Keck School Faculty

Bruce Pawel
Bruce Pawel
Professor of Clinical Pathology
Pathology
4640 West Sunset Boulevard Off Campus Los Angeles

Phase I Clinical Trial of the Wee1 inhibitor Adavosertib (AZD1775) with Irinotecan in Children with Relapsed Solid TumorsA COG Phase 1 Consortium Report (ADVL1312). Clin Cancer Res. 2019 Dec 19. . View in PubMed

An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma Sci Transl Med. 2019 03 13; 11(483). . View in PubMed

Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma Int J Cancer. 2019 06 01; 144(11):2707-2717. . View in PubMed

Diffuse Strong BCOR Immunoreactivity Is a Sensitive and Specific Marker for Clear Cell Sarcoma of the Kidney (CCSK) in Pediatric Renal Neoplasia Am J Surg Pathol. 2018 08; 42(8):1128-1131. . View in PubMed

Assessment of programmed death-ligand 1 expression and tumor-associated immune cells in pediatric cancer tissues Cancer. 2017 Oct 01; 123(19):3807-3815. . View in PubMed

Advancing Clinicopathologic Diagnosis of High-risk Neuroblastoma Using Computerized Image Analysis and Proteomic Profiling Pediatr Dev Pathol. 2017 Sep-Oct; 20(5):394-402. . View in PubMed

Multimodality imaging findings of massive ovarian edema in children Pediatr Radiol. 2017 May; 47(5):576-583. . View in PubMed

Fetal Lymphatic Malformations: More Variable Than We Think? J Ultrasound Med. 2017 May; 36(5):1051-1058.. View in PubMed

Pediatric Cystic Nephroma Is Morphologically, Immunohistochemically, and Genetically Distinct From Adult Cystic Nephroma Am J Surg Pathol. 2017 Apr; 41(4):472-481. . View in PubMed

Giant hepatic regenerative nodules in Alagille syndrome Pediatr Radiol. 2017 Feb; 47(2):197-204. . View in PubMed

Frequency and pathogenesis of central liver nodules in Alagille syndrome patients: Reply to Libbrecht and Cassiman Pediatr Radiol. 2017 07; 47(8):1025. . View in PubMed

Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk NeuroblastomaCancer Cell. 2017 09 11; 32(3):295-309. e12. . View in PubMed

Identification of CASZ1 NES reveals potential mechanisms for loss of CASZ1 tumor suppressor activity in neuroblastoma Oncogene. 2017 01 05; 36(1):97-109. . View in PubMed

Polyamine Antagonist Therapies Inhibit Neuroblastoma Initiation and Progression Clin Cancer Res. 2016 Sep 01; 22(17):4391-404. . View in PubMed

Advancing clinicopathologic diagnosis of high-risk neuroblastoma using computerized image analysis and proteomic profiling Pediatr Dev Pathol. 2016 Jul 21. . View in PubMed

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape Science. 2016 May 13; 352(6287):844-9. . View in PubMed

Hypertension and proteinuria-the needle in the haystack? : Questions. Pediatr Nephrol. 2016 09; 31(9):1455-6.. View in PubMed

Hypertension and proteinuria-the needle in the haystack? : Answers. Pediatr Nephrol. 2016 09; 31(9):1457-8.. View in PubMed

Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion Mol Cell. 2014 Oct 23; 56(2):205-218. . View in PubMed

Malignant rhabdoid tumor of the bladder and ganglioglioma in a 14 year-old male with a germline 22q112 deletion. Cancer Genet. 2014 Sep; 207(9):415-9. . View in PubMed

Acquired isochromosome 12p, somatic TP53 and PTEN mutations, and a germline ATM variant in an adolescent male with concurrent acute megakaryoblastic leukemia and mediastinal germ cell tumor Cancer Genet. 2014 Apr; 207(4):153-9. . View in PubMed

Mutations in the ABCC6 gene as a cause of generalized arterial calcification of infancy: genotypic overlap with pseudoxanthoma elasticum J Invest Dermatol. 2014 Mar; 134(3):658-665. . View in PubMed

High ALK mRNA expression has a negative prognostic significance in rhabdomyosarcoma Br J Cancer. 2013 Dec 10; 109(12):3084-91. . View in PubMed

Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma Clin Cancer Res. 2013 Nov 15; 19(22):6173-82. . View in PubMed

Immunohistochemical expression of glypican-3 in pediatric tumors: an analysis of 414 cases Pediatr Dev Pathol. 2013 Jul-Aug; 16(4):272-7. . View in PubMed

Epithelioid sarcoma is associated with a high percentage of SMARCB1 deletions Mod Pathol. 2013 Mar; 26(3):385-92. . View in PubMed

Clonal trisomy 4 cells detected in the ossifying renal tumor of infancy: study of 3 cases Mod Pathol. 2013 Feb; 26(2):275-81. . View in PubMed

Combination therapy targeting the Chk1 and Wee1 kinases shows therapeutic efficacy in neuroblastoma Cancer Res. 2013 Jan 15; 73(2):776-84. . View in PubMed

Acanthosis nigricans associated with an adrenocortical tumor in a pediatric patient Case Rep Endocrinol. 2013; 2013:174593. . View in PubMed

Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group J Clin Oncol. 2012 Nov 20; 30(33):4148-54. . View in PubMed

Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma Oncogene. 2012 Nov 15; 31(46):4859-67. . View in PubMed

Expression of therapeutic targets in Ewing sarcoma family tumors Hum Pathol. 2012 Jul; 43(7):1077-83. . View in PubMed

Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity Cancer Res. 2012 Apr 15; 72(8):2068-78. . View in PubMed

Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group Int J Mol Imaging. 2012; 2012:250834. . View in PubMed

Claudin-6 is a nonspecific marker for malignant rhabdoid and other pediatric tumors Am J Surg Pathol. 2012 Jan; 36(1):73-80. . View in PubMed

Investigation of the insulin-like growth factor-1 signaling pathway in localized Ewing sarcoma: a report from the Children's Oncology Group Cancer. 2011 Nov 01; 117(21):4966-76. . View in PubMed

Polyps and masses of the pediatric urinary bladder: a 21-year pathology review Pediatr Dev Pathol. 2011 Nov-Dec; 14(6):438-44. . View in PubMed

Malignant rhabdoid tumors express stem cell factors, which relate to the expression of EZH2 and Id proteins Am J Surg Pathol. 2011 Oct; 35(10):1463-72. . View in PubMed

p16INK4A and p14ARF tumor suppressor pathways are deregulated in malignant rhabdoid tumors J Neuropathol Exp Neurol. 2011 Jul; 70(7):596-609. . View in PubMed

Eosinophilic fasciitis mimicking angioedema and treatment response to infliximab in a pediatric patient Ann Allergy Asthma Immunol. 2011 May; 106(5):444-5. . View in PubMed

Congenital peribronchial myofibroblastic tumor: comparison of fetal and postnatal morphology Pediatr Dev Pathol. 2011 Mar-Apr; 14(2):124-9. . View in PubMed

Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha Cancer Res. 2010 Dec 15; 70(24):10351-61. . View in PubMed

EWSR1-POU5F1 fusion in soft tissue myoepithelial tumorsA molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene. Genes Chromosomes Cancer. 2010 Dec; 49(12):1114-24. . View in PubMed

Lipoprotein lipase deficiency with visceral xanthomas Pediatr Radiol. 2010 Aug; 40(8):1440-2. . View in PubMed

Congenital epulis Ear Nose Throat J. 2010 Jul; 89(7):299-300. . View in PubMed

Serial transcriptome analysis and cross-species integration identifies centromere-associated protein E as a novel neuroblastoma target Cancer Res. 2010 Apr 01; 70(7):2749-58. . View in PubMed

High expression of the PAX3-FKHR oncoprotein is required to promote tumorigenesis of human myoblasts Am J Pathol. 2009 Dec; 175(6):2600-8. . View in PubMed

Interferon-gamma-dependent infiltration of human T cells into neuroblastoma tumors in vivo Clin Cancer Res. 2009 Nov 01; 15(21):6602-8. . View in PubMed

Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists Cancer Biol Ther. 2009 Aug; 8(16):1587-95. . View in PubMed

ALK expression in rhabdomyosarcomas: correlation with histologic subtype and fusion status Pediatr Dev Pathol. 2009 Jul-Aug; 12(4):275-83. . View in PubMed

Loss of INI1 expression defines a unique subset of pediatric undifferentiated soft tissue sarcomas Mod Pathol. 2009 Jan; 22(1):142-50. . View in PubMed

ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma Cancer Res. 2008 Dec 01; 68(23):9735-45. . View in PubMed

Schistosomiasis: an unexpected finding in an inguinal hernia sac Pediatr Dev Pathol. 2008 Sep-Oct; 11(5):402-4. . View in PubMed

Recurrent pedal hobnail (Dabska-retiform) hemangioendothelioma with forefoot reconstructive surgery using a digital fillet flap J Foot Ankle Surg. 2008 Sep-Oct; 47(5):487-93. . View in PubMed

Primary cardiac sarcomas: a clinicopathologic analysis of a series with follow-up information in 17 patients and emphasis on long-term survival Hum Pathol. 2008 Sep; 39(9):1385-95. . View in PubMed

CHD5, a tumor suppressor gene deleted from 1p3631 in neuroblastomas. J Natl Cancer Inst. 2008 Jul 02; 100(13):940-9. . View in PubMed

Neural cell adhesion molecule (NCAM) isoform expression is associated with neuroblastoma differentiation status Pediatr Blood Cancer. 2008 Jul; 51(1):10-6. . View in PubMed

Interstitial granulomatous lesions as part of the spectrum of presenting cutaneous signs in pediatric sarcoidosis Pediatr Dermatol. 2007 Sep-Oct; 24(5):517-24. . View in PubMed

Prominent microvascular proliferation in clinically aggressive neuroblastoma Clin Cancer Res. 2007 Jun 15; 13(12):3499-506. . View in PubMed

Global gene expression profiling of PAX-FKHR fusion-positive alveolar and PAX-FKHR fusion-negative embryonal rhabdomyosarcomas J Pathol. 2007 Jun; 212(2):143-51. . View in PubMed

Atraumatic compartment syndrome: a manifestation of toxic shock and infectious pyomyositis in a childA case report. J Bone Joint Surg Am. 2007 Jun; 89(6):1337-42. . View in PubMed

Multiple ectopic lesions of focal islet adenomatosis identified by positron emission tomography scan in an infant with congenital hyperinsulinism J Pediatr Surg. 2007 Jan; 42(1):188-92. . View in PubMed

Immunosurveillance and survivin-specific T-cell immunity in children with high-risk neuroblastoma J Clin Oncol. 2006 Dec 20; 24(36):5725-34. . View in PubMed

Congenital pulmonary lymphangiectasis sequence: a rare, heterogeneous, and lethal etiology for prenatal pleural effusion Prenat Diagn. 2006 Nov; 26(11):1058-61. . View in PubMed

Mesenchymal hamartoma of the chest wall Pediatr Surg Int. 2006 Apr; 22(4):398-400. . View in PubMed

Idiopathic infantile arterial calcification: two case reports, a review of the literature and a role for cardiac transplantation Pediatr Transplant. 2006 Mar; 10(2):225-33. . View in PubMed

Langerhans cell histiocytosis and human herpes virus 6 (HHV-6), an analysis by real-time polymerase chain reaction J Orthop Res. 2006 Mar; 24(3):313-20. . View in PubMed

Klippel-Trenaunay syndrome Arch Dis Child. 2005 Nov; 90(11):1127. . View in PubMed

Desmoplastic small round cell tumor in the abdomen and pelvis: report of CT findings in 11 affected children and young adults AJR Am J Roentgenol. 2005 Jun; 184(6):1910-4. . View in PubMed

Methionine aminopeptidase 2 inhibition is an effective treatment strategy for neuroblastoma in preclinical models Clin Cancer Res. 2005 Apr 01; 11(7):2680-5. . View in PubMed

Pediatric inflammatory myofibroblastic tumor with late metastasis to the lung: case report and review of the literature Pediatr Dev Pathol. 2005 Mar-Apr; 8(2):224-9. . View in PubMed

PDGF-A, PDGF-Rbeta, TGFbeta3 and bone morphogenic protein-4 in desmoplastic small round cell tumors with EWS-WT1 gene fusion product and their role in stromal desmoplasia: an immunohistochemical study Mod Pathol. 2005 Mar; 18(3):382-7. . View in PubMed

Prenatal diagnosis and management of mainstem bronchial atresia Fetal Diagn Ther. 2005 Jan-Feb; 20(1):74-8. . View in PubMed

Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression Lab Invest. 2004 Aug; 84(8):1060-70. . View in PubMed

Cellular neurothekeoma of the maxilla Ann Otol Rhinol Laryngol. 2004 May; 113(5):384-7. . View in PubMed

Congenital neuroblastoma arising in the deltoid muscle J Pediatr Hematol Oncol. 2004 Feb; 26(2):101-3. . View in PubMed

Elbow mass in a 2-year-old girl Clin Orthop Relat Res. 2004 Jan; (418):272-8. . View in PubMed

Lower leg pain in a 17-year-old boy Clin Orthop Relat Res. 2004 Jan; (418):279-87. . View in PubMed

Calf mass in a 2-year-old boy Clin Orthop Relat Res. 2003 Dec; (417):333-40. . View in PubMed

Leg pain in an 8-year-old boy Clin Orthop Relat Res. 2003 Dec; (417):321-32. . View in PubMed

Hip pain in a 13-year old boy with a pelvic mass Clin Orthop Relat Res. 2003 Apr; (409):332-41. . View in PubMed

Immunophenotype of desmoplastic small round cell tumors as detected in cases with EWS-WT1 gene fusion product Mod Pathol. 2003 Mar; 16(3):229-35. . View in PubMed

Knee pain in a 13-year-old boy Clin Orthop Relat Res. 2003 Jan; (406):317-27. . View in PubMed

Detection and diagnostic utilization of placental alkaline phosphatase in muscular tissue and tumors with myogenic differentiation Am J Surg Pathol. 2002 Dec; 26(12):1627-33. . View in PubMed

Ankle pain in an 8-year-old boy Clin Orthop Relat Res. 2002 Dec; (405):306-10320-5. . View in PubMed

Knee pain and swelling in a 5-year-old girl Clin Orthop Relat Res. 2002 Mar; (396):258-65. . View in PubMed

Knee pain in a 16-year-old girl Clin Orthop Relat Res. 2001 Oct; (391):302-5308-11. . View in PubMed

Angiogenesis inhibitor TNP-470 during bone marrow transplant: safety in a preclinical model Clin Cancer Res. 2001 Apr; 7(4):1026-32. . View in PubMed

Isolated endobronchial atypical mycobacterium in a child: a case report and review of the literature Int J Pediatr Otorhinolaryngol. 2000 Sep 15; 55(1):65-8. . View in PubMed

ETV6-NTRK3 gene fusion in metastasizing congenital fibrosarcoma Med Pediatr Oncol. 2000 Aug; 35(2):137-9. . View in PubMed

Central neck dissection for the treatment of recurrent thyroglossal duct cysts in childhood Otolaryngol Head Neck Surg. 1999 Nov; 121(5):543-7. . View in PubMed

Extrarenal nephroblastic proliferation in spinal dysraphismA report of 4 cases. Pediatr Neurosurg. 1999 Jul; 31(1):40-4. . View in PubMed

Hereditary Langerhans cell histiocytosis: instances of apparent vertical transmission Med Pediatr Oncol. 1998 Dec; 31(6):559. . View in PubMed

Refusal to walk in a 3-year-old girl Clin Orthop Relat Res. 1997 Dec; (345):248-53258-60. . View in PubMed

Pathological case of the monthHereditary fructose intolerance. Arch Pediatr Adolesc Med. 1997 Nov; 151(11):1165-6. . View in PubMed

Mesenteric pleomorphic liposarcoma in an adolescent Arch Pathol Lab Med. 1997 Feb; 121(2):173-6. . View in PubMed

Ménétrier disease of childhood: role of cytomegalovirus and transforming growth factor alpha J Pediatr. 1996 Feb; 128(2):213-9. . View in PubMed

Pulmonary hypertension and HIV infection: new observations and review of the syndrome Mod Pathol. 1994 Aug; 7(6):685-9. . View in PubMed

Anonymous human immunodeficiency virus surveillance and clinically directed testing in a Newark, NJ, hospital Arch Intern Med. 1991 May; 151(5):965-8. . View in PubMed

Aggravation of diabetic nephropathy by lithium: a case report and review of the literature J Clin Psychiatry. 1989 Mar; 50(3):101-3. . View in PubMed

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