Keck School Faculty

Brian Michael Luna, PhD
Brian Michael Luna, PhD
Assistant Professor of Molecular Microbiology and Immunology
Molecular Microbiology and Immunology
1441 Eastlake Ave Health Sciences Campus Los Angeles
In the United States there has been a rapid increase in the disease burden caused by antibiotic resistant members of the ESKAPE pathogens: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species. More than 2,000,000 illnesses and 23,000 deaths were attributed to antibiotic resistant infections in the US in 2013, with an added $20 billion dollar cost to the healthcare system. Continued research is needed to understand antibiotic tolerance mechanisms for the purpose of developing the next generation of therapeutics that can subvert these mechanisms.

I am interested in the study of antibiotic tolerance mechanisms by bacterial pathogens; including both antibiotic resistance and antibiotic persister cell formation. Better understanding of antibiotic tolerance mechanisms will guide improved therapeutic strategies for combating these infections. We use multiple research strategies including synthetic biology, microbial genetics, next-generation sequencing, and preclinical mouse models in our work.

Adjunctive transferrin to reduce the emergence of antibiotic resistance in Gram-negative bacteria J Antimicrob Chemother. 2019 Jun 06. . View in PubMed

Apotransferrin in Combination with Ciprofloxacin Slows Bacterial Replication, Prevents Resistance Amplification, and Increases Antimicrobial Regimen Effect Antimicrob Agents Chemother. 2019 May; 63(5). . View in PubMed

Apotransferrin in Combination with Ciprofloxacin Slows Bacterial Replication, Prevents Resistance Amplification, and Increases Antimicrobial Regimen Effect Antimicrob Agents Chemother. 2019 Feb 19. . View in PubMed

Vaccines targeting Staphylococcus aureus skin and bloodstream infections require different composition PLoS One. 2019; 14(6):e0217439. . View in PubMed

Natural history of Acinetobacter baumannii infection in mice PLoS One. 2019; 14(7):e0219824. . View in PubMed

Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells Lab Chip. 2018 Aug 09. . View in PubMed

Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data Sci Transl Med. 2018 Apr 04; 10(435). . View in PubMed

Joint solution for PET image segmentation, denoising, and partial volume correction Med Image Anal. 2018 05; 46:229-243. . View in PubMed

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia J Vis Exp. 2018 06 28; (136). . View in PubMed

Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells Lab Chip. 2018 09 11; 18(18):2776-2786. . View in PubMed

Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE MBio. 2017 Aug 22; 8(4). . View in PubMed

Monoclonal Antibody Protects Against Acinetobacter baumannii Infection by Enhancing Bacterial Clearance and Evading Sepsis J Infect Dis. 2017 Aug 15; 216(4):489-501. . View in PubMed

Selectable Markers for Use in Genetic Manipulation of Extensively Drug-Resistant (XDR) Acinetobacter baumannii HUMC1 mSphere. 2017 Mar-Apr; 2(2). . View in PubMed

Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges Clin Microbiol Rev. 2017 01; 30(1):409-447. . View in PubMed

Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges Clin Microbiol Rev. 2017 Jan; 30(1):409-447. . View in PubMed

Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE MBio. 2017 08 22; 8(4). . View in PubMed

Monoclonal Antibody Protects Against Acinetobacter baumannii Infection by Enhancing Bacterial Clearance and Evading Sepsis J Infect Dis. 2017 08 15; 216(4):489-501. . View in PubMed

Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis J Infect Dis. 2016 Feb 15; 213(4):618-27. . View in PubMed

Computer-aided pulmonary image analysis in small animal models Med Phys. 2015 Jul; 42(7):3896-910. . View in PubMed

In vivo prediction of tuberculosis-associated cavity formation in rabbits J Infect Dis. 2015 Feb 01; 211(3):481-5. . View in PubMed

Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation J Pathol. 2015 Feb; 235(3):431-44. . View in PubMed

Segmentation of PET images for computer-aided functional quantification of tuberculosis in small animal models IEEE Trans Biomed Eng. 2014 Mar; 61(3):711-24. . View in PubMed

Computer-aided detection and quantification of cavitary tuberculosis from CT scans Med Phys. 2013 Nov; 40(11):113701. . View in PubMed

A computational pipeline for quantification of pulmonary infections in small animal models using serial PET-CT imaging EJNMMI Res. 2013 Jul 23; 3(1):55. . View in PubMed

Gene expression of Mycobacterium tuberculosis putative transcription factors whiB1-7 in redox environments PLoS One. 2012; 7(7):e37516. . View in PubMed

Injection of dsRNA into female Aaegypti mosquitos. J Vis Exp. 2007; (5):215. . View in PubMed

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