Keck School Faculty

Darryl Shibata, MD
Darryl Shibata, MD
Professor of Pathology
Pathology
NOR 1441 Eastlake Ave Health Sciences Campus Los Angeles
After attending UCLA for his undergraduate degree, Dr. Shibata obtained his medical degree from the Keck School of Medicine of USC. After completing his internship training in pediatrics from UC San Diego, Dr. Shibata returned to USC for his residency and fellowship at LAC+USC Medical Center. Currently, Dr. Shibata has clinical appointments at both LAC+USC Medical Center and USC/Norris Comprehensive Cancer Center. In addition to his wide array of responsibilities in the research, education and practitioner capacities, Dr. Shibata sits on the editorial board of the BMC Cancer Journal and the American Journal of Pathology.

Cancer cell evolution through the ages Science. 2019 08 02; 365(6452):440-441. . View in PubMed

Evolutionary Stem Cell Poker and Cancer Risks: The Paradox of The Large And Small Intestines Curr Pathobiol Rep. 2018 Sep; 6(3):193-198. . View in PubMed

Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance Sci Rep. 2018 11 23; 8(1):17292. . View in PubMed

Between-region genetic divergence reflects the mode and tempo of tumor evolution Nat Genet. 2017 Jul; 49(7):1015-1024. . View in PubMed

Classifying the evolutionary and ecological features of neoplasms Nat Rev Cancer. 2017 10; 17(10):605-619. . View in PubMed

Early mutation bursts in colorectal tumors PLoS One. 2017; 12(3):e0172516. . View in PubMed

At least two well-spaced samples are needed to genotype a solid tumor BMC Cancer. 2016 Mar 25; 16:250. . View in PubMed

Derivation of induced pluripotent stem cells from orangutan skin fibroblasts BMC Res Notes. 2015 Oct 16; 8:577. . View in PubMed

Nat Rev Clin Oncol. 2015 May; 12(5):273-85. . View in PubMed

A Big Bang model of human colorectal tumor growth Nat Genet. 2015 Mar; 47(3):209-16. . View in PubMed

Diffuse large B-cell lymphoma of germinal center and nongerminal center phenotypes presenting concurrently at the same anatomic site: intratumoral heterogeneity or composite lymphoma? Appl Immunohistochem Mol Morphol. 2015 Jan; 23(1):78-80.. View in PubMed

Ancestral inference in tumors: how much can we know? J Theor Biol. 2014 Oct 21; 359:136-45.. View in PubMed

Deep sequencing reveals lack of a clonal relationship between a metachronous classical hodgkin and diffuse large B-cell lymphoma Clin Lymphoma Myeloma Leuk. 2014 Jun; 14(3):e87-93. . View in PubMed

Direct measurements of human colon crypt stem cell niche genetic fidelity: the role of chance in non-darwinian mutation selection Front Oncol. 2013 Oct 14; 3:264. . View in PubMed

Heterogeneity and randomness of DNA methylation patterns in human embryonic stem cells DNA Cell Biol. 2012 Jun; 31(6):893-907. . View in PubMed

CancerHeterogeneity and tumor history. Science. 2012 Apr 20; 336(6079):304-5. . View in PubMed

Different phenotypic consequences of simultaneous versus stepwise Apc loss Oncogene. 2012 Apr 19; 31(16):2028-38. . View in PubMed

A stem cell niche dominance theorem BMC Syst Biol. 2011 Jan 08; 5:4. . View in PubMed

Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors PLoS One. 2011; 6(10):e25985. . View in PubMed

High DNA methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers PLoS One. 2011; 6(6):e21657. . View in PubMed

A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates BMC Cancer. 2010 Jan 05; 10:3. . View in PubMed

A stem cell niche dominance theorem J Stem Cells Regen Med. 2010; 6(2):98. . View in PubMed

Ancestral trees for modeling stem cell lineages genetically rather than functionally: understanding mutation accumulation and distinguishing the restrictive cancer stem cell propagation theory and the unrestricted cell propagation theory of human tumorigenesis Breast Dis. 2008; 29:15-25. . View in PubMed

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statementSociety of Surgical Oncology. Ann Surg Oncol. 2007 Jan; 14(1):128-33. . View in PubMed

Clonal diversity in tumor progression Nat Genet. 2006 Apr; 38(4):402-3. . View in PubMed

Counting divisions in a human somatic cell tree: how, what and why? Cell Cycle. 2006 Mar; 5(6):610-4.. View in PubMed

Counting human somatic cell replications: methylation mirrors endometrial stem cell divisions Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17739-44. . View in PubMed

Diethylstilbestrol effects and lymphomagenesis in Mlh1-deficient mice Int J Cancer. 2005 Jul 01; 115(4):666-9. . View in PubMed

Age-related human small intestine methylation: evidence for stem cell niches BMC Med. 2005 Jun 23; 3:10. . View in PubMed

Generation and characterization of endonuclease G null mice Mol Cell Biol. 2005 Jan; 25(1):294-302. . View in PubMed

Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors Cancer Res. 2004 May 01; 64(9):3096-102. . View in PubMed

Colorectal pretumor progression before and after loss of DNA mismatch repair Am J Pathol. 2004 Apr; 164(4):1447-53. . View in PubMed

Enhanced stem cell survival in familial adenomatous polyposis Am J Pathol. 2004 Apr; 164(4):1369-77. . View in PubMed

Diet, cancer and aging in DNA mismatch repair deficient mice Carcinogenesis. 2002 Nov; 23(11):1807-10. . View in PubMed

DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair Mol Cell Biol. 2002 May; 22(9):2906-17. . View in PubMed

Global gene expression profiling in Barrett's esophagus and esophageal cancer: a comparative analysis using cDNA microarrays Oncogene. 2002 Jan 17; 21(3):475-8. . View in PubMed

Dietary heterocyclic amines and microsatellite instability in colon adenocarcinomas Carcinogenesis. 2001 Oct; 22(10):1681-4. . View in PubMed

Global and gene-specific epigenetic patterns in human bladder cancer genomes are relatively stable in vivo and in vitro over time Cancer Res. 2001 Aug 01; 61(15):5875-84. . View in PubMed

Extensive somatic microsatellite mutations in normal human tissue Cancer Res. 2001 Jun 01; 61(11):4541-4. . View in PubMed

Genetic predisposition and somatic diversification in tumor development and progression Adv Cancer Res. 2001; 80:83-114. . View in PubMed

Bladder cancer genotype stability during clinical progression Genes Chromosomes Cancer. 2000 Sep; 29(1):26-32. . View in PubMed

Heterozygous DNA mismatch repair gene PMS2-knockout mice are susceptible to intestinal tumor induction with N-methyl-N-nitrosourea Carcinogenesis. 2000 Apr; 21(4):833-8. . View in PubMed

Characteristics and pitfalls of contrast-enhanced, T1-weighted magnetization transfer images of the brain Acad Radiol. 2000 Mar; 7(3):156-64. . View in PubMed

Clinical significance of p53 mutations in adenocarcinoma of the esophagus and cardia Ann Surg. 2000 Feb; 231(2):179-87. . View in PubMed

Genetic reconstruction of individual colorectal tumor histories Proc Natl Acad Sci U S A. 2000 Feb 01; 97(3):1236-41. . View in PubMed

Epstein-Barr virus (EBV) nuclear antigen (EBNA)-4 mutation in EBV-associated malignancies in three different populations Am J Pathol. 1999 Sep; 155(3):941-7. . View in PubMed

Colorectal adenoma and cancer divergenceEvidence of multilineage progression. Am J Pathol. 1999 Jun; 154(6):1815-24. . View in PubMed

Complementation of plant mutants with large genomic DNA fragments by a transformation-competent artificial chromosome vector accelerates positional cloning Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6535-40. . View in PubMed

FILAMENTOUS FLOWER, a meristem and organ identity gene of Arabidopsis, encodes a protein with a zinc finger and HMG-related domains Genes Dev. 1999 May 01; 13(9):1079-88. . View in PubMed

Epstein-Barr virus-associated nuclear antigen-1 carboxy-terminal gene sequences in Japanese and American patients with gastric carcinoma Lab Invest. 1998 Jul; 78(7):877-82. . View in PubMed

Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice Cancer Res. 1998 Mar 15; 58(6):1087-9. . View in PubMed

DNA mismatch repair in mammals: role in disease and meiosis Curr Opin Genet Dev. 1997 Jun; 7(3):364-70. . View in PubMed

Epstein-Barr virus and gastric carcinoma Jpn J Cancer Res. 1996 Aug; 87(8):Inside front cover. . View in PubMed

Effects of mutation and growth rates on patterns of microsatellite instability Am J Pathol. 1996 Jun; 148(6):1757-61. . View in PubMed

High-dose chemotherapy and autologous bone marrow plus peripheral blood stem cell transplantation for patients with lymphoma or metastatic breast cancer: use of marker genes to investigate hematopoietic reconstitution in adults Hum Gene Ther. 1996 Mar 20; 7(5):669-84. . View in PubMed

Heterogeneity in intratumor distribution of p53 mutations in human prostate cancer Am J Pathol. 1995 Jul; 147(1):92-101. . View in PubMed

Elevated antibody titers to Epstein-Barr virus prior to the diagnosis of Epstein-Barr-virus-associated gastric adenocarcinoma Int J Cancer. 1995 Mar 03; 60(5):642-4. . View in PubMed

Concordance for Hodgkin's disease in identical twins suggesting genetic susceptibility to the young-adult form of the disease N Engl J Med. 1995 Feb 16; 332(7):413-8. . View in PubMed

Epstein-Barr virus-associated non-Hodgkin's lymphoma in HIV-infected patients Leuk Lymphoma. 1995 Jan; 16(3-4):217-21. . View in PubMed

Follicular small lymphocytic lymphoma Am J Surg Pathol. 1994 Oct; 18(10):999-1009. . View in PubMed

BCL2 translocation frequency rises with age in humans Proc Natl Acad Sci U S A. 1994 Sep 13; 91(19):8910-4. . View in PubMed

Further evidence that one of the earliest alterations in colorectal carcinogenesis involves APC Am J Pathol. 1994 Sep; 145(3):531-4. . View in PubMed

Biologic aspects of AIDS-related lymphoma Curr Opin Oncol. 1994 Sep; 6(5):503-7. . View in PubMed

Extraction of DNA from paraffin-embedded tissue for analysis by polymerase chain reaction: new tricks from an old friend Hum Pathol. 1994 Jun; 25(6):561-3. . View in PubMed

Early mutational activation of the c-Ki-ras oncogene in endometrial carcinoma Cancer Res. 1994 Mar 15; 54(6):1604-7. . View in PubMed

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation Nat Genet. 1994 Mar; 6(3):273-81. . View in PubMed

A novel lipoxygenase from ricePrimary structure and specific expression upon incompatible infection with rice blast fungus. J Biol Chem. 1994 Feb 04; 269(5):3755-61. . View in PubMed

c-k-ras and p53 mutations occur very early in adenocarcinoma of the lung Am J Pathol. 1994 Feb; 144(2):303-9. . View in PubMed

Anatomical distribution of HTLV-I proviral sequence in an autopsy case of HTLV-I associated myelopathy: a polymerase chain reaction study Pathol Int. 1994 Jan; 44(1):27-33. . View in PubMed

Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas J Natl Cancer Inst. 1993 Jul 07; 85(13):1058-63. . View in PubMed

Epstein-Barr virus-associated gastric adenocarcinoma among Japanese Americans in Hawaii Cancer Epidemiol Biomarkers Prev. 1993 May-Jun; 2(3):213-7. . View in PubMed

Epstein-Barr virus-associated non-Hodgkin's lymphoma in patients infected with the human immunodeficiency virus Blood. 1993 Apr 15; 81(8):2102-9. . View in PubMed

Description of an in situ hybridization methodology for detection of Epstein-Barr virus RNA in paraffin-embedded tissues, with a survey of normal and neoplastic tissues Diagn Mol Pathol. 1992 Dec; 1(4):246-55. . View in PubMed

Epidemiological and biological study of acquired immunodeficiency syndrome-related lymphoma in the County of Los Angeles: preliminary results Cancer Res. 1992 Oct 01; 52(19 Suppl):5482s-5484s. . View in PubMed

Characterization of the topography of Epstein-Barr virus infection in human immunodeficiency virus-associated lymphoid tissues Mod Pathol. 1992 Sep; 5(5):559-66. . View in PubMed

Epstein-Barr virus genotypes in AIDS-associated lymphomas are similar to those in endemic Burkitt's lymphomas Leukemia. 1992 Sep; 6(9):875-8. . View in PubMed

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7370-4. . View in PubMed

cDNA cloning of rice lipoxygenase L-2 and characterization using an active enzyme expressed from the cDNA in Escherichia coli Eur J Biochem. 1992 Jun 01; 206(2):331-6. . View in PubMed

Detection and localization of Epstein-Barr viral genomes in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma Blood. 1992 Apr 01; 79(7):1789-95. . View in PubMed

Epstein-Barr virus-associated gastric adenocarcinoma Am J Pathol. 1992 Apr; 140(4):769-74. . View in PubMed

[Bcl-2 in potentials precursors of nodular paragranuloma and its dedifferentiated variant (large cell B-lymphoma)] Verh Dtsch Ges Pathol. 1992; 76:169-72. . View in PubMed

Epstein-Barr virus and Hodgkin's diseaseA correlative in situ hybridization and polymerase chain reaction study. Am J Pathol. 1991 Dec; 139(6):1259-65. . View in PubMed

Epstein-Barr virus infections and Hodgkin's disease: a study of fixed tissues using the polymerase chain reaction Hum Pathol. 1991 Dec; 22(12):1262-7. . View in PubMed

Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltrationLymphoepithelioma-like carcinoma. Am J Pathol. 1991 Sep; 139(3):469-74. . View in PubMed

Fixed human tissues: a resource for the identification of individuals J Forensic Sci. 1991 Jul; 36(4):1204-12. . View in PubMed

Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin's lymphoma Blood. 1991 Apr 01; 77(7):1527-33. . View in PubMed

Detection of human T-cell leukemia virus type I proviral sequences from fixed tissues of seropositive patients Am J Clin Pathol. 1991 Apr; 95(4):536-9. . View in PubMed

Epstein-Barr virus and T-cell lymphoma Am J Hematol. 1991 Feb; 36(2):160. . View in PubMed

Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas Cancer Res. 1990 Feb 15; 50(4):1279-83. . View in PubMed

Detection of specific t(14;18) chromosomal translocations in fixed tissues Hum Pathol. 1990 Feb; 21(2):199-203. . View in PubMed

Detection of occult CNS involvement of follicular small cleaved lymphoma by the polymerase chain reaction Mod Pathol. 1990 Jan; 3(1):71-5. . View in PubMed

Analysis of human immunodeficiency virus and cytomegalovirus infection by polymerase chain reaction in the acquired immunodeficiency syndromeAn autopsy study. Arch Pathol Lab Med. 1989 Nov; 113(11):1239-44. . View in PubMed

Detection of human papillomavirus in formalin-fixed, invasive squamous carcinomas using the polymerase chain reaction Am J Surg Pathol. 1989 Mar; 13(3):221-4. . View in PubMed

Detection of human papillomavirus DNA in fine-needle aspirations of metastatic squamous-cell carcinoma of the uterine cervix using the polymerase chain reaction Diagn Cytopathol. 1989; 5(1):40-3. . View in PubMed

Detection of cytomegalovirus DNA in peripheral blood of patients infected with human immunodeficiency virus J Infect Dis. 1988 Dec; 158(6):1185-92. . View in PubMed

Detection of human papillomavirus in normal and dysplastic tissue by the polymerase chain reaction Lab Invest. 1988 Oct; 59(4):555-9. . View in PubMed

Analysis of DNA sequences in forty-year-old paraffin-embedded thin-tissue sections: a bridge between molecular biology and classical histology Cancer Res. 1988 Aug 15; 48(16):4564-6. . View in PubMed

Cytomegalovirus infection in the acquired immunodeficiency syndromeClinical and autopsy findings. Arch Pathol Lab Med. 1988 May; 112(5):540-4. . View in PubMed

Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction J Exp Med. 1988 Jan 01; 167(1):225-30. . View in PubMed

Genetic complementation by cloned bacteriophage T4 late genes J Virol. 1981 Jul; 39(1):31-45. . View in PubMed

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