Christopher P. Gayer, MD, PhD

I am interested in bile acid metabolism and how specific bile acid receptors, such as FXR, influence the intestinal epithelial barrier in injury models

• The Post-Operative Handoff: Perceptions and Preferences of Pediatric Hospitalists and Surgeons. Hosp Pediatr. 2024 10 01; 14(10):843-851.. View in PubMed
• A Standardized Post-gastrostomy Feeding Protocol for Pediatric Patients Reduces Time to Postoperative Goal Feeding Volume. Am Surg. 2024 Oct; 90(10):2600-2608.. View in PubMed
• Evaluation of Postoperative Outcomes After Enterostomy Closure in Low Body Weight Infants: A Multi-Center Retrospective Analysis. Am Surg. 2024 Oct; 90(10):2534-2542.. View in PubMed
• FXR deletion attenuates intestinal barrier dysfunction in murine acute intestinal inflammation. Am J Physiol Gastrointest Liver Physiol. 2024 Aug 01; 327(2):G175-G187.. View in PubMed
• Clinical Characteristics of Avoidable Patient Transfers for Suspected Pediatric Appendicitis. J Surg Res. 2024 Aug; 300:54-62.. View in PubMed
• Utility of colonic manometry in children with Hirschsprung disease. J Pediatr Gastroenterol Nutr. 2024 Jun; 78(6):1217-1224.. View in PubMed
• Primary Adrenal Malignant Rhabdoid Tumor in a 14-Year-Old Female: A Case Report and Literature Review. Int J Surg Pathol. 2022 Apr; 30(2):172-176.. View in PubMed
• Children with large primary spontaneous pneumothoraxes may benefit from early operative intervention. Pediatr Surg Int. 2022 Mar; 38(3):423-429.. View in PubMed
• The Pathophysiology of Farnesoid X Receptor (FXR) in the GI Tract: Inflammation, Barrier Function and Innate Immunity. Cells. 2021 11 17; 10(11).. View in PubMed
• Decreased secondary faecal bile acids in children with ulcerative colitis and Clostridioides difficile infection. Aliment Pharmacol Ther. 2021 09; 54(6):792-804.. View in PubMed
• EP2 Receptor Blockade Attenuates COX-2 Upregulation During Intestinal Inflammation. Shock. 2020 09; 54(3):394-401.. View in PubMed
• The value of prophylactic chest tubes in tracheoesophageal fistula repair. Pediatr Surg Int. 2020 Jun; 36(6):687-696.. View in PubMed
• Serum bile acids profiling by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and its application on pediatric liver and intestinal diseases. Clin Chem Lab Med. 2020 04 28; 58(5):787-797.. View in PubMed
• Differences in Serum Alkaline Phosphatase Levels in Infants with Spontaneous Intestinal Perforation versus Necrotizing Enterocolitis with Perforation. Neonatology. 2020; 117(3):349-357.. View in PubMed
• Pilot Study of the Effect of Plant-Based Enteral Nutrition on the Gut Microbiota in Chronically Ill Tube-Fed Children. JPEN J Parenter Enteral Nutr. 2019 09; 43(7):899-911.. View in PubMed
• Screening for blunt cerebrovascular injuries in pediatric trauma patients. J Pediatr Surg. 2019 Sep; 54(9):1861-1865.. View in PubMed
• Variability in perioperative evaluation and resource utilization in pediatric patients with suspected biliary dyskinesia: A multi-institutional retrospective cohort study. J Pediatr Surg. 2019 Jun; 54(6):1118-1122.. View in PubMed
• Closing gastroschisis: The good, the bad, and the not-so ugly. J Pediatr Surg. 2019 Jan; 54(1):60-64.. View in PubMed
• Effects of artificially introduced Enterococcus faecalis strains in experimental necrotizing enterocolitis. PLoS One. 2019; 14(11):e0216762.. View in PubMed
• Ursodeoxycholic acid protects against intestinal barrier breakdown by promoting enterocyte migration via EGFR- and COX-2-dependent mechanisms. Am J Physiol Gastrointest Liver Physiol. 2018 08 01; 315(2):G259-G271.. View in PubMed
• Liquid chromatography-mass spectroscopy in the diagnosis of biliary atresia in children with hyperbilirubinemia. J Surg Res. 2018 08; 228:228-237.. View in PubMed
• Soybean-derived recombinant human epidermal growth factor protects against experimental necrotizing enterocolitis. J Pediatr Surg. 2018 Jun; 53(6):1203-1207.. View in PubMed
• Lactobacillus murinus HF12 colonizes neonatal gut and protects rats from necrotizing enterocolitis. PLoS One. 2018; 13(6):e0196710.. View in PubMed
• Discussion of: “Hospital admission unnecessary for successful uncomplicated radiographic reduction of pediatric intussusception”. Am J Surg. 2017 12; 214(6):1208-1209.. View in PubMed
• Hospital admission unnecessary for successful uncomplicated radiographic reduction of pediatric intussusception. Am J Surg. 2017 Dec; 214(6):1203-1207.. View in PubMed
• Advances in paediatric gastroenterology. Lancet. 2017 Sep 09; 390(10099):1072-1082.. View in PubMed
• Routine post-operative esophagram Is not necessary after repair of esophageal atresia. Am J Surg. 2017 Apr; 213(4):640-644.. View in PubMed
• Re-evaluation of liver transaminase cutoff for CT after pediatric blunt abdominal trauma. Pediatr Surg Int. 2017 Mar; 33(3):311-316.. View in PubMed
• Dissemination and Implementation of Shared Decision Making Into Clinical Practice: A Research Agenda. Acad Emerg Med. 2016 12; 23(12):1368-1379.. View in PubMed
• Funding Research in Emergency Department Shared Decision Making: A Summary of the 2016 Academic Emergency Medicine Consensus Conference Panel Discussion. Acad Emerg Med. 2016 12; 23(12):1340-1345.. View in PubMed
• Liver steatosis induced by small bowel resection is prevented by oral vancomycin. Surgery. 2016 12; 160(6):1485-1495.. View in PubMed
• Limiting chest computed tomography in the evaluation of pediatric thoracic trauma. J Trauma Acute Care Surg. 2016 08; 81(2):271-7.. View in PubMed
• Liquid chromatography-mass spectroscopy as a tool in the rapid diagnosis of biliary atresia: a pilot study. J Pediatr Surg. 2016 Jun; 51(6):923-6.. View in PubMed
• An ectopic renin-secreting adrenal corticoadenoma in a child with malignant hypertension. Physiol Rep. 2016 Mar; 4(5).. View in PubMed
• Bile acids regulate intestinal cell proliferation by modulating EGFR and FXR signaling. Am J Physiol Gastrointest Liver Physiol. 2016 Jan 15; 310(2):G81-92.. View in PubMed
• Admission hematocrit predicts the need for transfusion secondary to hemorrhage in pediatric blunt trauma patients. J Trauma Acute Care Surg. 2015 Oct; 79(4):555-62.. View in PubMed
• Images in clinical medicine. Gastric emphysema. N Engl J Med. 2014 May 29; 370(22):e33.. View in PubMed
• Recent developments in Hirschsprung’s-associated enterocolitis. Curr Gastroenterol Rep. 2013 Aug; 15(8):340.. View in PubMed
• Necrotizing enterocolitis: contemporary management and outcomes. Adv Pediatr. 2013; 60(1):263-79.. View in PubMed
• Isolated ruptured appendicitis presenting as pneumatosis intestinalis in a premature neonate. Pediatr Surg Int. 2012 Apr; 28(4):439-41.. View in PubMed
• Combined endoscopic and laparoscopic approach to a gastroesophageal tumor. JSLS. 2011 Apr-Jun; 15(2):228-31.. View in PubMed
• ERK regulates strain-induced migration and proliferation from different subcellular locations. J Cell Biochem. 2010 Mar 01; 109(4):711-25.. View in PubMed
• Acute lower gastrointestinal bleeding in 1,112 patients admitted to an urban emergency medical center. Surgery. 2009 Oct; 146(4):600-6; discussion 606-7.. View in PubMed
• The effects of increased extracellular deformation, pressure, and integrin phosphorylation on fibroblast migration. J Surg Res. 2009 Sep; 156(1):103-9.. View in PubMed
• The effects of mechanical forces on intestinal physiology and pathology. Cell Signal. 2009 Aug; 21(8):1237-44.. View in PubMed
• Delineating the signals by which repetitive deformation stimulates intestinal epithelial migration across fibronectin. Am J Physiol Gastrointest Liver Physiol. 2009 Apr; 296(4):G876-85.. View in PubMed
• Strain-induced proliferation requires the phosphatidylinositol 3-kinase/AKT/glycogen synthase kinase pathway. J Biol Chem. 2009 Jan 23; 284(4):2001-11.. View in PubMed
• Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789. Am J Physiol Cell Physiol. 2009 Jan; 296(1):C193-204.. View in PubMed
• Supraphysiologic extracellular pressure inhibits intestinal epithelial wound healing independently of luminal nutrient flow. Am J Surg. 2008 Nov; 196(5):683-9.. View in PubMed
• Repetitive deformation activates Src-independent FAK-dependent ERK motogenic signals in human Caco-2 intestinal epithelial cells. Am J Physiol Cell Physiol. 2008 Jun; 294(6):C1350-61.. View in PubMed
• Clinical evaluation and management of caustic injury in the upper gastrointestinal tract in 95 adult patients in an urban medical center. Surg Endosc. 2008 Apr; 22(4):1119-25.. View in PubMed

• Demetriades, Demetrios
• Inaba, Kenji
• Martin, Matthew
• Kohli, Rohit
• Matsushima, Kazuhide
• Lenz, Heinz-Josef
• Schellenberg, Morgan
• Gonzalez, Frank
• Kelley-Quon, Lorraine