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Brendan H. Grubbs, MD

Assistant Professor of Clinical Obstetrics & Gynecology

Co-Director of Fetal Maternal Center

MFM Fellowship Program Director

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Phone +1 323 409 3416
Email [email protected]
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Publications

  • Patterning human kidney organoids with synthetic Wnt-secreting organizers. Science. 2026 Jul 02; 393(6806):eadu9122.. View in PubMed
  • Enhancing the positive predictive value of early-stage ovarian cancer detection using a two-step machine learning framework. J Transl Med. 2026 Jul 01.. View in PubMed
  • Understanding the importance of social and environmental stressors in predicting maternal sleep quality during late pregnancy. Environ Res. 2026 Jun 13; 305(Pt 2):125013.. View in PubMed
  • Preconception and early-pregnancy exposure to ambient air pollution and trajectories of depressive symptoms during pregnancy. Environ Health. 2026 Jun 02.. View in PubMed
  • Maternal Heat Shock Protein as a Potential Biomarker of Adaptation to Heat Stress during Pregnancy and Its Relation to Preterm Birth. Environ Sci Technol. 2026 May 12; 60(18):13323-13332.. View in PubMed
  • mGluR6 coordinates cone terminal targeting and synaptic layer assembly during human retinal development. bioRxiv. 2026 Apr 27.. View in PubMed
  • Prenatal heat stress and predicted postpartum cardiovascular disease risk: a longitudinal cohort study. Sci Rep. 2026 Apr 02; 16(1).. View in PubMed
  • Hyperactivation of mTORC1 signaling mediates folliculin deficiency-induced pulmonary cyst formation in Birt-Hogg-Dubé syndrome. J Clin Invest. 2026 Feb 16; 136(4).. View in PubMed
  • Heterogeneous origins and functions of lung mesenchymal stromal cells. Stem Cell Res Ther. 2025 Oct 28; 16(1):587.. View in PubMed
  • Season of delivery and risk of hypertensive disorders of pregnancy in Los Angeles, California. Pregnancy Hypertens. 2025 Dec; 42:101261.. View in PubMed
  • RNA in Plasma Extracellular Vesicles of Adolescent Rhesus Macaques Reveals Immune, Bioenergetic, and Microbial Imprints of Early-Life Adversity: An Exploratory Analysis. Biol Psychiatry. 2026 Jul 01; 100(1):64-75.. View in PubMed
  • Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG. Oncogene. 2025 10; 44(39):3694-3712.. View in PubMed
  • Controlling nephron precursor differentiation to generate proximal-biased kidney organoids with emerging maturity. Nat Commun. 2025 Aug 30; 16(1):8136.. View in PubMed
  • Axial nephron fate switching demonstrates a plastic system tunable on demand. Nat Commun. 2025 Aug 25; 16(1):7912.. View in PubMed
  • Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features. Elife. 2025 Aug 06; 13.. View in PubMed
  • Adverse Birth Outcomes Associated with Heat Stress and Wildfire Smoke Exposure During Preconception and Pregnancy. Environ Sci Technol. 2025 Jul 01; 59(25):12458-12471.. View in PubMed
  • Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features. bioRxiv. 2025 Apr 24.. View in PubMed
  • Axial Nephron Fate Switching Demonstrates a Plastic System Tunable on Demand. bioRxiv. 2025 Apr 02.. View in PubMed
  • Gestational Blood Pressure Trajectories and 5-Year Postpartum Hypertension Risk in the MADRES Study. JACC Adv. 2025 Apr; 4(4):101660.. View in PubMed
  • Hypoxia-Inducible Factor 1-Alpha Gene Polymorphisms Impact Risk of Severespectrum Hypertensive Disorders of Pregnancy: A Case-Control Study. Reprod Sci. 2025 04; 32(4):993-1002.. View in PubMed
  • Prenatal Psychosocial Stressors and Blood Pressure Across 4 Years Postpartum. Hypertension. 2025 May; 82(5):849-858.. View in PubMed
  • Perceived Stress During Late Pregnancy and Infant Body Composition at 1 Month. J Endocr Soc. 2025 Jan 06; 9(2):bvae222.. View in PubMed
  • Prenatal exposure to ambient air pollution and persistent postpartum depression. Sci Total Environ. 2024 Nov 25; 953:176089.. View in PubMed
  • Organophosphate ester flame retardant chemicals and maternal depression during pregnancy. Environ Res. 2024 Oct 15; 259:119581.. View in PubMed
  • Stepwise developmental mimicry generates proximal-biased kidney organoids. bioRxiv. 2024 Jul 02.. View in PubMed
  • Temporal trends of obstetric hemorrhage and product-specific blood transfusion at time of delivery. Am J Obstet Gynecol. 2024 10; 231(4):e139-e145.. View in PubMed
  • Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts. Elife. 2024 Jun 10; 12.. View in PubMed
  • Joint effects of traffic-related air pollution and hypertensive disorders of pregnancy on maternal postpartum depressive and anxiety symptoms. J Expo Sci Environ Epidemiol. 2025 Apr; 35(2):278-287.. View in PubMed
  • Non-canonical Wnt pathway expression in the developing mouse and human retina. Exp Eye Res. 2024 Jul; 244:109947.. View in PubMed
  • Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease. Cell Stem Cell. 2024 06 06; 31(6):921-939.e17.. View in PubMed
  • Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts. bioRxiv. 2024 Apr 02.. View in PubMed
  • Prenatal air pollution exposure is associated with inflammatory, cardiovascular, and metabolic biomarkers in mothers and newborns. Environ Res. 2024 Jul 01; 252(Pt 1):118797.. View in PubMed
  • Increased Risk of Gestational Hypertension by Periconceptional Exposure to Ambient Air Pollution and Effect Modification by Prenatal Depression. Hypertension. 2024 Jun; 81(6):1285-1295.. View in PubMed
  • Maternal Dietary Patterns During Pregnancy Are Linked to Hypertensive Disorders of Pregnancy Among a Predominantly Low-Income US Hispanic/Latina Pregnancy Cohort. J Am Heart Assoc. 2024 03 05; 13(5):e029848.. View in PubMed
  • Sources of personal PM2.5 exposure during pregnancy in the MADRES cohort. J Expo Sci Environ Epidemiol. 2024 09; 34(5):868-877.. View in PubMed
  • Prenatal exposures to organophosphate ester metabolites and early motor development in the MADRES cohort. Environ Pollut. 2024 Feb 01; 342:123131.. View in PubMed
  • The Role of Social Support and Acculturation Factors on Postpartum Mental Health Among Latinas in the MADRES Pregnancy Cohort. J Immigr Minor Health. 2024 Feb; 26(1):72-80.. View in PubMed
  • Poor Sleep Quality Increases Gestational Weight Gain Rate in Pregnant People: Findings from the MADRES Study. Res Sq. 2023 Sep 25.. View in PubMed
  • Prenatal exposures to organophosphate ester metabolite mixtures and children’s neurobehavioral outcomes in the MADRES pregnancy cohort. Environ Health. 2023 09 22; 22(1):66.. View in PubMed
  • Prenatal ambient air pollution exposure and child weight trajectories from the 3rd trimester of pregnancy to 2 years of age: a cohort study. BMC Med. 2023 09 07; 21(1):341.. View in PubMed
  • Single-nuclei multiomic analyses identify human cardiac lymphatic endothelial cells associated with coronary arteries in the epicardium. Cell Rep. 2023 Sep 26; 42(9):113106.. View in PubMed
  • Preconceptional and prenatal exposure to air pollutants and risk of gestational diabetes in the MADRES prospective pregnancy cohort study. Lancet Reg Health Am. 2023 Sep; 25:100575.. View in PubMed
  • Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids. bioRxiv. 2023 May 25.. View in PubMed
  • Identification and Characterization of the Wilms Tumor Cancer Stem Cell. Adv Sci (Weinh). 2023 07; 10(20):e2206787.. View in PubMed
  • Sex-specific effects of prenatal organophosphate ester (OPE) metabolite mixtures and adverse infant birth outcomes in the maternal and developmental risks from environmental and social stressors (MADRES) pregnancy cohort. Environ Res. 2023 06 01; 226:115703.. View in PubMed
  • A Vegetable, Oil, and Fruit Dietary Pattern in Late Pregnancy is Linked to Reduced Risks of Adverse Birth Outcomes in a Predominantly Low-Income Hispanic and Latina Pregnancy Cohort. J Nutr. 2023 01 14; 152(12):2837-2846.. View in PubMed
  • Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals. J Clin Invest. 2022 12 15; 132(24).. View in PubMed
  • Identifying pre-conception and pre-natal periods in which ambient air pollution exposure affects fetal growth in the predominately Hispanic MADRES cohort. Environ Health. 2022 11 26; 21(1):115.. View in PubMed
  • Association Between Ambient Air Pollution and Birth Weight by Maternal Individual- and Neighborhood-Level Stressors. JAMA Netw Open. 2022 10 03; 5(10):e2238174.. View in PubMed
  • Adverse childhood experiences and prenatal depression in the maternal and development risks from environmental and social stressors pregnancy cohort. J Obstet Gynaecol. 2022 Oct; 42(7):3014-3020.. View in PubMed
  • Detected prenatal perfluorooctanoic acid (PFOA) exposure is associated with decreased fetal head biometric parameters in participants experiencing higher perceived stress during pregnancy in the MADRES cohort. Environ Adv. 2022 Oct; 9.. View in PubMed
  • Wnt5a Promotes AT1 and Represses AT2 Lineage-Specific Gene Expression in a Cell-Context-Dependent Manner. Stem Cells. 2022 07 27; 40(7):691-703.. View in PubMed
  • Prenatal Perfluorooctanoic Acid (PFOA) Exposure Is Associated With Lower Infant Birthweight Within the MADRES Pregnancy Cohort. Front Epidemiol. 2022; 2:934715.. View in PubMed
  • An immature, dedifferentiated, and lineage-deconstrained cone precursor origin of N-Myc-initiated retinoblastoma. Proc Natl Acad Sci U S A. 2022 07 12; 119(28):e2200721119.. View in PubMed
  • In-utero personal exposure to PM2.5 impacted by indoor and outdoor sources and birthweight in the MADRES cohort. Environ Adv. 2022 Oct; 9.. View in PubMed
  • Activated and nonactivated MSCs increase survival in humanized mice after acute liver injury through alcohol binging. Hepatol Commun. 2022 07; 6(7):1549-1560.. View in PubMed
  • Association of Breastfeeding Duration with 12-Month Postpartum Blood Lipids in a Predominately Lower-Income Hispanic Pregnancy Cohort in Los Angeles. Int J Environ Res Public Health. 2022 03 04; 19(5).. View in PubMed
  • Perceived vulnerability to immigration policies among postpartum Hispanic/Latina women in the MADRES pregnancy cohort before and during the COVID-19 pandemic. Womens Health (Lond). 2022 Jan-Dec; 18:17455057221125103.. View in PubMed
  • Household pesticide exposures and infant gross motor development in the MADRES cohort. Paediatr Perinat Epidemiol. 2022 03; 36(2):220-229.. View in PubMed
  • Characterization and staging of outer plexiform layer development in human retina and retinal organoids. Development. 2021 12 01; 148(23).. View in PubMed
  • Prenatal ambient air pollution and maternal depression at 12 months postpartum in the MADRES pregnancy cohort. Environ Health. 2021 11 27; 20(1):121.. View in PubMed
  • Third trimester cortisol is positively associated with gestational weight gain in pregnant women with class one obesity. Int J Obes (Lond). 2022 02; 46(2):366-373.. View in PubMed
  • Spatial transcriptional mapping of the human nephrogenic program. Dev Cell. 2021 08 23; 56(16):2381-2398.e6.. View in PubMed
  • Role of Race, Ethnicity, and Immigration in Perceived Stress and Depressive Symptomatology Trends During Pregnancy. J Immigr Minor Health. 2022 Jun; 24(3):561-569.. View in PubMed
  • Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors. Nat Commun. 2021 06 15; 12(1):3641.. View in PubMed
  • Abrogation of mesenchyme-specific TGF-β signaling results in lung malformation with prenatal pulmonary cysts in mice. Am J Physiol Lung Cell Mol Physiol. 2021 06 01; 320(6):L1158-L1168.. View in PubMed
  • Extracellular vesicle microRNA in early versus late pregnancy with birth outcomes in the MADRES study. Epigenetics. 2022 03; 17(3):269-285.. View in PubMed
  • Clinical perspective on the use of human amniotic epithelial cells to treat congenital metabolic diseases with a focus on maple syrup urine disease. Stem Cells Transl Med. 2021 06; 10(6):829-835.. View in PubMed
  • Reciprocal Induction of MDM2 and MYCN in Neural and Neuroendocrine Cancers. Front Oncol. 2020; 10:563156.. View in PubMed
  • Prenatal Metal Mixtures and Birth Weight for Gestational Age in a Predominately Lower-Income Hispanic Pregnancy Cohort in Los Angeles. Environ Health Perspect. 2020 11; 128(11):117001.. View in PubMed
  • Prenatal metal mixtures and fetal size in mid-pregnancy in the MADRES study. Environ Res. 2021 05; 196:110388.. View in PubMed
  • Rational Selection of CRISPR-Cas9 Guide RNAs for Homology-Directed Genome Editing. Mol Ther. 2021 Mar 03; 29(3):1057-1069.. View in PubMed
  • Prenatal Maternal Cortisol Levels and Infant Birth Weight in a Predominately Low-Income Hispanic Cohort. Int J Environ Res Public Health. 2020 09 21; 17(18).. View in PubMed
  • Glomerular endothelial cell heterogeneity in Alport syndrome. Sci Rep. 2020 07 10; 10(1):11414.. View in PubMed
  • Utility of the 3-tier grouping system for survival discriminatory ability in stage IIA cervical cancer. Eur J Surg Oncol. 2021 02; 47(2):331-337.. View in PubMed
  • Minimally invasive radical hysterectomy for early-stage cervical cancer: Volume-outcome relationship in the early experience period. Gynecol Oncol. 2020 08; 158(2):390-396.. View in PubMed
  • Malignant peritoneal cytology and decreased survival of women with stage I endometrioid endometrial cancer. Eur J Cancer. 2020 07; 133:33-46.. View in PubMed
  • Reply to de Steenhuijsen Piters and Bogaert: Bacterial DNA in Fetal Lung Samples May Be Explained by Sample Contamination. Am J Respir Crit Care Med. 2020 05 15; 201(10):1311-1312.. View in PubMed
  • Minimally invasive surgery for early-stage ovarian cancer: Association between hospital surgical volume and short-term perioperative outcomes. Gynecol Oncol. 2020 07; 158(1):59-65.. View in PubMed
  • Human Fetal Lungs Harbor a Microbiome Signature. Am J Respir Crit Care Med. 2020 04 15; 201(8):1002-1006.. View in PubMed
  • Delayed hysterectomy versus continuing conservative management for placenta percreta: which is better? Am J Obstet Gynecol. 2020 08; 223(2):304. Matsuzaki S, Grubbs BH , Matsuo K . View in PubMed
  • Arsenic and birth outcomes in a predominately lower income Hispanic pregnancy cohort in Los Angeles. Environ Res. 2020 05; 184:109294.. View in PubMed
  • Management of Stage IIB Cervical Cancer: an Overview of the Current Evidence. Curr Oncol Rep. 2020 02 12; 22(3):28.. View in PubMed
  • Robust RNA-Seq of aRNA-amplified single cell material collected by patch clamp. Sci Rep. 2020 02 06; 10(1):1979.. View in PubMed
  • Percent Absent End-Diastolic Velocity in the Umbilical Artery and Donor Twin Demise after Laser Surgery for Twin-Twin Transfusion Syndrome. Fetal Diagn Ther. 2020; 47(7):572-579.. View in PubMed
  • Cesarean radical hysterectomy for cervical cancer in the United States: a national study of surgical outcomes. Am J Obstet Gynecol. 2020 05; 222(5):507-511.e2.. View in PubMed
  • Association between hospital surgical volume and perioperative outcomes of fertility-sparing trachelectomy for cervical cancer: A national study in the United States. Gynecol Oncol. 2020 04; 157(1):173-180.. View in PubMed
  • Amylase concentration and activity in the amniotic fluid of fetal rats with retinoic acid induced myelomeningocele. J Matern Fetal Neonatal Med. 2022 Jan; 35(1):147-154.. View in PubMed
  • Evolving population-based statistics for rare epithelial ovarian cancers. Gynecol Oncol. 2020 04; 157(1):3-11.. View in PubMed
  • Diagnosis-shift between low-grade serous ovarian cancer and serous borderline ovarian tumor: A population-based study. Gynecol Oncol. 2020 04; 157(1):21-28.. View in PubMed
  • Implementation of multidisciplinary practice change to improve outcomes for women with placenta accreta spectrum. Eur J Obstet Gynecol Reprod Biol. 2020 Mar; 246:194-196.. View in PubMed
  • Hospital surgical volume and perioperative mortality of pelvic exenteration for gynecologic malignancies. J Surg Oncol. 2020 Feb; 121(2):402-409.. View in PubMed
  • Populational trends and outcomes of postoperative radiotherapy for high-risk early-stage cervical cancer with lymph node metastasis: concurrent chemo-radiotherapy versus radiotherapy alone. Am J Obstet Gynecol. 2020 05; 222(5):484.e1-484.e15.. View in PubMed
  • SOX9+/PTF1A+ Cells Define the Tip Progenitor Cells of the Human Fetal Pancreas of the Second Trimester. Stem Cells Transl Med. 2019 12; 8(12):1249-1264.. View in PubMed
  • Cellular Recruitment by Podocyte-Derived Pro-migratory Factors in Assembly of the Human Renal Filter. iScience. 2019 Oct 25; 20:402-414.. View in PubMed
  • Effectiveness of postoperative chemotherapy for stage IC mucinous ovarian cancer. Gynecol Oncol. 2019 09; 154(3):505-515.. View in PubMed
  • In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes. Dev Cell. 2019 07 01; 50(1):102-116.e6.. View in PubMed
  • Ultrasound-guided in Utero Transplantation of Placental Stem Cells into the Liver of Crigler-Najjar Syndrome Model Rat. Transplantation. 2019 07; 103(7):e182-e187.. View in PubMed
  • Study Design, Protocol and Profile of the Maternal And Developmental Risks from Environmental and Social Stressors (MADRES) Pregnancy Cohort: a Prospective Cohort Study in Predominantly Low-Income Hispanic Women in Urban Los Angeles. BMC Pregnancy Childbirth. 2019 May 30; 19(1):189.. View in PubMed
  • Construction and Evaluation of a Subcutaneous Splenic Injection Port for Serial Intraportal Vein Cell Delivery in Murine Disease Models. Stem Cells Int. 2019; 2019:5419501.. View in PubMed

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