Cheng-Ming Chuong, MD, PhD

Professor of Pathology

Websites

Programs in Biomedical and Biological Sciences

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Research Funding

Multi-scale modulation of organ adaptation
NIH · R35GM153402 · Sep 1, 2024 – Jul 31, 2029 · Role: Principal Investigator
Channel activity during skin morphogenesis
NIH · R01AR078050 · May 1, 2021 – Feb 28, 2026 · Role: Co-Principal Investigator
Tissue mechanics in regenerative wound healing of the skin
NIH · R01GM125322 · Sep 1, 2018 – Jul 31, 2022 · Role: Principal Investigator
Training in Developmental Biology, Stem Cells and Regeneration
NIH · T32HD060549 · May 1, 2011 – Apr 30, 2027 · Role: Co-Principal Investigator
Tissue Patterning in living skin and organ explants
NIH · R37AR060306 · Sep 21, 2010 – Aug 31, 2030 · Role: Principal Investigator
Phenotypic Specification in Skin Organogenesis
NIH · R01AR060306 · Sep 21, 2010 – Aug 31, 2020 · Role: Principal Investigator
Repair and regeneration in a novel animal model
NIH · R03AG027932 · Feb 1, 2007 – Jan 31, 2009 · Role: Principal Investigator
High Resolution Microarray Analysis of Cancer
NIH · R21CA094392 · Sep 1, 2002 – Aug 31, 2003 · Role: Principal Investigator
Epigenetic Regulation of Skin Regional Specificity
NIH · R01AR047364 · Jan 1, 2001 – Mar 31, 2028 · Role: Principal Investigator
Development and Regeneration of Skin Appendages
NIH · R01AR042177 · Jan 1, 1995 – Apr 30, 2015 · Role: Principal Investigator
LIMB CHONDROGENESIS
NIH · R01HD024301 · May 1, 1988 – Apr 30, 1994 · Role: Principal Investigator

Publications

Hierarchical Gene Cluster Regulation Across Vertebrate Skins: Developmental Control of Keratin Gene Expression. bioRxiv. 2026 Jul 15.. View in PubMed
Bioelectric state transitions enable de novo feather bud formation in developing skin. bioRxiv. 2026 Jun 29.. View in PubMed
Development of a 3D nnU-Net-based cell tracking platform for quantifying myocardial deformation in zebrafish. iScience. 2026 Jul 17; 29(7):116376.. View in PubMed
A novel reaction-diffusion architecture for engineering self-organized patterns in mammalian cells. bioRxiv. 2026 May 25.. View in PubMed
Novel tissue mechanics-guided cellular flows drive the formation of feather follicles. EMBO J. 2026 Jun; 45(11):3926-3953.. View in PubMed
Metabolic adaptation drives self-organization during skin organoid morphogenesis. Nat Commun. 2026 Apr 11; 17(1).. View in PubMed
Roles of K-channel activity in feather bud morphogenesis. Dev Biol. 2026 Jun; 534:38-49.. View in PubMed
Evolutionary insights into a skin fold. Nature. 2026 Mar; 651(8104):41-42.. View in PubMed
Epigenetic Coalitions Couple Tissue Growth to Generate Periodic Colour Patterns in Birds. bioRxiv. 2025 Dec 25.. View in PubMed
Sexually dimorphic sail feathers in the Mandarin duck as a model for lifelong developmental modulation. Sci Rep. 2025 Oct 21; 15(1):36593.. View in PubMed
Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression. Elife. 2025 Oct 02; 14.. View in PubMed
Novel Tissue Mechanics-Guided Cellular Flows Enable the Evolution of Feather Follicles. bioRxiv. 2025 Oct 01.. View in PubMed
Roles of K-channel activity in feather bud morphogenesis. bioRxiv. 2025 Sep 30.. View in PubMed
Derivation of embryonic stem cells across avian species. Nat Biotechnol. 2025 Sep 30.. View in PubMed
Roles of Msx2 in exogen control: modulating the stem cell niche during the transition from hair shedding to regeneration. J Adv Res. 2026 06; 84:345-359.. View in PubMed
Regulation of feather length: FGF/IGF signaling and NOTCH/YAP modulation of progenitor cell topology. Sci Adv. 2025 Aug 22; 11(34):eadw2382.. View in PubMed
Embryonic Avian Skin Explant Cultures: A Versatile Model for Investigating Tissue Patterning Mechanisms. J Invest Dermatol. 2025 Oct; 145(10):2398-2409.. View in PubMed
Fibroblast bioelectric signaling drives hair growth. Cell. 2025 Sep 18; 188(19):5175-5193.e21.. View in PubMed
Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C. Adv Sci (Weinh). 2025 Sep; 12(36):e02436.. View in PubMed
Spatiotemporal Adaptations-Driven Dynamic Thra Activation Simulates a Skin Wound Healing Response. Adv Sci (Weinh). 2025 Sep; 12(34):e06651.. View in PubMed
Two waves of adipogenesis in developing avian skin and dermal plasticity. Dev Biol. 2025 Sep; 525:58-70.. View in PubMed
Molecular insights into region-specific sexual dichromatism: Comparative transcriptome analysis of red cheek pigmentation in zebra finches. PLoS Genet. 2025 May; 21(5):e1011693.. View in PubMed
Wound-Induced Regeneration in Feather Follicles: A Stepwise Strategy to Regenerate Stem Cells. J Dev Biol. 2025 Mar 27; 13(2).. View in PubMed
Skin regional specification and higher-order HoxC regulation. Sci Adv. 2025 Mar 21; 11(12):eado2223.. View in PubMed
Cyclic renewal in three ectodermal appendage follicles: Hairs, feathers and teeth. Dev Biol. 2025 06; 522:76-90.. View in PubMed
Organizational principles of integumentary organs: Maximizing variations for effective adaptation. Dev Biol. 2025 06; 522:171-195.. View in PubMed
THSD4 promotes hair growth by facilitating dermal papilla and hair matrix interactions. Theranostics. 2025; 15(8):3571-3588.. View in PubMed
Histological characterization of γδ T cells in cutaneous wound healing in Fraser’s dolphins (Lagenodelphis hosei). Dev Comp Immunol. 2025 02; 163:105326.. View in PubMed
Automated cell tracking using 3D nnUnet and Light Sheet Microscopy to quantify regional deformation in zebrafish. bioRxiv. 2024 Nov 06.. View in PubMed
Mitophagy Promotes Hair Regeneration by Activating Glutathione Metabolism. Research (Wash D C). 2024; 7:0433.. View in PubMed
Author Correction: Conserved regulatory switches for the transition from natal down to juvenile feather in birds. Nat Commun. 2024 Jun 25; 15(1):5367.. View in PubMed
Parsing patterns: Emerging roles of tissue self-organization in health and disease. Cell. 2024 Jun 20; 187(13):3165-3186.. View in PubMed
Energy competition remodels the metabolic glucose landscape of psoriatic epidermal cells. Theranostics. 2024; 14(8):3339-3357.. View in PubMed
Conserved regulatory switches for the transition from natal down to juvenile feather in birds. Nat Commun. 2024 May 16; 15(1):4174.. View in PubMed
Gap junctions in Turing-type periodic feather pattern formation. PLoS Biol. 2024 May; 22(5):e3002636.. View in PubMed
Crosstalk between endothelial cells and dermal papilla entails hair regeneration and angiogenesis during aging. J Adv Res. 2025 Apr; 70:339-353.. View in PubMed
Adaptive patterning of vascular network during avian skin development: Mesenchymal plasticity and dermal vasculogenesis. Cells Dev. 2024 09; 179:203922.. View in PubMed
Epidermal-dermal coupled spheroids are important for tissue pattern regeneration in reconstituted skin explant cultures. NPJ Regen Med. 2023 Nov 23; 8(1):65.. View in PubMed
Autofluorescence microscopy as a non-invasive probe to characterize the complex mechanical properties of keratin-based integumentary organs: A feather paradigm. Chin J Phys. 2023 Dec; 86:561-571.. View in PubMed
Transition from natal downs to juvenile feathers: conserved regulatory switches in Neoaves. Res Sq. 2023 Oct 03.. View in PubMed
Using Avian Skin Explants to Study Tissue Patterning and Organogenesis. J Vis Exp. 2023 09 15.. View in PubMed
The mechano-chemical circuit drives skin organoid self-organization. Proc Natl Acad Sci U S A. 2023 09 05; 120(36):e2221982120.. View in PubMed
Bioinspired Strategies for Wound Regeneration. Cold Spring Harb Perspect Biol. 2023 07 05; 15(7).. View in PubMed
Molecular and Cellular Characterization of Avian Reticulate Scales Implies the Evo-Devo Novelty of Skin Appendages in Foot Sole. J Dev Biol. 2023 Jul 03; 11(3).. View in PubMed
Gap junctions in Turing-type periodic feather pattern formation. bioRxiv. 2023 Apr 16.. View in PubMed
Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis. Sci Transl Med. 2023 03 22; 15(688):eabq2395.. View in PubMed
Ventricular anisotropic deformation and contractile function of the developing heart of zebrafish in vivo. Dev Dyn. 2023 02; 252(2):247-262.. View in PubMed
Topological Distribution of Wound Stiffness Modulates Wound-Induced Hair Follicle Neogenesis. Pharmaceutics. 2022 Sep 12; 14(9).. View in PubMed
Scale space detector for analyzing spatiotemporal ventricular contractility and nuclear morphogenesis in zebrafish. iScience. 2022 Sep 16; 25(9):104876.. View in PubMed
Regulation and dysregulation of hair regeneration: aiming for clinical application. Cell Regen. 2022 Jul 01; 11(1):22.. View in PubMed
Successful Repigmentation of Full-Thickness Wound Healing in Fraser’s Dolphins (Lagenodelphis hosei). Animals (Basel). 2022 Jun 08; 12(12).. View in PubMed
Defining Wound Healing Progression in Cetacean Skin: Characteristics of Full-Thickness Wound Healing in Fraser’s Dolphins (Lagenodelphis hosei). Animals (Basel). 2022 Feb 22; 12(5).. View in PubMed
Corrigendum to “The crest phenotype in domestic chicken is caused by a 195 bp duplication in the intron of HOXC10”. G3 (Bethesda). 2022 Feb 04; 12(2).. View in PubMed
Editorial: Hair Follicle Stem Cell Regeneration in Aging. Front Cell Dev Biol. 2021; 9:799268.. View in PubMed
Cis-acting mutation affecting GJA5 transcription is underlying the Melanotic within-feather pigmentation pattern in chickens. Proc Natl Acad Sci U S A. 2021 10 12; 118(41).. View in PubMed
Regional Specific Differentiation of Integumentary Organs: Regulation of Gene Clusters within the Avian Epidermal Differentiation Complex and Impacts of SATB2 Overexpression. Genes (Basel). 2021 08 23; 12(8).. View in PubMed
Cyclic growth of dermal papilla and regeneration of follicular mesenchymal components during feather cycling. Development. 2021 09 15; 148(18).. View in PubMed
Regional specific differentiation of integumentary organs: SATB2 is involved in α- and β-keratin gene cluster switching in the chicken. Dev Dyn. 2022 09; 251(9):1490-1508.. View in PubMed
A quantitative image-based protocol for morphological characterization of cellular solids in feather shafts. STAR Protoc. 2021 09 17; 2(3):100661.. View in PubMed
The global regulatory logic of organ regeneration: circuitry lessons from skin and its appendages. Biol Rev Camb Philos Soc. 2021 12; 96(6):2573-2583.. View in PubMed
Global feather orientations changed by electric current. iScience. 2021 Jun 25; 24(6):102671.. View in PubMed
Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice. Nat Commun. 2021 05 10; 12(1):2595.. View in PubMed
The feather pattern autosomal barring in chicken is strongly associated with segregation at the MC1R locus. Pigment Cell Melanoma Res. 2021 11; 34(6):1015-1028.. View in PubMed
Making region-specific integumentary organs in birds: evolution and modifications. Curr Opin Genet Dev. 2021 08; 69:103-111.. View in PubMed
Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging. Front Cell Dev Biol. 2021; 9:635340.. View in PubMed
The crest phenotype in domestic chicken is caused by a 197 bp duplication in the intron of HOXC10. G3 (Bethesda). 2021 02 09; 11(2).. View in PubMed
Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures. Front Cell Dev Biol. 2020; 8:628114.. View in PubMed
Niche Modulation of IGF-1R Signaling: Its Role in Stem Cell Pluripotency, Cancer Reprogramming, and Therapeutic Applications. Front Cell Dev Biol. 2020; 8:625943.. View in PubMed
Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells. Front Cell Dev Biol. 2020; 8:583434.. View in PubMed
Connectivity between nidopallium caudolateral and visual pathways in color perception of zebra finches. Sci Rep. 2020 11 09; 10(1):19382.. View in PubMed
Development of injectable chitosan/biphasic calcium phosphate bone cement and in vitro and in vivo evaluation. Biomed Mater. 2020 09 08; 15(5):055038.. View in PubMed
The Effects of Premature Tooth Extraction and Damage on Replacement Timing in the Green Iguana. Integr Comp Biol. 2020 09 01; 60(3):581-593.. View in PubMed
Integrating Bioelectrical Currents and Ca2+ Signaling with Biochemical Signaling in Development and Pathogenesis. Bioelectricity. 2020 Sep 01; 2(3):210-220.. View in PubMed
Variations of Mesozoic feathers: Insights from the morphogenesis of extant feather rachises. Evolution. 2020 09; 74(9):2121-2133.. View in PubMed
Avian Pigment Pattern Formation: Developmental Control of Macro- (Across the Body) and Micro- (Within a Feather) Level of Pigment Patterns. Front Cell Dev Biol. 2020; 8:620.. View in PubMed
Folding Keratin Gene Clusters during Skin Regional Specification. Dev Cell. 2020 06 08; 53(5):561-576.e9.. View in PubMed
PP2A Deficiency Enhances Carcinogenesis of Lgr5+ Intestinal Stem Cells Both in Organoids and In Vivo. Cells. 2019 Dec 30; 9(1).. View in PubMed
The Making of a Flight Feather: Bio-architectural Principles and Adaptation. Cell. 2019 11 27; 179(6):1409-1423.e17.. View in PubMed
Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis. Nat Commun. 2019 05 20; 10(1):2226.. View in PubMed
Self-assembly of biological networks via adaptive patterning revealed by avian intradermal muscle network formation. Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10858-10867.. View in PubMed
Understanding skin morphogenesis across developmental, regenerative and evolutionary levels. Exp Dermatol. 2019 04; 28(4):327-331.. View in PubMed
STAT3 signalling pathway is implicated in keloid pathogenesis by preliminary transcriptome and open chromatin analyses. Exp Dermatol. 2019 04; 28(4):480-484.. View in PubMed
Self-organizing hair peg-like structures from dissociated skin progenitor cells: New insights for human hair follicle organoid engineering and Turing patterning in an asymmetric morphogenetic field. Exp Dermatol. 2019 04; 28(4):355-366.. View in PubMed
Comparative regenerative biology of spiny (Acomys cahirinus) and laboratory (Mus musculus) mouse skin. Exp Dermatol. 2019 04; 28(4):442-449.. View in PubMed
Turing patterning with and without a global wave. PLoS Biol. 2019 03; 17(3):e3000195.. View in PubMed
Instructive role of melanocytes during pigment pattern formation of the avian skin. Proc Natl Acad Sci U S A. 2019 04 02; 116(14):6884-6890.. View in PubMed
Regeneration of rete ridges in Lanyu pig (Sus scrofa): Insights for human skin wound healing. Exp Dermatol. 2019 04; 28(4):472-479.. View in PubMed
Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials. Exp Dermatol. 2019 04; 28(4):395-405.. View in PubMed
Morpho-regulation in diverse chicken feather formation: Integrating branching modules and sex hormone-dependent morpho-regulatory modules. Dev Growth Differ. 2019 Jan; 61(1):124-138.. View in PubMed
Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks. Nat Commun. 2018 12 18; 9(1):5377.. View in PubMed
Comprehensive molecular and cellular studies suggest avian scutate scales are secondarily derived from feathers, and more distant from reptilian scales. Sci Rep. 2018 11 13; 8(1):16766.. View in PubMed
Epidermal Darwinism and Competitive Equilibrium within the Epidermis. Cell Stem Cell. 2018 11 01; 23(5):627-629.. View in PubMed
Transcriptome analyses of reprogrammed feather / scale chimeric explants revealed co-expressed epithelial gene networks during organ specification. BMC Genomics. 2018 Oct 29; 19(1):780.. View in PubMed
Comparative genomics and transcriptomics of Chrysolophus provide insights into the evolution of complex plumage coloration. Gigascience. 2018 10 01; 7(10).. View in PubMed
Spatial and temporal variations in hemodynamic forces initiate cardiac trabeculation. JCI Insight. 2018 07 12; 3(13).. View in PubMed
Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling. Nat Commun. 2018 04 09; 9(1):1345.. View in PubMed
Msx2 Supports Epidermal Competency during Wound-Induced Hair Follicle Neogenesis. J Invest Dermatol. 2018 09; 138(9):2041-2050.. View in PubMed
Multiple Regulatory Modules Are Required for Scale-to-Feather Conversion. Mol Biol Evol. 2018 02 01; 35(2):417-430.. View in PubMed
The tension biology of wound healing. Exp Dermatol. 2019 04; 28(4):464-471.. View in PubMed
Getting to the Core of the Dermal Papilla. J Invest Dermatol. 2017 11; 137(11):2250-2253.. View in PubMed

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