Keck School Faculty

Bruce Pawel
Bruce Pawel
Professor of Clinical Pathology
4640 West Sunset Boulevard Off Campus Los Angeles

Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma Int J Cancer. 2019 06 01; 144(11):2707-2717. . View in PubMed

An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma Sci Transl Med. 2019 03 13; 11(483). . View in PubMed

Diffuse Strong BCOR Immunoreactivity Is a Sensitive and Specific Marker for Clear Cell Sarcoma of the Kidney (CCSK) in Pediatric Renal Neoplasia Am J Surg Pathol. 2018 08; 42(8):1128-1131. . View in PubMed

Assessment of programmed death-ligand 1 expression and tumor-associated immune cells in pediatric cancer tissues Cancer. 2017 Oct 01; 123(19):3807-3815. . View in PubMed

Advancing Clinicopathologic Diagnosis of High-risk Neuroblastoma Using Computerized Image Analysis and Proteomic Profiling Pediatr Dev Pathol. 2017 Sep-Oct; 20(5):394-402. . View in PubMed

Multimodality imaging findings of massive ovarian edema in children Pediatr Radiol. 2017 May; 47(5):576-583. . View in PubMed

Fetal Lymphatic Malformations: More Variable Than We Think? J Ultrasound Med. 2017 May; 36(5):1051-1058.. View in PubMed

Pediatric Cystic Nephroma Is Morphologically, Immunohistochemically, and Genetically Distinct From Adult Cystic Nephroma Am J Surg Pathol. 2017 Apr; 41(4):472-481. . View in PubMed

Giant hepatic regenerative nodules in Alagille syndrome Pediatr Radiol. 2017 Feb; 47(2):197-204. . View in PubMed

Frequency and pathogenesis of central liver nodules in Alagille syndrome patients: Reply to Libbrecht and Cassiman Pediatr Radiol. 2017 07; 47(8):1025. . View in PubMed

Identification of CASZ1 NES reveals potential mechanisms for loss of CASZ1 tumor suppressor activity in neuroblastoma Oncogene. 2017 01 05; 36(1):97-109. . View in PubMed

Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk NeuroblastomaCancer Cell. 2017 09 11; 32(3):295-309. e12. . View in PubMed

Polyamine Antagonist Therapies Inhibit Neuroblastoma Initiation and Progression Clin Cancer Res. 2016 Sep 01; 22(17):4391-404. . View in PubMed

Advancing clinicopathologic diagnosis of high-risk neuroblastoma using computerized image analysis and proteomic profiling Pediatr Dev Pathol. 2016 Jul 21. . View in PubMed

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape Science. 2016 May 13; 352(6287):844-9. . View in PubMed

Hypertension and proteinuria-the needle in the haystack? : Answers. Pediatr Nephrol. 2016 09; 31(9):1457-8.. View in PubMed

Hypertension and proteinuria-the needle in the haystack? : Questions. Pediatr Nephrol. 2016 09; 31(9):1455-6.. View in PubMed

Serine catabolism regulates mitochondrial redox control during hypoxia Cancer Discov. 2014 Dec; 4(12):1406-17. . View in PubMed

Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion Mol Cell. 2014 Oct 23; 56(2):205-218. . View in PubMed

Malignant rhabdoid tumor of the bladder and ganglioglioma in a 14 year-old male with a germline 22q112 deletion. Cancer Genet. 2014 Sep; 207(9):415-9. . View in PubMed

Acquired isochromosome 12p, somatic TP53 and PTEN mutations, and a germline ATM variant in an adolescent male with concurrent acute megakaryoblastic leukemia and mediastinal germ cell tumor Cancer Genet. 2014 Apr; 207(4):153-9. . View in PubMed

Mutations in the ABCC6 gene as a cause of generalized arterial calcification of infancy: genotypic overlap with pseudoxanthoma elasticum J Invest Dermatol. 2014 Mar; 134(3):658-665. . View in PubMed

High ALK mRNA expression has a negative prognostic significance in rhabdomyosarcoma Br J Cancer. 2013 Dec 10; 109(12):3084-91. . View in PubMed

Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma Clin Cancer Res. 2013 Nov 15; 19(22):6173-82. . View in PubMed

Immunohistochemical expression of glypican-3 in pediatric tumors: an analysis of 414 cases Pediatr Dev Pathol. 2013 Jul-Aug; 16(4):272-7. . View in PubMed

Epithelioid sarcoma is associated with a high percentage of SMARCB1 deletions Mod Pathol. 2013 Mar; 26(3):385-92. . View in PubMed

Clonal trisomy 4 cells detected in the ossifying renal tumor of infancy: study of 3 cases Mod Pathol. 2013 Feb; 26(2):275-81. . View in PubMed

Combination therapy targeting the Chk1 and Wee1 kinases shows therapeutic efficacy in neuroblastoma Cancer Res. 2013 Jan 15; 73(2):776-84. . View in PubMed

Acanthosis nigricans associated with an adrenocortical tumor in a pediatric patient Case Rep Endocrinol. 2013; 2013:174593. . View in PubMed

Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group J Clin Oncol. 2012 Nov 20; 30(33):4148-54. . View in PubMed

Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma Oncogene. 2012 Nov 15; 31(46):4859-67. . View in PubMed

Expression of therapeutic targets in Ewing sarcoma family tumors Hum Pathol. 2012 Jul; 43(7):1077-83. . View in PubMed

Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity Cancer Res. 2012 Apr 15; 72(8):2068-78. . View in PubMed

Claudin-6 is a nonspecific marker for malignant rhabdoid and other pediatric tumors Am J Surg Pathol. 2012 Jan; 36(1):73-80. . View in PubMed

Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group Int J Mol Imaging. 2012; 2012:250834. . View in PubMed

Polyps and masses of the pediatric urinary bladder: a 21-year pathology review Pediatr Dev Pathol. 2011 Nov-Dec; 14(6):438-44. . View in PubMed

Investigation of the insulin-like growth factor-1 signaling pathway in localized Ewing sarcoma: a report from the Children's Oncology Group Cancer. 2011 Nov 01; 117(21):4966-76. . View in PubMed

Malignant rhabdoid tumors express stem cell factors, which relate to the expression of EZH2 and Id proteins Am J Surg Pathol. 2011 Oct; 35(10):1463-72. . View in PubMed

p16INK4A and p14ARF tumor suppressor pathways are deregulated in malignant rhabdoid tumors J Neuropathol Exp Neurol. 2011 Jul; 70(7):596-609. . View in PubMed

Eosinophilic fasciitis mimicking angioedema and treatment response to infliximab in a pediatric patient Ann Allergy Asthma Immunol. 2011 May; 106(5):444-5. . View in PubMed

Congenital peribronchial myofibroblastic tumor: comparison of fetal and postnatal morphology Pediatr Dev Pathol. 2011 Mar-Apr; 14(2):124-9. . View in PubMed

Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha Cancer Res. 2010 Dec 15; 70(24):10351-61. . View in PubMed

EWSR1-POU5F1 fusion in soft tissue myoepithelial tumorsA molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene. Genes Chromosomes Cancer. 2010 Dec; 49(12):1114-24. . View in PubMed

Lipoprotein lipase deficiency with visceral xanthomas Pediatr Radiol. 2010 Aug; 40(8):1440-2. . View in PubMed

Congenital epulis Ear Nose Throat J. 2010 Jul; 89(7):299-300. . View in PubMed

Serial transcriptome analysis and cross-species integration identifies centromere-associated protein E as a novel neuroblastoma target Cancer Res. 2010 Apr 01; 70(7):2749-58. . View in PubMed

High expression of the PAX3-FKHR oncoprotein is required to promote tumorigenesis of human myoblasts Am J Pathol. 2009 Dec; 175(6):2600-8. . View in PubMed

Interferon-gamma-dependent infiltration of human T cells into neuroblastoma tumors in vivo Clin Cancer Res. 2009 Nov 01; 15(21):6602-8. . View in PubMed

Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists Cancer Biol Ther. 2009 Aug; 8(16):1587-95. . View in PubMed

ALK expression in rhabdomyosarcomas: correlation with histologic subtype and fusion status Pediatr Dev Pathol. 2009 Jul-Aug; 12(4):275-83. . View in PubMed

Loss of INI1 expression defines a unique subset of pediatric undifferentiated soft tissue sarcomas Mod Pathol. 2009 Jan; 22(1):142-50. . View in PubMed

ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma Cancer Res. 2008 Dec 01; 68(23):9735-45. . View in PubMed

Primary cardiac sarcomas: a clinicopathologic analysis of a series with follow-up information in 17 patients and emphasis on long-term survival Hum Pathol. 2008 Sep; 39(9):1385-95. . View in PubMed

Schistosomiasis: an unexpected finding in an inguinal hernia sac Pediatr Dev Pathol. 2008 Sep-Oct; 11(5):402-4. . View in PubMed

Recurrent pedal hobnail (Dabska-retiform) hemangioendothelioma with forefoot reconstructive surgery using a digital fillet flap J Foot Ankle Surg. 2008 Sep-Oct; 47(5):487-93. . View in PubMed

CHD5, a tumor suppressor gene deleted from 1p3631 in neuroblastomas. J Natl Cancer Inst. 2008 Jul 02; 100(13):940-9. . View in PubMed

Neural cell adhesion molecule (NCAM) isoform expression is associated with neuroblastoma differentiation status Pediatr Blood Cancer. 2008 Jul; 51(1):10-6. . View in PubMed

Interstitial granulomatous lesions as part of the spectrum of presenting cutaneous signs in pediatric sarcoidosis Pediatr Dermatol. 2007 Sep-Oct; 24(5):517-24. . View in PubMed

Prominent microvascular proliferation in clinically aggressive neuroblastoma Clin Cancer Res. 2007 Jun 15; 13(12):3499-506. . View in PubMed

Atraumatic compartment syndrome: a manifestation of toxic shock and infectious pyomyositis in a childA case report. J Bone Joint Surg Am. 2007 Jun; 89(6):1337-42. . View in PubMed

Global gene expression profiling of PAX-FKHR fusion-positive alveolar and PAX-FKHR fusion-negative embryonal rhabdomyosarcomas J Pathol. 2007 Jun; 212(2):143-51. . View in PubMed

Multiple ectopic lesions of focal islet adenomatosis identified by positron emission tomography scan in an infant with congenital hyperinsulinism J Pediatr Surg. 2007 Jan; 42(1):188-92. . View in PubMed

Immunosurveillance and survivin-specific T-cell immunity in children with high-risk neuroblastoma J Clin Oncol. 2006 Dec 20; 24(36):5725-34. . View in PubMed

Congenital pulmonary lymphangiectasis sequence: a rare, heterogeneous, and lethal etiology for prenatal pleural effusion Prenat Diagn. 2006 Nov; 26(11):1058-61. . View in PubMed

Mesenchymal hamartoma of the chest wall Pediatr Surg Int. 2006 Apr; 22(4):398-400. . View in PubMed

Idiopathic infantile arterial calcification: two case reports, a review of the literature and a role for cardiac transplantation Pediatr Transplant. 2006 Mar; 10(2):225-33. . View in PubMed

Langerhans cell histiocytosis and human herpes virus 6 (HHV-6), an analysis by real-time polymerase chain reaction J Orthop Res. 2006 Mar; 24(3):313-20. . View in PubMed

Klippel-Trenaunay syndrome Arch Dis Child. 2005 Nov; 90(11):1127. . View in PubMed

Desmoplastic small round cell tumor in the abdomen and pelvis: report of CT findings in 11 affected children and young adults AJR Am J Roentgenol. 2005 Jun; 184(6):1910-4. . View in PubMed

Methionine aminopeptidase 2 inhibition is an effective treatment strategy for neuroblastoma in preclinical models Clin Cancer Res. 2005 Apr 01; 11(7):2680-5. . View in PubMed

PDGF-A, PDGF-Rbeta, TGFbeta3 and bone morphogenic protein-4 in desmoplastic small round cell tumors with EWS-WT1 gene fusion product and their role in stromal desmoplasia: an immunohistochemical study Mod Pathol. 2005 Mar; 18(3):382-7. . View in PubMed

Pediatric inflammatory myofibroblastic tumor with late metastasis to the lung: case report and review of the literature Pediatr Dev Pathol. 2005 Mar-Apr; 8(2):224-9. . View in PubMed

Prenatal diagnosis and management of mainstem bronchial atresia Fetal Diagn Ther. 2005 Jan-Feb; 20(1):74-8. . View in PubMed

Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression Lab Invest. 2004 Aug; 84(8):1060-70. . View in PubMed

Cellular neurothekeoma of the maxilla Ann Otol Rhinol Laryngol. 2004 May; 113(5):384-7. . View in PubMed

Congenital neuroblastoma arising in the deltoid muscle J Pediatr Hematol Oncol. 2004 Feb; 26(2):101-3. . View in PubMed

Lower leg pain in a 17-year-old boy Clin Orthop Relat Res. 2004 Jan; (418):279-87. . View in PubMed

Elbow mass in a 2-year-old girl Clin Orthop Relat Res. 2004 Jan; (418):272-8. . View in PubMed

Leg pain in an 8-year-old boy Clin Orthop Relat Res. 2003 Dec; (417):321-32. . View in PubMed

Calf mass in a 2-year-old boy Clin Orthop Relat Res. 2003 Dec; (417):333-40. . View in PubMed

Hip pain in a 13-year old boy with a pelvic mass Clin Orthop Relat Res. 2003 Apr; (409):332-41. . View in PubMed

Immunophenotype of desmoplastic small round cell tumors as detected in cases with EWS-WT1 gene fusion product Mod Pathol. 2003 Mar; 16(3):229-35. . View in PubMed

Knee pain in a 13-year-old boy Clin Orthop Relat Res. 2003 Jan; (406):317-27. . View in PubMed

Ankle pain in an 8-year-old boy Clin Orthop Relat Res. 2002 Dec; (405):306-10320-5. . View in PubMed

Detection and diagnostic utilization of placental alkaline phosphatase in muscular tissue and tumors with myogenic differentiation Am J Surg Pathol. 2002 Dec; 26(12):1627-33. . View in PubMed

Knee pain and swelling in a 5-year-old girl Clin Orthop Relat Res. 2002 Mar; (396):258-65. . View in PubMed

Knee pain in a 16-year-old girl Clin Orthop Relat Res. 2001 Oct; (391):302-5308-11. . View in PubMed

Angiogenesis inhibitor TNP-470 during bone marrow transplant: safety in a preclinical model Clin Cancer Res. 2001 Apr; 7(4):1026-32. . View in PubMed

Isolated endobronchial atypical mycobacterium in a child: a case report and review of the literature Int J Pediatr Otorhinolaryngol. 2000 Sep 15; 55(1):65-8. . View in PubMed

ETV6-NTRK3 gene fusion in metastasizing congenital fibrosarcoma Med Pediatr Oncol. 2000 Aug; 35(2):137-9. . View in PubMed

Central neck dissection for the treatment of recurrent thyroglossal duct cysts in childhood Otolaryngol Head Neck Surg. 1999 Nov; 121(5):543-7. . View in PubMed

Extrarenal nephroblastic proliferation in spinal dysraphismA report of 4 cases. Pediatr Neurosurg. 1999 Jul; 31(1):40-4. . View in PubMed

Hereditary Langerhans cell histiocytosis: instances of apparent vertical transmission Med Pediatr Oncol. 1998 Dec; 31(6):559. . View in PubMed

Refusal to walk in a 3-year-old girl Clin Orthop Relat Res. 1997 Dec; (345):248-53258-60. . View in PubMed

Pathological case of the monthHereditary fructose intolerance. Arch Pediatr Adolesc Med. 1997 Nov; 151(11):1165-6. . View in PubMed

Mesenteric pleomorphic liposarcoma in an adolescent Arch Pathol Lab Med. 1997 Feb; 121(2):173-6. . View in PubMed

Ménétrier disease of childhood: role of cytomegalovirus and transforming growth factor alpha J Pediatr. 1996 Feb; 128(2):213-9. . View in PubMed

Pulmonary hypertension and HIV infection: new observations and review of the syndrome Mod Pathol. 1994 Aug; 7(6):685-9. . View in PubMed

Anonymous human immunodeficiency virus surveillance and clinically directed testing in a Newark, NJ, hospital Arch Intern Med. 1991 May; 151(5):965-8. . View in PubMed

Aggravation of diabetic nephropathy by lithium: a case report and review of the literature J Clin Psychiatry. 1989 Mar; 50(3):101-3. . View in PubMed

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