Darryl Shibata, MD

Professor of Pathology

Vice Chair of Academic Affairs, Department of Pathology,

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Overview

After attending UCLA for his undergraduate degree, Dr. Shibata obtained his medical degree from the Keck School of Medicine of USC. After completing his internship training in pediatrics from UC San Diego, Dr. Shibata returned to USC for his residency and fellowship at LAC+USC Medical Center. Currently, Dr. Shibata has clinical appointments at both LAC+USC Medical Center and USC/Norris Comprehensive Cancer Center. In addition to his wide array of responsibilities in the research, education and practitioner capacities, Dr. Shibata sits on the editorial board of the BMC Cancer Journal and the American Journal of Pathology.

Publications

  • Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life bioRxiv. 2024 Mar 05. . View in PubMed
  • Editorial Expression of Concern: Adenomatous polyposis coli (APC) regulates miR17-92 cluster through ß-catenin pathway in colorectal cancer Oncogene. 2024 Feb 20. . View in PubMed
  • Testing Adaptive Therapy Protocols Using Gemcitabine and Capecitabine in a Preclinical Model of Endocrine-Resistant Breast Cancer Cancers (Basel). 2024 Jan 06; 16(2). . View in PubMed
  • Growth Dynamics of Ductal Carcinoma in Situ Recapitulate Normal Breast Development bioRxiv. 2023 Oct 02. . View in PubMed
  • Testing Adaptive Therapy Protocols using Gemcitabine and Capecitabine on a Mouse Model of Endocrine-Resistant Breast Cancer bioRxiv. 2023 Sep 22. . View in PubMed
  • The co-evolution of the genome and epigenome in colorectal cancer Nature. 2022 11; 611(7937):733-743. . View in PubMed
  • Phenotypic plasticity and genetic control in colorectal cancer evolution Nature. 2022 11; 611(7937):744-753. . View in PubMed
  • Lineage tracing in human tissues J Pathol. 2022 07; 257(4):501-512. . View in PubMed
  • Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues Nat Biotechnol. 2022 05; 40(5):720-730. . View in PubMed
  • Gattaca: Base-Pair Resolution Mutation Tracking for Somatic Evolution Studies using Agent-based Models Mol Biol Evol. 2022 04 11; 39(4). . View in PubMed
  • Homeostasis limits keratinocyte evolution Proc Natl Acad Sci U S A. 2022 08 30; 119(35):e2006487119. . View in PubMed
  • A Bayesian hierarchical model to estimate DNA methylation conservation in colorectal tumors Bioinformatics. 2021 12 22; 38(1):22-29. . View in PubMed
  • Functional human genes typically exhibit epigenetic conservation PLoS One. 2021; 16(9):e0253250. . View in PubMed
  • Visualizing Human Colorectal Cancer Intratumor Heterogeneity with Phylogeography iScience. 2020 Jul 24; 23(7):101304. . View in PubMed
  • Navigating the path to distant metastasis Nat Genet. 2020 07; 52(7):642-643. . View in PubMed
  • Epigenetic Conservation Is a Beacon of Function: An Analysis Using Methcon5 Software for Studying Gene Methylation JCO Clin Cancer Inform. 2020 02; 4:100-107. . View in PubMed
  • Minimal barriers to invasion during human colorectal tumor growth Nat Commun. 2020 03 09; 11(1):1280. . View in PubMed
  • Deep learned tissue “fingerprints” classify breast cancers by ER/PR/Her2 status from H&E images Sci Rep. 2020 04 29; 10(1):7275. . View in PubMed
  • Mutational signatures in colon cancer BMC Res Notes. 2019 Dec 03; 12(1):788. . View in PubMed
  • Tumorigenesis as the Paradigm of Quasi-neutral Molecular Evolution Mol Biol Evol. 2019 07 01; 36(7):1430-1441. . View in PubMed
  • Cancer cell evolution through the ages Science. 2019 08 02; 365(6452):440-441. . View in PubMed
  • Somatic cell evolution: how to improve with age J Pathol. 2019 Jan; 247(1):3-5. . View in PubMed
  • HiLDA: a statistical approach to investigate differences in mutational signatures PeerJ. 2019; 7:e7557. . View in PubMed
  • Evolutionary Stem Cell Poker and Cancer Risks: The Paradox of The Large And Small Intestines Curr Pathobiol Rep. 2018 Sep; 6(3):193-198. . View in PubMed
  • Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance Sci Rep. 2018 11 23; 8(1):17292. . View in PubMed
  • Spatial mutation patterns as markers of early colorectal tumor cell mobility Proc Natl Acad Sci U S A. 2018 05 29; 115(22):5774-5779. . View in PubMed
  • Management and outcomes following pancreaticoduodenectomy for ampullary adenocarcinoma Am J Surg. 2017 Nov; 214(5):856-861. . View in PubMed
  • Between-region genetic divergence reflects the mode and tempo of tumor evolution Nat Genet. 2017 Jul; 49(7):1015-1024. . View in PubMed
  • Classifying the evolutionary and ecological features of neoplasms Nat Rev Cancer. 2017 10; 17(10):605-619. . View in PubMed
  • Early mutation bursts in colorectal tumors PLoS One. 2017; 12(3):e0172516. . View in PubMed
  • At least two well-spaced samples are needed to genotype a solid tumor BMC Cancer. 2016 Mar 25; 16:250. . View in PubMed
  • HistoMosaic Detecting KRAS G12V Mutation Across Colorectal Cancer Tissue Slices through in Situ PCR Anal Chem. 2016 Mar 01; 88(5):2792-8. . View in PubMed
  • Synchronous rectal adenocarcinoma and splenic marginal zone lymphoma Curr Oncol. 2016 Feb; 23(1):e70-4. . View in PubMed
  • Single cell lineage tracing reveals a role for TgfßR2 in intestinal stem cell dynamics and differentiation Proc Natl Acad Sci U S A. 2016 10 25; 113(43):12192-12197. . View in PubMed
  • Many private mutations originate from the first few divisions of a human colorectal adenoma J Pathol. 2015 Nov; 237(3):355-62. . View in PubMed
  • Derivation of induced pluripotent stem cells from orangutan skin fibroblasts BMC Res Notes. 2015 Oct 16; 8:577. . View in PubMed
  • Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities Stem Cell Res Ther. 2015 Aug 29; 6:158. . View in PubMed
  • Nat Rev Clin Oncol. 2015 May; 12(5):273-85. . View in PubMed
  • A Big Bang model of human colorectal tumor growth Nat Genet. 2015 Mar; 47(3):209-16. . View in PubMed
  • Diffuse large B-cell lymphoma of germinal center and nongerminal center phenotypes presenting concurrently at the same anatomic site: intratumoral heterogeneity or composite lymphoma? Appl Immunohistochem Mol Morphol. 2015 Jan; 23(1):78-80.. View in PubMed
  • Ancestral inference in tumors: how much can we know? J Theor Biol. 2014 Oct 21; 359:136-45.. View in PubMed
  • Deep sequencing reveals lack of a clonal relationship between a metachronous classical hodgkin and diffuse large B-cell lymphoma Clin Lymphoma Myeloma Leuk. 2014 Jun; 14(3):e87-93. . View in PubMed
  • Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention Carcinogenesis. 2014 Jan; 35(1):237-46. . View in PubMed
  • miR-675 mediates downregulation of Twist1 and Rb in AFP-secreting hepatocellular carcinoma Ann Surg Oncol. 2013 Dec; 20 Suppl 3:S625-35. . View in PubMed
  • Direct measurements of human colon crypt stem cell niche genetic fidelity: the role of chance in non-darwinian mutation selection Front Oncol. 2013 Oct 14; 3:264. . View in PubMed
  • Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer Science. 2013 Feb 01; 339(6119):543-8. . View in PubMed
  • Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization Cancer Res. 2013 Jan 01; 73(1):41-9. . View in PubMed
  • The gene expression profiles of induced pluripotent stem cells from individuals with childhood cerebral adrenoleukodystrophy are consistent with proposed mechanisms of pathogenesis Stem Cell Res Ther. 2012 Oct 04; 3(5):39. . View in PubMed
  • Heterogeneity and randomness of DNA methylation patterns in human embryonic stem cells DNA Cell Biol. 2012 Jun; 31(6):893-907. . View in PubMed
  • The role of theorem proving in systems biology J Theor Biol. 2012 May 07; 300:57-61. . View in PubMed
  • CancerHeterogeneity and tumor history. Science. 2012 Apr 20; 336(6079):304-5. . View in PubMed
  • Different phenotypic consequences of simultaneous versus stepwise Apc loss Oncogene. 2012 Apr 19; 31(16):2028-38. . View in PubMed
  • Molecular tumor clocks to study the evolution of drug resistance Mol Pharm. 2011 Dec 05; 8(6):2050-4. . View in PubMed
  • Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice Carcinogenesis. 2011 Jun; 32(6):829-35. . View in PubMed
  • Mutation and epigenetic molecular clocks in cancer Carcinogenesis. 2011 Feb; 32(2):123-8. . View in PubMed
  • A stem cell niche dominance theorem BMC Syst Biol. 2011 Jan 08; 5:4. . View in PubMed
  • High DNA methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers PLoS One. 2011; 6(6):e21657. . View in PubMed
  • Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors PLoS One. 2011; 6(10):e25985. . View in PubMed
  • Using DNA methylation patterns to infer tumor ancestry PLoS One. 2010 Aug 09; 5(8):e12002. . View in PubMed
  • Is there any genetic instability in human cancer? DNA Repair (Amst). 2010 Aug 05; 9(8):858; discussion 859-60.. View in PubMed
  • Hormone therapy, DNA methylation and colon cancer Carcinogenesis. 2010 Jun; 31(6):1060-7. . View in PubMed
  • Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations J Cell Biochem. 2010 Mar 01; 109(4):818-27. . View in PubMed
  • A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates BMC Cancer. 2010 Jan 05; 10:3. . View in PubMed
  • A stem cell niche dominance theorem J Stem Cells Regen Med. 2010; 6(2):98. . View in PubMed
  • Systems biologists seek fuller integration of systems biology approaches in new cancer research programs Cancer Res. 2010 Jan 01; 70(1):12-3. . View in PubMed
  • Many colorectal cancers are “flat” clonal expansions Cell Cycle. 2009 Jul 15; 8(14):2187-93. . View in PubMed
  • Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4828-33. . View in PubMed
  • Urinary tract infections and reduced risk of bladder cancer in Los Angeles Br J Cancer. 2009 Mar 10; 100(5):834-9. . View in PubMed
  • Older individuals appear to acquire mitotically older colorectal cancers J Pathol. 2009 Mar; 217(4):483-8. . View in PubMed
  • Inferring human stem cell behaviour from epigenetic drift J Pathol. 2009 Jan; 217(2):199-205. . View in PubMed
  • Water intake and bladder cancer risk in Los Angeles County Int J Cancer. 2008 Oct 01; 123(7):1649-56. . View in PubMed
  • Inferring relative numbers of human leucocyte genome replications Br J Haematol. 2008 Jun; 141(6):862-71. . View in PubMed
  • Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice J Transl Med. 2008 May 19; 6:26. . View in PubMed
  • Unregulated smooth-muscle myosin in human intestinal neoplasia Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5513-8. . View in PubMed
  • Tractable Cre-lox system for stochastic alteration of genes in mice Nat Methods. 2008 Mar; 5(3):227-9. . View in PubMed
  • Mistakes make history: visualizing intestinal tectonics Gastroenterology. 2008 Feb; 134(2):628-31. . View in PubMed
  • Ancestral trees for modeling stem cell lineages genetically rather than functionally: understanding mutation accumulation and distinguishing the restrictive cancer stem cell propagation theory and the unrestricted cell propagation theory of human tumorigenesis Breast Dis. 2008; 29:15-25. . View in PubMed
  • Modeling DNA methylation in a population of cancer cells Stat Appl Genet Mol Biol. 2008; 7(1):Article 18. . View in PubMed
  • Stem cells as common ancestors in a colorectal cancer ancestral tree Curr Opin Gastroenterol. 2008 Jan; 24(1):59-63. . View in PubMed
  • The fuzzy math of solid tumor stem cells: a perspective Cancer Res. 2007 Oct 01; 67(19):8985-8. . View in PubMed
  • Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging BMC Med Genet. 2007 Jul 31; 8:50. . View in PubMed
  • The stem cell population of the human colon crypt: analysis via methylation patterns PLoS Comput Biol. 2007 Mar 02; 3(3):e28. . View in PubMed
  • IL-12 facilitates both the recovery of endogenous hematopoiesis and the engraftment of stem cells after ionizing radiation Exp Hematol. 2007 Feb; 35(2):203-13. . View in PubMed
  • Stem cell chronicles: autobiographies within genomes Stem Cell Rev. 2007 Jan; 3(1):94-103. . View in PubMed
  • Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statementSociety of Surgical Oncology. Ann Surg Oncol. 2007 Jan; 14(1):128-33. . View in PubMed
  • Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice Cancer Res. 2006 Sep 01; 66(17):8430-8. . View in PubMed
  • Clonal diversity in tumor progression Nat Genet. 2006 Apr; 38(4):402-3. . View in PubMed
  • Counting divisions in a human somatic cell tree: how, what and why? Cell Cycle. 2006 Mar; 5(6):610-4.. View in PubMed
  • Human hair genealogies and stem cell latency BMC Biol. 2006 Feb 03; 4:2. . View in PubMed
  • When does MMR loss occur during HNPCC progression? Cancer Biomark. 2006; 2(1-2):29-35.. View in PubMed
  • Counting human somatic cell replications: methylation mirrors endometrial stem cell divisions Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17739-44. . View in PubMed
  • Numbers of mutations to different types of colorectal cancer BMC Cancer. 2005 Oct 03; 5:126. . View in PubMed
  • Diethylstilbestrol effects and lymphomagenesis in Mlh1-deficient mice Int J Cancer. 2005 Jul 01; 115(4):666-9. . View in PubMed
  • Age-related human small intestine methylation: evidence for stem cell niches BMC Med. 2005 Jun 23; 3:10. . View in PubMed
  • Stability of colon stem cell methylation after neo-adjuvant therapy in a patient with attenuated familial adenomatous polyposis BMC Gastroenterol. 2005 Jun 07; 5:19. . View in PubMed
  • Generation and characterization of endonuclease G null mice Mol Cell Biol. 2005 Jan; 25(1):294-302. . View in PubMed
  • Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors Cancer Res. 2004 May 01; 64(9):3096-102. . View in PubMed
  • Colorectal pretumor progression before and after loss of DNA mismatch repair Am J Pathol. 2004 Apr; 164(4):1447-53. . View in PubMed
  • Pretumor progression: clonal evolution of human stem cell populations Am J Pathol. 2004 Apr; 164(4):1337-46. . View in PubMed
  • Enhanced stem cell survival in familial adenomatous polyposis Am J Pathol. 2004 Apr; 164(4):1369-77. . View in PubMed
  • Tracing ancestry with methylation patterns: most crypts appear distantly related in normal adult human colon BMC Gastroenterol. 2004 Apr 01; 4:8. . View in PubMed
  • In vitro mutation artifacts after formalin fixation and error prone translesion synthesis during PCR BMC Clin Pathol. 2004 Feb 12; 4(1):1. . View in PubMed
  • The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants DNA Repair (Amst). 2002 Dec 05; 1(12):1017-26. . View in PubMed
  • Molecular tumour clocks and colorectal cancer: seeing the unseen Pathology. 2002 Dec; 34(6):534-40. . View in PubMed
  • Methylation reveals a niche: stem cell succession in human colon crypts Oncogene. 2002 Aug 12; 21(35):5441-9. . View in PubMed
  • DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair Mol Cell Biol. 2002 May; 22(9):2906-17. . View in PubMed
  • PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper Am J Pathol. 2002 Apr; 160(4):1503-6. . View in PubMed
  • Low-level microsatellite instability in most colorectal carcinomas Cancer Res. 2002 Feb 15; 62(4):1166-70. . View in PubMed
  • Dietary heterocyclic amines and microsatellite instability in colon adenocarcinomas Carcinogenesis. 2001 Oct; 22(10):1681-4. . View in PubMed
  • Global and gene-specific epigenetic patterns in human bladder cancer genomes are relatively stable in vivo and in vitro over time Cancer Res. 2001 Aug 01; 61(15):5875-84. . View in PubMed
  • Mismatch repair deficiency and CpG island hypermethylation in sporadic colon adenocarcinomas Cancer Epidemiol Biomarkers Prev. 2001 Jul; 10(7):799-803. . View in PubMed
  • Stepwise deletions of polyA sequences in mismatch repair-deficient colorectal cancers Am J Pathol. 2001 May; 158(5):1867-70. . View in PubMed
  • Talking tumours: histories from sequences Ann Med. 2001 Mar; 33(2):148-52. . View in PubMed
  • Genetic predisposition and somatic diversification in tumor development and progression Adv Cancer Res. 2001; 80:83-114. . View in PubMed
  • The SURF Technique : Selective Genetic Analysis of Microscopic Tissue Heterogeneity Methods Mol Med. 2001; 50:59-67. . View in PubMed
  • Bladder cancer genotype stability during clinical progression Genes Chromosomes Cancer. 2000 Sep; 29(1):26-32. . View in PubMed
  • MethyLight: a high-throughput assay to measure DNA methylation Nucleic Acids Res. 2000 Apr 15; 28(8):E32. . View in PubMed
  • Heterozygous DNA mismatch repair gene PMS2-knockout mice are susceptible to intestinal tumor induction with N-methyl-N-nitrosourea Carcinogenesis. 2000 Apr; 21(4):833-8. . View in PubMed
  • Characteristics and pitfalls of contrast-enhanced, T1-weighted magnetization transfer images of the brain Acad Radiol. 2000 Mar; 7(3):156-64. . View in PubMed
  • Genetic reconstruction of individual colorectal tumor histories Proc Natl Acad Sci U S A. 2000 Feb 01; 97(3):1236-41. . View in PubMed
  • Clinical significance of p53 mutations in adenocarcinoma of the esophagus and cardia Ann Surg. 2000 Feb; 231(2):179-87. . View in PubMed
  • Transjugular intrahepatic portosystemic shunt for treatment of bleeding ectopic varices with portal hypertension Dis Colon Rectum. 1999 Dec; 42(12):1581-5. . View in PubMed
  • Epstein-Barr virus (EBV) nuclear antigen (EBNA)-4 mutation in EBV-associated malignancies in three different populations Am J Pathol. 1999 Sep; 155(3):941-7. . View in PubMed
  • Colorectal adenoma and cancer divergenceEvidence of multilineage progression. Am J Pathol. 1999 Jun; 154(6):1815-24. . View in PubMed
  • Complementation of plant mutants with large genomic DNA fragments by a transformation-competent artificial chromosome vector accelerates positional cloning Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6535-40. . View in PubMed
  • FILAMENTOUS FLOWER, a meristem and organ identity gene of Arabidopsis, encodes a protein with a zinc finger and HMG-related domains Genes Dev. 1999 May 01; 13(9):1079-88. . View in PubMed
  • Loss of function of Trp53, but not Apc, leads to the development of esophageal adenocarcinoma in mice with jejunoesophageal reflux J Surg Res. 1999 May 01; 83(1):48-55. . View in PubMed
  • Pattern recognition and arrays: the times are a-changing Am J Pathol. 1999 Apr; 154(4):979-80. . View in PubMed
  • Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture Am J Pathol. 1998 Oct; 153(4):1189-200. . View in PubMed
  • Epstein-Barr virus-associated nuclear antigen-1 carboxy-terminal gene sequences in Japanese and American patients with gastric carcinoma Lab Invest. 1998 Jul; 78(7):877-82. . View in PubMed
  • Overexpression of pp60c-src elicits invasive behavior in rat colon epithelial cells Gastroenterology. 1998 Jun; 114(6):1287-95. . View in PubMed
  • Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice Cancer Res. 1998 Mar 15; 58(6):1087-9. . View in PubMed
  • Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair Nat Genet. 1998 Mar; 18(3):276-9. . View in PubMed
  • The SURF techniqueSelective genetic analysis of microscopic tissue heterogeneity. Methods Mol Biol. 1998; 92:39-47. . View in PubMed
  • The dynamics of early intestinal tumour proliferation: to be or not to be Cancer Surv. 1998; 32:181-200. . View in PubMed
  • Molecular tumor clocks and dynamic phenotype Am J Pathol. 1997 Sep; 151(3):643-6. . View in PubMed
  • Intestinal stem cell division and genetic diversityA computer and experimental analysis. Am J Pathol. 1997 Aug; 151(2):573-9. . View in PubMed
  • DNA mismatch repair in mammals: role in disease and meiosis Curr Opin Genet Dev. 1997 Jun; 7(3):364-70. . View in PubMed
  • Telomerase activity in normal and neoplastic breast Clin Cancer Res. 1997 Apr; 3(4):627-31. . View in PubMed
  • Molecular tumour clocks Ann Med. 1997 Feb; 29(1):5-7. . View in PubMed
  • Microsatellite instability is rare in B-cell non-Hodgkin’s lymphomas Blood. 1997 Feb 01; 89(3):975-9. . View in PubMed
  • Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis Nat Genet. 1997 Jan; 15(1):87-90. . View in PubMed
  • The DCC protein and prognosis in colorectal cancer N Engl J Med. 1996 Dec 05; 335(23):1727-32. . View in PubMed
  • Loss of DNA mismatch repair: life in the fast lane? Gastroenterology. 1996 Aug; 111(2):519-21.. View in PubMed
  • Epstein-Barr virus and gastric carcinoma Jpn J Cancer Res. 1996 Aug; 87(8):Inside front cover. . View in PubMed
  • Somatic microsatellite mutations as molecular tumor clocks Nat Med. 1996 Jun; 2(6):676-81. . View in PubMed
  • Effects of mutation and growth rates on patterns of microsatellite instability Am J Pathol. 1996 Jun; 148(6):1757-61. . View in PubMed
  • Telomerase activity is commonly detected in hereditary nonpolyposis colorectal cancers Am J Pathol. 1996 Apr; 148(4):1075-9. . View in PubMed
  • Human papillomavirus investigation of patients with cervical intraepithelial neoplasia 3, some of whom progressed to invasive cancer Int J Gynecol Pathol. 1996 Apr; 15(2):127-30. . View in PubMed
  • High-dose chemotherapy and autologous bone marrow plus peripheral blood stem cell transplantation for patients with lymphoma or metastatic breast cancer: use of marker genes to investigate hematopoietic reconstitution in adults Hum Gene Ther. 1996 Mar 20; 7(5):669-84. . View in PubMed
  • Role of zidovudine antiretroviral therapy in the pathogenesis of acquired immunodeficiency syndrome-related lymphoma Blood. 1995 Dec 15; 86(12):4612-6. . View in PubMed
  • Somatic mitochondrial mutation in gastric cancer Am J Pathol. 1995 Oct; 147(4):1105-11. . View in PubMed
  • Heterogeneity in intratumor distribution of p53 mutations in human prostate cancer Am J Pathol. 1995 Jul; 147(1):92-101. . View in PubMed
  • Nodal benign and malignant monocytoid B cells with and without follicular lymphomas: a comparative study of follicular colonization, light chain restriction, bcl-2, and t(14;18) in 39 cases Hum Pathol. 1995 Jun; 26(6):625-32. . View in PubMed
  • Elevated antibody titers to Epstein-Barr virus prior to the diagnosis of Epstein-Barr-virus-associated gastric adenocarcinoma Int J Cancer. 1995 Mar 03; 60(5):642-4. . View in PubMed
  • Concordance for Hodgkin’s disease in identical twins suggesting genetic susceptibility to the young-adult form of the disease N Engl J Med. 1995 Feb 16; 332(7):413-8. . View in PubMed
  • Epstein-Barr virus-associated non-Hodgkin’s lymphoma in HIV-infected patients Leuk Lymphoma. 1995 Jan; 16(3-4):217-21. . View in PubMed
  • Patterns of p53 mutations in squamous cell carcinoma of the lungAcquisition at a relatively early age. Am J Pathol. 1994 Dec; 145(6):1444-9. . View in PubMed
  • Follicular small lymphocytic lymphoma Am J Surg Pathol. 1994 Oct; 18(10):999-1009. . View in PubMed
  • BCL2 translocation frequency rises with age in humans Proc Natl Acad Sci U S A. 1994 Sep 13; 91(19):8910-4. . View in PubMed
  • Biologic aspects of AIDS-related lymphoma Curr Opin Oncol. 1994 Sep; 6(5):503-7. . View in PubMed
  • Further evidence that one of the earliest alterations in colorectal carcinogenesis involves APC Am J Pathol. 1994 Sep; 145(3):531-4. . View in PubMed
  • p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail Cancer Res. 1994 Sep 01; 54(17):4750-5. . View in PubMed
  • Microsatellite instability in sporadic endometrial carcinoma J Natl Cancer Inst. 1994 Aug 17; 86(16):1216-21. . View in PubMed
  • Rearrangements of the BCL-6 gene in acquired immunodeficiency syndrome-associated non-Hodgkin’s lymphoma: association with diffuse large-cell subtype Blood. 1994 Jul 15; 84(2):397-402. . View in PubMed
  • Mutations in the coding region of c-MYC in AIDS-associated and other aggressive lymphomas Cancer Res. 1994 Jul 01; 54(13):3383-6. . View in PubMed
  • Extraction of DNA from paraffin-embedded tissue for analysis by polymerase chain reaction: new tricks from an old friend Hum Pathol. 1994 Jun; 25(6):561-3. . View in PubMed
  • Early mutational activation of the c-Ki-ras oncogene in endometrial carcinoma Cancer Res. 1994 Mar 15; 54(6):1604-7. . View in PubMed
  • Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation Nat Genet. 1994 Mar; 6(3):273-81. . View in PubMed
  • Incidence of Epstein-Barr virus bcl-2 expression and chromosomal translocation t(14;18) in large cell lymphoma associated with paragranuloma (lymphocyte-predominant Hodgkin’s disease) Hum Pathol. 1994 Mar; 25(3):240-3. . View in PubMed
  • A novel lipoxygenase from ricePrimary structure and specific expression upon incompatible infection with rice blast fungus. J Biol Chem. 1994 Feb 04; 269(5):3755-61. . View in PubMed
  • c-k-ras and p53 mutations occur very early in adenocarcinoma of the lung Am J Pathol. 1994 Feb; 144(2):303-9. . View in PubMed
  • Anatomical distribution of HTLV-I proviral sequence in an autopsy case of HTLV-I associated myelopathy: a polymerase chain reaction study Pathol Int. 1994 Jan; 44(1):27-33. . View in PubMed
  • Selective ultraviolet radiation fractionation and polymerase chain reaction analysis of genetic alterations Am J Pathol. 1993 Dec; 143(6):1523-6. . View in PubMed
  • Identification of mismatched fixed specimens with a commercially available kit based on the polymerase chain reaction Am J Clin Pathol. 1993 Dec; 100(6):666-70. . View in PubMed
  • Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas J Natl Cancer Inst. 1993 Jul 07; 85(13):1058-63. . View in PubMed
  • Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis Nature. 1993 Jun 10; 363(6429):558-61. . View in PubMed
  • Epstein-Barr virus-associated gastric adenocarcinoma among Japanese Americans in Hawaii Cancer Epidemiol Biomarkers Prev. 1993 May-Jun; 2(3):213-7. . View in PubMed
  • Epstein-Barr virus-associated non-Hodgkin’s lymphoma in patients infected with the human immunodeficiency virus Blood. 1993 Apr 15; 81(8):2102-9. . View in PubMed
  • Description of an in situ hybridization methodology for detection of Epstein-Barr virus RNA in paraffin-embedded tissues, with a survey of normal and neoplastic tissues Diagn Mol Pathol. 1992 Dec; 1(4):246-55. . View in PubMed
  • Epidemiological and biological study of acquired immunodeficiency syndrome-related lymphoma in the County of Los Angeles: preliminary results Cancer Res. 1992 Oct 01; 52(19 Suppl):5482s-5484s. . View in PubMed
  • Specific genetic analysis of microscopic tissue after selective ultraviolet radiation fractionation and the polymerase chain reaction Am J Pathol. 1992 Sep; 141(3):539-43. . View in PubMed
  • Characterization of the topography of Epstein-Barr virus infection in human immunodeficiency virus-associated lymphoid tissues Mod Pathol. 1992 Sep; 5(5):559-66. . View in PubMed
  • Epstein-Barr virus genotypes in AIDS-associated lymphomas are similar to those in endemic Burkitt’s lymphomas Leukemia. 1992 Sep; 6(9):875-8. . View in PubMed
  • A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7370-4. . View in PubMed
  • PCR diagnostics of herpes-virus-group infections Ann Med. 1992 Jun; 24(3):221-4. . View in PubMed
  • cDNA cloning of rice lipoxygenase L-2 and characterization using an active enzyme expressed from the cDNA in Escherichia coli Eur J Biochem. 1992 Jun 01; 206(2):331-6. . View in PubMed
  • Recombination between feline leukemia virus subgroup B or C and endogenous env elements alters the in vitro biological activities of the viruses J Virol. 1992 Jun; 66(6):3976. . View in PubMed
  • Epstein-Barr virus-associated gastric adenocarcinoma Am J Pathol. 1992 Apr; 140(4):769-74. . View in PubMed
  • Detection and localization of Epstein-Barr viral genomes in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma Blood. 1992 Apr 01; 79(7):1789-95. . View in PubMed
  • [Bcl-2 in potentials precursors of nodular paragranuloma and its dedifferentiated variant (large cell B-lymphoma)] Verh Dtsch Ges Pathol. 1992; 76:169-72. . View in PubMed
  • Recombination between feline leukemia virus subgroup B or C and endogenous env elements alters the in vitro biological activities of the viruses J Virol. 1991 Dec; 65(12):6495-508. . View in PubMed
  • Epstein-Barr virus and Hodgkin’s diseaseA correlative in situ hybridization and polymerase chain reaction study. Am J Pathol. 1991 Dec; 139(6):1259-65. . View in PubMed
  • Epstein-Barr virus infections and Hodgkin’s disease: a study of fixed tissues using the polymerase chain reaction Hum Pathol. 1991 Dec; 22(12):1262-7. . View in PubMed
  • Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltrationLymphoepithelioma-like carcinoma. Am J Pathol. 1991 Sep; 139(3):469-74. . View in PubMed
  • Lymphoepithelioma-like carcinoma and its relationship to Epstein-Barr virus Am J Clin Pathol. 1991 Aug; 96(2):156-8. . View in PubMed
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