Berislav V Zlokovic
Mary Hayley and Selim Zilkha Chair in Alzheimer's Disease Research
Director, Zilkha Neurogenetic Institute
The small HDL particle hypothesis of Alzheimer's disease Alzheimers Dement. 2022 Apr 13. . View in PubMed
Blood-brain barrier link to human cognitive impairment and Alzheimer's Disease Nat Cardiovasc Res. 2022 Feb; 1(2):108-115. . View in PubMed
Brain barriers and their potential role in migraine pathophysiology J Headache Pain. 2022 Jan 26; 23(1):16. . View in PubMed
Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging J Cereb Blood Flow Metab. 2022 10; 42(10):1813-1826. . View in PubMed
Imaging subtle leaks in the blood-brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions Geroscience. 2022 06; 44(3):1339-1351. . View in PubMed
How the brain regulates its own immune system Nat Neurosci. 2022 05; 25(5):532-534. . View in PubMed
Prenatal disruption of blood-brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2113310119. . View in PubMed
A single-cell atlas of the normal and malformed human brain vasculature Science. 2022 03 04; 375(6584):eabi7377. . View in PubMed
Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C J Exp Med. 2022 01 03; 219(1). . View in PubMed
3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice Front Neurosci. 2022; 16:841916. . View in PubMed
APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-ß Nat Aging. 2021 Jun; 1(6):506-520. . View in PubMed
Investigating the blood-spinal cord barrier in preclinical models: a systematic review of in vivo imaging techniques Spinal Cord. 2021 Jun; 59(6):596-612. . View in PubMed
Evidence that blood-CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen Headache. 2021 Mar; 61(3):536-545. . View in PubMed
Editorial for "MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure" J Magn Reson Imaging. 2021 11; 54(5):1527-1528. . View in PubMed
Reply to: Rethink the classical view of cerebrospinal fluid production Nat Rev Neurol. 2021 09; 17(9):590-591. . View in PubMed
Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model Environ Health Perspect. 2021 08; 129(8):87006. . View in PubMed
Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults Brain Behav Immun. 2021 05; 94:299-307. . View in PubMed
A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease Transl Stroke Res. 2021 02; 12(1):15-30. . View in PubMed
Microglia have a grip on brain microvasculature Nat Commun. 2021 09 06; 12(1):5290. . View in PubMed
Can prehospital "plasma supplement" neutralize the systemic storm in severe trauma? Cell Rep Med. 2021 12 21; 2(12):100481.. View in PubMed
Acetylated tau: A missing link between head injury and dementia Med (N Y). 2021 06 11; 2(6):637-639. . View in PubMed
Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation Front Neurol. 2021; 12:593582. . View in PubMed
Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion Front Immunol. 2021; 12:785519. . View in PubMed
Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in CraniosynostosisCell. 2021 01 07; 184(1):243-256. e18. . View in PubMed
On the intersection between systemic infection, brain vascular dysfunction and dementia Brain. 2021 07 28; 144(6):1629-1631. . View in PubMed
Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A J Exp Med. 2021 04 05; 218(4). . View in PubMed
Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial EBioMedicine. 2020 Sep; 59:102883. . View in PubMed
Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop Alzheimers Dement. 2020 12; 16(12):1714-1733. . View in PubMed
3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase Stroke. 2020 07; 51(7):2236-2239. . View in PubMed
A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid Alzheimers Dement. 2020 06; 16(6):821-830. . View in PubMed
Building vascular roadmaps: A novel toolset for visualizing and annotating whole mouse brain vasculature Lab Anim (NY). 2020 06; 49(6):175-176. . View in PubMed
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline Nature. 2020 05; 581(7806):71-76. . View in PubMed
Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer's disease Neurobiol Dis. 2020 03; 136:104745. . View in PubMed
APOE4 Accelerates Development of Dementia After Stroke: Is There a Role for Cerebrovascular Dysfunction? Stroke. 2020 03; 51(3):699-700.. View in PubMed
Perivascular spaces in the brain: anatomy, physiology and pathology Nat Rev Neurol. 2020 03; 16(3):137-153. . View in PubMed
Functional connectivity among brain regions affected in Alzheimer's disease is associated with CSF TNF-a in APOE4 carriers Neurobiol Aging. 2020 02; 86:112-122. . View in PubMed
Correction: Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline PLoS One. 2020; 15(7):e0236379. . View in PubMed
Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid J Neurosci. 2020 10 28; 40(44):8573-8586. . View in PubMed
Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling Front Cell Neurosci. 2020; 14:27. . View in PubMed
Therapeutic TVs for Crossing Barriers in the Brain Cell. 2020 07 23; 182(2):267-269. . View in PubMed
Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo Front Aging Neurosci. 2020; 12:108. . View in PubMed
Endothelial Tip Cell Finds Its Way with Piezo1 Neuron. 2020 10 14; 108(1):5-7. . View in PubMed
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy Alzheimers Dement (Amst). 2020; 12(1):e12053. . View in PubMed
Comparison Between Blood-Brain Barrier Water Exchange Rate and Permeability to Gadolinium-Based Contrast Agent in an Elderly Cohort Front Neurosci. 2020; 14:571480. . View in PubMed
Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline PLoS One. 2020; 15(5):e0232785. . View in PubMed
Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto Int J Stroke. 2019 Sep 22; 1747493019871915. . View in PubMed
Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment Alzheimers Dement. 2019 12; 15(12):1568-1575. . View in PubMed
Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss Nat Neurosci. 2019 07; 22(7):1089-1098. . View in PubMed
Preventing dementia by preventing stroke: The Berlin Manifesto Alzheimers Dement. 2019 07; 15(7):961-984. . View in PubMed
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction Nat Med. 2019 02; 25(2):270-276. . View in PubMed
Prion Protein Antagonists Rescue Alzheimer's Amyloid-ß-Related Cognitive Deficits Trends Mol Med. 2019 02; 25(2):74-76. . View in PubMed
Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum J Cereb Blood Flow Metab. 2019 02; 39(2):240-250. . View in PubMed
Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke Ann Neurol. 2019 01; 85(1):125-136. . View in PubMed
Vascular dysfunction-The disregarded partner of Alzheimer's disease Alzheimers Dement. 2019 01; 15(1):158-167. . View in PubMed
Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular ReprogrammingCell Stem Cell. 2019 10 03; 25(4):486-500. e9. . View in PubMed
Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis Am J Physiol Heart Circ Physiol. 2019 08 01; 317(2):H255-H263. . View in PubMed
TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in MiceCell Rep. 2019 04 09; 27(2):549-560. e6. . View in PubMed
3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice J Exp Med. 2019 02 04; 216(2):279-293. . View in PubMed
Short-term fish oil supplementation applied in presymptomatic stage of Alzheimer's disease enhances microglial/macrophage barrier and prevents neuritic dystrophy in parietal cortex of 5xFAD mouse model PLoS One. 2019; 14(5):e0216726. . View in PubMed
Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons JCI Insight. 2019 07 16; 5. . View in PubMed
Blood-Brain Barrier: From Physiology to Disease and Back Physiol Rev. 2019 01 01; 99(1):21-78. . View in PubMed
The role of brain vasculature in neurodegenerative disorders Nat Neurosci. 2018 10; 21(10):1318-1331. . View in PubMed
A lymphatic waste-disposal system implicated in Alzheimer's disease Nature. 2018 08; 560(7717):172-174. . View in PubMed
In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain Nat Protoc. 2018 06; 13(6):1377-1402. . View in PubMed
Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage J Cereb Blood Flow Metab. 2018 06; 38(6):973-979. . View in PubMed
Pericyte degeneration causes white matter dysfunction in the mouse central nervous system Nat Med. 2018 03; 24(3):326-337. . View in PubMed
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons Nat Med. 2018 03; 24(3):313-325. . View in PubMed
Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders Nat Rev Neurol. 2018 03; 14(3):133-150. . View in PubMed
Neuropharmacology. 2018 05 15; 134(Pt B):293-301. . View in PubMed
Understanding the role of the perivascular space in cerebral small vessel disease Cardiovasc Res. 2018 09 01; 114(11):1462-1473. . View in PubMed
Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol Neurosurgery. 2018 06 01; 82(6):770-780. . View in PubMed
PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke Blood. 2018 03 15; 131(11):1163-1171. . View in PubMed
Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-ß42 by LRP1-dependent apolipoprotein E isoform-specific mechanism Mol Neurodegener. 2018 10 19; 13(1):57. . View in PubMed
Activated protein C, protease activated receptor 1, and neuroprotection Blood. 2018 07 12; 132(2):159-169. . View in PubMed
Alzheimer's disease: A matter of blood-brain barrier dysfunction? J Exp Med. 2017 Nov 06; 214(11):3151-3169.. View in PubMed
NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface Fluids Barriers CNS. 2017 May 01; 14(1):12. . View in PubMed
Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain Nat Neurosci. 2017 Mar; 20(3):406-416. . View in PubMed
Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease Nat Rev Neurosci. 2017 07; 18(7):419-434. . View in PubMed
Remote control of BBB: A tale of exosomes and microRNA Cell Res. 2017 07; 27(7):849-850. . View in PubMed
Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-ß signaling PLoS One. 2017; 12(4):e0176225. . View in PubMed
Role of clusterin in the brain vascular clearance of amyloid-ß Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8681-8682. . View in PubMed
Brain imaging of neurovascular dysfunction in Alzheimer's disease Acta Neuropathol. 2016 May; 131(5):687-707. . View in PubMed
Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI Magn Reson Med. 2016 May; 75(5):1967-77. . View in PubMed
Activated protein C promotes neuroprotection: mechanisms and translation to the clinic Thromb Res. 2016 May; 141 Suppl 2:S62-4. . View in PubMed
Clearance systems in the brain--implications for Alzheimer diseaser Nat Rev Neurol. 2016 Apr; 12(4):248. . View in PubMed
2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C Arterioscler Thromb Vasc Biol. 2016 11; 36(11):2143-2151. . View in PubMed
3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice Nat Med. 2016 09; 22(9):1050-5. . View in PubMed
Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease Biochim Biophys Acta. 2016 05; 1862(5):887-900. . View in PubMed
Pericytes of the neurovascular unit: key functions and signaling pathways Nat Neurosci. 2016 05 26; 19(6):771-83. . View in PubMed
Consensus statement for diagnosis of subcortical small vessel disease J Cereb Blood Flow Metab. 2016 Jan; 36(1):6-25. . View in PubMed
Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy Cell Stem Cell. 2016 11 03; 19(5):663-671. . View in PubMed
Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research JAMA Neurol. 2016 Jan; 73(1):13-4. . View in PubMed
Neurovascular and Immuno-Imaging: From Mechanisms to TherapiesProceedings of the Inaugural Symposium. Front Neurosci. 2016; 10:46. . View in PubMed
Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease J Cereb Blood Flow Metab. 2016 Jan; 36(1):216-27. . View in PubMed
Establishment and Dysfunction of the Blood-Brain Barrier Cell. 2015 Nov 19; 163(5):1064-1078. . View in PubMed
Shedding of soluble platelet-derived growth factor receptor-ß from human brain pericytes Neurosci Lett. 2015 Oct 21; 607:97-101. . View in PubMed
Clearance systems in the brain-implications for Alzheimer disease Nat Rev Neurol. 2015 Aug; 11(8):457-70. . View in PubMed
Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease J Cereb Blood Flow Metab. 2015 Jul; 35(7):1055-68. . View in PubMed
Central role for PICALM in amyloid-ß blood-brain barrier transcytosis and clearance Nat Neurosci. 2015 Jul; 18(7):978-87. . View in PubMed
ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies BMC Med Imaging. 2015 Jun 16; 15:19. . View in PubMed
Vascular contributions to cognitive impairment and dementia including Alzheimer's disease Alzheimers Dement. 2015 Jun; 11(6):710-7. . View in PubMed
Activated protein C: biased for translation Blood. 2015 May 07; 125(19):2898-907. . View in PubMed
Vascular plasticity and cognition during normal aging and dementia JAMA Neurol. 2015 May; 72(5):495-6. . View in PubMed
GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration Nat Neurosci. 2015 Apr; 18(4):521-530. . View in PubMed
7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice Proc SPIE Int Soc Opt Eng. 2015 Mar 20; 9413. . View in PubMed
Blood-brain barrier breakdown in the aging human hippocampus Neuron. 2015 Jan 21; 85(2):296-302. . View in PubMed
Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke Front Cell Neurosci. 2015; 9:344. . View in PubMed
Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1 Front Aging Neurosci. 2015; 7:136. . View in PubMed
Cytoprotective-selective activated protein C therapy for ischaemic stroke Thromb Haemost. 2014 Nov; 112(5):883-92. . View in PubMed
Nat Commun. 2014 Sep 05; 5:4820. . View in PubMed
Recommendations of the Alzheimer's disease-related dementias conference Neurology. 2014 Aug 26; 83(9):851-60. . View in PubMed
The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathol. 2014 Jul; 24(4):371-86.. View in PubMed
Blood-brain barrier: a dual life of MFSD2A? Neuron. 2014 May 21; 82(4):728-30.. View in PubMed
Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. . View in PubMed
Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats Stroke. 2013 Dec; 44(12):3529-36. . View in PubMed
Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity J Thromb Haemost. 2013 Nov; 11(11):2059-62. . View in PubMed
Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown JAMA Neurol. 2013 Sep 01; 70(9):1198-200. . View in PubMed
Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice Blood Cells Mol Dis. 2013 Aug; 51(2):104-8. . View in PubMed
A lipoprotein receptor cluster IV mutant preferentially binds amyloid-ß and regulates its clearance from the mouse brain J Biol Chem. 2013 May 24; 288(21):15154-66. . View in PubMed
Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease Brain Pathol. 2013 May; 23(3):303-10. . View in PubMed
Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1 Brain Res. 2013 Apr 24; 1507:97-104. . View in PubMed
An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway J Neurosci. 2013 Apr 03; 33(14):6181-90. . View in PubMed
A gliovascular idea for the white matter repair? J Neurochem. 2013 Apr; 125(2):172-4.. View in PubMed
Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease JAMA Neurol. 2013 Apr; 70(4):440-4. . View in PubMed
Pericyte loss influences Alzheimer-like neurodegeneration in mice Nat Commun. 2013; 4:2932. . View in PubMed
Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers Curr Pharm Des. 2013; 19(42):7479-85. . View in PubMed
Neurovascular defects and faulty amyloid-ß vascular clearance in Alzheimer's disease J Alzheimers Dis. 2013; 33 Suppl 1:S87-100. . View in PubMed
Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis Acta Neuropathol. 2013 Jan; 125(1):111-20. . View in PubMed
Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability J Cereb Blood Flow Metab. 2012 Oct; 32(10):1841-52. . View in PubMed
Neurovascular dysfunction and faulty amyloid ß-peptide clearance in Alzheimer disease Cold Spring Harb Perspect Med. 2012 Oct 01; 2(10). . View in PubMed
Low-density lipoprotein receptor-related protein 1: a physiological Aß homeostatic mechanism with multiple therapeutic opportunities Pharmacol Ther. 2012 Oct; 136(1):94-105. . View in PubMed
Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aß clearance in a mouse model of ß-amyloidosis Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15502-7. . View in PubMed
An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents Stroke. 2012 Sep; 43(9):2444-9. . View in PubMed
Hypertension induces brain ß-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature Hypertension. 2012 Jul; 60(1):188-97. . View in PubMed
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A Nature. 2012 May 16; 485(7399):512-6. . View in PubMed
Protein C anticoagulant and cytoprotective pathways Int J Hematol. 2012 Apr; 95(4):333-45. . View in PubMed
A multimodal RAGE-specific inhibitor reduces amyloid ß-mediated brain disorder in a mouse model of Alzheimer disease J Clin Invest. 2012 Apr; 122(4):1377-92. . View in PubMed
Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke Curr Pharm Des. 2012; 18(27):4215-22. . View in PubMed
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders Nat Rev Neurosci. 2011 Nov 03; 12(12):723-38. . View in PubMed
Central nervous system pericytes in health and disease Nat Neurosci. 2011 Oct 26; 14(11):1398-1405. . View in PubMed
From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-ß levels J Neurosci Res. 2011 Jul; 89(7):967-8. . View in PubMed
Microhemorrhages: undetectable but clinically meaningful the question persists Amyotroph Lateral Scler. 2011 May; 12(3):231-2; author reply 233-4. . View in PubMed
Cytoprotective protein C pathways and implications for stroke and neurological disorders Trends Neurosci. 2011 Apr; 34(4):198-209. . View in PubMed
Lack of Smad or Notch leads to a fatal game of brain pericyte hopscotch Dev Cell. 2011 Mar 15; 20(3):279-80. . View in PubMed
Methamphetamine causes sustained depression in cerebral blood flow Brain Res. 2011 Feb 10; 1373:91-100. . View in PubMed
Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway Mol Neurodegener. 2011 Feb 03; 6:13. . View in PubMed
Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-ß is an early biomarker for mild cognitive impairment preceding Alzheimer's disease J Alzheimers Dis. 2011; 24(1):25-34. . View in PubMed
Neurodegeneration and the neurovascular unit Nat Med. 2010 Dec; 16(12):1370-1. . View in PubMed
Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid ß-peptide elimination from the brain J Neurochem. 2010 Dec; 115(5):1077-89. . View in PubMed
Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region J Neurosci. 2010 Nov 17; 30(46):15521-34. . View in PubMed
Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging Neuron. 2010 Nov 04; 68(3):409-27. . View in PubMed
Pericyte constriction after stroke: the jury is still out Nat Med. 2010 Sep; 16(9):959; author reply 960. . View in PubMed
Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling Mol Neurodegener. 2010 Aug 25; 5:32. . View in PubMed
Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact Brain Res. 2010 Aug 06; 1347:125-31. . View in PubMed
Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor Blood. 2010 Jun 10; 115(23):4963-72. . View in PubMed
Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice Brain Res. 2010 Mar 04; 1317:218-26. . View in PubMed
Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact Neurosurgery. 2010 Jan; 66(1):165-71; discussion 171-2. . View in PubMed
Species-specific anticoagulant and mitogenic activities of murine protein S Haematologica. 2009 Dec; 94(12):1721-31. . View in PubMed
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells J Clin Invest. 2009 Nov; 119(11):3437-49. . View in PubMed
Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease Acta Neuropathol. 2009 Jul; 118(1):103-13. . View in PubMed
Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity Stroke. 2009 May; 40(5):1864-9. . View in PubMed
Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity J Neurochem. 2009 Apr; 109(1):116-24. . View in PubMed
Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease CNS Neurol Disord Drug Targets. 2009 Mar; 8(1):16-30. . View in PubMed
Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity Eur J Neurosci. 2009 Mar; 29(6):1119-30. . View in PubMed
SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells Nat Cell Biol. 2009 Feb; 11(2):143-53. . View in PubMed
Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier J Cereb Blood Flow Metab. 2009 Jan; 29(1):25-33. . View in PubMed
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain J Clin Invest. 2008 Dec; 118(12):4002-13. . View in PubMed
Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1 J Neurosci. 2008 Nov 26; 28(48):12788-97. . View in PubMed
Myocardin is sufficient for a smooth muscle-like contractile phenotype Arterioscler Thromb Vasc Biol. 2008 Aug; 28(8):1505-10. . View in PubMed
New therapeutic targets in the neurovascular pathway in Alzheimer's disease Neurotherapeutics. 2008 Jul; 5(3):409-14. . View in PubMed
Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke J Cereb Blood Flow Metab. 2008 Apr; 28(4):764-71. . View in PubMed
ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration Nat Neurosci. 2008 Apr; 11(4):420-2. . View in PubMed
The blood-brain barrier in health and chronic neurodegenerative disorders Neuron. 2008 Jan 24; 57(2):178-201. . View in PubMed
The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease Curr Pharm Des. 2008; 14(16):1601-5. . View in PubMed
Clearance of amyloid-beta by circulating lipoprotein receptors Nat Med. 2007 Sep; 13(9):1029-31. . View in PubMed
Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system J Cereb Blood Flow Metab. 2007 May; 27(5):909-18. . View in PubMed
The cytoprotective protein C pathway Blood. 2007 Apr 15; 109(8):3161-72. . View in PubMed
Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease Curr Alzheimer Res. 2007 Apr; 4(2):191-7. . View in PubMed
Endothelial cell protein C receptor: role beyond endothelium? Circ Res. 2007 Feb 02; 100(2):155-7.. View in PubMed
Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease Ann N Y Acad Sci. 2007 Feb; 1097:40-50. . View in PubMed
Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):823-8. . View in PubMed
Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage Nat Med. 2006 Nov; 12(11):1278-85. . View in PubMed
Remodeling after stroke Nat Med. 2006 Apr; 12(4):390-1. . View in PubMed
The promise of protein C Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):211-6. . View in PubMed
IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor J Neurosci. 2005 Dec 14; 25(50):11495-503. . View in PubMed
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model J Clin Invest. 2005 Nov; 115(11):3285-90. . View in PubMed
Functional recovery after embolic stroke in rodents by activated protein C Ann Neurol. 2005 Sep; 58(3):474-7. . View in PubMed
Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease Nat Med. 2005 Sep; 11(9):959-65. . View in PubMed
Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1 Am J Physiol Cell Physiol. 2005 Aug; 289(2):C264-76. . View in PubMed
Neurovascular mechanisms of Alzheimer's neurodegeneration Trends Neurosci. 2005 Apr; 28(4):202-8. . View in PubMed
Neurovascular pathways and Alzheimer amyloid beta-peptide Brain Pathol. 2005 Jan; 15(1):78-83. . View in PubMed
Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C Nat Med. 2004 Dec; 10(12):1379-83. . View in PubMed
RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier Stroke. 2004 Nov; 35(11 Suppl 1):2628-31. . View in PubMed
Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice J Neurosci Methods. 2004 Sep 30; 138(1-2):233-42. . View in PubMed
LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms Neuron. 2004 Aug 05; 43(3):333-44. . View in PubMed
Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes Neurotoxicology. 2004 Jun; 25(4):605-16. . View in PubMed
Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor J Biol Chem. 2004 May 07; 279(19):20296-306. . View in PubMed
Clearing amyloid through the blood-brain barrier J Neurochem. 2004 May; 89(4):807-11. . View in PubMed
Activated protein C and ischemic stroke Crit Care Med. 2004 May; 32(5 Suppl):S247-53. . View in PubMed
Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3 Neuron. 2004 Feb 19; 41(4):563-72. . View in PubMed
Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain J Neurochem. 2004 Feb; 88(4):813-20. . View in PubMed
A simple method for isolation and characterization of mouse brain microvascular endothelial cells J Neurosci Methods. 2003 Nov 30; 130(1):53-63. . View in PubMed
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain Nat Med. 2003 Jul; 9(7):907-13. . View in PubMed
Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1 Blood. 2003 Jun 15; 101(12):4797-801. . View in PubMed
Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model Blood Cells Mol Dis. 2003 May-Jun; 30(3):271-6. . View in PubMed
Protein S confers neuronal protection during ischemic/hypoxic injury in mice Circulation. 2003 Apr 08; 107(13):1791-6. . View in PubMed
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective Nat Med. 2003 Mar; 9(3):338-42. . View in PubMed
Endovascular restorative neurosurgery: a novel concept for molecular and cellular therapy of the nervous system Neurosurgery. 2003 Feb; 52(2):402-12; discussion 412-3. . View in PubMed
Vascular disorder in Alzheimer's disease: role in pathogenesis of dementia and therapeutic targets Adv Drug Deliv Rev. 2002 Dec 07; 54(12):1553-9. . View in PubMed
Current treatments and therapeutic targets in Alzheimer's disease Adv Drug Deliv Rev. 2002 Dec 07; 54(12):1533-7. . View in PubMed
Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium Am J Physiol Cell Physiol. 2002 Sep; 283(3):C895-904. . View in PubMed
Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke Semin Hematol. 2002 Jul; 39(3):197-205. . View in PubMed
The cerebromicrovasculature: a key player in the pathogenesis of Alzheimer's disease J Alzheimers Dis. 2002 Jun; 4(3):217-23. . View in PubMed
Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy J Drug Target. 2002 Jun; 10(4):359-68. . View in PubMed
Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions Vascul Pharmacol. 2002 Jun; 38(6):303-13. . View in PubMed
Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood Neurobiol Aging. 2002 May-Jun; 23(3):405-12. . View in PubMed
Lower cognitive performance of older football players possessing apolipoprotein E epsilon4 Neurosurgery. 2001 May; 48(5):1196-7. . View in PubMed
Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brain-derived endothelial cell cultures J Neuroimmunol. 2001 May 01; 116(1):62-73. . View in PubMed
Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke Circulation. 2001 Apr 03; 103(13):1799-805. . View in PubMed
Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist Neurosurgery. 2001 Jan; 48(1):151-7. . View in PubMed
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier J Clin Invest. 2000 Dec; 106(12):1489-99. . View in PubMed
beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1 Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1772-81. . View in PubMed
Apolipoprotein J (clusterin) and Alzheimer's disease Microsc Res Tech. 2000 Aug 15; 50(4):305-15. . View in PubMed
Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid beta-peptide Biochim Biophys Acta. 2000 Jul 26; 1502(1):145-57. . View in PubMed
Clearance of amyloid beta-peptide from brain: transport or metabolism? Nat Med. 2000 Jul; 6(7):718-9.. View in PubMed
Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides Biochem J. 2000 Jun 01; 348 Pt 2:359-65. . View in PubMed
Brain injury and cerebrovascular fibrin deposition correlate with reduced antithrombotic brain capillary functions in a hypertensive stroke model J Cereb Blood Flow Metab. 2000 Jun; 20(6):998-1009. . View in PubMed
Differential regulation of leptin transport by the choroid plexus and blood-brain barrier and high affinity transport systems for entry into hypothalamus and across the blood-cerebrospinal fluid barrier Endocrinology. 2000 Apr; 141(4):1434-41. . View in PubMed
Functional and structural properties of lipid-associated apolipoprotein J (clusterin) Biochem J. 1999 Dec 01; 344 Pt 2:375-83. . View in PubMed
Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background Arterioscler Thromb Vasc Biol. 1999 Nov; 19(11):2801-6. . View in PubMed
Retroviral vector-mediated transfer and expression of human tissue plasminogen activator cDNA in bovine brain endothelial cells Neurosurgery. 1999 Oct; 45(4):962-8; discussion 968-70. . View in PubMed
Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions Neurosci Lett. 1999 Sep 10; 272(2):127-30. . View in PubMed
Cereport (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers Pharm Res. 1999 Sep; 16(9):1360-5. . View in PubMed
Corneal transport of circulating glutathione in normal and galactosemic guinea pigs Cornea. 1999 May; 18(3):321-7. . View in PubMed
Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus Exp Neurol. 1999 May; 157(1):194-201. . View in PubMed
Detection of brain tumor invasion and micrometastasis in vivo by expression of enhanced green fluorescent protein Neurosurgery. 1998 Dec; 43(6):1437-42; discussion 1442-3. . View in PubMed
Rat brain capillary thrombomodulin: structure and function Thromb Res. 1998 Dec 01; 92(5):213-9. . View in PubMed
Immunohistochemical localization of tissue plasminogen activator in vascular endothelium of stroke-prone regions of the rat brain Neurosurgery. 1998 Oct; 43(4):909-13. . View in PubMed
Strategies to circumvent vascular barriers of the central nervous system Neurosurgery. 1998 Oct; 43(4):877-8. . View in PubMed
Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J Clin Invest. 1998 Aug 15; 102(4):734-43. . View in PubMed
Measurement of thrombomodulin mRNA expression in brain capillaries by polymerase chain reaction Thromb Res. 1998 Aug 15; 91(4):191-7. . View in PubMed
Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy Hum Gene Ther. 1998 May 01; 9(7):989-95. . View in PubMed
Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury J Cereb Blood Flow Metab. 1998 Jan; 18(1):52-8. . View in PubMed
Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy J Neurochem. 1998 Jan; 70(1):210-5. . View in PubMed
Thrombomodulin expression in bovine brain capillariesAnticoagulant function of the blood-brain barrier, regional differences, and regulatory mechanisms. Arterioscler Thromb Vasc Biol. 1997 Nov; 17(11):3139-46. . View in PubMed
Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta J Neurochem. 1997 Nov; 69(5):1995-2004. . View in PubMed
Attenuation of brain injury and reduction of neuron-specific enolase by nicardipine in systemic circulation following focal ischemia and reperfusion in a rat model J Neurosurg. 1997 Nov; 87(5):731-7. . View in PubMed
Antithrombotic, procoagulant, and fibrinolytic mechanisms in cerebral circulation: implications for brain injury and protection Neurosurg Focus. 1997 Jun 15; 2(6):e5. . View in PubMed
Liver and lens glutathione and cysteine regulation in galactose-fed guinea pigs Curr Eye Res. 1997 Apr; 16(4):365-71. . View in PubMed
Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epithelium Exp Eye Res. 1997 Apr; 64(4):615-26. . View in PubMed
Cellular and molecular neurosurgery: pathways from concept to reality--part II: vector systems and delivery methodologies for gene therapy of the central nervous system Neurosurgery. 1997 Apr; 40(4):805-12; discussion 812-3. . View in PubMed
Cellular and molecular neurosurgery: pathways from concept to reality--part I: target disorders and concept approaches to gene therapy of the central nervous system Neurosurgery. 1997 Apr; 40(4):789-803; discussion 803-4. . View in PubMed
Chronic nicotine treatment enhances focal ischemic brain injury and depletes free pool of brain microvascular tissue plasminogen activator in rats J Cereb Blood Flow Metab. 1997 Feb; 17(2):136-46. . View in PubMed
Can blood-brain barrier play a role in the development of cerebral amyloidosis and Alzheimer's disease pathology Neurobiol Dis. 1997; 4(1):23-6. . View in PubMed
Intravenous infusion of RMP-7 increases ocular uptake of ganciclovir Pharm Res. 1997 Jan; 14(1):80-5. . View in PubMed
Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2269-75. . View in PubMed
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4229-34. . View in PubMed
Evidence for the existence of a sodium-dependent glutathione (GSH) transporterExpression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. J Biol Chem. 1996 Apr 19; 271(16):9754-8. . View in PubMed
Brain capillary tissue plasminogen activator in a diabetes stroke model Stroke. 1996 Apr; 27(4):712-9. . View in PubMed
Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs Neurosci Lett. 1996 Mar 15; 206(2-3):157-60. . View in PubMed
Transport of dopamine at the blood-brain barrier of the guinea pig: inhibition by psychotropic drugs and nicotine Pharm Res. 1996 Feb; 13(2):290-5. . View in PubMed
Cellular uptake and transport of methylprednisolone at the blood-brain barrier Neurosurgery. 1996 Feb; 38(2):348-54. . View in PubMed
Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: physiologic importance and manipulations Exp Eye Res. 1996 Jan; 62(1):29-37. . View in PubMed
Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood-brain barrier Life Sci. 1996; 59(18):1483-97. . View in PubMed
RMP-7, a bradykinin agonist, increases permeability of blood-ocular barriers in the guinea pig Invest Ophthalmol Vis Sci. 1995 Nov; 36(12):2542-7. . View in PubMed
Expression of tissue plasminogen activator in cerebral capillaries: possible fibrinolytic function of the blood-brain barrier Neurosurgery. 1995 Nov; 37(5):955-61. . View in PubMed
Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier Pharm Res. 1995 Oct; 12(10):1395-406. . View in PubMed
Molecular characterization of a reduced glutathione transporter in the lens Invest Ophthalmol Vis Sci. 1995 Aug; 36(9):1785-92. . View in PubMed
Slow penetration of [3H] tiazofurin into guinea pig brain by a saturable mechanism Methods Find Exp Clin Pharmacol. 1995 Jul-Aug; 17(6):407-14. . View in PubMed
Penetration of [3H] tiazofurin into guinea pig eye by a saturable mechanism Eur J Ophthalmol. 1995 Apr-Jun; 5(2):131-5. . View in PubMed
Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta Biochem Biophys Res Commun. 1994 Dec 15; 205(2):1431-7. . View in PubMed
Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye Exp Eye Res. 1994 Oct; 59(4):487-96. . View in PubMed
Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain Biochem Biophys Res Commun. 1994 May 30; 201(1):402-8. . View in PubMed
Nicotine downregulates alpha 2 isoform of Na,K-ATPase at the blood-brain barrier and brain in rats Biochem Biophys Res Commun. 1994 Mar 30; 199(3):1422-7. . View in PubMed
Galactose-induced cataract formation in guinea pigs: morphologic changes and accumulation of galactitol Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):804-10. . View in PubMed
Blood-brain barrier transport of circulating Alzheimer's amyloid beta Biochem Biophys Res Commun. 1993 Dec 30; 197(3):1034-40. . View in PubMed
The blood-brain barrier in vitro: recent progress Neurochem Int. 1993 Dec; 23(6):523. . View in PubMed
Differential expression of Na,K-ATPase alpha and beta subunit isoforms at the blood-brain barrier and the choroid plexus J Biol Chem. 1993 Apr 15; 268(11):8019-25. . View in PubMed
Metaphit-induced audiogenic seizures in mice: IPharmacologic characterization. Epilepsia. 1993 Mar-Apr; 34(2):201-10. . View in PubMed
Metaphit-induced audiogenic seizures in mice: IIStudies on N-methyl-D-aspartic acid, GABA, and sodium channel receptors and on the disposition of metaphit in the brain. Epilepsia. 1993 Mar-Apr; 34(2):211-9. . View in PubMed
Expression of Na,K-ATPase at the blood-brain interface Adv Exp Med Biol. 1993; 331:55-60. . View in PubMed
Blood-brain transport of vasopressin Adv Exp Med Biol. 1993; 331:143-7. . View in PubMed
Differential brain penetration of cerebroprotective drugs Adv Exp Med Biol. 1993; 331:117-20. . View in PubMed
A simple technique to determine glutathione (GSH) levels and synthesis in ocular tissues as GSH-bimane adduct: application to normal and galactosemic guinea-pigs Exp Eye Res. 1993 Jan; 56(1):45-50. . View in PubMed
Transport, uptake, and metabolism of blood-borne vasopressin by the blood-brain barrier Brain Res. 1992 Sep 11; 590(1-2):213-8. . View in PubMed
An in situ perfused guinea-pig eye model for blood-ocular transport studies: application to amino acids Exp Eye Res. 1992 Mar; 54(3):471-7. . View in PubMed
Neuroactive peptides and amino acids at the blood-brain barrier: possible implications for drug abuse NIDA Res Monogr. 1992; 120:26-42. . View in PubMed
Electroencephalographic characteristics of audiogenic seizures induced in metaphit-treated small rodents Epilepsia. 1991 Nov-Dec; 32(6):783-90. . View in PubMed
Vasopressin uptake by hypothalamopituitary axis and pineal gland in guinea pigs Am J Physiol. 1991 Apr; 260(4 Pt 1):E633-40. . View in PubMed
Kinetics of circulating vasopressin uptake by choroid plexus Am J Physiol. 1991 Feb; 260(2 Pt 2):F216-24. . View in PubMed
The effects of (R) alpha-methyl histamine on the isolated guinea pig aorta Agents Actions Suppl. 1991; 33:283-7. . View in PubMed
Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A J Neurochem. 1990 Oct; 55(4):1222-30. . View in PubMed
Kinetics of arginine-vasopressin uptake at the blood-brain barrier Biochim Biophys Acta. 1990 Jun 27; 1025(2):191-8. . View in PubMed
Kinetics and Na independence of amino acid uptake by blood side of perfused sheep choroid plexus Am J Physiol. 1990 May; 258(5 Pt 2):F1288-94. . View in PubMed
Comparison between blood and saline perfusion on the uptake of amino acids by choroid plexus of the sheep Endocrinol Exp. 1990 Mar; 24(1-2):29-36. . View in PubMed
Circulating neuroactive peptides and the blood-brain and blood-cerebrospinal fluid barriers Endocrinol Exp. 1990 Mar; 24(1-2):9-17. . View in PubMed
A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig Exp Neurol. 1990 Mar; 107(3):263-70. . View in PubMed
Immunoneurology: a serum protein afferent limb to the CNS Adv Exp Med Biol. 1990; 274:345-70. . View in PubMed
Chronic amphetamine intoxication and the blood-brain barrier permeability to inert polar molecules studied in the vascularly perfused guinea pig brain J Neurol Sci. 1989 Dec; 94(1-3):41-50. . View in PubMed
Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain J Neurochem. 1989 Nov; 53(5):1333-40. . View in PubMed
Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice Eur J Pharmacol. 1989 Jun 08; 165(1):155-9. . View in PubMed
Blood-brain barrier permeability changes during acute allergic encephalomyelitis induced in the guinea pig Metab Brain Dis. 1989 Mar; 4(1):33-40. . View in PubMed
Effects of sensory-motor cortical lesions on blood-brain permeability in guinea pigs Metab Brain Dis. 1989 Mar; 4(1):9-15. . View in PubMed
Saturable mechanism for delta sleep-inducing peptide (DSIP) at the blood-brain barrier of the vascularly perfused guinea pig brain Peptides. 1989 Mar-Apr; 10(2):249-54. . View in PubMed
Neutral amino acid uptake by the isolated perfused sheep choroid plexus J Physiol. 1989 Jan; 408:31-43. . View in PubMed
Slow penetration of thyrotropin-releasing hormone across the blood-brain barrier of an in situ perfused guinea pig brain J Neurochem. 1988 Jul; 51(1):252-7. . View in PubMed
Passage of delta sleep-inducing peptide (DSIP) across the blood-cerebrospinal fluid barrier Peptides. 1988 May-Jun; 9(3):533-8. . View in PubMed
Glucagon effect on myocardial transport and utilization of energy-metabolites from the coronary microcirculation in the perfused rabbit heart Arch Int Physiol Biochim. 1988 Mar; 96(1):7-16. . View in PubMed
Unidirectional uptake of enkephalins at the blood-tissue interface of the blood-cerebrospinal fluid barrier: a saturable mechanism Regul Pept. 1988 Jan; 20(1):33-44. . View in PubMed
The effects of aluminum chloride on the rate of secretion of the cerebrospinal fluid Exp Neurol. 1987 Nov; 98(2):436-52. . View in PubMed
Transport of leucine-enkephalin across the blood-brain barrier in the perfused guinea pig brain J Neurochem. 1987 Jul; 49(1):310-5. . View in PubMed
Measurement of solute transport across the blood-brain barrier in the perfused guinea pig brain: method and application to N-methyl-alpha-aminoisobutyric acid J Neurochem. 1986 May; 46(5):1444-51. . View in PubMed
Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone Brain Res. 1985 Dec 09; 358(1-2):191-9. . View in PubMed
Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: kinetics of unidirectional influx, carrier specificity and effects of glucagon Biochim Biophys Acta. 1985 Oct 10; 819(2):241-8. . View in PubMed
Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine) Brain Res. 1985 Jun 10; 336(1):125-32. . View in PubMed
Blood-brain barrier permeability to dipeptides and their constituent amino acids Brain Res. 1983 Jul 18; 271(1):65-71. . View in PubMed
Protective effects of glucagon during the anaphylactic response in guinea-pig isolated heart Br J Pharmacol. 1982 Jul; 76(3):483-9. . View in PubMed
Current research interests
• We study humans at genetic risk for AD, and use transgenic models, and iPSC-based human models of the BBB and brain on a chip to understand how genes that carry risk for sporadic AD (e.g., APOE4, PICALM) affect the cerebrovascular system contributing to dementia, and AD disease onset and progression.
• We are developing cell and gene therapy approaches for AD using i) iPSC-derived human pericytes that express different protective target genes, and/or ii) BBB cell-specific gene delivery to influence neuronal and synaptic functions.
• We study APC biologics and mimetic peptides for white matter stroke, AD and ALS.
• We work on identifying small molecules that influence genes/pathways linked to AD.
• We work on CSF and imaging BBB biomarkers of human cognitive dysfunction.
• Recently, we have initiated studies to understand how gut microbiome influences BBB in relation to neuronal and synaptic functions using transgenic and human iPSC models.
• We initiated program on BBB molecular signatures (snRNAseq, proteome) in health and disease using transgenic and human models, and human brain tissue.
Zlokovic is recognized internationally as a leader in the fields of AD and stroke research. Thomson Reuters and Clarivate Analytics listed Zlokovic as one of “The World’s Most Influential Scientific Minds” for 18 consecutive years (2002-2020) for ranking in 1 % of the most-cited authors in the field of neurosciences and behavioral sciences. He received MetLife Award for Medical Research for “significant contributions to our understanding of Alzheimer’s disease and for bringing us closer to a cure”, Potamkin Prize from the American Academy of Neurology in recognition of outstanding achievements in research on Alzheimer’s and related neurodegenerative diseases”, Javits Award from NINDS in recognition of distinguished record of substantial contributions in a field of neurological sciences”, MERIT Award from NIA in recognition of sustained contribution to aging and leadership and commitment to the field”, and more recently USC Associates Award for Creativity in Research and Scholarship “the highest honor the university faculty bestows on its members for distinguished intellectual achievements” He is a fellow of the AAAS, The European Academy of Sciences, and The Dana Alliance for Brain Initiative. In 2017, 2018, 2019, 2020 and 2021, he was asked by the Nobel Assembly at Karolinska Institutet, The Nobel Committee to nominate candidates for the Nobel Prize in Physiology and Medicine. He is an active entrepreneur and inventor. He co-founded ZZ Biotech, a biotechnology company that is developing treatments for stroke and neurological disorders.
Featured Publications representing interests of the Zlokovic laboratory:
i-10 index: 259; h-index: 107; 51,753 citations (Google Scholar, Mar 2021); complete list in Google Scholar: https://goo.gl/2Npcj2
Nikolakopoulou AM, Wang Y, Ma Q, Sagare AP, Montagne A, Huuskonen MT, Rege SV, Dai Z, Körbelin J, Herz J, Zhao Z, Zlokovic BV. (2021) Endothelial LRP1 protects against neurodegeneration via cyclophilin A. Journal of Experimental Medicine 218(4):e20202207
Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D’Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Julia TCW, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV. (2020) APOE4 leads to early blood-brain barrier dysfunction predicting human cognitive decline. Nature 581, 71-76.
Zhao Z, Zlokovic BV. (2020) Therapeutic TVs for crossing barriers in the brain. Cell 182(2):267-269.
Nation DA, Sweeney MD, Montagne A, Sagare AP, D’Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel D, Liu CY, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Chui HC, Law M, Toga AW, Zlokovic BV (2019) Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nature Medicine 25, 270-276.
Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, Zlokovic BV (2019) Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nature Neuroscience 22, 1089–1098.
Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV (2019) Blood-Brain Barrier: From Physiology to Disease and Back. Physiological Reviews 99, 21-78.
Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV (2019) 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. Journal of Experimental Medicine 216(2), 279-293.
Lyden P, Pryor KE, Coffey CS, Cudkowicz M, …Davis TP, Toga AW, Griffin JH, Zlokovic BV, NeuroNEXT Clinical Trials Network NN104 Investigators. (2019) Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke. Annals of Neurology 85(1), 125-136.
Sweeney MD, Kisler K, Montagne A, Toga A, Zlokovic BV (2018) The role of brain vasculature in neurodegenerative disorders. Nature Neuroscience 21(10), 1318-1331
Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV (2018) Pericyte degeneration causes white matter dysfunction in the mouse CNS. Nature Medicine 24(3), 326-337.
Sweeney MD, Sagare AP, Zlokovic BV (2018) Blood-brain barrier breakdown in Alzheimer’s disease and other neurodegenerative disorders. Nature Reviews Neurology 14(3), 133-150.
Kisler K, Lazic D, Sweeney M, Plunkett S, Khatib ME, Vinogradov SA, Boas DA, Sakadzic S, Zlokovic BV (2018) Diverse protocols for in vivo measurements of cerebrovascular hemodynamic responses and tissue oxygen levels and delivery in the mouse brain. Nature Protocols 13(6), 1377-1402.
Sweeney MD, Zlokovic BV (2018) A lymphatic waste-disposal system implicated in Alzheimer’s disease. Nature 560 (7717) 172-174.
Kisler K, Nelson A, Montagne A, Zlokovic BV (2017) Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer’s disease. Nature Reviews Neuroscience 18, 419-434.
Kisler K, Nelson AR, Rege SV, Ramanathan A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, Boas DA, Sakadžic S, Zlokovic BV (2017) Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nature Neuroscience 20, 406-416.
Wang Y, Zhao Z, Rege S, Griffin JH, Goldman SA, Zlokovic BV (2016) 3K3A-APC stimulates post-ischemic neuronal repair by human neural progenitor cells in mice. Nature Medicine 22 (9): 1050-1055.
Sweeney MD, Ayyadurai S, Zlokovic BV (2016) Pericytes of the neurovascular unit: key functions and signaling pathways. Nature Neuroscience 19 (6): 771-783.
Zhao Z, Nelson A, Betsholtz C, Zlokovic BV (2015) Establishment and dysfunction of blood-brain barrier. Cell 163, Nov 19;163(5):1064-78.
Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NQ, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV (2015) Central role for PICALM in amyloid-? blood-brain barrier transcytosis and clearance. Nature Neuroscience 18, 978-987.
Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wendy RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV (2015) GLUT1 reductions exacerbate Alzheimer’s disease vasculo-neuronal dysfunction and degeneration. Nature Neuroscience 18, 521-530.
Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV (2015) Blood-brain barrier breakdown in the aging human hippocampus. Neuron 85, 296-302.
Griffin JH, Zlokovic BV, Mosnier LO (2015) Activated Protein C: Biased for Translation. Blood 125 (19), 2898-2907.
Zhao Z and Zlokovic BV (2014) Blood-Brain Barrier: A Dual Life of MFSD2A? Neuron 82, 728–730.
Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong G, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV (2014) Blood-spinal cord barrier disruption contributes to early motor neuron degeneration in ALS model mice. Proceedings of the National Academy of Sciences USA 111(11), E1035-42.
Bell RD, Winkler E, Sagare A, Singh I, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk B, Zlokovic BV (2012) Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 485, 512-516.
Deane R, Singh I, Sagare A, Bell R, Ross NT, Larue B, Love R, Perry S, Deane RJ, Thiyagarajan M, Zarcone T, Friedman A, Miller BL, Zlokovic BV (2012) A novel multi-modal RAGE-specific inhibitor controls amyloid-beta-mediated brain disorder in mice. Journal of Clinical Investigation 122 (4), 1377-1392.
Winkler E, Bell R, Zlokovic BV (2011) Functions of CNS pericytes in health and disease. Nature Neuroscience 14, 1398-1405.
Zlokovic BV (2011) Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders. Nature Reviews Neuroscience 12, 723-738.
Winkler EA, Bell RD, Zlokovic BV (2011) Lack of Smad and Notch Leads to a Fatal Game of Brain Pericyte Hopscotch. Developmental Cell (Cell) 20 (3), 279-281.
Zlokovic BV, Griffin JH (2011) Activated protein C cytoprotective pathways and implications for stroke and neurological disorders. Trends in Neurosciences 34 (4), 1198-2009.
Zlokovic BV (2010) Neurodegeneration and the neurovascular unit. Nature Medicine 16(12), 1370-71.
Bell RD, Winkler EA, Sagare A, Singh I, LaRue B, Deane R, Zlokovic BV (2010) Pericytes control key neurovascular functions and the neuronal phenotype in the adult brain and during brain aging. Neuron 68, 409-427.
Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV (2010) Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood 115, 4963-4972.
Bell RD , Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JP, Zlokovic BV (2009) SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nature Cell Biology 11(2), 143-153.
Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino F, Stojanovic K, Cleveland DW, Zlokovic BV (2009) Activated protein C slows ALS-like disease by transcrptionally inhibiting SOD1 in motor neurons and microglial cells. Journal of Clinical Investigation 119(11), 3437-3440.
Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV (2008) Apolipoprotein E isoform-specific disruption of Alzheimer’s amyloid ?-peptide clearance from mouse brain. Journal of Clinical Investigation 118(12), 4002-4013.
Zhong Z, Deane R, Zarina A, Parisi M, Shapovalov Y, 0’Banion K, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV (2008) ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nature Neuroscience 11(4), 420-422.
Zlokovic BV (2008) Blood-brain barrier in health and chronic neurodegenerative disorders. Neuron, 57, 178-201.
Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Pelmutter D, Coma M, Zhong Z, Zlokovic BV (2007) Clearance of amyloid-beta by circulating lipoprotein receptors. Nature Medicine 13 (9), 1029-1031.
Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV (2007). Serum response factor and myocardin mediate cerebral arterial hypercontractility and blood flow dysregulation in Alzheimer’s phenotype. Proceedings of the National Academy of Sciences USA 104, 823-828.
Mosnier L, Zlokovic BV, Griffin JH (2007) The cellular protein C pathway. Blood 109(8), 161-172.
Cheng T, Petraglia A, Li Z, Meedakshisudaram T, Wu Z, Zhong Z, Liu D, Maggirwar SB, Deane R, Fernandez J, LaRue B, Griffin J, Chopp M, Zlokovic BV (2006) Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nature Medicine 12 (11), 1278-1285.
Zlokovic BV (2006) Remodeling after stroke. Nature Medicine 12 (4) 390-391.
Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks A, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetski R, Song H, Hofman F, Zlokovic BV (2005) Role of MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nature Medicine 11(9), 959-965.
Zlokovic BV (2005) Neurovascular mechanisms of Alzheimer’s neurodegeneration. Trends in Neurosciences 28, 202-208.
Deane R, Wu Z, Davis J, Yan SD, Hamm K, Sagare A, Xu F, Spijkers P, Lenting PJ, Van Nostrand WE, Zlokovic BV (2004) LRP-amyloid-beta interaction mediates differential brain efflux of Abeta isoforms. Neuron 43, 33-44.
Liu D, Cheng T, Guo H, Fernandez AJ, Griffin JH, Song X, Zlokovic BV (2004) Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nature Medicine 10, (12), 1379-1383.
Guo H, Liu D, Gelbard H, Cheng T, Fernandez JA, Insalaca R, Griffin JH, Zlokovic BV (2004) Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron 41, 563-572.
Deane R, Yan SD, Kumar R, Jovanovic S, LaRue B, Welch D, Maness L, Yu J, Zhu H, Ghiso J, Frangione B, Schmidt AM, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic BV (2003) RAGE mediates amyloid-ß peptide transport across the blood-brain barrier and accumulation in brain. Nature Medicine 9(7), 907-913.
Cheng T, Liu D, Fernández JA, Griffin JH, Castellino F, Rosen E, Fukudome K, Zlokovic BV (2003) Activated protein C blocks P53-mediated apoptosis in ischemic human brain endothelium and is neuroportective. Nature Medicine 9, 338-342.
Domotor E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV (2003) Activated protein C alters cytosolic Ca2+ flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease-activated receptor-1. Blood 101, 4797-4801.
Shibata M, Subramanyan RK, Amar A, Fernandez J, Griffin J, Zlokovic BV (2001) Anti-inflammatory, antithrombotic and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke with cerebrovascular thrombosis. Circulation 103, 1799-1805.
Shibata M, Yamada S, Kumar RS, Calero M, Bading B, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV (2000) Clearance of Alzheimer’s amyloid-ß1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. Journal of Clinical Investigation 106(12), 1489-1499.
Zlokovic BV, Shinya Y, Holtzman D, Ghiso J, Frangione B (2000) Clearance of amyloid ß-peptide from brain: transport or metabolism? Nature Medicine 6, 718-719.
Mackic JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern D, Schmidt AM, Frangione B, Zlokovic BV (1998) Human blood-brain barrier receptors for Alzheimer's amyloid-? 1-40: Asymmetrical binding, endocytosis and transcytosis at the apical side of brain microvascular endothelial cell monolayer. Journal of Clinical Investigation 102, 734-743.
Zlokovic BV, Martel CL, Matsubara E, McComb JG, Zheng G, McCluskey RT, Frangione B, Ghiso J (1996) Glycoprotein 330/megalin: Porbable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer's Disease amyloid-? at the blood-brain and blood-cerebrospinal fluid barriers. Proceedings of the National Academy of Sciences USA 93, 4229-4236.