Keck School Faculty

Cheng-Ming Chuong, MD, PhD
Cheng-Ming Chuong, MD, PhD
Professor of Pathology;Director of Graduate Programs
Pathology
HMR 2011 Zonal Ave Health Sciences Campus Los Angeles

Spatial and temporal variations in hemodynamic forces initiate cardiac trabeculation JCI Insight. 2018 Jul 12; 3(13). . View in PubMed

Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling Nat Commun. 2018 Apr 09; 9(1):1345. . View in PubMed

Msx2 supports epidermal competency during wound induced hair follicle neogenesis J Invest Dermatol. 2018 Mar 22. . View in PubMed

Multiple Regulatory Modules Are Required for Scale-to-Feather Conversion Mol Biol Evol. 2018 Feb 01; 35(2):417-430. . View in PubMed

The tension biology of wound healing Exp Dermatol. 2017 Nov 04. . View in PubMed

Getting to the Core of the Dermal Papilla J Invest Dermatol. 2017 Nov; 137(11):2250-2253. . View in PubMed

Heterochronic truncation of odontogenesis in theropod dinosaurs provides insight into the macroevolution of avian beaks Proc Natl Acad Sci U S A. 2017 Oct 10; 114(41):10930-10935. . View in PubMed

Genetic Mapping and Biochemical Basis of Yellow Feather Pigmentation in BudgerigarsCell. 2017 Oct 05; 171(2):427-439. e21. . View in PubMed

Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells Proc Natl Acad Sci U S A. 2017 Aug 22; 114(34):E7101-E7110. . View in PubMed

Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme Nat Commun. 2017 Jan 20; 8:ncomms14139. . View in PubMed

The GCaMP-R Family of Genetically Encoded Ratiometric Calcium Indicators ACS Chem Biol. 2017 04 21; 12(4):1066-1074. . View in PubMed

MicroCT Imaging on Living Alligator Teeth Reveals Natural Tooth Cycling Methods Mol Biol. 2017; 1650:355-362. . View in PubMed

Systems Biology Analyses in Chicken: Workflow for Transcriptome and ChIP-Seq Analyses Using the Chicken Skin Paradigm Methods Mol Biol. 2017; 1650:87-100. . View in PubMed

Quorum sensing and other collective regenerative behavior in organ populations Curr Opin Genet Dev. 2016 Oct; 40:138-143. . View in PubMed

The Modulatable Stem Cell Niche: Tissue Interactions during Hair and Feather Follicle Regeneration J Mol Biol. 2016 Apr 10; 428(7):1423-40. . View in PubMed

STEM CELLSAging, alopecia, and stem cells. Science. 2016 Feb 05; 351(6273):559-60. . View in PubMed

Regulatory Differences in Natal Down Development between Altricial Zebra Finch and Precocial Chicken Mol Biol Evol. 2016 08; 33(8):2030-43. . View in PubMed

Corrigendum: Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction Sci Rep. 2016 11 14; 6:31257. . View in PubMed

The "tao" of integuments Science. 2016 12 23; 354(6319):1533-1534. . View in PubMed

Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction Sci Rep. 2016 05 23; 6:26436. . View in PubMed

Topographical mapping of a- and ß-keratins on developing chicken skin integuments: Functional interaction and evolutionary perspectives Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):E6770-9. . View in PubMed

Proper BMP Signaling Levels Are Essential for 3D Assembly of Hepatic Cords from Hepatoblasts and Mesenchymal Cells Dig Dis Sci. 2015 Dec; 60(12):3669-80. . View in PubMed

Transcriptomic analyses of regenerating adult feathers in chicken BMC Genomics. 2015 Oct 06; 16:756. . View in PubMed

Roles of GasderminA3 in Catagen-Telogen Transition During Hair Cycling J Invest Dermatol. 2015 Sep; 135(9):2162-2172. . View in PubMed

Prolonged overexpression of Wnt10b induces epidermal keratinocyte transformation through activating EGF pathway Histochem Cell Biol. 2015 Sep; 144(3):209-21. . View in PubMed

Deciphering principles of morphogenesis from temporal and spatial patterns on the integument Dev Dyn. 2015 Aug; 244(8):905-20. . View in PubMed

Feather on the Cap of Medicine J Invest Dermatol. 2015 Jul; 135(7):1719-1721. . View in PubMed

Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis Nat Commun. 2015 Apr 13; 6:6798. . View in PubMed

Organ-level quorum sensing directs regeneration in hair stem cell populations Cell. 2015 Apr 09; 161(2):277-90. . View in PubMed

Perivascular-derived stem cells with neural crest characteristics are involved in tendon repair Stem Cells Dev. 2015 Apr 01; 24(7):857-68. . View in PubMed

Emergence of differentially regulated pathways associated with the development of regional specificity in chicken skin BMC Genomics. 2015 Jan 23; 16:22. . View in PubMed

Development, regeneration, and evolution of feathers Annu Rev Anim Biosci. 2015; 3:169-95. . View in PubMed

An integrative approach to understanding bird origins Science. 2014 Dec 12; 346(6215):1253293. . View in PubMed

Bifunctional ectodermal stem cells around the nail display dual fate homeostasis and adaptive wounding response toward nail regeneration Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15114-9. . View in PubMed

Defining dermal adipose tissue Exp Dermatol. 2014 Sep; 23(9):629-31. . View in PubMed

SnapShot: Branching MorphogenesisCell. 2014 Aug 28; 158(5):1212-1212. e1. . View in PubMed

Genomic organization, transcriptomic analysis, and functional characterization of avian a- and ß-keratins in diverse feather forms Genome Biol Evol. 2014 Aug 24; 6(9):2258-73. . View in PubMed

Regenerative hair waves in aging mice and extra-follicular modulators follistatin, dkk1, and sfrp4 J Invest Dermatol. 2014 Aug; 134(8):2086-2096. . View in PubMed

Ultrastructural characteristics of 5BrdU labeling retention cells including stem cells of regenerating feathers in chicken J Morphol. 2014 Jul; 275(7):768-74. . View in PubMed

Modulating hair follicle size with Wnt10b/DKK1 during hair regeneration Exp Dermatol. 2014 Jun; 23(6):407-13. . View in PubMed

Dkk2/Frzb in the dermal papillae regulates feather regeneration Dev Biol. 2014 Mar 15; 387(2):167-78. . View in PubMed

Regeneration of reptilian scales after wounding: neogenesis, regional difference, and molecular modules Regeneration (Oxf). 2014 Feb 01; 1(1):15-26. . View in PubMed

Macroenvironmental regulation of hair cycling and collective regenerative behavior Cold Spring Harb Perspect Med. 2014 Jan 01; 4(1):a015198. . View in PubMed

Disrupted ectodermal organ morphogenesis in mice with a conditional histone deacetylase 1, 2 deletion in the epidermis J Invest Dermatol. 2014 Jan; 134(1):24-32. . View in PubMed

Environmental reprogramming and molecular profiling in reconstitution of human hair follicles Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):19658-9. . View in PubMed

Nuclear topology, epigenetics, and keratinocyte differentiation J Invest Dermatol. 2013 Sep; 133(9):2130-3. . View in PubMed

Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling Proc Natl Acad Sci U S A. 2013 Jun 04; 110(23):E2106-15. . View in PubMed

Many paths to alopecia via compromised regeneration of hair follicle stem cells J Invest Dermatol. 2013 Jun; 133(6):1450-2. . View in PubMed

Specialized stem cell niche enables repetitive renewal of alligator teeth Proc Natl Acad Sci U S A. 2013 May 28; 110(22):E2009-18. . View in PubMed

Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):E1452-61. . View in PubMed

Sox2 marks epithelial competence to generate teeth in mammals and reptiles Development. 2013 Apr; 140(7):1424-32. . View in PubMed

Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering Expert Opin Biol Ther. 2013 Mar; 13(3):377-91. . View in PubMed

Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1351-6. . View in PubMed

Tuning Wnt signals for more or fewer hairs J Invest Dermatol. 2013 Jan; 133(1):7-9. . View in PubMed

Feather regeneration as a model for organogenesis Dev Growth Differ. 2013 Jan; 55(1):139-48. . View in PubMed

Module-based complexity formation: periodic patterning in feathers and hairs Wiley Interdiscip Rev Dev Biol. 2013 Jan-Feb; 2(1):97-112. . View in PubMed

Sprouty/FGF signaling regulates the proximal-distal feather morphology and the size of dermal papillae Dev Biol. 2012 Dec 01; 372(1):45-54. . View in PubMed

Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1 J Invest Dermatol. 2012 Dec; 132(12):2681-90. . View in PubMed

Homology and Potential Cellular and Molecular Mechanisms for the Development of Unique Feather Morphologies in Early Birds Geosciences (Basel). 2012 Sep 14; 2(3):157-177. . View in PubMed

Physiological regeneration of skin appendages and implications for regenerative medicine Physiology (Bethesda). 2012 Apr; 27(2):61-72. . View in PubMed

Multi-layered environmental regulation on the homeostasis of stem cells: the saga of hair growth and alopecia J Dermatol Sci. 2012 Apr; 66(1):3-11. . View in PubMed

Patterning skin by planar cell polarity: the multi-talented hair designer Exp Dermatol. 2012 Feb; 21(2):81-5. . View in PubMed

The chicken frizzle feather is due to an a-keratin (KRT75) mutation that causes a defective rachis PLoS Genet. 2012; 8(7):e1002748. . View in PubMed

Modelling hair follicle growth dynamics as an excitable medium PLoS Comput Biol. 2012; 8(12):e1002804. . View in PubMed

Roles of EphB3/ephrin-B1 in feather morphogenesis Int J Dev Biol. 2012; 56(9):719-28. . View in PubMed

Toward the isolation and culture of melanocyte stem cells J Invest Dermatol. 2011 Dec; 131(12):2341-3. . View in PubMed

PI3K, Erk signaling in BMP7-induced epithelial-mesenchymal transition (EMT) of PC-3 prostate cancer cells in 2- and 3-dimensional cultures Horm Cancer. 2011 Oct; 2(5):298-309. . View in PubMed

From buds to follicles: matrix metalloproteinases in developmental tissue remodeling during feather morphogenesis Differentiation. 2011 Jun; 81(5):307-14. . View in PubMed

Self-organizing and stochastic behaviors during the regeneration of hair stem cells Science. 2011 Apr 29; 332(6029):586-9. . View in PubMed

In search of the Golden Fleece: unraveling principles of morphogenesis by studying the integrative biology of skin appendages Integr Biol (Camb). 2011 Apr; 3(4):388-407. . View in PubMed

A simplified procedure to reconstitute hair-producing skin Tissue Eng Part C Methods. 2011 Apr; 17(4):391-400. . View in PubMed

The cycling hair follicle as an ideal systems biology research model Exp Dermatol. 2010 Aug; 19(8):707-13. . View in PubMed

Spots and stripes: pleomorphic patterning of stem cells via p-ERK-dependent cell chemotaxis shown by feather morphogenesis and mathematical simulation Dev Biol. 2009 Oct 15; 334(2):369-82. . View in PubMed

Accelerated closure of skin wounds in mice deficient in the homeobox gene Msx2 Wound Repair Regen. 2009 Sep-Oct; 17(5):639-48. . View in PubMed

Building complex tissues: high-throughput screening for molecules required in hair engineering J Invest Dermatol. 2009 Apr; 129(4):815-7. . View in PubMed

The river of stem cells Cell Stem Cell. 2009 Feb 06; 4(2):100-2. . View in PubMed

Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity Int J Dev Biol. 2009; 53(5-6):857-68. . View in PubMed

Preface to pattern formation special issue Int J Dev Biol. 2009; 53(5-6):651. . View in PubMed

Pattern formation today Int J Dev Biol. 2009; 53(5-6):653-8. . View in PubMed

Reptile scale paradigm: Evo-Devo, pattern formation and regeneration Int J Dev Biol. 2009; 53(5-6):813-26. . View in PubMed

Regenerative patterning in Swarm Robots: mutual benefits of research in robotics and stem cell biology Int J Dev Biol. 2009; 53(5-6):869-81. . View in PubMed

Conversion of the nipple to hair-bearing epithelia by lowering bone morphogenetic protein pathway activity at the dermal-epidermal interface Am J Pathol. 2008 Nov; 173(5):1339-48. . View in PubMed

Complex hair cycle domain patterns and regenerative hair waves in living rodents J Invest Dermatol. 2008 May; 128(5):1071-80. . View in PubMed

Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration Nature. 2008 Jan 17; 451(7176):340-4. . View in PubMed

Defining hair follicles in the age of stem cell bioengineering J Invest Dermatol. 2007 Sep; 127(9):2098-100. . View in PubMed

An integrated gene regulatory network controls stem cell proliferation in teeth PLoS Biol. 2007 Jun; 5(6):e159. . View in PubMed

Regenerative biology: new hair from healing wounds Nature. 2007 May 17; 447(7142):265-6. . View in PubMed

The Edar subfamily in feather placode formation Dev Biol. 2007 May 01; 305(1):232-45. . View in PubMed

Mammary glands and feathers: comparing two skin appendages which help define novel classes during vertebrate evolution Semin Cell Dev Biol. 2007 Apr; 18(2):255-66. . View in PubMed

Developmental biologyThe Turing model comes of molecular age. Science. 2006 Dec 01; 314(5804):1397-8. . View in PubMed

Molecular signaling in feather morphogenesis Curr Opin Cell Biol. 2006 Dec; 18(6):730-41. . View in PubMed

PubFocus: semantic MEDLINE/PubMed citations analytics through integration of controlled biomedical dictionaries and ranking algorithm BMC Bioinformatics. 2006 Oct 02; 7:424. . View in PubMed

Distinct mechanisms underlie pattern formation in the skin and skin appendages Birth Defects Res C Embryo Today. 2006 Sep; 78(3):280-91. . View in PubMed

Morphoregulation of avian beaks: comparative mapping of growth zone activities and morphological evolution Dev Dyn. 2006 May; 235(5):1400-12. . View in PubMed

Wnt3a gradient converts radial to bilateral feather symmetry via topological arrangement of epithelia Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):951-5. . View in PubMed

Engineering stem cells into organs: topobiological transformations demonstrated by beak, feather, and other ectodermal organ morphogenesis Curr Top Dev Biol. 2006; 72:237-74. . View in PubMed

Mapping stem cell activities in the feather follicle Nature. 2005 Dec 15; 438(7070):1026-9. . View in PubMed

Morphoregulation of teeth: modulating the number, size, shape and differentiation by tuning Bmp activity Evol Dev. 2005 Sep-Oct; 7(5):440-57. . View in PubMed

Rooster feathering, androgenic alopecia, and hormone-dependent tumor growth: what is in common? Differentiation. 2004 Dec; 72(9-10):474-88.. View in PubMed

Molecular shaping of the beak Science. 2004 Sep 03; 305(5689):1465-6. . View in PubMed

Sculpting skin appendages out of epidermal layers via temporally and spatially regulated apoptotic events J Invest Dermatol. 2004 Jun; 122(6):1348-55. . View in PubMed

Making waves with hairs J Invest Dermatol. 2004 Apr; 122(4):vii-ix. . View in PubMed

Morpho-regulation of ectodermal organs: integument pathology and phenotypic variations in K14-Noggin engineered mice through modulation of bone morphogenic protein pathway Am J Pathol. 2004 Mar; 164(3):1099-114. . View in PubMed

Morphogenesis of chicken liver: identification of localized growth zones and the role of beta-catenin/Wnt in size regulation Dev Biol. 2004 Feb 01; 266(1):109-22. . View in PubMed

Distinct Wnt members regulate the hierarchical morphogenesis of skin regions (spinal tract) and individual feathers Mech Dev. 2004 Feb; 121(2):157-71. . View in PubMed

Evo-Devo of amniote integuments and appendages Int J Dev Biol. 2004; 48(2-3):249-70. . View in PubMed

New Early Cretaceous fossil from China documents a novel trophic specialization for Mesozoic birds Naturwissenschaften. 2004 Jan; 91(1):22-5. . View in PubMed

Integument pattern formation involves genetic and epigenetic controls: feather arrays simulated by digital hormone models Int J Dev Biol. 2004; 48(2-3):117-35. . View in PubMed

The biology of feather follicles Int J Dev Biol. 2004; 48(2-3):181-91. . View in PubMed

A mouthful of epithelial-mesenchymal interactions J Invest Dermatol. 2003 Dec; 121(6):vii-viii. . View in PubMed

Adaptation to the sky: Defining the feather with integument fossils from mesozoic China and experimental evidence from molecular laboratories J Exp Zool B Mol Dev Evol. 2003 Aug 15; 298(1):42-56. . View in PubMed

Development and evolution of the amniote integument: current landscape and future horizon J Exp Zool B Mol Dev Evol. 2003 Aug 15; 298(1):1-11. . View in PubMed

Molecular biology of feather morphogenesis: a testable model for evo-devo research J Exp Zool B Mol Dev Evol. 2003 Aug 15; 298(1):109-22. . View in PubMed

Homeobox genes, fetal wound healing, and skin regional specificity J Invest Dermatol. 2003 Jan; 120(1):9-11. . View in PubMed

Shift of localized growth zones contributes to skin appendage morphogenesis: role of the Wnt/beta-catenin pathway J Invest Dermatol. 2003 Jan; 120(1):20-6. . View in PubMed

'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation Development. 2003 Jan; 130(2):379-89. . View in PubMed

The morphogenesis of feathers Nature. 2002 Nov 21; 420(6913):308-12. . View in PubMed

Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators J Biol Chem. 2002 Jul 19; 277(29):26031-5. . View in PubMed

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