Daniel A. Oakes, MD

Professor Of Clinical Orthopaedic Surgery

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Dr. Oakes is a Professor in the Department of Orthopaedic Surgery at the Keck School of Medicine of USC and the Director of the USC Joint Replacement Program.

Dr. Oakes is nationally recognized for his expertise in knee and hip replacement and reconstruction. He has extensive experience with both primary and revision of hip and knee replacement procedures. Dr. Oakes is actively engaged in the role of emerging computer assisted navigation technologies for hip and knee joint replacement procedures and robotic surgery for full and partial knee replacement. Dr. Oakes performed the first robotic total knee surgery at Keck Medical Center of USC in 2018.

Dr. Oakes is interested in the technology advances that improve the longevity implants and patient outcomes. He and his team have worked to develop strategies both to prevent and treat infected joint replacements. His active research focuses on the long-term outcomes of robotic partial and total knee replacement outcomes, of porous metal technology in complex primary and complex revision improving longevity of implant technologies and the prevention and treatment of infected joint replacements, of porous metal technology in complex revision knee replacements, of single stage treatments for infection and of hip resurfacing as an alternative to joint replacement.

Dr. Oakes has consistently been voted a Top Doctor by Pasadena Magazine, Super Doctor by Los Angeles Magazine, and one of America’s Top Doctors by Castle Connolly. He is a fellow in the American Academy of Orthopaedic Surgeons (AAOS). He is a member of the American Association of Hip and Knee Surgeons(AAHKS) and has served as chair of its membership committee.

Dr. Oakes received his medical degree from Harvard Medical School and completed his fellowship training at the Mayo Clinic, where he received the Mark B. Coventry Adult Reconstruction Fellowship Award.

Dr. Oakes is the Joint Replacement fellowship director. He has twice been the recipient of the departments award for teaching excellence.


  • USC: Residency Faculty Teaching Award, 2018
  • Los Angeles Magazine: Top Doctors, 2018
  • Los Angeles Magazine: Super Doctor, 2016-2022
  • Castle Connolly: America’s Top Doctors, 2014-2020
  • USC: Residency Faculty Teaching Award, 2011
  • Pasadena Magazine: Top Doctor, 2010-2019
  • Mayo Clinic: Mark B. Coventry Adult Reconstruction Fellowship Award, 2004
  • American Orthopaedic Society for Sports Medicine : Excellence in Research Award, 2002


  • Trabecular Metal Augments During Complex Primary Total Hip Arthroplasty Arthroplast Today. 2024 Jun; 27:101435. . View in PubMed
  • Robotic-Assisted Total Knee Arthroplasty in Obese Patients Arthroplast Today. 2024 Apr; 26:101320. . View in PubMed
  • An Updated Estimate of Total Hip and Total Knee Arthroplasty Inpatient Case Volume During the 2020 COVID-19 Pandemic in the United States Arthroplast Today. 2024 Apr; 26:101336. . View in PubMed
  • Limited Durability of Extensor Mechanism Reconstruction Following Total Knee Arthroplasty: Mesh and Allograft Show Equivalent Outcomes at Five-Year Follow-Up J Arthroplasty. 2024 Mar; 39(3):772-777. . View in PubMed
  • Metal artifact reduction sequence-MRI abnormalities in asymptomatic patients with dual-mobility hip prostheses Bone Joint J. 2024 Mar 01; 106-B(3 Supple A):89-96. . View in PubMed
  • Postoperative Complications Associated with Non-Steroidal Anti-Inflammatory Combinations Used Status-Post Total Hip and Knee Arthroplasty J Clin Med. 2023 Nov 07; 12(22). . View in PubMed
  • Peripheral Nerve Block Utilization is Associated With Decreased Postoperative Opioid Consumption and Shorter Length of Stay Following Total Knee Arthroplasty Arthroplast Today. 2023 Apr; 20:101101. . View in PubMed
  • A double-blinded, placebo-controlled, randomized study to evaluate the efficacy of perioperative dextromethorphan compared to placebo for the treatment of postoperative pain: a study protocol Trials. 2023 Mar 29; 24(1):238. . View in PubMed
  • Refining the Role of Routine Synovial Alpha-Defensin in Periprosthetic Joint Infection Following Total Knee Arthroplasty: An Analysis of Limitations J Arthroplasty. 2023 12; 38(12):2691-2697. . View in PubMed
  • Factors Associated With Failure Following Proximal Femoral Replacement for Salvage Hip Surgery for Nononcologic IndicationsJ Arthroplasty. 2023 11; 38(11):2429-2435. e2. . View in PubMed
  • Positive COVID-19 Diagnosis Following Primary Elective Total Joint Arthroplasty: Increased Complication and Mortality RatesJ Arthroplasty. 2023 09; 38(9):1682-1692. e2. . View in PubMed
  • The Persistent Effects of the COVID-19 Pandemic on Total Joint Arthroplasty Changes in Practice Patterns in the United States From 2020 to 2021J Arthroplasty. 2023 08; 38(8):1438-1443. e1. . View in PubMed
  • Aspirin for Venous Thromboembolic Prophylaxis Following Total Hip and Total Knee Arthroplasty: An Analysis of Safety and Efficacy Accounting for Surgeon Selection BiasJ Arthroplasty. 2023 07; 38(7 Suppl 2):S412-S419. e1. . View in PubMed
  • Does Prednisone Dose Affect Rates of Periprosthetic Joint Infection Following Primary Total Hip and Total Knee Arthroplasty? J Arthroplasty. 2023 06; 38(6):1024-1031.. View in PubMed
  • Influence of donor age and comorbidities on transduced human adipose-derived stem cell in vitro osteogenic potential Gene Ther. 2023 04; 30(3-4):369-376. . View in PubMed
  • Tranexamic Acid and Prothrombotic Complications Following Total Hip and Total Knee Arthroplasty: A Population-Wide Safety Analysis Accounting for Surgeon Selection Bias J Arthroplasty. 2023 02; 38(2):215-223. . View in PubMed
  • Drill Bone with Both Hands: Plunge Depth and Accuracy with 4 Bracing Positions JB JS Open Access. 2023 Jan-Mar; 8(1). . View in PubMed
  • Modern Proximal Femoral Replacement in Revision Total Hip Arthroplasty for Nononcologic Indications J Arthroplasty. 2022 08; 37(8S):S958-S963. . View in PubMed
  • Systematic Review and Meta-Analysis of Intrawound Vancomycin in Total Hip and Total Knee Arthroplasty: A Continued Call for a Prospective Randomized TrialJ Arthroplasty. 2022 07; 37(7):1405-1415. e1. . View in PubMed
  • Monomicrobial Joint Infection by Leclercia adecarboxylata in an Immunocompetent Patient After Knee Arthroscopy: A Case Report JBJS Case Connect. 2022 07 01; 12(3). . View in PubMed
  • Elective Inpatient Total Joint Arthroplasty Case Volume in the United States in 2020: Effects of the COVID-19 Pandemic J Bone Joint Surg Am. 2022 07 06; 104(13):e56. . View in PubMed
  • Utilization of technology-assisted total hip arthroplasty in the United States from 2005 to 2018 Arthroplast Today. 2021 Dec; 12:36-44. . View in PubMed
  • Patient Perception Regarding the Safety of Elective Joint Arthroplasty Surgery During the COVID-19 Pandemic Arthroplast Today. 2021 Oct; 11:113-121. . View in PubMed
  • Limited potential of AAV-mediated gene therapy in transducing human mesenchymal stem cells for bone repair applications Gene Ther. 2021 12; 28(12):729-739. . View in PubMed
  • Regional Gene Therapy with Transduced Human Cells: The Influence of “Cell Dose” on Bone Repair Tissue Eng Part A. 2021 11; 27(21-22):1422-1433. . View in PubMed
  • Regional gene therapy for bone healing using a 3D printed scaffold in a rat femoral defect model J Biomed Mater Res A. 2021 11; 109(11):2346-2356. . View in PubMed
  • Dose-Dependent Early Postoperative Opioid Use Is Associated with Periprosthetic Joint Infection and Other Complications in Primary TJA J Bone Joint Surg Am. 2021 08 18; 103(16):1531-1542. . View in PubMed
  • Population-based Survivorship of Computer-navigated Versus Conventional Total Knee Arthroplasty J Am Acad Orthop Surg. 2020 Oct 15; 28(20):857-864. . View in PubMed
  • Systematic Review and Meta-Analysis of Intrawound Vancomycin in Total Hip and Total Knee Arthroplasty: A Call for a Prospective Randomized Trial J Arthroplasty. 2019 Aug; 34(8):1815-1822. . View in PubMed
  • Trends in computer navigation and robotic assistance for total knee arthroplasty in the United States: an analysis of patient and hospital factors Arthroplast Today. 2019 Mar; 5(1):88-95. . View in PubMed
  • Complex Reconstruction of the Knee with a Free Vertical Rectus Abdominis Flap after Periprosthetic Soft Tissue Necrosis Cureus. 2019 Jan 28; 11(1):e3969. . View in PubMed
  • Ex vivo gene therapy using human bone marrow cells overexpressing BMP-2: “Next-day” gene therapy versus standard “two-step” approach Bone. 2019 11; 128:115032. . View in PubMed
  • In vitro evaluation of a lentiviral two-step transcriptional amplification system using GAL4FF transactivator for gene therapy applications in bone repair Gene Ther. 2018 07; 25(4):260-268. . View in PubMed
  • Gene Therapy for Bone Repair Using Human Cells: Superior Osteogenic Potential of Bone Morphogenetic Protein 2-Transduced Mesenchymal Stem Cells Derived from Adipose Tissue Compared to Bone Marrow Hum Gene Ther. 2018 04; 29(4):507-519. . View in PubMed
  • The Cost of Getting Into Orthopedic Residency: Analysis of Applicant Demographics, Expenditures, and the Value of Away Rotations J Surg Educ. 2016 Sep-Oct; 73(5):886-91. . View in PubMed
  • Orthopedic Surgery Applicants: What They Want in an Interview and How They Are Influenced by Post-Interview Contact J Surg Educ. 2016 Jul-Aug; 73(4):709-14. . View in PubMed
  • Effect of proximal femoral bone support on the fixation of a press-fit noncemented total hip replacement femoral component J Appl Biomater Funct Mater. 2013 Jun 24; 11(1):e26-34. . View in PubMed
  • Disappointing short-term results with the DePuy ASR XL metal-on-metal total hip arthroplasty J Arthroplasty. 2012 Apr; 27(4):539-44. . View in PubMed
  • How long do endoprosthetic reconstructions for proximal femoral tumors last? Clin Orthop Relat Res. 2010 Nov; 468(11):2867-74.. View in PubMed
  • Acetabular morphology in bladder exstrophy complex Clin Orthop Relat Res. 2007 May; 458:125-30. . View in PubMed
  • Impaction bone grafting for revision hip arthroplasty: biology and clinical applications J Am Acad Orthop Surg. 2006 Oct; 14(11):620-8. . View in PubMed
  • Magnetic resonance imaging with metal suppression for evaluation of periprosthetic osteolysis after total knee arthroplasty J Arthroplasty. 2006 Sep; 21(6):826-31. . View in PubMed
  • Safety of rasagiline in elderly patients with Parkinson disease Neurology. 2006 May 09; 66(9):1427-9. . View in PubMed
  • Persistent bladder entrapment following acetabular fracture with subsequent vesical injury during total hip arthroplastyA case report. J Bone Joint Surg Am. 2005 Apr; 87(4):870-3. . View in PubMed
  • Compressive intrapelvic synovial cysts: an early complication of an HA-coated cup Clin Orthop Relat Res. 2005 Jan; (430):232-6. . View in PubMed
  • Bilateral total knee replacement using the same anesthetic is not justified by assessment of the risks Clin Orthop Relat Res. 2004 Nov; (428):87-91. . View in PubMed
  • The effect of femoral tunnel position on graft forces during inlay posterior cruciate ligament reconstruction Am J Sports Med. 2003 Sep-Oct; 31(5):667-72. . View in PubMed
  • An evaluation of human demineralized bone matrices in a rat femoral defect model Clin Orthop Relat Res. 2003 Aug; (413):281-90. . View in PubMed
  • Failure of heat shrinkage for treatment of a posterior cruciate ligament tear Arthroscopy. 2003 Jul-Aug; 19(6):E1-4. . View in PubMed
  • The impact of the garden classification on proposed operative treatment Clin Orthop Relat Res. 2003 Apr; (409):232-40. . View in PubMed
  • Effects of notchplasty and femoral tunnel position on excursion patterns of an anterior cruciate ligament graft Arthroscopy. 2003 Apr; 19(4):340-5. . View in PubMed
  • Biomechanical effects of medial-lateral tibial tunnel placement in posterior cruciate ligament reconstruction J Orthop Res. 2003 Jan; 21(1):177-82. . View in PubMed
  • Effects of femoral tunnel placement on knee laxity and forces in an anterior cruciate ligament graft J Orthop Res. 2002 Sep; 20(5):1016-24. . View in PubMed
  • Injury to the anterior cruciate ligament during alpine skiing: a biomechanical analysis of tibial torque and knee flexion angle Am J Sports Med. 2002 Jul-Aug; 30(4):537-40. . View in PubMed
  • Biomechanical comparison of tibial inlay and tibial tunnel techniques for reconstruction of the posterior cruciate ligamentAnalysis of graft forces. J Bone Joint Surg Am. 2002 Jun; 84(6):938-44. . View in PubMed
  • A biomechanical comparison of tibial inlay and tibial tunnel posterior cruciate ligament reconstruction techniques: graft pretension and knee laxity Am J Sports Med. 2002 May-Jun; 30(3):312-7. . View in PubMed
  • Biomechanical effects of femoral notchplasty in anterior cruciate ligament reconstruction Am J Sports Med. 2002 Jan-Feb; 30(1):83-9. . View in PubMed
  • An atypical appearance of a posterior dislocation of the shoulder with a fracture of the proximal humerus J Shoulder Elbow Surg. 2001 Mar-Apr; 10(2):182-5. . View in PubMed
  • Osteoinductive applications of regional gene therapy: ex vivo gene transfer Clin Orthop Relat Res. 2000 Oct; (379 Suppl):S101-12. . View in PubMed
  • Covering the “open abdomen”: a better technique Am Surg. 1998 Sep; 64(9):854-7. . View in PubMed
  • Development of a risk assessment for BSE in the aquatic environment J Appl Microbiol. 1998 Apr; 84(4):467-77. . View in PubMed
  • A randomized, double-blind, placebo-controlled trial of systemically administered interferon-alpha, -beta, or -gamma in combination with cryotherapy for the treatment of condyloma acuminatum J Infect Dis. 1995 May; 171(5):1081-9. . View in PubMed