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Darrin Jason Lee, MD, PhD

Associate Professor of Neurological Surgery and Psychiatry and the Behavioral Sciences (Clinical Scholar)

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Email darrinjl@usc.edu
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Awards

  • Brian and Behavior Research Foundation : Brain and Behavior Research Foundation Young Investigator, 2022
  • American Geriatrics Society: Clinician Specialists Rising Star, 2021
  • American Academy of Neurological Surgeons: Emerging Investigator Scholar, 2019-2020
  • American Association of Neurological Surgeons: William P. Van Wagenen Fellow, 2017-2018
  • Howard Hughes Medical Institute: Howard Hughes Medical Institute Fellow, 2007-2008

Publications

  • Human adult neurogenesis loss corresponds with cognitive decline during epilepsy progressionCell Stem Cell. 2025 Feb 06; 32(2):293-301. e3. . View in PubMed
  • Electric field stimulation directs target-specific axon regeneration and partial restoration of vision after optic nerve crush injury PLoS One. 2025; 20(1):e0315562. . View in PubMed
  • Neuromodulation of Eating Disorders: A Review of Underlying Neural Network Activity and Neuromodulatory Treatments Brain Sci. 2024 Feb 22; 14(3). . View in PubMed
  • Theta-frequency medial septal nucleus deep brain stimulation increases neurovascular activity in MK-801-treated mice Front Neurosci. 2024; 18:1372315. . View in PubMed
  • Immediate and long-term electrophysiological biomarkers of antidepressant-like behavioral effects after subanesthetic ketamine and medial prefrontal cortex deep brain stimulation treatment Front Neurosci. 2024; 18:1389096. . View in PubMed
  • Sex differences in regional gray matter density in pre-adolescent binge eating disorder: a voxel-based morphometry study Psychol Med. 2023 10; 53(13):6077-6089. . View in PubMed
  • Aberrant functional connectivity between reward and inhibitory control networks in pre-adolescent binge eating disorder Psychol Med. 2023 07; 53(9):3869-3878. . View in PubMed
  • Deep Brain Stimulation beyond the Clinic: Navigating the Future of Parkinson’s and Alzheimer’s Disease Therapy Cells. 2023 05 25; 12(11). . View in PubMed
  • Developing Predictive Models to Anticipate Shunt Complications in 33,248 Pediatric Patients with Shunted Hydrocephalus Utilizing Machine Learning Pediatr Neurosurg. 2023; 58(4):206-214. . View in PubMed
  • Frequency-specific medial septal nucleus deep brain stimulation improves spatial memory in MK-801-treated male rats Neurobiol Dis. 2022 08; 170:105756. . View in PubMed
  • Early life social instability stress causes lasting cognitive decrement and elevated hippocampal stress-related gene expression Exp Neurol. 2022 08; 354:114099. . View in PubMed
  • A Review of Medical and Surgical Options for the Treatment of Facial Pain Otolaryngol Clin North Am. 2022 Jun; 55(3):607-632. . View in PubMed
  • Preexisting Ventricular Shunts Are Associated with Failed Evacuation of Acute Subdural Hematomas: Single-Institution Case Series of Complications and Management Strategies World Neurosurg. 2022 02; 158:e1011-e1016. . View in PubMed
  • Pathophysiological Mechanisms Underlying Idiopathic Normal Pressure Hydrocephalus: A Review of Recent Insights Front Aging Neurosci. 2022; 14:866313. . View in PubMed
  • Subthreshold repetitive transcranial magnetic stimulation suppresses ketamine-induced poly population spikes in rat sensorimotor cortex Front Neurosci. 2022; 16:998704. . View in PubMed
  • Neuromodulation of OCD: A review of invasive and non-invasive methods Front Neurol. 2022; 13:909264. . View in PubMed
  • Gamified Dual-Task Training for Individuals with Parkinson Disease: An Exploratory Study on Feasibility, Safety, and Efficacy Int J Environ Res Public Health. 2021 11 25; 18(23). . View in PubMed
  • Transcranial magnetic stimulation & the conundrum of concurrent patient activity: Does symptom provocation matter? Psychiatry Res. 2021 11; 305:114249.. View in PubMed
  • Commentary: Application of Augmented Reality in Percutaneous Procedures-Rhizotomy of the Gasserian Ganglion Oper Neurosurg (Hagerstown). 2021 08 16; 21(3):E224-E225. . View in PubMed
  • Acute low frequency dorsal subthalamic nucleus stimulation improves verbal fluency in Parkinson’s disease Brain Stimul. 2021 Jul-Aug; 14(4):754-760. . View in PubMed
  • Gray Matter Atrophy: The Impacts of Resective Surgery and Vagus Nerve Stimulation in Drug-Resistant Epilepsy World Neurosurg. 2021 05; 149:e535-e545. . View in PubMed
  • Cognitive outcomes following vagus nerve stimulation, responsive neurostimulation and deep brain stimulation for epilepsy: A systematic review Epilepsy Res. 2021 05; 172:106591. . View in PubMed
  • Cognitive effects of theta frequency bilateral subthalamic nucleus stimulation in Parkinson’s disease: A pilot study Brain Stimul. 2021 Mar-Apr; 14(2):230-240. . View in PubMed
  • Deep Brain Stimulation for Alzheimer’s Disease: Tackling Circuit Dysfunction Neuromodulation. 2021 Feb; 24(2):171-186. . View in PubMed
  • Nucleus basalis of Meynert neuronal activity in Parkinson’s disease J Neurosurg. 2020 02 01; 132(2):574-582. . View in PubMed
  • In Reply to the Letter to the Editor Regarding “Subdural Catheter Injection of Tissue Plasminogen Activator for Residual Hematoma Post Drainage of Acute-on-Chronic Subdural Hematoma: Novel Case Report of 2 Patients” World Neurosurg. 2020 02; 134:681. . View in PubMed
  • Subdural Catheter Injection of Tissue Plasminogen Activator for Residual Hematoma Post Drainage of Acute-on-Chronic Subdural Hematoma: Novel Case Report of 2 Patients World Neurosurg. 2020 Jan; 133:266-270. . View in PubMed
  • Current and future directions of deep brain stimulation for neurological and psychiatric disorders J Neurosurg. 2019 08 01; 131(2):333-342. . View in PubMed
  • Medial septal stimulation increases seizure threshold and improves cognition in epileptic rats Brain Stimul. 2019 May – Jun; 12(3):735-742. . View in PubMed
  • Successful pallidotomy for post-hyperglycemic hemichorea-ballism Parkinsonism Relat Disord. 2019 04; 61:228-230. . View in PubMed
  • Outcomes from stereotactic surgery for essential tremor J Neurol Neurosurg Psychiatry. 2019 04; 90(4):474-482. . View in PubMed
  • Corrigendum to ‘Reoperation for Symptomatic Nonunions in Atlantoaxial (C1-C2) Fusions with and without Bone Morphogenetic Protein: A Cohort of 108 Patients with >2 Years Follow-Up’ [World Neurosurgery 121 (2019) e458-e466] World Neurosurg. 2019 03; 123:476. . View in PubMed
  • Inferior thalamic peduncle deep brain stimulation for treatment-refractory obsessive-compulsive disorder: A phase 1 pilot trial Brain Stimul. 2019 Mar – Apr; 12(2):344-352. . View in PubMed
  • Deep brain stimulation for pantothenate kinase-associated neurodegeneration: A meta-analysis Mov Disord. 2019 02; 34(2):264-273. . View in PubMed
  • Ultra-high-frequency deep brain stimulation at 10,000 Hz improves motor function Mov Disord. 2019 01; 34(1):146-148. . View in PubMed
  • Deep brain stimulation: potential for neuroprotection Ann Clin Transl Neurol. 2019 01; 6(1):174-185. . View in PubMed
  • Long-term results after deep brain stimulation of nucleus accumbens and the anterior limb of the internal capsule for preventing heroin relapse: An open-label pilot study Brain Stimul. 2019 Jan – Feb; 12(1):175-183. . View in PubMed
  • Reoperation for Symptomatic Nonunions in Atlantoaxial (C1-C2) Fusions with and without Bone Morphogenetic Protein: A Cohort of 108 Patients with >2 Years Follow-Up World Neurosurg. 2019 Jan; 121:e458-e466. . View in PubMed
  • Long-term relief of intractable hiccups with vagal nerve stimulation Brain Stimul. 2018 Nov – Dec; 11(6):1385-1387. . View in PubMed
  • Current surgical treatments for Parkinson’s disease and potential therapeutic targets Neural Regen Res. 2018 Aug; 13(8):1342-1345. . View in PubMed
  • Neuromodulation for the treatment of eating disorders and obesity Ther Adv Psychopharmacol. 2018 Feb; 8(2):73-92. . View in PubMed
  • Pallidal deep brain stimulation modulates cortical excitability and plasticity Ann Neurol. 2018 02; 83(2):352-362. . View in PubMed
  • Cervical spine fractures in osteopetrosis: a case report and review of the literature J Biomed Res. 2018 Jan 18; 32(1):68-76. . View in PubMed
  • Current Status of Deep Brain Stimulation for Alzheimer’s Disease: From Chance Observation to Clinical Trials Cold Spring Harb Symp Quant Biol. 2018; 83:201-205. . View in PubMed
  • Toward a Neuroscience of Adult Cognitive Developmental Theory Front Neurosci. 2018; 12:4. . View in PubMed
  • Review of the Neural Oscillations Underlying Meditation Front Neurosci. 2018; 12:178. . View in PubMed
  • The Future of Surgical Treatments for Parkinson’s Disease J Parkinsons Dis. 2018; 8(s1):S79-S83. . View in PubMed
  • Intradural Chordoma of Cerebellopontine Angle: Case Report and ReviewWorld Neurosurg. 2017 Nov; 107:1052. e11-1052. e16. . View in PubMed
  • Effect of Stereoscopic Anaglyphic 3-Dimensional Video Didactics on Learning Neuroanatomy World Neurosurg. 2017 Nov; 107:35-39. . View in PubMed
  • Mycobacterium Genavense Granuloma Mimicking a Brain Tumor: A Case Report Cureus. 2017 Aug 07; 9(8):e1547. . View in PubMed
  • Temporary stabilization of unstable spine fractures Curr Rev Musculoskelet Med. 2017 Jun; 10(2):199-206. . View in PubMed
  • Stimulation of the medial septum improves performance in spatial learning following pilocarpine-induced status epilepticus Epilepsy Res. 2017 02; 130:53-63. . View in PubMed
  • Management and outcome of spontaneous cerebral venous sinus thrombosis in a 5-year consecutive single-institution cohort J Neurointerv Surg. 2017 Jan; 9(1):34-38. . View in PubMed
  • Cost Utility Analysis of the Cervical Artificial Disc vs Fusion for the Treatment of 2-Level Symptomatic Degenerative Disc Disease: 5-Year Follow-up Neurosurgery. 2016 Jul; 79(1):135-45. . View in PubMed
  • Stereotactic guidance for navigated percutaneous sacroiliac joint fusion J Biomed Res. 2016 Mar; 30(2):162-167. . View in PubMed
  • Making Waves in the Brain: What Are Oscillations, and Why Modulating Them Makes Sense for Brain Injury Front Syst Neurosci. 2016; 10:30. . View in PubMed
  • Septohippocampal Neuromodulation Improves Cognition after Traumatic Brain Injury J Neurotrauma. 2015 Nov 15; 32(22):1822-32. . View in PubMed
  • Dysphagia Secondary to Anterior Osteophytes of the Cervical Spine Global Spine J. 2015 Oct; 5(5):e78-83. . View in PubMed
  • Commentary on: “Postoperative Shingles Mimicking Recurrent Radiculopathy after Anterior Cervical Diskectomy and Fusion” Global Spine J. 2015 Jun; 5(3):224. . View in PubMed
  • Antegrade rheolytic thrombectomy and thrombolysis for superior sagittal sinus thrombosis using burr hole access J Neurointerv Surg. 2015 Mar; 7(3):e11. . View in PubMed
  • Intraoperative computed tomography for intracranial electrode implantation surgery in medically refractory epilepsy J Neurosurg. 2015 Mar; 122(3):526-31. . View in PubMed
  • Intradural extramedullary capillary hemangioma of the cauda equina: Case report and literature review Surg Neurol Int. 2015; 6(Suppl 3):S127-31. . View in PubMed
  • Intracerebroventricular opiate infusion for refractory head and facial pain World J Clin Cases. 2014 Aug 16; 2(8):351-6. . View in PubMed
  • Antegrade rheolytic thrombectomy and thrombolysis for superior sagittal sinus thrombosis using burr hole access BMJ Case Rep. 2014 Apr 01; 2014. . View in PubMed
  • A comparative study of human and rat hippocampal low-frequency oscillations during spatial navigation Hippocampus. 2013 Aug; 23(8):656-661. . View in PubMed
  • Medial septal nucleus theta frequency deep brain stimulation improves spatial working memory after traumatic brain injury J Neurotrauma. 2013 Jan 15; 30(2):131-9. . View in PubMed
  • Frontal bur hole through an eyebrow incision for image-guided endoscopic evacuation of spontaneous intracerebral hemorrhage J Neurosurg. 2012 Oct; 117(4):767-73. . View in PubMed
  • Decreased expression of the glial water channel aquaporin-4 in the intrahippocampal kainic acid model of epileptogenesis Exp Neurol. 2012 May; 235(1):246-55. . View in PubMed
  • Aquaporin-4-dependent edema clearance following status epilepticus Epilepsy Res. 2012 Feb; 98(2-3):264-8. . View in PubMed
  • Robert Bentley Todd’s contribution to cell theory and the neuron doctrine J Hist Neurosci. 2011 Apr; 20(2):123-34. . View in PubMed
  • Characterization of inpatient moyamoya in the United States: 1988-2004 Front Neurol. 2011; 2:43. . View in PubMed
  • Factors predicting language lateralization in patients with perisylvian vascular malformationsClinical article. J Neurosurg. 2010 Oct; 113(4):723-30. . View in PubMed
  • Isolated amygdala neurocysticercosis in a patient presenting with déjà vu and olfactory aurasCase report. J Neurosurg Pediatr. 2009 Jun; 3(6):538-41. . View in PubMed
  • Intra-arterial calcium channel blocker infusion for treatment of severe vasospasm in traumatic brain injury: case report Neurosurgery. 2008 Nov; 63(5):E1004-6; discussion E1006. . View in PubMed
  • An algorithm for extracting intracranial pressure latency relative to electrocardiogram R wave Physiol Meas. 2008 Apr; 29(4):459-71. . View in PubMed
  • Morphological changes of intracranial pressure pulses are correlated with acute dilatation of ventricles Acta Neurochir Suppl. 2008; 102:131-6. . View in PubMed
  • Mathematical models of cerebral hemodynamics for detection of vasospasm in major cerebral arteries Acta Neurochir Suppl. 2008; 102:63-9. . View in PubMed
  • Potential role of the glial water channel aquaporin-4 in epilepsy Neuron Glia Biol. 2007 Nov; 3(4):287-97. . View in PubMed
  • Microinfusion into the rat brain of antibodies against Semliki Forest Virus produces changes in behavioral response to apomorphine J Neuroimmunol. 2007 Mar; 184(1-2):149-55. . View in PubMed

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