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Darryl Shibata, MD

Professor of Pathology

Vice Chair of Academic Affairs, Department of Pathology,

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Phone +1 323 865 3298
Email [email protected]
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Overview

After attending UCLA for his undergraduate degree, Dr. Shibata obtained his medical degree from the Keck School of Medicine of USC. After completing his internship training in pediatrics from UC San Diego, Dr. Shibata returned to USC for his residency and fellowship at LAC+USC Medical Center. Currently, Dr. Shibata has clinical appointments at both LAC+USC Medical Center and USC/Norris Comprehensive Cancer Center. In addition to his wide array of responsibilities in the research, education and practitioner capacities, Dr. Shibata sits on the editorial board of the BMC Cancer Journal and the American Journal of Pathology.

Research Funding

  • Photolithographic Tumor DNA Isolation
    NIH · R21CA267245 · Jul 22, 2022 – May 31, 2025 · Role: Principal Investigator
  • Arizona Cancer and Evolution Center (ACE)
    NIH · U54CA217376 · Apr 12, 2018 – Mar 31, 2024 · Role: Co-Principal Investigator
  • Born to be Bad: Is Abnormal Cell Mobility Already Present At Initiation?
    NIH · R21CA185016 · Jul 30, 2014 – May 31, 2018 · Role: Principal Investigator
  • How Do NSAIDs Prevent Colorectal Cancer
    NIH · R21CA170814 · Sep 13, 2012 – Aug 31, 2015 · Role: Principal Investigator
  • Tumor Diversity As A Biomarker For Colorectal Cancer
    NIH · R21CA149990 · Apr 1, 2010 – Mar 31, 2014 · Role: Principal Investigator
  • How Do Colorectal Cancers Arise Despite Surveillance?
    NIH · R33CA111940 · Aug 1, 2005 – Jun 30, 2010 · Role: Principal Investigator
  • HUMAN COLON STEM CELL AND CRYPT DYNAMICS
    NIH · R21DK061140 · Sep 30, 2001 – Aug 31, 2005 · Role: Principal Investigator
  • Fixing Fixed DNA
    NIH · R21CA091301 · Jul 1, 2001 – Jun 30, 2004 · Role: Principal Investigator
  • Mouse Models of Early Intestinal Neoplasia
    NIH · R01CA080077 · Jan 1, 1999 – Mar 31, 2010 · Role: Principal Investigator
  • PATHOLOGY OF TUMOR GROWTH
    NIH · R01CA070858 · May 21, 1997 – Apr 30, 2001 · Role: Principal Investigator
  • PATHOLOGY OF TUMOR GROWTH
    NIH · R55CA070858 · Sep 15, 1996 – Apr 30, 1997 · Role: Principal Investigator
  • PATHOLOGY OF GASTRIC CANCER
    NIH · R01CA058704 · Feb 1, 1993 – Jan 31, 1999 · Role: Principal Investigator

Publications

  • Differences between mitotically old and young endometrial tumors. J Pathol. 2026 Jul 08.. View in PubMed
  • Fluctuating DNA methylation sites encode colorectal tumour growth history. bioRxiv. 2026 Jul 02.. View in PubMed
  • Annotation-Based Gene-Peak Links Improve Regulatory Network Prediction of Gene Expression in Human Kidney Multi-Omics. bioRxiv. 2026 Jun 17.. View in PubMed
  • Conception-calibrated male pediatric tumor mitotic clocks. Commun Biol. 2026 Jun 09.. View in PubMed
  • PHYFUM: Phylogenetic Reconstruction of Normal and Pre-malignant Tissue Evolution Using Fluctuating Methylation. bioRxiv. 2026 May 07.. View in PubMed
  • Aggressive Neuroblastomas Start Growing after Infancy. bioRxiv. 2026 Mar 13.. View in PubMed
  • Negative Selection Maintains Grossly Altered but Broadly Stable Karyotypes in Metastatic Colorectal Cancer. Cancer Discov. 2026 Feb 06; 16(2):218-234.. View in PubMed
  • Spatially Discontinuous Mutation Topographies in Ductal Carcinoma In Situ Reveal Noncompetitive Growth Dynamics. Cancer Res. 2025 12 15; 85(24):5084-5097.. View in PubMed
  • Epigenetic conservation infers that colorectal cancer progenitors retain the phenotypic plasticity of normal colon. Sci Rep. 2025 Nov 20; 15(1):40941.. View in PubMed
  • Mapping the temporal landscape of breast cancer using epigenetic entropy. Commun Biol. 2025 Oct 16; 8(1):1477.. View in PubMed

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