Brian P. Lee, MD

Associate Professor of Clinical Medicine

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Overview

Dr. Lee is a transplant hepatologist and Associate Professor at Keck School of Medicine of USC with joint appointment in the USC Institute for Addiction Science. He cares for patients with advanced liver disease, including alcohol and metabolic liver disease, and those being evaluated for or living after liver transplantation.

His research examines how alcohol, metabolic disease, and health policy shape liver disease and access to liver transplantation. He led the first multicenter US study of early liver transplantation for severe alcohol-associated hepatitis, which helped establish the practice as standard of care, and he founded and leads ACCELERATE, the NIH-funded national consortium committed to further improve outcomes in this practice. His research on insurance barriers to transplant led to changes in Medicaid policy.

He is lead author of studies in The Lancet, JAMA Internal Medicine, Annals of Internal Medicine, Journal of Hepatology, and Gastroenterology. His work has been cited in clinical practice guidelines in North America, Europe, Latin America, and Asia, and covered by the New York Times, Wall Street Journal, NPR, CNN, the New Yorker, and NBC Nightly News. He has served on national and international guideline and consensus panels in alcohol-associated liver disease, including as first author of the NIAAA-commissioned guidelines for clinical trial design.

Dr. Lee mentors residents, fellows, and junior faculty, with published work in Annals of Internal Medicine, Journal of Hepatology, and Gastroenterology. He serves as Associate Editor of Hepatology and as a voting member of the FDA Gastrointestinal Drugs Advisory Committee and the FDA Pharmacy Compounding Advisory Committee.

Awards

  • European Association for the Study of the Liver: Young Investigator Bursary Award, 2019
  • American Association for the Study of Liver Diseases: Clinical/Translational Early Career Investigator Award, 2018
  • American Society of Transplantation: Young Investigator Award, 2018
  • International Liver Transplantation Society: Young Investigator Award, 2017
  • Johns Hopkins Hospital: Resident Teaching Award, 2016
  • Summa Cum Laude, 2013
  • Alpha Omega Alpha (AOA), 2013
  • Phi Beta Kappa, 2010

Education and Training

  • Johns Hopkins Osler Program — 2016 — Internal Medicine
  • UCSF — 2019 — Gastroenterology
  • UCSF — 2020 — Transplant Hepatology

Research Funding

  • American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)
    NIH · R01AA030960 · Aug 1, 2023 – Jul 31, 2030
  • Estimating the Contribution of Alcohol and Metabolic Risk to Liver Disease Progression to Inform Personalized Interventions
    NIH · K23AA029752 · Jul 15, 2022 – Jun 30, 2026 · Role: Principal Investigator
  • Estimating the Contribution of Alcohol and Metabolic Risk to Liver Disease Progression to Inform Personalized Interventions
    NIH · K23AA029752 · Jul 1, 2022 – Jun 30, 2026

Media

Publications

  • Review of Alcohol-Related Liver Disease-Reply. JAMA. 2026 Nov 02.. View in PubMed
  • Government digital maturity and liver-related mortality: A multinational ecological study. Hepatology. 2026 Oct 26.. View in PubMed
  • Two diseases, one trial: designing integrated treatments for alcohol-associated hepatitis and alcohol use disorder. Hepatology. 2026 Oct 22.. View in PubMed
  • Alcohol-associated liver disease. Clin Gastroenterol Hepatol. 2026 Oct 12.. View in PubMed
  • Alcohol Use Between 2018 and 2024: A National Cross-Sectional Study. Ann Intern Med. 2026 Sep 22.. View in PubMed
  • The global burden of metabolic and alcohol-associated liver disease (MetALD). Hepatol Commun. 2026 Oct 01; 10(10).. View in PubMed
  • Detection of Potential MetALD and ALD Using Phosphatidylethanol in a Large Multicenter MASH Trial Screening Cohort. Clin Gastroenterol Hepatol. 2026 Aug 25.. View in PubMed
  • Machine learning-derived clinical phenotypes of ascites in cirrhosis: A multi-center latent class analysis with external validation. Liver Transpl. 2026 Aug 06.. View in PubMed
  • Alcohol-Related Liver Disease: A Review. JAMA. 2026 Aug 04; 336(5):413-425.. View in PubMed
  • High Prevalence of Abnormal Anthropometrics in Lean Metabolic Dysfunction-Associated Steatotic Liver Disease: A National Cross-Sectional Study. Gastroenterology. 2026 Jul 17.. View in PubMed