Charleston Chiang, PhD

Associate Professor of Population and Public Health Sciences and Quantitative and Computational Biology

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Overview

Charleston Chiang is Associate Professor in the Department of Population and Public Health Sciences at Keck School of Medicine, USC. He is the Associate Director for Center of Genetic Epidemiology, and also jointly affiliated with the Department of Quantitative and Computational Biology and Dornsife School of Letters, Arts, and Sciences, USC. Dr. Chiang is a medical population geneticist focused on understanding how the evolutionary forces, specifically demographic history and natural selection, shaped the genetic architecture of complex traits within and between human populations. To this end, he has led a number of large-scale genomic studies in humans to characterize the fine-scale population structure, to investigate signals of natural selection and adaptation, and to leverage these evolutionary insights to map the genetic loci underlying human complex traits. He is most interested in studying diverse populations with a unique history; projects in his group has included populations from Finland, China, Sardinia, as well as the Latino American and Native Hawaiian cohorts. Prior to his position at Center for Genetic Epidemiology, Dr. Chiang received his B.S. in Microbiology, Immunology, and Molecular Genetics from University of California Los Angeles (UCLA), Ph.D. in Genetics from Harvard University, and completed his postdoctoral training in Population Genetics and Human Genetics at UCLA. His current lab website can be found at http://chianglab.usc.edu

Awards

  • Keck School of Medicine, USC: Dean’s Early Career Award for Excellence in Mentoring, 2024
  • American Society of Human Genetics: ASHG Human Genetics and Genomics Advances Outstanding Early Career Publication Award, 2023
  • American Society of Human Genetics: ASHG Charles J. Epstein Trainee Award for Excellence in Human Genetics Research Semi-finalist, 2017

Education and Training

  • UCLA, Los Angeles, California — Postdoc — 11/2017 — Human Genetics and Population Genetics
  • Harvard University, Boston, Massachusetts — Ph.D. — 9/2011 — Genetics
  • UCLA, Los Angeles, California — B.S. — 6/2005 — Microbiology, Immunology, and Molecular Genetics

Research Funding

  • A genome-wide genealogical framework for statistical and population genetic analysis
    NIH · R01HG012605 · Sep 1, 2023 – Jun 30, 2027 · Role: Principal Investigator
  • Leveraging the Evolutionary History to Improve Identification of Trait-Associated Alleles and Risk Stratification Models in Native Hawaiians
    NIH · R01HG011646 · Sep 1, 2022 – Jun 30, 2027 · Role: Principal Investigator
  • Leveraging the Evolutionary History to Improve Identification of Trait-Associated Alleles and Risk Stratification Models in Native Hawaiians
    NIH/NHGRI · R01HG011646 · Sep 1, 2022 – Jun 30, 2027 · Role: Principal Investigator
  • An evolutionary framework to elucidate and interpret the genetic architecture of complex traits in diverse populations
    NIH · R35GM142783 · Aug 1, 2021 – May 31, 2026 · Role: Principal Investigator
  • Using whole genomes to study demography and mapping power of a population isolate
    NIH · F32GM106656 · Apr 1, 2013 – Mar 31, 2015 · Role: Principal Investigator

Research Keywords

  • Human Genetics
  • Population Genetics
  • Genetic Epidemiology

Publications

  • The Multiethnic Cohort: A Resource for the Study of Genetic and Nongenetic Cancer Risk across Populations. Cancer Epidemiol Biomarkers Prev. 2026 Jul 01; 35(7):1088-1099.. View in PubMed
  • Genome-wide association study and predictors of neonatal blood cell traits in Hispanic newborns. Am J Hum Genet. 2026 Jul 01.. View in PubMed
  • Challenges and recommendations in establishing national human diversity genomic projects. Nat Methods. 2026 Jul; 23(7):1261-1266.. View in PubMed
  • Incorporating dietary information to enhance polygenic prediction models with applications to body mass index and type 2 diabetes. Genes Nutr. 2026 Jun 18.. View in PubMed
  • Meta-analysis of over 8,000 individuals from Hawai’i and Samoa for genetic associations to cardiometabolic phenotypes. medRxiv. 2026 May 12.. View in PubMed
  • Polygenic predisposition modifies the associations of fish oil supplementation with circulating omega-3 fatty acids: a cross-sectional gene-diet interaction study in UK Biobank. medRxiv. 2026 Apr 30.. View in PubMed
  • Incorporating Dietary Information to Enhance Polygenic Prediction Models with Applications to Body Mass Index and Type 2 Diabetes. medRxiv. 2025 Dec 04.. View in PubMed
  • The impact of Indigenous American-like ancestry on the risk of acute lymphoblastic leukemia in Hispanic/Latino children. HGG Adv. 2026 Jan 15; 7(1):100534.. View in PubMed
  • Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci. Nat Commun. 2025 Oct 22; 16(1):8974.. View in PubMed
  • Widespread but moderate genetic overlap between circulating polyunsaturated fatty acids and brain disorders. J Lipid Res. 2025 Oct; 66(10):100890.. View in PubMed