Keck School Faculty

Daniel J. Weisenberger, PhD
Daniel J. Weisenberger, PhD
Assistant Professor of Research Biochemistry & Molecular Medicine
Medicine
NRT 511D 1450 Biggy Street Health Sciences Campus Los Angeles

Integrative Epigenetic Analysis Reveals Therapeutic Targets to the DNA Methyltransferase Inhibitor SGI-110 in Hepatocellular Carcinoma Hepatology. 2018 May 18. . View in PubMed

DNA methylation loss in late-replicating domains is linked to mitotic cell division Nat Genet. 2018 Apr; 50(4):591-602. . View in PubMed

Rewiring of cisplatin-resistant bladder cancer cells through epigenetic regulation of genes involved in amino acid metabolism Theranostics. 2018; 8(16):4520-4534. . View in PubMed

MethyLight and Digital MethyLight Methods Mol Biol. 2018; 1708:497-513. . View in PubMed

The genomic landscape of tuberous sclerosis complex Nat Commun. 2017 Jun 15; 8:15816. . View in PubMed

Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study Clin Cancer Res. 2017 Jun 01; 23(11):2691-2701. . View in PubMed

Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat: a phase 2 consortium/stand up 2 cancer study Oncotarget. 2017 May 23; 8(21):35326-35338. . View in PubMed

A Clinically Distinct and 'Atypical' Subgroup of Head and Neck Cancers Positive for a CpG Island Methylator Phenotype EBioMedicine. 2017 Mar; 17:22-23. . View in PubMed

Improving needle biopsy accuracy in small renal mass using tumor-specific DNA methylation markers Oncotarget. 2017 Jan 17; 8(3):5439-5448. . View in PubMed

DNA methylation aberrancies as a guide for surveillance and treatment of human cancers Epigenetics. 2017 06 03; 12(6):416-432. . View in PubMed

Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy PLoS One. 2017; 12(4):e0175112. . View in PubMed

Identifying aggressive prostate cancer foci using a DNA methylation classifier Genome Biol. 2017 01 12; 18(1):3. . View in PubMed

Genetic and Epigenetic Alterations in Bladder Cancer Int Neurourol J. 2016 Nov; 20(Suppl 2):S84-94. . View in PubMed

Effects of folylpolyglutamate synthase modulation on global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells J Nutr Biochem. 2016 Mar; 29:27-35. . View in PubMed

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma N Engl J Med. 2016 Jan 14; 374(2):135-45. . View in PubMed

Identification of DNA Methylation-Independent Epigenetic Events Underlying Clear Cell Renal Cell Carcinoma Cancer Res. 2016 04 01; 76(7):1954-64. . View in PubMed

Promoter Methylation Analysis Reveals That KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation Mol Cancer Res. 2016 Jan; 14(1):26-34. . View in PubMed

Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling Cell Rep. 2016 10 04; 17(2):596-608. . View in PubMed

Clinicopathologic Risk Factor Distributions for MLH1 Promoter Region Methylation in CIMP-Positive Tumors Cancer Epidemiol Biomarkers Prev. 2016 Jan; 25(1):68-75. . View in PubMed

Tumor Budding in Colorectal Carcinoma: Confirmation of Prognostic Significance and Histologic Cutoff in a Population-based Cohort Am J Surg Pathol. 2015 Oct; 39(10):1340-6. . View in PubMed

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas N Engl J Med. 2015 Jun 25; 372(26):2481-98. . View in PubMed

Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history Cancer Epidemiol Biomarkers Prev. 2015 Mar; 24(3):512-519. . View in PubMed

Association between molecular subtypes of colorectal cancer and patient survivalGastroenterology. 2015 Jan; 148(1):77-87. e2. . View in PubMed

Characterizing DNA methylation alterations from The Cancer Genome Atlas J Clin Invest. 2014 Jan; 124(1):17-23. . View in PubMed

A pilot genome-scale profiling of DNA methylation in sporadic pituitary macroadenomas: association with tumor invasion and histopathological subtype PLoS One. 2014; 9(4):e96178. . View in PubMed

Genomic and transcriptome analysis revealing an oncogenic functional module in meningiomas Neurosurg Focus. 2013 Dec; 35(6):E3. . View in PubMed

Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine Oncotarget. 2013 Nov; 4(11):2067-79. . View in PubMed

The somatic genomic landscape of glioblastoma Cell. 2013 Oct 10; 155(2):462-77. . View in PubMed

Associations between colorectal cancer molecular markers and pathways with clinicopathologic features in older womenGastroenterology. 2013 Aug; 145(2):348-56. e1-2. . View in PubMed

Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse modelUrology. 2013 Jul; 82(1):253. e9-15. . View in PubMed

Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer Genes Chromosomes Cancer. 2013 May; 52(5):450-66. . View in PubMed

Low-level processing of Illumina Infinium DNA Methylation BeadArrays Nucleic Acids Res. 2013 Apr; 41(7):e90. . View in PubMed

3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models BMC Pharmacol Toxicol. 2013 Feb 11; 14:11. . View in PubMed

DNA methylation in the malignant transformation of meningiomas PLoS One. 2013; 8(1):e54114. . View in PubMed

Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes among older women Gut. 2012 Sep; 61(9):1299-305. . View in PubMed

Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry Cancer Prev Res (Phila). 2012 Feb; 5(2):328-35. . View in PubMed

Genome-scale analysis of aberrant DNA methylation in colorectal cancer Genome Res. 2012 Feb; 22(2):271-82. . View in PubMed

Associations between intake of folate and related micronutrients with molecularly defined colorectal cancer risks in the Iowa Women's Health Study Nutr Cancer. 2012; 64(7):899-910. . View in PubMed

cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue PLoS One. 2012; 7(2):e30477. . View in PubMed

Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer PLoS One. 2012; 7(11):e50266. . View in PubMed

Alcohol intake and colorectal cancer risk by molecularly defined subtypes in a prospective study of older women Cancer Prev Res (Phila). 2011 Dec; 4(12):2035-43. . View in PubMed

Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains Nat Genet. 2011 Nov 27; 44(1):40-6. . View in PubMed

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage Nat Biotechnol. 2011 Nov 27; 29(12):1132-44. . View in PubMed

Modeling measurement error in tumor characterization studies BMC Bioinformatics. 2011 Jul 13; 12:284. . View in PubMed

Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors PLoS One. 2011; 6(10):e25985. . View in PubMed

Frequency of deletions of EPCAM (TACSTD1) in MSH2-associated Lynch syndrome cases J Mol Diagn. 2011 Jan; 13(1):93-9. . View in PubMed

Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue Cancer Res. 2010 Oct 15; 70(20):8169-78. . View in PubMed

Cigarette smoking and colorectal cancer risk by molecularly defined subtypes J Natl Cancer Inst. 2010 Jul 21; 102(14):1012-22. . View in PubMed

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma Cancer Cell. 2010 May 18; 17(5):510-22. . View in PubMed

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer Genome Res. 2010 Apr; 20(4):440-6. . View in PubMed

Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling PLoS One. 2009 Dec 21; 4(12):e8357. . View in PubMed

Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns Hum Mol Genet. 2009 Dec 15; 18(24):4808-17. . View in PubMed

The relationship of DNA methylation with age, gender and genotype in twins and healthy controls PLoS One. 2009 Aug 26; 4(8):e6767. . View in PubMed

The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification Int J Cancer. 2009 May 01; 124(9):1999-2005. . View in PubMed

Locking in on the human methylome Nat Biotechnol. 2009 Apr; 27(4):341-2. . View in PubMed

MethyLight Methods Mol Biol. 2009; 507:325-37. . View in PubMed

Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening Cancer Epidemiol Biomarkers Prev. 2008 Nov; 17(11):3208-15. . View in PubMed

DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight Nucleic Acids Res. 2008 Aug; 36(14):4689-98. . View in PubMed

Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer Mol Cancer. 2008 Jul 10; 7:62. . View in PubMed

DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis Lab Invest. 2008 Feb; 88(2):161-70. . View in PubMed

DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons PLoS One. 2007 Sep 19; 2(9):e895. . View in PubMed

Epigenetic stem cell signature in cancer Nat Genet. 2007 Feb; 39(2):157-8. . View in PubMed

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer Nat Genet. 2006 Jul; 38(7):787-93. . View in PubMed

Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis J Mol Diagn. 2006 May; 8(2):209-17. . View in PubMed

Footprinting of mammalian promoters: use of a CpG DNA methyltransferase revealing nucleosome positions at a single molecule level Nucleic Acids Res. 2005 Nov 27; 33(20):e176. . View in PubMed

Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma Eur J Cancer. 2005 Nov; 41(17):2769-78. . View in PubMed

Gene-specific methylation and subsequent risk of colorectal adenomas among participants of the polyp prevention trial Cancer Epidemiol Biomarkers Prev. 2005 May; 14(5):1219-23. . View in PubMed

Analysis of repetitive element DNA methylation by MethyLight Nucleic Acids Res. 2005; 33(21):6823-36. . View in PubMed

Detection of methylated apoptosis-associated genes in urine sediments of bladder cancer patients Clin Cancer Res. 2004 Nov 15; 10(22):7457-65. . View in PubMed

Preferential response of cancer cells to zebularine Cancer Cell. 2004 Aug; 6(2):151-8. . View in PubMed

Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7357-62. . View in PubMed

Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells Mol Cell Biol. 2004 Feb; 24(3):1270-8. . View in PubMed

Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation Mol Cancer Res. 2004 Jan; 2(1):62-72. . View in PubMed

Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine Cancer Res. 2002 Nov 15; 62(22):6456-61. . View in PubMed

Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells Gene. 2002 Sep 18; 298(1):91-9. . View in PubMed

Cell division is required for de novo methylation of CpG islands in bladder cancer cells Cancer Res. 2002 Apr 15; 62(8):2378-84. . View in PubMed

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