Keck School Faculty

Cheng-Ming Chuong

Cheng-Ming Chuong

Professor of Pathology
Director of Graduate Programs
Pathology
HMR 2011 Zonal Ave Health Sciences Campus Los Angeles

Development of injectable chitosan/biphasic calcium phosphate bone cement and in vitro and in vivo evaluation Biomed Mater. 2020 Sep 08; 15(5):055038. . View in PubMed

Folding Keratin Gene Clusters during Skin Regional SpecificationDev Cell. 2020 Jun 08; 53(5):561-576. e9. . View in PubMed

Avian Pigment Pattern Formation: Developmental Control of Macro- (Across the Body) and Micro- (Within a Feather) Level of Pigment Patterns Front Cell Dev Biol. 2020; 8:620. . View in PubMed

Comparative regenerative biology of spiny (Acomys cahirinus) and laboratory (Mus musculus) mouse skin Exp Dermatol. 2019 04; 28(4):442-449. . View in PubMed

Instructive role of melanocytes during pigment pattern formation of the avian skin Proc Natl Acad Sci U S A. 2019 04 02; 116(14):6884-6890. . View in PubMed

Comprehensive molecular and cellular studies suggest avian scutate scales are secondarily derived from feathers, and more distant from reptilian scales Sci Rep. 2018 11 13; 8(1):16766. . View in PubMed

Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling Nat Commun. 2018 04 09; 9(1):1345. . View in PubMed

Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks Nat Commun. 2018 12 18; 9(1):5377. . View in PubMed

Epidermal Darwinism and Competitive Equilibrium within the Epidermis Cell Stem Cell. 2018 11 01; 23(5):627-629. . View in PubMed

Comparative genomics and transcriptomics of Chrysolophus provide insights into the evolution of complex plumage coloration Gigascience. 2018 10 01; 7(10). . View in PubMed

Genetic Mapping and Biochemical Basis of Yellow Feather Pigmentation in BudgerigarsCell. 2017 Oct 05; 171(2):427-439. e21. . View in PubMed

Getting to the Core of the Dermal Papilla J Invest Dermatol. 2017 11; 137(11):2250-2253. . View in PubMed

Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme Nat Commun. 2017 01 20; 8:ncomms14139. . View in PubMed

Heterochronic truncation of odontogenesis in theropod dinosaurs provides insight into the macroevolution of avian beaks Proc Natl Acad Sci U S A. 2017 10 10; 114(41):10930-10935. . View in PubMed

Corrigendum: Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction Sci Rep. 2016 11 14; 6:31257. . View in PubMed

Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction Sci Rep. 2016 05 23; 6:26436. . View in PubMed

Deciphering principles of morphogenesis from temporal and spatial patterns on the integument Dev Dyn. 2015 Aug; 244(8):905-20. . View in PubMed

Evolution and functional significance of derived sternal ossification patterns in ornithothoracine birds J Evol Biol. 2015 Aug; 28(8):1550-67. . View in PubMed

Feather on the Cap of Medicine J Invest Dermatol. 2015 Jul; 135(7):1719-1721. . View in PubMed

Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis Nat Commun. 2015 Apr 13; 6:6798. . View in PubMed

Emergence of differentially regulated pathways associated with the development of regional specificity in chicken skin BMC Genomics. 2015 Jan 23; 16:22. . View in PubMed

Development, regeneration, and evolution of feathers Annu Rev Anim Biosci. 2015; 3:169-95. . View in PubMed

An integrative approach to understanding bird origins Science. 2014 Dec 12; 346(6215):1253293. . View in PubMed

Bifunctional ectodermal stem cells around the nail display dual fate homeostasis and adaptive wounding response toward nail regeneration Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15114-9. . View in PubMed

Defining dermal adipose tissue Exp Dermatol. 2014 Sep; 23(9):629-31. . View in PubMed

Genomic organization, transcriptomic analysis, and functional characterization of avian a- and ß-keratins in diverse feather forms Genome Biol Evol. 2014 Aug 24; 6(9):2258-73. . View in PubMed

Dkk2/Frzb in the dermal papillae regulates feather regeneration Dev Biol. 2014 Mar 15; 387(2):167-78. . View in PubMed

Disrupted ectodermal organ morphogenesis in mice with a conditional histone deacetylase 1, 2 deletion in the epidermis J Invest Dermatol. 2014 Jan; 134(1):24-32. . View in PubMed

Environmental reprogramming and molecular profiling in reconstitution of human hair follicles Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):19658-9. . View in PubMed

Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1351-6. . View in PubMed

Feather regeneration as a model for organogenesis Dev Growth Differ. 2013 Jan; 55(1):139-48. . View in PubMed

Homology and Potential Cellular and Molecular Mechanisms for the Development of Unique Feather Morphologies in Early Birds Geosciences (Basel). 2012 Sep 14; 2(3):157-177. . View in PubMed

From buds to follicles: matrix metalloproteinases in developmental tissue remodeling during feather morphogenesis Differentiation. 2011 Jun; 81(5):307-14. . View in PubMed

A simplified procedure to reconstitute hair-producing skin Tissue Eng Part C Methods. 2011 Apr; 17(4):391-400. . View in PubMed

In search of the Golden Fleece: unraveling principles of morphogenesis by studying the integrative biology of skin appendages Integr Biol (Camb). 2011 Apr; 3(4):388-407. . View in PubMed

Accelerated closure of skin wounds in mice deficient in the homeobox gene Msx2 Wound Repair Regen. 2009 Sep-Oct; 17(5):639-48. . View in PubMed

Building complex tissues: high-throughput screening for molecules required in hair engineering J Invest Dermatol. 2009 Apr; 129(4):815-7. . View in PubMed

Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity Int J Dev Biol. 2009; 53(5-6):857-68. . View in PubMed

Conversion of the nipple to hair-bearing epithelia by lowering bone morphogenetic protein pathway activity at the dermal-epidermal interface Am J Pathol. 2008 Nov; 173(5):1339-48. . View in PubMed

Complex hair cycle domain patterns and regenerative hair waves in living rodents J Invest Dermatol. 2008 May; 128(5):1071-80. . View in PubMed

Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration Nature. 2008 Jan 17; 451(7176):340-4. . View in PubMed

Defining hair follicles in the age of stem cell bioengineering J Invest Dermatol. 2007 Sep; 127(9):2098-100. . View in PubMed

An integrated gene regulatory network controls stem cell proliferation in teeth PLoS Biol. 2007 Jun; 5(6):e159. . View in PubMed

Developmental biologyThe Turing model comes of molecular age. Science. 2006 Dec 01; 314(5804):1397-8. . View in PubMed

Distinct mechanisms underlie pattern formation in the skin and skin appendages Birth Defects Res C Embryo Today. 2006 Sep; 78(3):280-91. . View in PubMed

Engineering stem cells into organs: topobiological transformations demonstrated by beak, feather, and other ectodermal organ morphogenesis Curr Top Dev Biol. 2006; 72:237-74. . View in PubMed

Distinct Wnt members regulate the hierarchical morphogenesis of skin regions (spinal tract) and individual feathers Mech Dev. 2004 Feb; 121(2):157-71. . View in PubMed

Integument pattern formation involves genetic and epigenetic controls: feather arrays simulated by digital hormone models Int J Dev Biol. 2004; 48(2-3):117-35. . View in PubMed

Evo-Devo of amniote integuments and appendages Int J Dev Biol. 2004; 48(2-3):249-70. . View in PubMed

A mouthful of epithelial-mesenchymal interactions J Invest Dermatol. 2003 Dec; 121(6):vii-viii. . View in PubMed

Adaptation to the sky: Defining the feather with integument fossils from mesozoic China and experimental evidence from molecular laboratories J Exp Zool B Mol Dev Evol. 2003 Aug 15; 298(1):42-56. . View in PubMed

Development and evolution of the amniote integument: current landscape and future horizon J Exp Zool B Mol Dev Evol. 2003 Aug 15; 298(1):1-11. . View in PubMed

'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation Development. 2003 Jan; 130(2):379-89. . View in PubMed

Homeobox genes, fetal wound healing, and skin regional specificity J Invest Dermatol. 2003 Jan; 120(1):9-11. . View in PubMed

D-RNAi (messenger RNA-antisense DNA interference) as a novel defense system against cancer and viral infections Curr Cancer Drug Targets. 2001 Nov; 1(3):241-7. . View in PubMed

Eur J Dermatol. 2001 Jul-Aug; 11(4):286-92. . View in PubMed

Immunohistochemical localization of deleted-in-colon-cancer (DCC) protein in human epithelial, neural, and neuro-endocrine tissues in paraffin sections with antigen retrieval Kaohsiung J Med Sci. 2001 Jun; 17(7):351-7. . View in PubMed

A Novel mRNA-cDNA interference phenomenon for silencing bcl-2 expression in human LNCaP cells Biochem Biophys Res Commun. 2001 Mar 02; 281(3):639-44. . View in PubMed

Conservation of early odontogenic signaling pathways in Aves Proc Natl Acad Sci U S A. 2000 Aug 29; 97(18):10044-9. . View in PubMed

Evo-devo of feathers and scales: building complex epithelial appendages Curr Opin Genet Dev. 2000 Aug; 10(4):449-56. . View in PubMed

beta-catenin in epithelial morphogenesis: conversion of part of avian foot scales into feather buds with a mutated beta-catenin Dev Biol. 2000 Mar 01; 219(1):98-114. . View in PubMed

Dynamic expression of lunatic fringe during feather morphogenesis: a switch from medial-lateral to anterior-posterior asymmetry Mech Dev. 2000 Mar 01; 91(1-2):351-4. . View in PubMed

Avian integument provides multiple possibilities to analyse different phases of skin appendage morphogenesis J Investig Dermatol Symp Proc. 1999 Dec; 4(3):333-7. . View in PubMed

Early events in skin appendage formation: induction of epithelial placodes and condensation of dermal mesenchyme J Investig Dermatol Symp Proc. 1999 Dec; 4(3):302-6. . View in PubMed

In vivo analysis of cancerous gene expression by RNA-polymerase chain reaction Nucleic Acids Res. 1999 Dec 01; 27(23):4585-9. . View in PubMed

Generation of full-length cDNA library from single human prostate cancer cells Biotechniques. 1999 Sep; 27(3):410-2414. . View in PubMed

Epidermal dysplasia and abnormal hair follicles in transgenic mice overexpressing homeobox gene MSX-2 J Invest Dermatol. 1999 Aug; 113(2):230-7. . View in PubMed

Expression of two Ig family adhesion molecules in the murine hair cycle: DCC in the bulge epithelia and NCAM in the follicular papilla J Invest Dermatol. 1997 Nov; 109(5):672-8. . View in PubMed

Dual action of sonic hedgehog on chondrocyte hypertrophy: retrovirus mediated ectopic sonic hedgehog expression in limb bud micromass culture induces novel cartilage nodules that are positive for alkaline phosphatase and type X collagen J Cell Sci. 1997 Nov; 110 ( Pt 21):2691-701. . View in PubMed

Asymmetric expression of Notch/Delta/Serrate is associated with the anterior-posterior axis of feather buds Dev Biol. 1997 Aug 01; 188(1):181-7. . View in PubMed

Activation of protein kinase A is a pivotal step involved in both BMP-2- and cyclic AMP-induced chondrogenesis J Cell Physiol. 1997 Feb; 170(2):153-65. . View in PubMed

FGF induces new feather buds from developing avian skin J Invest Dermatol. 1996 Dec; 107(6):797-803. . View in PubMed

Early events during avian skin appendage regeneration: dependence on epithelial-mesenchymal interaction and order of molecular reappearance J Invest Dermatol. 1996 Oct; 107(4):639-46. . View in PubMed

cAMP, an activator of protein kinase A, suppresses the expression of sonic hedgehog Biochem Biophys Res Commun. 1996 Feb 06; 219(1):180-5. . View in PubMed

Homeobox genes Msx-1 and Msx-2 are associated with induction and growth of skin appendages J Invest Dermatol. 1995 May; 104(5):711-9. . View in PubMed

cDCC (chicken homologue to a gene deleted in colorectal carcinoma) is an epithelial adhesion molecule expressed in the basal cells and involved in epithelial-mesenchymal interaction Dev Biol. 1994 Aug; 164(2):383-97. . View in PubMed

Effect of in ovo retinoic acid exposure on forebrain neural crest: in vitro analysis reveals up-regulation of N-CAM and loss of mesenchymal phenotype Dev Dyn. 1994 Jun; 200(2):89-102. . View in PubMed

Asymmetric patterns of gap junctional communication in developing chicken skin Development. 1993 Sep; 119(1):85-96. . View in PubMed

Adhesion molecules in skeletogenesis: IINeural cell adhesion molecules mediate precartilaginous mesenchymal condensations and enhance chondrogenesis. J Cell Physiol. 1993 Aug; 156(2):399-411. . View in PubMed

Design of compact multiple cloning sites Biotechniques. 1993 Aug; 15(2):208210-2214. . View in PubMed

Adhesion molecules and homeoproteins in the phenotypic determination of skin appendages J Invest Dermatol. 1993 Jul; 101(1 Suppl):10S-15S. . View in PubMed

Activin enhances chondrogenesis of limb bud cells: stimulation of precartilaginous mesenchymal condensations and expression of NCAM Dev Biol. 1993 Feb; 155(2):545-57. . View in PubMed

Adhesion molecules in skeletogenesis: ITransient expression of neural cell adhesion molecules (NCAM) in osteoblasts during endochondral and intramembranous ossification. J Bone Miner Res. 1992 Dec; 7(12):1435-46. . View in PubMed

Adhesion molecules in skin development: morphogenesis of feather and hair Ann N Y Acad Sci. 1991 Dec 26; 642:263-80. . View in PubMed

Enhanced expression of neural cell adhesion molecules and tenascin (cytotactin) during wound healing Am J Pathol. 1991 Feb; 138(2):427-40. . View in PubMed

Gradients of homeoproteins in developing feather buds Development. 1990 Dec; 110(4):1021-30. . View in PubMed

Differential roles of multiple adhesion molecules in cell migration: granule cell migration in cerebellum Experientia. 1990 Sep 15; 46(9):892-9. . View in PubMed

Adhesion molecules (N-CAM and tenascin) in embryonic development and tissue regeneration J Craniofac Genet Dev Biol. 1990; 10(2):147-61. . View in PubMed

Alterations in the Xenopus retinotectal projection by antibodies to Xenopus N-CAM Dev Biol. 1988 Sep; 129(1):217-30. . View in PubMed

Expression of cell adhesion molecules during embryonic inductionIII. Development of the otic placode. Dev Biol. 1987 Jan; 119(1):217-30. . View in PubMed

Antibodies to liver cell adhesion molecule perturb inductive interactions and alter feather pattern and structure Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8235-9. . View in PubMed

Differential contributions of Ng-CAM and N-CAM to cell adhesion in different neural regions J Cell Biol. 1986 Jul; 103(1):145-58. . View in PubMed

Differential distribution of cell adhesion molecules during histogenesis of the chick nervous system J Neurosci. 1986 Mar; 6(3):739-58. . View in PubMed

Expression sequences of cell adhesion molecules Proc Natl Acad Sci U S A. 1985 Oct; 82(20):6942-6. . View in PubMed

Expression of cell-adhesion molecules in embryonic inductionII. Morphogenesis of adult feathers. J Cell Biol. 1985 Sep; 101(3):1027-43. . View in PubMed

Expression of cell-adhesion molecules in embryonic inductionI. Morphogenesis of nestling feathers. J Cell Biol. 1985 Sep; 101(3):1009-26. . View in PubMed

Evolutionary conservation of key structures and binding functions of neural cell adhesion molecules Proc Natl Acad Sci U S A. 1984 Nov; 81(21):6881-5. . View in PubMed

Alterations in neural cell adhesion molecules during development of different regions of the nervous system J Neurosci. 1984 Sep; 4(9):2354-68. . View in PubMed

Alteration of the retinotectal map in Xenopus by antibodies to neural cell adhesion molecules Proc Natl Acad Sci U S A. 1984 Jul; 81(13):4222-6. . View in PubMed

Embryonic to adult conversion of neural cell adhesion molecules in normal and staggerer mice Proc Natl Acad Sci U S A. 1982 Nov; 79(22):7036-40. . View in PubMed

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