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Daniel Nation

Professor of Gerontology and Medicine, Merle H. Bensinger Professorship in Gerontology

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Phone +1 213 740 2219
Email [email protected]
CTSI Profile

Publications

  • Automatic detection of arterial input function for brain DCE-MRI in multi-site cohorts. Magn Reson Med. 2025 Dec; 94(6):2732-2744.. View in PubMed
  • Impaired parasympathetic network function confers susceptibility to neurodegeneration and memory impairment in older adults with elevated beat-to-beat blood pressure variability. J Alzheimers Dis. 2025 Nov; 108(1):411-420.. View in PubMed
  • High precision and cost-effective multiplex quantification of amyloid-β40, amyloid-β42, p181Tau, p217Tau, neurofilament light chain, and glial fibrillary acidic protein from plasma and serum. J Alzheimers Dis. 2025 Jul; 106(2):739-755.. View in PubMed
  • Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers. Geroscience. 2025 Jun; 47(3):4973-4986.. View in PubMed
  • Elevated vascular endothelial growth factor a is associated with disruption of default network connectivity in older adults. Brain Imaging Behav. 2025 Apr; 19(2):379-383.. View in PubMed
  • Locus coeruleus MRI contrast, cerebral perfusion, and plasma Alzheimer’s disease biomarkers in older adults. Neurobiol Aging. 2025 03; 147:12-21.. View in PubMed
  • Beat-to-beat blood pressure variability, hippocampal atrophy, and memory impairment in older adults. Geroscience. 2025 Feb; 47(1):993-1003.. View in PubMed
  • Association of Medial Temporal Lobe Cerebrovascular Reactivity and Memory Function in Older Adults With and Without Cognitive Impairment. Neurology. 2025 Jan 14; 104(1):e210210.. View in PubMed
  • Endothelial progenitor cells and cerebral small vessel disease in APOE4 carriers. Cereb Circ Cogn Behav. 2025; 8:100378.. View in PubMed
  • Comparison of visit-to-visit blood pressure variability and time in target range in predicting risk for cognitive outcomes in the SPRINT trial. J Alzheimers Dis. 2025 Jan; 103(2):396-405.. View in PubMed
  • Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits. Alzheimers Dement. 2025 Jan; 21(1):e14396.. View in PubMed
  • Cerebral perfusion and amyloidosis in the oldest-old. Alzheimers Dement. 2024 Dec; 20(12):9068-9075.. View in PubMed
  • Reliability of beat-to-beat blood pressure variability in older adults. Sci Rep. 2024 08 30; 14(1):20197.. View in PubMed
  • Older Adults With Smaller and Less Complex Social Networks Show Deficits in Medial Temporal Cerebrovascular Reactivity. J Am Heart Assoc. 2024 Aug 06; 13(15):e034390.. View in PubMed
  • Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden. Neurobiol Aging. 2024 07; 139:5-10.. View in PubMed
  • Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits. medRxiv. 2024 Jun 19.. View in PubMed
  • Central autonomic network dysfunction and plasma Alzheimer’s disease biomarkers in older adults. Alzheimers Res Ther. 2024 06 08; 16(1):124.. View in PubMed
  • Blood Pressure Variability, Central Autonomic Network Dysfunction, and Cerebral Small-Vessel Disease in APOE4 Carriers. J Am Heart Assoc. 2024 May 07; 13(9):e034116.. View in PubMed
  • The interactive effect of intra-beat and inter-beat blood pressure variability on neurodegeneration in older adults. medRxiv. 2024 May 03.. View in PubMed
  • Robust reference group normative data for neuropsychological tests accounting for primary language use in Asian American older adults. J Int Neuropsychol Soc. 2024 05; 30(4):402-409.. View in PubMed
  • Reliability of beat-to-beat blood pressure variability in older adults. Res Sq. 2024 04 19.. View in PubMed
  • Short-term blood pressure variability and brain functional network connectivity in older adults. Neuroimage Rep. 2024 Mar; 4(1).. View in PubMed
  • Pulse pressure and APOE ε4 dose interact to affect cerebral blood flow in older adults without dementia. Cereb Circ Cogn Behav. 2024; 6:100206.. View in PubMed
  • 24-Hour Blood Pressure Variability Via Ambulatory Monitoring and Risk for Probable Dementia in the SPRINT Trial. J Prev Alzheimers Dis. 2024; 11(3):684-692.. View in PubMed
  • Blood Pressure Variability and Plasma Alzheimer’s Disease Biomarkers in the SPRINT Trial. J Alzheimers Dis. 2024; 97(4):1851-1860.. View in PubMed
  • Blood pressure variability, central autonomic network dysfunction and cerebral small vessel disease in APOE4 carriers. medRxiv. 2023 Dec 14.. View in PubMed
  • Enlarged perivascular spaces and plasma Aβ42/Aβ40 ratio in older adults without dementia. Neurobiol Aging. 2023 08; 128:43-48.. View in PubMed
  • Multimodal neuroimaging data from a 5-week heart rate variability biofeedback randomized clinical trial. Sci Data. 2023 07 29; 10(1):503.. View in PubMed
  • Blood Pressure Variability and Cerebral Perfusion Decline: A Post Hoc Analysis of the SPRINT MIND Trial. J Am Heart Assoc. 2023 06 20; 12(12):e029797.. View in PubMed
  • Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults. Sci Rep. 2023 03 09; 13(1):3967.. View in PubMed
  • Blood Pressure Variability and Cognitive Decline: A Post Hoc Analysis of the SPRINT MIND Trial. Am J Hypertens. 2023 02 24; 36(3):168-175.. View in PubMed
  • Increasing coordination and responsivity of emotion-related brain regions with a heart rate variability biofeedback randomized trial. Cogn Affect Behav Neurosci. 2023 02; 23(1):66-83.. View in PubMed
  • The small HDL particle hypothesis of Alzheimer’s disease. Alzheimers Dement. 2023 02; 19(2):391-404.. View in PubMed
  • Older Adults With Higher Blood Pressure Variability Exhibit Cerebrovascular Reactivity Deficits. Am J Hypertens. 2023 01 01; 36(1):63-68.. View in PubMed
  • Short-term blood pressure variability is inversely related to regional amplitude of low frequency fluctuations in older and younger adults. Aging Brain. 2023; 4:100085.. View in PubMed
  • White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia. J Alzheimers Dis. 2023; 94(2):695-707.. View in PubMed
  • Visit-to-Visit Blood Pressure Variability and Cognitive Decline in Apolipoprotein ɛ4 Carriers versus Apolipoprotein ɛ3 Homozygotes. J Alzheimers Dis. 2023; 93(2):533-543.. View in PubMed
  • Blood-Derived Progenitor Cells Are Depleted in Older Adults with Cognitive Impairment: A Role for Vascular Resilience? J Alzheimers Dis. 2023; 93(3):1041-1050.. View in PubMed
  • Older adults with perivascular spaces exhibit cerebrovascular reactivity deficits. Neuroimage. 2022 12 01; 264:119746.. View in PubMed
  • Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults. Sci Rep. 2022 10 13; 12(1):17197.. View in PubMed
  • Visit-To-Visit Blood Pressure Variability and Subthreshold Depressive Symptoms in Older Adults. Am J Geriatr Psychiatry. 2022 10; 30(10):1110-1119.. View in PubMed
  • Visit-to-Visit Blood Pressure Variability and CSF Alzheimer Disease Biomarkers in Cognitively Unimpaired and Mildly Impaired Older Adults. Neurology. 2022 06 14; 98(24):e2446-e2453.. View in PubMed
  • Imaging subtle leaks in the blood-brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions. Geroscience. 2022 06; 44(3):1339-1351.. View in PubMed
  • Cerebrovascular reactivity deficits in cognitively unimpaired older adults: vasodilatory versus vasoconstrictive responses. Neurobiol Aging. 2022 05; 113:55-62.. View in PubMed
  • Blood pressure variability and medial temporal atrophy in apolipoprotein ϵ4 carriers. Brain Imaging Behav. 2022 Apr; 16(2):792-801.. View in PubMed
  • Selective vulnerability of medial temporal regions to short-term blood pressure variability and cerebral hypoperfusion in older adults. Neuroimage Rep. 2022 Mar; 2(1).. View in PubMed
  • Visit-to-Visit Blood Pressure Variability and Longitudinal Tau Accumulation in Older Adults. Hypertension. 2022 03; 79(3):629-637.. View in PubMed
  • Platelet-derived growth factor-BB and white matter hyperintensity burden in APOE4 carriers. Cereb Circ Cogn Behav. 2022; 3.. View in PubMed
  • Interactive Effects of Pulse Pressure and Tau Imaging on Longitudinal Cognition. J Alzheimers Dis. 2022; 89(2):633-640.. View in PubMed
  • Editorial: The importance of cognitive practice effects in aging neuroscience. Front Aging Neurosci. 2022; 14:1079021.. View in PubMed
  • Neuropsychological Decline Stratifies Dementia Risk in Cognitively Unimpaired and Impaired Older Adults. Front Aging Neurosci. 2022; 14:838459.. View in PubMed
  • Brainstem substructures and cognition in prodromal Alzheimer’s disease. Brain Imaging Behav. 2021 Oct; 15(5):2572-2582.. View in PubMed
  • Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis. Hypertension. 2021 09; 78(3):629-643.. View in PubMed
  • Visit-to-visit blood pressure variability and regional cerebral perfusion decline in older adults. Neurobiol Aging. 2021 09; 105:57-63.. View in PubMed
  • Role of Notch signaling in neurovascular aging and Alzheimer’s disease. Semin Cell Dev Biol. 2021 08; 116:90-97.. View in PubMed
  • Reader Response: Simple MRI Score Aids Prediction of Dementia in Cerebral Small Vessel Disease. Neurology. 2021 01 05; 96(1):39-40.. View in PubMed
  • Antemortem Visit-To-Visit Blood Pressure Variability Predicts Cerebrovascular Lesion Burden in Autopsy-Confirmed Alzheimer’s Disease. J Alzheimers Dis. 2021; 83(1):65-75.. View in PubMed
  • Resting-State Functional Connectivity Signatures of Apathy in Community-Living Older Adults. Front Aging Neurosci. 2021; 13:691710.. View in PubMed
  • Arterial Stiffening Moderates the Relationship Between Type-2 Diabetes Mellitus and White Matter Hyperintensity Burden in Older Adults With Mild Cognitive Impairment. Front Aging Neurosci. 2021; 13:716638.. View in PubMed
  • Increased Levels of Circulating Angiogenic Cells and Signaling Proteins in Older Adults With Cerebral Small Vessel Disease. Front Aging Neurosci. 2021; 13:711784.. View in PubMed
  • A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid. Alzheimers Dement. 2020 06; 16(6):821-830.. View in PubMed
  • APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 2020 05; 581(7806):71-76.. View in PubMed
  • Distilling Heterogeneity of Mild Cognitive Impairment in the National Alzheimer Coordinating Center Database Using Latent Profile Analysis. JAMA Netw Open. 2020 03 02; 3(3):e200413.. View in PubMed
  • APOE4 Accelerates Development of Dementia After Stroke: Is There a Role for Cerebrovascular Dysfunction? Stroke. 2020 03; 51(3):699-700.. View in PubMed
  • Hypertension and Alzheimer’s disease: indirect effects through circle of Willis atherosclerosis. Brain Commun. 2020; 2(2):fcaa114.. View in PubMed
  • Long-Term Blood Pressure Variability Across the Clinical and Biomarker Spectrum of Alzheimer’s Disease. J Alzheimers Dis. 2020; 77(4):1655-1669.. View in PubMed
  • Does Gender Influence the Relationship Between High Blood Pressure and Dementia? Highlighting Areas for Further Investigation. J Alzheimers Dis. 2020; 78(1):23-48.. View in PubMed
  • Brainstem Volumetric Integrity in Preclinical and Prodromal Alzheimer’s Disease. J Alzheimers Dis. 2020; 77(4):1579-1594.. View in PubMed
  • Affective Neuropsychiatric Symptoms as Early Signs of Dementia Risk in Older Adults. J Alzheimers Dis. 2020; 77(3):1195-1207.. View in PubMed
  • Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment. Alzheimers Dement. 2019 12; 15(12):1568-1575.. View in PubMed
  • Importance of Treatment Status in Links Between Type 2 Diabetes and Alzheimer’s Disease. Diabetes Care. 2019 05; 42(5):972-979.. View in PubMed
  • Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat Med. 2019 02; 25(2):270-276.. View in PubMed
  • Neuropsychological Deficit Profiles, Vascular Risk Factors, and Neuropathological Findings in Hispanic Older Adults with Autopsy-Confirmed Alzheimer’s Disease. J Alzheimers Dis. 2019; 67(1):291-302.. View in PubMed
  • Vascular dysfunction-The disregarded partner of Alzheimer’s disease. Alzheimers Dement. 2019 01; 15(1):158-167.. View in PubMed
  • Neuropsychological Decline Improves Prediction of Dementia Beyond Alzheimer’s Disease Biomarker and Mild Cognitive Impairment Diagnoses. J Alzheimers Dis. 2019; 69(4):1171-1182.. View in PubMed
  • Disentangling Heterogeneity in Alzheimer’s Disease: Two Empirically-Derived Subtypes. J Alzheimers Dis. 2019; 70(1):227-239.. View in PubMed
  • Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans. Neurosci Biobehav Rev. 2018 11; 94:49-58.. View in PubMed
  • Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies. Neurosci Biobehav Rev. 2018 09; 92:209-225.. View in PubMed
  • Neuropsychological Profiles and Trajectories in Preclinical Alzheimer’s Disease. J Int Neuropsychol Soc. 2018 08; 24(7):693-702.. View in PubMed
  • Blood Pressure and Cerebral Blood Flow in Alzheimer Disease. Hypertension. 2018 07; 72(1):68-69.. View in PubMed
  • Assessing Working Memory in Mild Cognitive Impairment with Serial Order Recall. J Alzheimers Dis. 2018; 61(3):917-928.. View in PubMed
  • Reduced Regional Cerebral Blood Flow Relates to Poorer Cognition in Older Adults With Type 2 Diabetes. Front Aging Neurosci. 2018; 10:270.. View in PubMed
  • Differential Effect of APOE ɛ4 Status and Elevated Pulse Pressure on Functional Decline in Cognitively Normal Older Adults. J Alzheimers Dis. 2018; 62(4):1567-1578.. View in PubMed
  • Circulating Progenitor Cells Correlate with Memory, Posterior Cortical Thickness, and Hippocampal Perfusion. J Alzheimers Dis. 2018; 61(1):91-101.. View in PubMed
  • Correction to: Detectable Neuropsychological Differences in Early Preclinical Alzheimer’s Disease: a Meta-Analysis. Neuropsychol Rev. 2017 12; 27(4):326-327.. View in PubMed
  • Detectable Neuropsychological Differences in Early Preclinical Alzheimer’s Disease: A Meta-Analysis. Neuropsychol Rev. 2017 12; 27(4):305-325.. View in PubMed
  • Cerebrovascular resistance: effects on cognitive decline, cortical atrophy, and progression to dementia. Brain. 2017 Jul 01; 140(7):1987-2001.. View in PubMed
  • Memory is preserved in older adults taking AT1 receptor blockers. Alzheimers Res Ther. 2017 Apr 26; 9(1):33.. View in PubMed
  • Mechanisms of Memory Dysfunction during High Altitude Hypoxia Training in Military Aircrew. J Int Neuropsychol Soc. 2017 01; 23(1):1-10.. View in PubMed
  • Cerebral Blood Flow and Amyloid-β Interact to Affect Memory Performance in Cognitively Normal Older Adults. Front Aging Neurosci. 2017; 9:181.. View in PubMed
  • Patterns of Cortical and Subcortical Amyloid Burden across Stages of Preclinical Alzheimer’s Disease. J Int Neuropsychol Soc. 2016 11; 22(10):978-990.. View in PubMed
  • Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer’s Disease Pathology. J Alzheimers Dis. 2016 07 06; 53(4):1553-62.. View in PubMed
  • Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-ε4. Alzheimer Dis Assoc Disord. 2016 Jul-Sep; 30(3):210-5.. View in PubMed
  • Brain imaging of neurovascular dysfunction in Alzheimer’s disease. Acta Neuropathol. 2016 May; 131(5):687-707.. View in PubMed
  • Cortical Amyloid Burden Differences Across Empirically-Derived Mild Cognitive Impairment Subtypes and Interaction with APOE ɛ4 Genotype. J Alzheimers Dis. 2016 03 29; 52(3):849-61.. View in PubMed
  • Older Adults Taking AT1-Receptor Blockers Exhibit Reduced Cerebral Amyloid Retention. J Alzheimers Dis. 2016; 50(3):779-89.. View in PubMed
  • Visuoconstructional Impairment in Subtypes of Mild Cognitive Impairment. Appl Neuropsychol Adult. 2016; 23(1):43-52.. View in PubMed
  • Pulse pressure in relation to tau-mediated neurodegeneration, cerebral amyloidosis, and progression to dementia in very old adults. JAMA Neurol. 2015 May; 72(5):546-53.. View in PubMed
  • Susceptibility of the conventional criteria for mild cognitive impairment to false-positive diagnostic errors. Alzheimers Dement. 2015 Apr; 11(4):415-24.. View in PubMed
  • Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer’s disease. Alzheimers Dement. 2015 Apr; 11(4):394-403.e1.. View in PubMed
  • Elevated cerebrovascular resistance index is associated with cognitive dysfunction in the very-old. Alzheimers Res Ther. 2015 01 21; 7(1):3.. View in PubMed
  • White matter integrity in veterans with mild traumatic brain injury: associations with executive function and loss of consciousness. J Head Trauma Rehabil. 2014 Jan-Feb; 29(1):21-32.. View in PubMed
  • Interactive effects of vascular risk burden and advanced age on cerebral blood flow. Front Aging Neurosci. 2014; 6:159.. View in PubMed
  • Neuropsychological syndromes associated with Alzheimer’s/vascular dementia: a latent class analysis. J Alzheimers Dis. 2014; 42(3):999-1014.. View in PubMed
  • Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates. J Alzheimers Dis. 2014; 42(1):275-89.. View in PubMed
  • Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults. Neurology. 2013 Dec 03; 81(23):2024-7.. View in PubMed
  • APOE genotype modifies the relationship between midlife vascular risk factors and later cognitive decline. J Stroke Cerebrovasc Dis. 2013 Nov; 22(8):1361-9.. View in PubMed
  • Are empirically-derived subtypes of mild cognitive impairment consistent with conventional subtypes? J Int Neuropsychol Soc. 2013 Jul; 19(6):635-45.. View in PubMed
  • An accelerometry-based study of lower and upper limb tremor in Parkinson’s disease. J Clin Neurosci. 2013 Jun; 20(6):827-30.. View in PubMed
  • Cortical and subcortical cerebrovascular resistance index in mild cognitive impairment and Alzheimer’s disease. J Alzheimers Dis. 2013; 36(4):689-98.. View in PubMed
  • Posterior cingulum white matter disruption and its associations with verbal memory and stroke risk in mild cognitive impairment. J Alzheimers Dis. 2012; 29(3):589-603.. View in PubMed
  • Antemortem pulse pressure elevation predicts cerebrovascular disease in autopsy-confirmed Alzheimer’s disease. J Alzheimers Dis. 2012; 30(3):595-603.. View in PubMed
  • Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin. Psychosom Med. 2011 Jun; 73(5):393-400.. View in PubMed
  • Stress, exercise, and Alzheimer’s disease: a neurovascular pathway. Med Hypotheses. 2011 Jun; 76(6):847-54.. View in PubMed
  • Altered brain response for semantic knowledge in Alzheimer’s disease. Neuropsychologia. 2011 Feb; 49(3):392-404.. View in PubMed
  • Elevated pulse pressure is associated with age-related decline in language ability. J Int Neuropsychol Soc. 2010 Sep; 16(5):933-8.. View in PubMed
  • Oxytocin attenuates atherosclerosis and adipose tissue inflammation in socially isolated ApoE-/- mice. Psychosom Med. 2010 May; 72(4):376-82.. View in PubMed
  • Subthreshold depression in Parkinson’s disease. Int J Geriatr Psychiatry. 2009 Sep; 24(9):937-43.. View in PubMed
  • Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells. Am J Physiol Endocrinol Metab. 2008 Dec; 295(6):E1495-501.. View in PubMed
  • A questionnaire-based (UM-PDHQ) study of hallucinations in Parkinson’s disease. BMC Neurol. 2008 Jun 20; 8:21.. View in PubMed
  • The effect of social environment on markers of vascular oxidative stress and inflammation in the Watanabe heritable hyperlipidemic rabbit. Psychosom Med. 2008 Apr; 70(3):269-75.. View in PubMed

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