Darryl Shibata
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Deep learned tissue "fingerprints" classify breast cancers by ER/PR/Her2 status from H&E images Sci Rep. 2020 Apr 29; 10(1):7275. . View in PubMed
Epigenetic Conservation Is a Beacon of Function: An Analysis Using Methcon5 Software for Studying Gene Methylation JCO Clin Cancer Inform. 2020 02; 4:100-107. . View in PubMed
Cancer cell evolution through the ages Science. 2019 08 02; 365(6452):440-441. . View in PubMed
Evolutionary Stem Cell Poker and Cancer Risks: The Paradox of The Large And Small Intestines Curr Pathobiol Rep. 2018 Sep; 6(3):193-198. . View in PubMed
Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance Sci Rep. 2018 11 23; 8(1):17292. . View in PubMed
Between-region genetic divergence reflects the mode and tempo of tumor evolution Nat Genet. 2017 Jul; 49(7):1015-1024. . View in PubMed
Classifying the evolutionary and ecological features of neoplasms Nat Rev Cancer. 2017 10; 17(10):605-619. . View in PubMed
Early mutation bursts in colorectal tumors PLoS One. 2017; 12(3):e0172516. . View in PubMed
At least two well-spaced samples are needed to genotype a solid tumor BMC Cancer. 2016 Mar 25; 16:250. . View in PubMed
Derivation of induced pluripotent stem cells from orangutan skin fibroblasts BMC Res Notes. 2015 Oct 16; 8:577. . View in PubMed
Nat Rev Clin Oncol. 2015 May; 12(5):273-85. . View in PubMed
A Big Bang model of human colorectal tumor growth Nat Genet. 2015 Mar; 47(3):209-16. . View in PubMed
Diffuse large B-cell lymphoma of germinal center and nongerminal center phenotypes presenting concurrently at the same anatomic site: intratumoral heterogeneity or composite lymphoma? Appl Immunohistochem Mol Morphol. 2015 Jan; 23(1):78-80.. View in PubMed
Ancestral inference in tumors: how much can we know? J Theor Biol. 2014 Oct 21; 359:136-45.. View in PubMed
Deep sequencing reveals lack of a clonal relationship between a metachronous classical hodgkin and diffuse large B-cell lymphoma Clin Lymphoma Myeloma Leuk. 2014 Jun; 14(3):e87-93. . View in PubMed
Direct measurements of human colon crypt stem cell niche genetic fidelity: the role of chance in non-darwinian mutation selection Front Oncol. 2013 Oct 14; 3:264. . View in PubMed
Heterogeneity and randomness of DNA methylation patterns in human embryonic stem cells DNA Cell Biol. 2012 Jun; 31(6):893-907. . View in PubMed
CancerHeterogeneity and tumor history. Science. 2012 Apr 20; 336(6079):304-5. . View in PubMed
Different phenotypic consequences of simultaneous versus stepwise Apc loss Oncogene. 2012 Apr 19; 31(16):2028-38. . View in PubMed
A stem cell niche dominance theorem BMC Syst Biol. 2011 Jan 08; 5:4. . View in PubMed
Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors PLoS One. 2011; 6(10):e25985. . View in PubMed
A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates BMC Cancer. 2010 Jan 05; 10:3. . View in PubMed
A stem cell niche dominance theorem J Stem Cells Regen Med. 2010; 6(2):98. . View in PubMed
Ancestral trees for modeling stem cell lineages genetically rather than functionally: understanding mutation accumulation and distinguishing the restrictive cancer stem cell propagation theory and the unrestricted cell propagation theory of human tumorigenesis Breast Dis. 2008; 29:15-25. . View in PubMed
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statementSociety of Surgical Oncology. Ann Surg Oncol. 2007 Jan; 14(1):128-33. . View in PubMed
Clonal diversity in tumor progression Nat Genet. 2006 Apr; 38(4):402-3. . View in PubMed
Counting divisions in a human somatic cell tree: how, what and why? . 2006 Mar; 5(6):610-4.. View in PubMed
Counting human somatic cell replications: methylation mirrors endometrial stem cell divisions Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17739-44. . View in PubMed
Diethylstilbestrol effects and lymphomagenesis in Mlh1-deficient mice Int J Cancer. 2005 Jul 01; 115(4):666-9. . View in PubMed
Age-related human small intestine methylation: evidence for stem cell niches BMC Med. 2005 Jun 23; 3:10. . View in PubMed
Generation and characterization of endonuclease G null mice Mol Cell Biol. 2005 Jan; 25(1):294-302. . View in PubMed
Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors Cancer Res. 2004 May 01; 64(9):3096-102. . View in PubMed
Colorectal pretumor progression before and after loss of DNA mismatch repair Am J Pathol. 2004 Apr; 164(4):1447-53. . View in PubMed
Enhanced stem cell survival in familial adenomatous polyposis Am J Pathol. 2004 Apr; 164(4):1369-77. . View in PubMed
Diet, cancer and aging in DNA mismatch repair deficient mice Carcinogenesis. 2002 Nov; 23(11):1807-10. . View in PubMed
DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair Mol Cell Biol. 2002 May; 22(9):2906-17. . View in PubMed
Global gene expression profiling in Barrett's esophagus and esophageal cancer: a comparative analysis using cDNA microarrays Oncogene. 2002 Jan 17; 21(3):475-8. . View in PubMed
Dietary heterocyclic amines and microsatellite instability in colon adenocarcinomas Carcinogenesis. 2001 Oct; 22(10):1681-4. . View in PubMed
Global and gene-specific epigenetic patterns in human bladder cancer genomes are relatively stable in vivo and in vitro over time Cancer Res. 2001 Aug 01; 61(15):5875-84. . View in PubMed
Extensive somatic microsatellite mutations in normal human tissue Cancer Res. 2001 Jun 01; 61(11):4541-4. . View in PubMed
Genetic predisposition and somatic diversification in tumor development and progression Adv Cancer Res. 2001; 80:83-114. . View in PubMed
Bladder cancer genotype stability during clinical progression Genes Chromosomes Cancer. 2000 Sep; 29(1):26-32. . View in PubMed
Heterozygous DNA mismatch repair gene PMS2-knockout mice are susceptible to intestinal tumor induction with N-methyl-N-nitrosourea Carcinogenesis. 2000 Apr; 21(4):833-8. . View in PubMed
Characteristics and pitfalls of contrast-enhanced, T1-weighted magnetization transfer images of the brain Acad Radiol. 2000 Mar; 7(3):156-64. . View in PubMed
Genetic reconstruction of individual colorectal tumor histories Proc Natl Acad Sci U S A. 2000 Feb 01; 97(3):1236-41. . View in PubMed
Clinical significance of p53 mutations in adenocarcinoma of the esophagus and cardia Ann Surg. 2000 Feb; 231(2):179-87. . View in PubMed
Epstein-Barr virus (EBV) nuclear antigen (EBNA)-4 mutation in EBV-associated malignancies in three different populations Am J Pathol. 1999 Sep; 155(3):941-7. . View in PubMed
Colorectal adenoma and cancer divergenceEvidence of multilineage progression. Am J Pathol. 1999 Jun; 154(6):1815-24. . View in PubMed
Complementation of plant mutants with large genomic DNA fragments by a transformation-competent artificial chromosome vector accelerates positional cloning Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6535-40. . View in PubMed
FILAMENTOUS FLOWER, a meristem and organ identity gene of Arabidopsis, encodes a protein with a zinc finger and HMG-related domains Genes Dev. 1999 May 01; 13(9):1079-88. . View in PubMed
Epstein-Barr virus-associated nuclear antigen-1 carboxy-terminal gene sequences in Japanese and American patients with gastric carcinoma Lab Invest. 1998 Jul; 78(7):877-82. . View in PubMed
Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice Cancer Res. 1998 Mar 15; 58(6):1087-9. . View in PubMed
DNA mismatch repair in mammals: role in disease and meiosis Curr Opin Genet Dev. 1997 Jun; 7(3):364-70. . View in PubMed
Epstein-Barr virus and gastric carcinoma Jpn J Cancer Res. 1996 Aug; 87(8):Inside front cover. . View in PubMed
Effects of mutation and growth rates on patterns of microsatellite instability Am J Pathol. 1996 Jun; 148(6):1757-61. . View in PubMed
Heterogeneity in intratumor distribution of p53 mutations in human prostate cancer Am J Pathol. 1995 Jul; 147(1):92-101. . View in PubMed
Elevated antibody titers to Epstein-Barr virus prior to the diagnosis of Epstein-Barr-virus-associated gastric adenocarcinoma Int J Cancer. 1995 Mar 03; 60(5):642-4. . View in PubMed
Concordance for Hodgkin's disease in identical twins suggesting genetic susceptibility to the young-adult form of the disease N Engl J Med. 1995 Feb 16; 332(7):413-8. . View in PubMed
Epstein-Barr virus-associated non-Hodgkin's lymphoma in HIV-infected patients Leuk Lymphoma. 1995 Jan; 16(3-4):217-21. . View in PubMed
Follicular small lymphocytic lymphoma Am J Surg Pathol. 1994 Oct; 18(10):999-1009. . View in PubMed
BCL2 translocation frequency rises with age in humans Proc Natl Acad Sci U S A. 1994 Sep 13; 91(19):8910-4. . View in PubMed
Biologic aspects of AIDS-related lymphoma Curr Opin Oncol. 1994 Sep; 6(5):503-7. . View in PubMed
Further evidence that one of the earliest alterations in colorectal carcinogenesis involves APC Am J Pathol. 1994 Sep; 145(3):531-4. . View in PubMed
Extraction of DNA from paraffin-embedded tissue for analysis by polymerase chain reaction: new tricks from an old friend Hum Pathol. 1994 Jun; 25(6):561-3. . View in PubMed
Early mutational activation of the c-Ki-ras oncogene in endometrial carcinoma Cancer Res. 1994 Mar 15; 54(6):1604-7. . View in PubMed
Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation Nat Genet. 1994 Mar; 6(3):273-81. . View in PubMed
A novel lipoxygenase from ricePrimary structure and specific expression upon incompatible infection with rice blast fungus. J Biol Chem. 1994 Feb 04; 269(5):3755-61. . View in PubMed
c-k-ras and p53 mutations occur very early in adenocarcinoma of the lung Am J Pathol. 1994 Feb; 144(2):303-9. . View in PubMed
Anatomical distribution of HTLV-I proviral sequence in an autopsy case of HTLV-I associated myelopathy: a polymerase chain reaction study Pathol Int. 1994 Jan; 44(1):27-33. . View in PubMed
Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas J Natl Cancer Inst. 1993 Jul 07; 85(13):1058-63. . View in PubMed
Epstein-Barr virus-associated gastric adenocarcinoma among Japanese Americans in Hawaii Cancer Epidemiol Biomarkers Prev. 1993 May-Jun; 2(3):213-7. . View in PubMed
Epstein-Barr virus-associated non-Hodgkin's lymphoma in patients infected with the human immunodeficiency virus Blood. 1993 Apr 15; 81(8):2102-9. . View in PubMed
Description of an in situ hybridization methodology for detection of Epstein-Barr virus RNA in paraffin-embedded tissues, with a survey of normal and neoplastic tissues Diagn Mol Pathol. 1992 Dec; 1(4):246-55. . View in PubMed
Epidemiological and biological study of acquired immunodeficiency syndrome-related lymphoma in the County of Los Angeles: preliminary results Cancer Res. 1992 Oct 01; 52(19 Suppl):5482s-5484s. . View in PubMed
Characterization of the topography of Epstein-Barr virus infection in human immunodeficiency virus-associated lymphoid tissues Mod Pathol. 1992 Sep; 5(5):559-66. . View in PubMed
Epstein-Barr virus genotypes in AIDS-associated lymphomas are similar to those in endemic Burkitt's lymphomas Leukemia. 1992 Sep; 6(9):875-8. . View in PubMed
A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7370-4. . View in PubMed
cDNA cloning of rice lipoxygenase L-2 and characterization using an active enzyme expressed from the cDNA in Escherichia coli Eur J Biochem. 1992 Jun 01; 206(2):331-6. . View in PubMed
Detection and localization of Epstein-Barr viral genomes in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma Blood. 1992 Apr 01; 79(7):1789-95. . View in PubMed
Epstein-Barr virus-associated gastric adenocarcinoma Am J Pathol. 1992 Apr; 140(4):769-74. . View in PubMed
[Bcl-2 in potentials precursors of nodular paragranuloma and its dedifferentiated variant (large cell B-lymphoma)] Verh Dtsch Ges Pathol. 1992; 76:169-72. . View in PubMed
Epstein-Barr virus infections and Hodgkin's disease: a study of fixed tissues using the polymerase chain reaction Hum Pathol. 1991 Dec; 22(12):1262-7. . View in PubMed
Epstein-Barr virus and Hodgkin's diseaseA correlative in situ hybridization and polymerase chain reaction study. Am J Pathol. 1991 Dec; 139(6):1259-65. . View in PubMed
Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltrationLymphoepithelioma-like carcinoma. Am J Pathol. 1991 Sep; 139(3):469-74. . View in PubMed
Fixed human tissues: a resource for the identification of individuals J Forensic Sci. 1991 Jul; 36(4):1204-12. . View in PubMed
Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin's lymphoma Blood. 1991 Apr 01; 77(7):1527-33. . View in PubMed
Detection of human T-cell leukemia virus type I proviral sequences from fixed tissues of seropositive patients Am J Clin Pathol. 1991 Apr; 95(4):536-9. . View in PubMed
Epstein-Barr virus and T-cell lymphoma Am J Hematol. 1991 Feb; 36(2):160. . View in PubMed
Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas Cancer Res. 1990 Feb 15; 50(4):1279-83. . View in PubMed
Detection of specific t(14;18) chromosomal translocations in fixed tissues Hum Pathol. 1990 Feb; 21(2):199-203. . View in PubMed
Detection of occult CNS involvement of follicular small cleaved lymphoma by the polymerase chain reaction Mod Pathol. 1990 Jan; 3(1):71-5. . View in PubMed
Analysis of human immunodeficiency virus and cytomegalovirus infection by polymerase chain reaction in the acquired immunodeficiency syndromeAn autopsy study. Arch Pathol Lab Med. 1989 Nov; 113(11):1239-44. . View in PubMed
Detection of human papillomavirus in formalin-fixed, invasive squamous carcinomas using the polymerase chain reaction Am J Surg Pathol. 1989 Mar; 13(3):221-4. . View in PubMed
Detection of human papillomavirus DNA in fine-needle aspirations of metastatic squamous-cell carcinoma of the uterine cervix using the polymerase chain reaction Diagn Cytopathol. 1989; 5(1):40-3. . View in PubMed
Detection of cytomegalovirus DNA in peripheral blood of patients infected with human immunodeficiency virus J Infect Dis. 1988 Dec; 158(6):1185-92. . View in PubMed
Detection of human papillomavirus in normal and dysplastic tissue by the polymerase chain reaction Lab Invest. 1988 Oct; 59(4):555-9. . View in PubMed
Analysis of DNA sequences in forty-year-old paraffin-embedded thin-tissue sections: a bridge between molecular biology and classical histology Cancer Res. 1988 Aug 15; 48(16):4564-6. . View in PubMed
Cytomegalovirus infection in the acquired immunodeficiency syndromeClinical and autopsy findings. Arch Pathol Lab Med. 1988 May; 112(5):540-4. . View in PubMed
Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction J Exp Med. 1988 Jan 01; 167(1):225-30. . View in PubMed
Genetic complementation by cloned bacteriophage T4 late genes J Virol. 1981 Jul; 39(1):31-45. . View in PubMed
