid ?-peptide clearance from mouse brain Journal of Clinical Investigation 118(12), 4002-4013.
Zhong Z, Deane R, Zarina A, Parisi M, Shapovalov Y, 0’Banion K, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV (2008) ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nature Neuroscience 11(4), 420-422.
Zlokovic BV (2008) Blood-brain barrier in health and chronic neurodegenerative disorders. Neuron, 57, 178-201.
Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Pelmutter D, Coma M, Zhong Z, Zlokovic BV (2007) Clearance of amyloid-beta by circulating lipoprotein receptors. Nature Medicine 13 (9), 1029-1031.
Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV (2007). Serum response factor and myocardin mediate cerebral arterial hypercontractility and blood flow dysregulation in Alzheimer’s phenotype. Proceedings of the National Academy of Sciences USA 104, 823-828.
Mosnier L, Zlokovic BV, Griffin JH (2007) The cellular protein C pathway. Blood 109(8), 161-172.
Cheng T, Petraglia A, Li Z, Meedakshisudaram T, Wu Z, Zhong Z, Liu D, Maggirwar SB, Deane R, Fernandez J, LaRue B, Griffin J, Chopp M, Zlokovic BV (2006) Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nature Medicine 12 (11), 1278-1285.
Zlokovic BV (2006) Remodeling after stroke. Nature Medicine 12 (4) 390-391.
Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks A, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetski R, Song H, Hofman F, Zlokovic BV (2005) Role of MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nature Medicine 11(9), 959-965.
Zlokovic BV (2005) Neurovascular mechanisms of Alzheimer’s neurodegeneration. Trends in Neurosciences 28, 202-208.
Deane R, Wu Z, Davis J, Yan SD, Hamm K, Sagare A, Xu F, Spijkers P, Lenting PJ, Van Nostrand WE, Zlokovic BV (2004) LRP-amyloid-beta interaction mediates differential brain efflux of Abeta isoforms Neuron 43, 33-44.
Liu D, Cheng T, Guo H, Fernandez AJ, Griffin JH, Song X, Zlokovic BV (2004) Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nature Medicine 10, (12), 1379-1383.
Guo H, Liu D, Gelbard H, Cheng T, Fernandez JA, Insalaca R, Griffin JH, Zlokovic BV (2004) Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron 41, 563-572.
Deane R, Yan SD, Kumar R, Jovanovic S, LaRue B, Welch D, Maness L, Yu J, Zhu H, Ghiso J, Frangione B, Schmidt AM, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic BV (2003) RAGE mediates amyloid-ß peptide transport across the blood-brain barrier and accumulation in brain. Nature Medicine 9(7), 907-913.
Cheng T, Liu D, Fernández JA, Griffin JH, Castellino F, Rosen E, Fukudome K, Zlokovic BV (2003) Activated protein C blocks P53-mediated apoptosis in ischemic human brain endothelium and is neuroportective. Nature Medicine 9, 338-342.
Domotor E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV (2003) Activated protein C alters cytosolic Ca2+ flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease-activated receptor-1. Blood 101, 4797-4801.
Shibata M, Subramanyan RK, Amar A, Fernandez J, Griffin J, Zlokovic BV (2001) Anti-inflammatory, antithrombotic and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke with cerebrovascular thrombosis. Circulation 103, 1799-1805.
Shibata M, Yamada S, Kumar RS, Calero M, Bading B, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV (2000) Clearance of Alzheimer’s amyloid-ß1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. Journal of Clinical Investigation 106(12), 1489-1499.
Zlokovic BV, Shinya Y, Holtzman D, Ghiso J, Frangione B (2000) Clearance of amyloid ß-peptide from brain: transport or metabolism? Nature Medicine 6, 718-719.
Mackic JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern D, Schmidt AM, Frangione B, Zlokovic BV (1998) Human blood-brain barrier receptors for Alzheimer's amyloid-? 1-40: Asymmetrical binding, endocytosis and transcytosis at the apical side of brain microvascular endothelial cell monolayer. Journal of Clinical Investigation 102, 734-743.
Zlokovic BV, Martel CL, Matsubara E, McComb JG, Zheng G, McCluskey RT, Frangione B, Ghiso J (1996) Glycoprotein 330/megalin: Porbable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer's Disease amyloid-? at the blood-brain and blood-cerebrospinal fluid barriers. Proceedings of the National Academy of Sciences USA 93, 4229-4236.
Blood-Brain Barrier: From Physiology to Disease and Back Physiol Rev. 2019 Jan 01; 99(1):21-78. . View in PubMed
Final Results of the RHAPSODY trial: A multi-center, Phase 2 trial using a continual reassessment method to determine the safety and tolerability of 3K3A-APC, a Recombinant Variant of Human Activated Protein C, in combination with tissue plasminogen activator, mechanical thrombectomy or both in moderate to severe acute ischemic stroke Ann Neurol. 2018 Nov 18. . View in PubMed
The role of brain vasculature in neurodegenerative disorders Nat Neurosci. 2018 Oct; 21(10):1318-1331. . View in PubMed
A lymphatic waste-disposal system implicated in Alzheimer's disease Nature. 2018 Aug; 560(7717):172-174. . View in PubMed
Activated protein C, protease activated receptor 1 and neuroprotection Blood. 2018 Jun 04. . View in PubMed
Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol Neurosurgery. 2018 Jun 01; 82(6):770-780. . View in PubMed
In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain Nat Protoc. 2018 Jun; 13(6):1377-1402. . View in PubMed
Understanding the role of the perivascular space in cerebral small vessel disease Cardiovasc Res. 2018 May 02. . View in PubMed
PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke Blood. 2018 Mar 15; 131(11):1163-1171. . View in PubMed
Pericyte degeneration causes white matter dysfunction in the mouse central nervous system Nat Med. 2018 Mar; 24(3):326-337. . View in PubMed
Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders Nat Rev Neurol. 2018 Mar; 14(3):133-150. . View in PubMed
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons Nat Med. 2018 Feb 05. . View in PubMed
Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-ß42 by LRP1-dependent apolipoprotein E isoform-specific mechanism Mol Neurodegener. 2018 10 19; 13(1):57. . View in PubMed
Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage J Cereb Blood Flow Metab. 2018 Jan 01; 271678X18768670. . View in PubMed
Alzheimer's disease: A matter of blood-brain barrier dysfunction? J Exp Med. 2017 Nov 06; 214(11):3151-3169.. View in PubMed
Neuropharmacology. 2017 Sep 18. . View in PubMed
Role of clusterin in the brain vascular clearance of amyloid-ß Proc Natl Acad Sci U S A. 2017 Aug 15; 114(33):8681-8682. . View in PubMed
Remote control of BBB: A tale of exosomes and microRNA Cell Res. 2017 Jul; 27(7):849-850. . View in PubMed
NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface Fluids Barriers CNS. 2017 May 01; 14(1):12. . View in PubMed
Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain Nat Neurosci. 2017 Mar; 20(3):406-416. . View in PubMed
Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease Nat Rev Neurosci. 2017 07; 18(7):419-434. . View in PubMed
Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-ß signaling PLoS One. 2017; 12(4):e0176225. . View in PubMed
Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum J Cereb Blood Flow Metab. 2017 Jan 01; 271678X17743670. . View in PubMed
2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C Arterioscler Thromb Vasc Biol. 2016 Nov; 36(11):2143-2151. . View in PubMed
Activated protein C promotes neuroprotection: mechanisms and translation to the clinic Thromb Res. 2016 May; 141 Suppl 2:S62-4. . View in PubMed
Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI Magn Reson Med. 2016 May; 75(5):1967-77. . View in PubMed
Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease Biochim Biophys Acta. 2016 May; 1862(5):887-900. . View in PubMed
Brain imaging of neurovascular dysfunction in Alzheimer's disease Acta Neuropathol. 2016 May; 131(5):687-707. . View in PubMed
Clearance systems in the brain--implications for Alzheimer diseaser Nat Rev Neurol. 2016 Apr; 12(4):248. . View in PubMed
3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice Nat Med. 2016 09; 22(9):1050-5. . View in PubMed
Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy Cell Stem Cell. 2016 11 03; 19(5):663-671. . View in PubMed
Neurovascular and Immuno-Imaging: From Mechanisms to TherapiesProceedings of the Inaugural Symposium. Front Neurosci. 2016; 10:46. . View in PubMed
Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease J Cereb Blood Flow Metab. 2016 Jan; 36(1):216-27. . View in PubMed
Pericytes of the neurovascular unit: key functions and signaling pathways Nat Neurosci. 2016 05 26; 19(6):771-83. . View in PubMed
Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research JAMA Neurol. 2016 Jan; 73(1):13-4. . View in PubMed
Consensus statement for diagnosis of subcortical small vessel disease J Cereb Blood Flow Metab. 2016 Jan; 36(1):6-25. . View in PubMed
Establishment and Dysfunction of the Blood-Brain Barrier Cell. 2015 Nov 19; 163(5):1064-1078. . View in PubMed
Shedding of soluble platelet-derived growth factor receptor-ß from human brain pericytes Neurosci Lett. 2015 Oct 21; 607:97-101. . View in PubMed
Clearance systems in the brain-implications for Alzheimer disease Nat Rev Neurol. 2015 Aug; 11(8):457-70. . View in PubMed
Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease J Cereb Blood Flow Metab. 2015 Jul; 35(7):1055-68. . View in PubMed
Central role for PICALM in amyloid-ß blood-brain barrier transcytosis and clearance Nat Neurosci. 2015 Jul; 18(7):978-87. . View in PubMed
ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies BMC Med Imaging. 2015 Jun 16; 15:19. . View in PubMed
Vascular contributions to cognitive impairment and dementia including Alzheimer's disease Alzheimers Dement. 2015 Jun; 11(6):710-7. . View in PubMed
Activated protein C: biased for translation Blood. 2015 May 07; 125(19):2898-907. . View in PubMed
Vascular plasticity and cognition during normal aging and dementia JAMA Neurol. 2015 May; 72(5):495-6. . View in PubMed
GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration Nat Neurosci. 2015 Apr; 18(4):521-530. . View in PubMed
7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice Proc SPIE Int Soc Opt Eng. 2015 Mar 20; 9413. . View in PubMed
Blood-brain barrier breakdown in the aging human hippocampus Neuron. 2015 Jan 21; 85(2):296-302. . View in PubMed
Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1 Front Aging Neurosci. 2015; 7:136. . View in PubMed
Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke Front Cell Neurosci. 2015; 9:344. . View in PubMed
Cytoprotective-selective activated protein C therapy for ischaemic stroke Thromb Haemost. 2014 Nov; 112(5):883-92. . View in PubMed
Nat Commun. 2014 Sep 05; 5:4820. . View in PubMed
Recommendations of the Alzheimer's disease-related dementias conference Neurology. 2014 Aug 26; 83(9):851-60. . View in PubMed
The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathol. 2014 Jul; 24(4):371-86.. View in PubMed
Blood-brain barrier: a dual life of MFSD2A? Neuron. 2014 May 21; 82(4):728-30.. View in PubMed
Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. . View in PubMed
Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats Stroke. 2013 Dec; 44(12):3529-36. . View in PubMed
Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity J Thromb Haemost. 2013 Nov; 11(11):2059-62. . View in PubMed
Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown JAMA Neurol. 2013 Sep 01; 70(9):1198-200. . View in PubMed
Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice Blood Cells Mol Dis. 2013 Aug; 51(2):104-8. . View in PubMed
A lipoprotein receptor cluster IV mutant preferentially binds amyloid-ß and regulates its clearance from the mouse brain J Biol Chem. 2013 May 24; 288(21):15154-66. . View in PubMed
Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease Brain Pathol. 2013 May; 23(3):303-10. . View in PubMed
Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1 Brain Res. 2013 Apr 24; 1507:97-104. . View in PubMed
An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway J Neurosci. 2013 Apr 03; 33(14):6181-90. . View in PubMed
Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease JAMA Neurol. 2013 Apr; 70(4):440-4. . View in PubMed
A gliovascular idea for the white matter repair? J Neurochem. 2013 Apr; 125(2):172-4.. View in PubMed
Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis Acta Neuropathol. 2013 Jan; 125(1):111-20. . View in PubMed
Pericyte loss influences Alzheimer-like neurodegeneration in mice Nat Commun. 2013; 4:2932. . View in PubMed
Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers Curr Pharm Des. 2013; 19(42):7479-85. . View in PubMed
Neurovascular defects and faulty amyloid-ß vascular clearance in Alzheimer's disease J Alzheimers Dis. 2013; 33 Suppl 1:S87-100. . View in PubMed
Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability J Cereb Blood Flow Metab. 2012 Oct; 32(10):1841-52. . View in PubMed
Neurovascular dysfunction and faulty amyloid ß-peptide clearance in Alzheimer disease Cold Spring Harb Perspect Med. 2012 Oct 01; 2(10). . View in PubMed
Low-density lipoprotein receptor-related protein 1: a physiological Aß homeostatic mechanism with multiple therapeutic opportunities Pharmacol Ther. 2012 Oct; 136(1):94-105. . View in PubMed
Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aß clearance in a mouse model of ß-amyloidosis Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15502-7. . View in PubMed
An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents Stroke. 2012 Sep; 43(9):2444-9. . View in PubMed
Hypertension induces brain ß-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature Hypertension. 2012 Jul; 60(1):188-97. . View in PubMed
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A Nature. 2012 May 16; 485(7399):512-6. . View in PubMed
Protein C anticoagulant and cytoprotective pathways Int J Hematol. 2012 Apr; 95(4):333-45. . View in PubMed
A multimodal RAGE-specific inhibitor reduces amyloid ß-mediated brain disorder in a mouse model of Alzheimer disease J Clin Invest. 2012 Apr; 122(4):1377-92. . View in PubMed
Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke Curr Pharm Des. 2012; 18(27):4215-22. . View in PubMed
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders Nat Rev Neurosci. 2011 Nov 03; 12(12):723-38. . View in PubMed
Central nervous system pericytes in health and disease Nat Neurosci. 2011 Oct 26; 14(11):1398-1405. . View in PubMed
From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-ß levels J Neurosci Res. 2011 Jul; 89(7):967-8. . View in PubMed
Microhemorrhages: undetectable but clinically meaningful the question persists Amyotroph Lateral Scler. 2011 May; 12(3):231-2; author reply 233-4. . View in PubMed
Cytoprotective protein C pathways and implications for stroke and neurological disorders Trends Neurosci. 2011 Apr; 34(4):198-209. . View in PubMed
Lack of Smad or Notch leads to a fatal game of brain pericyte hopscotch Dev Cell. 2011 Mar 15; 20(3):279-80. . View in PubMed
Methamphetamine causes sustained depression in cerebral blood flow Brain Res. 2011 Feb 10; 1373:91-100. . View in PubMed
Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway Mol Neurodegener. 2011 Feb 03; 6:13. . View in PubMed
Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-ß is an early biomarker for mild cognitive impairment preceding Alzheimer's disease J Alzheimers Dis. 2011; 24(1):25-34. . View in PubMed
Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid ß-peptide elimination from the brain J Neurochem. 2010 Dec; 115(5):1077-89. . View in PubMed
Neurodegeneration and the neurovascular unit Nat Med. 2010 Dec; 16(12):1370-1. . View in PubMed
Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region J Neurosci. 2010 Nov 17; 30(46):15521-34. . View in PubMed
Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging Neuron. 2010 Nov 04; 68(3):409-27. . View in PubMed
Pericyte constriction after stroke: the jury is still out Nat Med. 2010 Sep; 16(9):959; author reply 960. . View in PubMed
Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling Mol Neurodegener. 2010 Aug 25; 5:32. . View in PubMed
Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact Brain Res. 2010 Aug 06; 1347:125-31. . View in PubMed
Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor Blood. 2010 Jun 10; 115(23):4963-72. . View in PubMed
Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice Brain Res. 2010 Mar 04; 1317:218-26. . View in PubMed
Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact Neurosurgery. 2010 Jan; 66(1):165-71; discussion 171-2. . View in PubMed
Species-specific anticoagulant and mitogenic activities of murine protein S Haematologica. 2009 Dec; 94(12):1721-31. . View in PubMed
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells J Clin Invest. 2009 Nov; 119(11):3437-49. . View in PubMed
Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease Acta Neuropathol. 2009 Jul; 118(1):103-13. . View in PubMed
Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity Stroke. 2009 May; 40(5):1864-9. . View in PubMed
Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity J Neurochem. 2009 Apr; 109(1):116-24. . View in PubMed
Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity Eur J Neurosci. 2009 Mar; 29(6):1119-30. . View in PubMed
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