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Brooke Erika Hjelm

Assistant Professor of Clinical Cancer Biology

Culture and Engagement Champion

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Email bhjelm@usc.edu
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Publications

  • Early life stress, psychiatric conditions, and mitochondrial DNA copy number (mtDNAcn) in medically healthy young adults. Psychoneuroendocrinology. 2025 Sep; 179:107504.. View in PubMed
  • Distinct Mitochondrial DNA Deletion Profiles in Pediatric B- and T-ALL During Diagnosis, Remission, and Relapse. Int J Mol Sci. 2025 Jul 23; 26(15).. View in PubMed
  • Evidence for cPLA2 activation in Alzheimer’s Disease Synaptic Pathology. bioRxiv. 2025 Apr 01.. View in PubMed
  • Increased Rate of Unique Mitochondrial DNA Deletion Breakpoints in Young Adults With Early-Life Stress. Biol Psychiatry Glob Open Sci. 2025 Mar; 5(2):100422.. View in PubMed
  • Cerebellum mitochondrial DNA copy number is increased in Parkinson’s disease. Brain Commun. 2025; 7(4):fcaf296.. View in PubMed
  • Common mitochondrial deletions in RNA-Seq: evaluation of bulk, single-cell, and spatial transcriptomic datasets. Commun Biol. 2024 02 17; 7(1):200.. View in PubMed
  • The miRNA Landscape of Lacrimal Glands in a Murine Model of Autoimmune Dacryoadenitis. Invest Ophthalmol Vis Sci. 2023 04 03; 64(4):1.. View in PubMed
  • The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism. Cell Genom. 2023 Mar 08; 3(3):100261.. View in PubMed
  • Large Common Mitochondrial DNA Deletions Are Associated with a Mitochondrial SNP T14798C Near the 3′ Breakpoints. Complex Psychiatry. 2023 Jan; 8(3-4):90-98.. View in PubMed
  • Mutations in genes related to myocyte contraction and ventricular septum development in non-syndromic tetralogy of Fallot. Front Cardiovasc Med. 2023; 10:1249605.. View in PubMed
  • Functional impairment of cortical AMPA receptors in schizophrenia. Schizophr Res. 2022 11; 249:25-37.. View in PubMed
  • Mitochondria DNA copy number, mitochondria DNA total somatic deletions, Complex I activity, synapse number, and synaptic mitochondria number are altered in schizophrenia and bipolar disorder. Transl Psychiatry. 2022 08 30; 12(1):353.. View in PubMed
  • Tear miRNAs Identified in a Murine Model of Sjögren’s Syndrome as Potential Diagnostic Biomarkers and Indicators of Disease Mechanism. Front Immunol. 2022; 13:833254.. View in PubMed
  • Splice-Break: exploiting an RNA-seq splice junction algorithm to discover mitochondrial DNA deletion breakpoints and analyses of psychiatric disorders. Nucleic Acids Res. 2019 06 04; 47(10):e59.. View in PubMed
  • Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses. Cell Stem Cell. 2018 05 03; 22(5):698-712.e9.. View in PubMed
  • Mitochondrial Complex I Deficiency in Schizophrenia and Bipolar Disorder and Medication Influence. Mol Neuropsychiatry. 2018 Feb; 3(3):157-169.. View in PubMed
  • Targets of polyamine dysregulation in major depression and suicide: Activity-dependent feedback, excitability, and neurotransmission. Neurosci Biobehav Rev. 2016 Jul; 66:80-91.. View in PubMed
  • Mifepristone-inducible transgene expression in neural progenitor cells in vitro and in vivo. Gene Ther. 2016 05; 23(5):424-37.. View in PubMed
  • Evidence of Mitochondrial Dysfunction within the Complex Genetic Etiology of Schizophrenia. Mol Neuropsychiatry. 2015 Dec; 1(4):201-19.. View in PubMed
  • TLR7 and 9 agonists are highly effective mucosal adjuvants for norovirus virus-like particle vaccines. Hum Vaccin Immunother. 2014; 10(2):410-6.. View in PubMed
  • In vitro-differentiated neural cell cultures progress towards donor-identical brain tissue. Hum Mol Genet. 2013 Sep 01; 22(17):3534-46.. View in PubMed
  • Lack of norovirus replication and histo-blood group antigen expression in 3-dimensional intestinal epithelial cells. Emerg Infect Dis. 2013 Mar; 19(3):431-8.. View in PubMed
  • Induction of pluripotent stem cells from autopsy donor-derived somatic cells. Neurosci Lett. 2011 Sep 20; 502(3):219-24.. View in PubMed
  • An intranasally delivered Toll-like receptor 7 agonist elicits robust systemic and mucosal responses to Norwalk virus-like particles. Clin Vaccine Immunol. 2010 Dec; 17(12):1850-8.. View in PubMed
  • Development and characterization of a three-dimensional organotypic human vaginal epithelial cell model. Biol Reprod. 2010 Mar; 82(3):617-27.. View in PubMed
  • A DNA replicon system for rapid high-level production of virus-like particles in plants. Biotechnol Bioeng. 2009 Jul 01; 103(4):706-14.. View in PubMed
  • An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles. Vaccine. 2008 Mar 28; 26(15):1846-54.. View in PubMed
  • Application of electron tomography to fungal ultrastructure studies. New Phytol. 2006; 172(2):208-20.. View in PubMed

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