Keck School Faculty

Caryn Lerman
Caryn Lerman
Director, USC Norris Comprehensive Cancer Center
Cancer Center
1441 Eastlake Avenue Health Sciences Campus Los Angeles

Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity Addict Biol. 2019 Feb 27. . View in PubMed

Evaluating the temporal relationships between withdrawal symptoms and smoking relapse Psychol Addict Behav. 2019 Jan 07. . View in PubMed

Lack of effect of transcranial direct current stimulation (tDCS) on short-term smoking cessation: Results of a randomized, sham-controlled clinical trial Drug Alcohol Depend. 2019 01 01; 194:244-251. . View in PubMed

Association of Reduced Nicotine Content Cigarettes With Smoking Behaviors and Biomarkers of Exposure Among Slow and Fast Nicotine Metabolizers: A Nonrandomized Clinical Trial JAMA Netw Open. 2018 Aug; 1(4). . View in PubMed

A Comparison of Direct and Indirect Analytical Approaches to Measuring Total Nicotine Equivalents in Urine Cancer Epidemiol Biomarkers Prev. 2018 Aug; 27(8):882-891. . View in PubMed

Improvement of the association between self-reported pill count and varenicline levels following exclusion of participants with misreported pill count: A commentary on Peng et al(2017). Addict Behav. 2018 Apr; 79:14-16. . View in PubMed

Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences Addiction. 2018 Mar; 113(3):509-523. . View in PubMed

Measures and predictors of varenicline adherence in the treatment of nicotine dependence Addict Behav. 2017 12; 75:122-129. . View in PubMed

Am J Addict. 2016 06; 25(4):291-6. . View in PubMed

Drug Alcohol Depend. 2016 11 01; 168:112-118. . View in PubMed

Brain Responses to Smoking Cues Differ Based on Nicotine Metabolism Rate Biol Psychiatry. 2016 08 01; 80(3):190-7. . View in PubMed

Initial Evaluation of Fenofibrate for Efficacy in Aiding Smoking Abstinence Nicotine Tob Res. 2016 Jan; 18(1):74-8. . View in PubMed

Decreased Nicotinic Receptor Availability in Smokers with Slow Rates of Nicotine Metabolism J Nucl Med. 2015 Nov; 56(11):1724-9. . View in PubMed

Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption PLoS One. 2015; 10(7):e0126113. . View in PubMed

Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers despite Associations with Baseline Smoking PLoS One. 2015; 10(5):e0128109. . View in PubMed

Age-related differences in working memory deficits during nicotine withdrawal Addict Biol. 2014 Sep; 19(5):907-17. . View in PubMed

Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers Cancer Epidemiol Biomarkers Prev. 2014 Sep; 23(9):1773-82. . View in PubMed

Nicotine dependence as a moderator of genetic influences on smoking cessation treatment outcome Drug Alcohol Depend. 2014 May 01; 138:109-17. . View in PubMed

Large-scale brain network coupling predicts acute nicotine abstinence effects on craving and cognitive function JAMA Psychiatry. 2014 May; 71(5):523-30. . View in PubMed

Effects of tolcapone on working memory and brain activity in abstinent smokers: a proof-of-concept study Drug Alcohol Depend. 2013 Dec 15; 133(3):852-6. . View in PubMed

Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion Addiction. 2013 Dec; 108(12):2202-11. . View in PubMed

Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls Neuropsychopharmacology. 2013 Nov; 38(12):2327-37. . View in PubMed

Effects of bupropion on cognitive performance during initial tobacco abstinence Drug Alcohol Depend. 2013 Nov 01; 133(1):283-6. . View in PubMed

Brain activity and emotional processing in smokers treated with varenicline Addict Biol. 2013 Jul; 18(4):732-8. . View in PubMed

Content matters: neuroimaging investigation of brain and behavioral impact of televised anti-tobacco public service announcements J Neurosci. 2013 Apr 24; 33(17):7420-7. . View in PubMed

Effects of smoking cues and argument strength of antismoking advertisements on former smokers' self-efficacy, attitude, and intention to refrain from smoking Nicotine Tob Res. 2013 Feb; 15(2):527-33. . View in PubMed

Cognitive effects of the acetylcholinesterase inhibitor, donepezil, in healthy, non-treatment seeking smokers: a pilot feasibility study Drug Alcohol Depend. 2012 Nov 01; 126(1-2):263-7. . View in PubMed

Comparative dynamics of four smoking withdrawal symptom scales Addiction. 2012 Aug; 107(8):1501-11. . View in PubMed

µ-Opioid receptor availability in the amygdala is associated with smoking for negative affect relief Psychopharmacology (Berl). 2012 Aug; 222(4):701-8. . View in PubMed

DRD1 associations with smoking abstinence across slow and normal nicotine metabolizers Pharmacogenet Genomics. 2012 Jul; 22(7):551-4. . View in PubMed

Extended duration therapy with transdermal nicotine may attenuate weight gain following smoking cessation Addict Behav. 2012 Apr; 37(4):565-8. . View in PubMed

A novel recruitment message to increase enrollment into a smoking cessation treatment program: preliminary results from a randomized trial Health Commun. 2011 Dec; 26(8):735-42. . View in PubMed

Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers Nicotine Tob Res. 2011 Jun; 13(6):498-503. . View in PubMed

Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers Proc Natl Acad Sci U S A. 2011 May 31; 108(22):9268-73. . View in PubMed

Mouse model predicts effects of smoking and varenicline on event-related potentials in humans Nicotine Tob Res. 2010 Jun; 12(6):589-97. . View in PubMed

Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence Neuropsychopharmacology. 2010 May; 35(6):1374-82. . View in PubMed

Effects of the alpha4beta2 partial agonist varenicline on brain activity and working memory in abstinent smokers Biol Psychiatry. 2010 Apr 15; 67(8):715-21. . View in PubMed

Effectiveness of extended-duration transdermal nicotine therapy: a randomized trial Ann Intern Med. 2010 Feb 02; 152(3):144-51. . View in PubMed

Dopamine genes and nicotine dependence in treatment-seeking and community smokers Neuropsychopharmacology. 2009 Sep; 34(10):2252-64. . View in PubMed

A systems biology network model for genetic association studies of nicotine addiction and treatment Pharmacogenet Genomics. 2009 Jul; 19(7):538-51. . View in PubMed

Dosimetry of 11C-carfentanil, a micro-opioid receptor imaging agent Nucl Med Commun. 2009 Apr; 30(4):314-8. . View in PubMed

Nicotine metabolic rate predicts successful smoking cessation with transdermal nicotine: a validation study Pharmacol Biochem Behav. 2009 Mar; 92(1):6-11. . View in PubMed

Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users Nicotine Tob Res. 2009 Jan; 11(1):99-105. . View in PubMed

Nicotine dependence pharmacogenetics: role of genetic variation in nicotine-metabolizing enzymes J Neurogenet. 2009; 23(3):252-61. . View in PubMed

Nicotine dependence: biology, behavior, and treatment Annu Rev Med. 2009; 60:247-60. . View in PubMed

Neuroimaging, genetics and the treatment of nicotine addiction Behav Brain Res. 2008 Nov 21; 193(2):159-69. . View in PubMed

A placebo-controlled trial of modafinil for nicotine dependence Drug Alcohol Depend. 2008 Nov 01; 98(1-2):86-93. . View in PubMed

Genetic variation in the serotonin pathway and smoking cessation with nicotine replacement therapy: new data from the Patch in Practice trial and pooled analyses Drug Alcohol Depend. 2008 Nov 01; 98(1-2):77-85. . View in PubMed

Identification of pharmacogenetic markers in smoking cessation therapy Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 05; 147B(6):712-9. . View in PubMed

Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokers Behav Pharmacol. 2008 Sep; 19(5-6):630-40. . View in PubMed

Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative mood Behav Pharmacol. 2008 Sep; 19(5-6):641-9. . View in PubMed

Association of retrospective early smoking experiences with prospective sensitivity to nicotine via nasal spray in nonsmokers Nicotine Tob Res. 2008 Aug; 10(8):1335-45. . View in PubMed

Genomics of smoking exposure and cessation: lessons for cancer prevention and treatment Cancer Prev Res (Phila). 2008 Jul; 1(2):80-3. . View in PubMed

Nicotine abstinence-induced cerebral blood flow changes by genotype Neurosci Lett. 2008 Jun 27; 438(3):275-80. . View in PubMed

Assessing dimensions of nicotine dependence: an evaluation of the Nicotine Dependence Syndrome Scale (NDSS) and the Wisconsin Inventory of Smoking Dependence Motives (WISDM) Nicotine Tob Res. 2008 Jun; 10(6):1009-20. . View in PubMed

Molecular genetics of successful smoking cessation: convergent genome-wide association study results Arch Gen Psychiatry. 2008 Jun; 65(6):683-93. . View in PubMed

Increase in anger symptoms after smoking cessation predicts relapse Drug Alcohol Depend. 2008 May 01; 95(1-2):173-6. . View in PubMed

J Subst Abuse Treat. 2008 Mar; 34(2):234-41. . View in PubMed

Neural substrates of abstinence-induced cigarette cravings in chronic smokers J Neurosci. 2007 Dec 19; 27(51):14035-40. . View in PubMed

Genetics and smoking cessation improving outcomes in smokers at risk Am J Prev Med. 2007 Dec; 33(6 Suppl):S398-405. . View in PubMed

Enhanced identification of smoking-related words during the attentional blink in smokers Addict Behav. 2007 Dec; 32(12):3077-82. . View in PubMed

Associations between Cloninger's temperament dimensions and acute tobacco withdrawal Addict Behav. 2007 Dec; 32(12):2976-89. . View in PubMed

Genetic variation in mu-opioid-receptor-interacting proteins and smoking cessation in a nicotine replacement therapy trial Nicotine Tob Res. 2007 Nov; 9(11):1237-41. . View in PubMed

Genetics and smoking behavior Curr Psychiatry Rep. 2007 Oct; 9(5):349-57. . View in PubMed

CYP2B6 genotype alters abstinence rates in a bupropion smoking cessation trial Biol Psychiatry. 2007 Sep 15; 62(6):635-41. . View in PubMed

CHRNA4 and tobacco dependence: from gene regulation to treatment outcome Arch Gen Psychiatry. 2007 Sep; 64(9):1078-86. . View in PubMed

CYP2B6 genotype does not alter nicotine metabolism, plasma levels, or abstinence with nicotine replacement therapy Cancer Epidemiol Biomarkers Prev. 2007 Jun; 16(6):1312-4. . View in PubMed

An association of CYP2A6 genotype and smoking topography Nicotine Tob Res. 2007 Apr; 9(4):511-8. . View in PubMed

Gender differences in acute tobacco withdrawal: effects on subjective, cognitive, and physiological measures Exp Clin Psychopharmacol. 2007 Feb; 15(1):21-36. . View in PubMed

New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure Drug Alcohol Depend. 2007 Jan 12; 86(2-3):294-300. . View in PubMed

Bupropion efficacy for smoking cessation is influenced by the DRD2 Taq1A polymorphism: analysis of pooled data from two clinical trials Nicotine Tob Res. 2007 12; 9(12):1251-7. . View in PubMed

Catechol-O-methyltransferase (COMT) gene variants predict response to bupropion therapy for tobacco dependence Biol Psychiatry. 2007 Jan 01; 61(1):111-8. . View in PubMed

Can pharmacogenetics help smokers quit? Pharmacogenomics. 2006 Dec; 7(8):1137-40.. View in PubMed

Current and emerging pharmacotherapies for treating tobacco dependence Expert Opin Emerg Drugs. 2006 Sep; 11(3):429-44. . View in PubMed

Helping smokers quit through pharmacogenetics LDI Issue Brief. 2006 May-Jun; 11(6):1-4. . View in PubMed

Evaluating smokers' reactions to advertising for new lower nicotine quest cigarettes Psychol Addict Behav. 2006 Mar; 20(1):80-4. . View in PubMed

Medication screening for smoking cessation: a proposal for new methodologies Psychopharmacology (Berl). 2006 Mar; 184(3-4):628-36. . View in PubMed

Lack of association of 5-HTTLPR genotype with smoking cessation in a nicotine replacement therapy randomized trial Cancer Epidemiol Biomarkers Prev. 2006 Feb; 15(2):398-400. . View in PubMed

A randomized pilot study of cognitive-behavioral therapy versus basic health education for smoking cessation among cancer patients Ann Behav Med. 2005 Aug; 30(1):1-11. . View in PubMed

Increases in hyperactive-impulsive symptoms predict relapse among smokers in nicotine replacement therapy J Subst Abuse Treat. 2005 Jun; 28(4):297-304. . View in PubMed

Naltrexone reduces the relative reinforcing value of nicotine in a cigarette smoking choice paradigm Psychopharmacology (Berl). 2005 Jun; 180(1):41-8. . View in PubMed

Association of catechol-O-methyltransferase with smoking cessation in two independent studies of women Pharmacogenet Genomics. 2005 Jun; 15(6):393-8. . View in PubMed

Barriers to translating emerging genetic research on smoking into clinical practicePerspectives of primary care physicians. J Gen Intern Med. 2005 Feb; 20(2):131-8. . View in PubMed

Effects of different nicotine replacement therapies on postcessation psychological responses Addict Behav. 2005 Jan; 30(1):9-17. . View in PubMed

Effect of bupropion on depression symptoms in a smoking cessation clinical trial Psychol Addict Behav. 2004 Dec; 18(4):362-6. . View in PubMed

Changes in food reward following smoking cessation: a pharmacogenetic investigation Psychopharmacology (Berl). 2004 Aug; 174(4):571-7. . View in PubMed

Interacting effects of genetic predisposition and depression on adolescent smoking progression Am J Psychiatry. 2004 Jul; 161(7):1224-30. . View in PubMed

Food hedonics and reinforcement as determinants of laboratory food intake in smokers Physiol Behav. 2004 May; 81(3):511-7. . View in PubMed

Do small lapses predict relapse to smoking behavior under bupropion treatment? Nicotine Tob Res. 2004 Apr; 6(2):357-66.. View in PubMed

Individualizing nicotine replacement therapy for the treatment of tobacco dependence: a randomized trial Ann Intern Med. 2004 Mar 16; 140(6):426-33. . View in PubMed

Comparing cancer patients who enroll in a smoking cessation program at a comprehensive cancer center with those who decline enrollment Head Neck. 2004 Mar; 26(3):278-86. . View in PubMed

Gender differences in smoking cessation in a placebo-controlled trial of bupropion with behavioral counseling Nicotine Tob Res. 2004 Feb; 6(1):27-37. . View in PubMed

Genetics and drug use as a complex phenotype Subst Use Misuse. 2004; 39(10-12):1515-69. . View in PubMed

Intergenerational transmission of tobacco use and dependence: a transdisciplinary perspective Nicotine Tob Res. 2003 Dec; 5 Suppl 1:S55-69. . View in PubMed

Genes, smoking, and treatment response Am J Health Syst Pharm. 2003 Sep 15; 60(18):1911. . View in PubMed

Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial Health Psychol. 2003 Sep; 22(5):541-8. . View in PubMed

Individual differences in nicotine intake per cigarette Cancer Epidemiol Biomarkers Prev. 2003 May; 12(5):468-71. . View in PubMed

Elucidating the role of genetic factors in smoking behavior and nicotine dependence Am J Med Genet B Neuropsychiatr Genet. 2003 Apr 01; 118B(1):48-54. . View in PubMed

Applying genetic approaches to the treatment of nicotine dependence Oncogene. 2002 Oct 21; 21(48):7412-20. . View in PubMed

Mediating mechanisms for the impact of bupropion in smoking cessation treatment Drug Alcohol Depend. 2002 Jul 01; 67(2):219-23. . View in PubMed

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