Somatic cell evolution: how to improve with age J Pathol. 2019 Jan; 247(1):3-5. . View in PubMed
Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance Sci Rep. 2018 Nov 23; 8(1):17292. . View in PubMed
Spatial mutation patterns as markers of early colorectal tumor cell mobility Proc Natl Acad Sci U S A. 2018 May 14. . View in PubMed
Spatial mutation patterns as markers of early colorectal tumor cell mobility Proc Natl Acad Sci U S A. 2018 05 29; 115(22):5774-5779. . View in PubMed
Between-region genetic divergence reflects the mode and tempo of tumor evolution Nat Genet. 2017 Jul; 49(7):1015-1024. . View in PubMed
Classifying the evolutionary and ecological features of neoplasms Nat Rev Cancer. 2017 10; 17(10):605-619. . View in PubMed
Early mutation bursts in colorectal tumors PLoS One. 2017; 12(3):e0172516. . View in PubMed
At least two well-spaced samples are needed to genotype a solid tumor BMC Cancer. 2016 Mar 25; 16:250. . View in PubMed
HistoMosaic Detecting KRAS G12V Mutation Across Colorectal Cancer Tissue Slices through in Situ PCR Anal Chem. 2016 Mar 01; 88(5):2792-8. . View in PubMed
Single cell lineage tracing reveals a role for TgfßR2 in intestinal stem cell dynamics and differentiation Proc Natl Acad Sci U S A. 2016 10 25; 113(43):12192-12197. . View in PubMed
Many private mutations originate from the first few divisions of a human colorectal adenoma J Pathol. 2015 Nov; 237(3):355-62. . View in PubMed
Derivation of induced pluripotent stem cells from orangutan skin fibroblasts BMC Res Notes. 2015 Oct 16; 8:577. . View in PubMed
Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities Stem Cell Res Ther. 2015 Aug 29; 6:158. . View in PubMed
Nat Rev Clin Oncol. 2015 May; 12(5):273-85. . View in PubMed
A Big Bang model of human colorectal tumor growth Nat Genet. 2015 Mar; 47(3):209-16. . View in PubMed
Diffuse large B-cell lymphoma of germinal center and nongerminal center phenotypes presenting concurrently at the same anatomic site: intratumoral heterogeneity or composite lymphoma? Appl Immunohistochem Mol Morphol. 2015 Jan; 23(1):78-80.. View in PubMed
Ancestral inference in tumors: how much can we know? J Theor Biol. 2014 Oct 21; 359:136-45.. View in PubMed
Deep sequencing reveals lack of a clonal relationship between a metachronous classical hodgkin and diffuse large B-cell lymphoma Clin Lymphoma Myeloma Leuk. 2014 Jun; 14(3):e87-93. . View in PubMed
Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention Carcinogenesis. 2014 Jan; 35(1):237-46. . View in PubMed
Direct measurements of human colon crypt stem cell niche genetic fidelity: the role of chance in non-darwinian mutation selection Front Oncol. 2013 Oct 14; 3:264. . View in PubMed
Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer Science. 2013 Feb 01; 339(6119):543-8. . View in PubMed
Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization Cancer Res. 2013 Jan 01; 73(1):41-9. . View in PubMed
The gene expression profiles of induced pluripotent stem cells from individuals with childhood cerebral adrenoleukodystrophy are consistent with proposed mechanisms of pathogenesis Stem Cell Res Ther. 2012 Oct 04; 3(5):39. . View in PubMed
Heterogeneity and randomness of DNA methylation patterns in human embryonic stem cells DNA Cell Biol. 2012 Jun; 31(6):893-907. . View in PubMed
The role of theorem proving in systems biology J Theor Biol. 2012 May 07; 300:57-61. . View in PubMed
CancerHeterogeneity and tumor history. Science. 2012 Apr 20; 336(6079):304-5. . View in PubMed
Molecular tumor clocks to study the evolution of drug resistance Mol Pharm. 2011 Dec 05; 8(6):2050-4. . View in PubMed
Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice Carcinogenesis. 2011 Jun; 32(6):829-35. . View in PubMed
Mutation and epigenetic molecular clocks in cancer Carcinogenesis. 2011 Feb; 32(2):123-8. . View in PubMed
A stem cell niche dominance theorem BMC Syst Biol. 2011 Jan 08; 5:4. . View in PubMed
Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors PLoS One. 2011; 6(10):e25985. . View in PubMed
High DNA methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers PLoS One. 2011; 6(6):e21657. . View in PubMed
Using DNA methylation patterns to infer tumor ancestry PLoS One. 2010 Aug 09; 5(8):e12002. . View in PubMed
Is there any genetic instability in human cancer? DNA Repair (Amst). 2010 Aug 05; 9(8):858; discussion 859-60.. View in PubMed
Hormone therapy, DNA methylation and colon cancer Carcinogenesis. 2010 Jun; 31(6):1060-7. . View in PubMed
Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations J Cell Biochem. 2010 Mar 01; 109(4):818-27. . View in PubMed
A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates BMC Cancer. 2010 Jan 05; 10:3. . View in PubMed
Systems biologists seek fuller integration of systems biology approaches in new cancer research programs Cancer Res. 2010 Jan 01; 70(1):12-3. . View in PubMed
Many colorectal cancers are "flat" clonal expansions Cell Cycle. 2009 Jul 15; 8(14):2187-93. . View in PubMed
Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4828-33. . View in PubMed
Older individuals appear to acquire mitotically older colorectal cancers J Pathol. 2009 Mar; 217(4):483-8. . View in PubMed
Water intake and bladder cancer risk in Los Angeles County Int J Cancer. 2008 Oct 01; 123(7):1649-56. . View in PubMed
Inferring relative numbers of human leucocyte genome replications Br J Haematol. 2008 Jun; 141(6):862-71. . View in PubMed
Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice J Transl Med. 2008 May 19; 6:26. . View in PubMed
Unregulated smooth-muscle myosin in human intestinal neoplasia Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5513-8. . View in PubMed
Tractable Cre-lox system for stochastic alteration of genes in mice Nat Methods. 2008 Mar; 5(3):227-9. . View in PubMed
Mistakes make history: visualizing intestinal tectonics Gastroenterology. 2008 Feb; 134(2):628-31. . View in PubMed
Stem cells as common ancestors in a colorectal cancer ancestral tree Curr Opin Gastroenterol. 2008 Jan; 24(1):59-63. . View in PubMed
Modeling DNA methylation in a population of cancer cells Stat Appl Genet Mol Biol. 2008; 7(1):Article 18. . View in PubMed
Ancestral trees for modeling stem cell lineages genetically rather than functionally: understanding mutation accumulation and distinguishing the restrictive cancer stem cell propagation theory and the unrestricted cell propagation theory of human tumorigenesis Breast Dis. 2008; 29:15-25. . View in PubMed
The fuzzy math of solid tumor stem cells: a perspective Cancer Res. 2007 Oct 01; 67(19):8985-8. . View in PubMed
Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging BMC Med Genet. 2007 Jul 31; 8:50. . View in PubMed
The stem cell population of the human colon crypt: analysis via methylation patterns PLoS Comput Biol. 2007 Mar 02; 3(3):e28. . View in PubMed
IL-12 facilitates both the recovery of endogenous hematopoiesis and the engraftment of stem cells after ionizing radiation Exp Hematol. 2007 Feb; 35(2):203-13. . View in PubMed
Stem cell chronicles: autobiographies within genomes Stem Cell Rev. 2007 Jan; 3(1):94-103. . View in PubMed
Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice Cancer Res. 2006 Sep 01; 66(17):8430-8. . View in PubMed
Clonal diversity in tumor progression Nat Genet. 2006 Apr; 38(4):402-3. . View in PubMed
Counting divisions in a human somatic cell tree: how, what and why? Cell Cycle. 2006 Mar; 5(6):610-4.. View in PubMed
Human hair genealogies and stem cell latency BMC Biol. 2006 Feb 03; 4:2. . View in PubMed
When does MMR loss occur during HNPCC progression? Cancer Biomark. 2006; 2(1-2):29-35.. View in PubMed
Counting human somatic cell replications: methylation mirrors endometrial stem cell divisions Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17739-44. . View in PubMed
Numbers of mutations to different types of colorectal cancer BMC Cancer. 2005 Oct 03; 5:126. . View in PubMed
Diethylstilbestrol effects and lymphomagenesis in Mlh1-deficient mice Int J Cancer. 2005 Jul 01; 115(4):666-9. . View in PubMed
Age-related human small intestine methylation: evidence for stem cell niches BMC Med. 2005 Jun 23; 3:10. . View in PubMed
Stability of colon stem cell methylation after neo-adjuvant therapy in a patient with attenuated familial adenomatous polyposis BMC Gastroenterol. 2005 Jun 07; 5:19. . View in PubMed
Generation and characterization of endonuclease G null mice Mol Cell Biol. 2005 Jan; 25(1):294-302. . View in PubMed
Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors Cancer Res. 2004 May 01; 64(9):3096-102. . View in PubMed
Tracing ancestry with methylation patterns: most crypts appear distantly related in normal adult human colon BMC Gastroenterol. 2004 Apr 01; 4:8. . View in PubMed
Enhanced stem cell survival in familial adenomatous polyposis Am J Pathol. 2004 Apr; 164(4):1369-77. . View in PubMed
Colorectal pretumor progression before and after loss of DNA mismatch repair Am J Pathol. 2004 Apr; 164(4):1447-53. . View in PubMed
Pretumor progression: clonal evolution of human stem cell populations Am J Pathol. 2004 Apr; 164(4):1337-46. . View in PubMed
In vitro mutation artifacts after formalin fixation and error prone translesion synthesis during PCR BMC Clin Pathol. 2004 Feb 12; 4(1):1. . View in PubMed
The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants DNA Repair (Amst). 2002 Dec 05; 1(12):1017-26. . View in PubMed
Molecular tumour clocks and colorectal cancer: seeing the unseen Pathology. 2002 Dec; 34(6):534-40. . View in PubMed
Diet, cancer and aging in DNA mismatch repair deficient mice Carcinogenesis. 2002 Nov; 23(11):1807-10. . View in PubMed
Methylation reveals a niche: stem cell succession in human colon crypts Oncogene. 2002 Aug 12; 21(35):5441-9. . View in PubMed
DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair Mol Cell Biol. 2002 May; 22(9):2906-17. . View in PubMed
PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper Am J Pathol. 2002 Apr; 160(4):1503-6. . View in PubMed
Low-level microsatellite instability in most colorectal carcinomas Cancer Res. 2002 Feb 15; 62(4):1166-70. . View in PubMed
