Bingfei Yu

Assistant Professor of Molecular Microbiology and Immunology

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The Yu Lab at USC is devoted to decoding intercellular immune recognition and intracellular molecular programming to advance immunotherapies for cancer, autoimmunity and infectious diseases.

We employ single-cell genomics, synthetic biology, and systems immunology to study the fundamental principles of how immune cells integrate antigen specificity and environmental cues to mount effective immune responses.

We ask
(1) How do immune cells see foreign antigens to evoke immune responses?
(2) How do immune cells alk to other cells to control their fate decisions?
(3) How can we write molecular circuits to modify immune cell behavior?

Lab website:


  • Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells bioRxiv. 2023 Mar 22. . View in PubMed
  • DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cellsImmunity. 2023 05 09; 56(5):959-978. e10. . View in PubMed
  • Engineered cell entry links receptor biology with single-cell genomicsCell. 2022 12 22; 185(26):4904-4920. e22. . View in PubMed
  • A microRNA expression and regulatory element activity atlas of the mouse immune system Nat Immunol. 2021 07; 22(7):914-927. . View in PubMed
  • B cell-specific XIST complex enforces X-inactivation and restrains atypical B cellsCell. 2021 04 01; 184(7):1790-1803. e17. . View in PubMed
  • Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection J Exp Med. 2021 08 02; 218(8). . View in PubMed
  • Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits Nat Immunol. 2020 07; 21(7):777-789. . View in PubMed
  • Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses Sci Immunol. 2020 08 21; 5(50). . View in PubMed
  • The cis-Regulatory Atlas of the Mouse Immune SystemCell. 2019 02 07; 176(4):897-912. e20. . View in PubMed
  • T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-? on B Cells. Immunity. 2019 05 21; 50(5):1172-1187.e7.. View in PubMed
  • The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte FormationImmunity. 2018 04 17; 48(4):659-674. e6. . View in PubMed
  • Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8+ T cells J Exp Med. 2018 03 05; 215(3):773-783. . View in PubMed
  • Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation Nat Immunol. 2017 05; 18(5):573-582. . View in PubMed
  • Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing Nat Immunol. 2017 04; 18(4):422-432. . View in PubMed
  • Apolipoprotein O expression in mouse liver enhances hepatic lipid accumulation by impairing mitochondrial function Biochem Biophys Res Commun. 2017 09 09; 491(1):8-14. . View in PubMed
  • Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours Nature. 2017 12 14; 552(7684):253-257. . View in PubMed
  • Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection J Exp Med. 2015 Nov 16; 212(12):2027-39. . View in PubMed
  • Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation Nucleic Acids Res. 2011 Dec; 39(22):9592-604. . View in PubMed