Keck School Faculty

David T Woodley

David T Woodley

Professor of Dermatology
USC/Norris Cancer Center -Topping #3405 Health Sciences Campus Los Angeles

Expert recommendations for the management of autoimmune bullous diseases during the COVID-19 pandemic J Eur Acad Dermatol Venereol. 2020 Jul; 34(7):e302-e303. . View in PubMed

Consensus reclassification of inherited epidermolysis bullosa and other disorders with skin fragility Br J Dermatol. 2020 Feb 04. . View in PubMed

Early-onset neutropenia after rituximab therapy for bullous pemphigoid Clin Exp Dermatol. 2019 Apr; 44(3):334-336. . View in PubMed

Bone marrow transplant with post-transplant cyclophosphamide for recessive dystrophic epidermolysis bullosa expands the related donor pool and permits tolerance of nonhaematopoietic cellular grafts Br J Dermatol. 2019 12; 181(6):1238-1246. . View in PubMed

Clinical outcomes of patients with pemphigus treated by the same physicians in a public safety net healthcare system vsa private healthcare system. Br J Dermatol. 2019 10; 181(4):850-852. . View in PubMed

Extracellular and Non-Chaperone Function of Heat Shock Protein-90a Is Required for Skin Wound Healing J Invest Dermatol. 2018 02; 138(2):423-433. . View in PubMed

Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression Oncogene. 2017 04; 36(15):2160-2171. . View in PubMed

Distinct Fibroblasts in the Papillary and Reticular Dermis: Implications for Wound Healing Dermatol Clin. 2017 Jan; 35(1):95-100. . View in PubMed

Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90a) to Survive a Hostile Hypoxic Environment Sci Rep. 2016 Feb 05; 6:20605. . View in PubMed

Dual therapeutic functions of F-5 fragment in burn wounds: preventing wound progression and promoting wound healing in pigs Mol Ther Methods Clin Dev. 2016; 3:16041. . View in PubMed

A multicentre randomized trial of the treatment of patients with pemphigus vulgaris with infliximab and prednisone compared with prednisone alone Br J Dermatol. 2015 Mar; 172(3):760-8. . View in PubMed

Definitions and outcome measures for mucous membrane pemphigoid: recommendations of an international panel of experts J Am Acad Dermatol. 2015 Jan; 72(1):168-74. . View in PubMed

Aminoglycosides restore full-length type VII collagen by overcoming premature termination codons: therapeutic implications for dystrophic epidermolysis bullosa Mol Ther. 2014 Oct; 22(10):1741-52. . View in PubMed

From epidemiology and genetics to diagnostics, outcome measures, and novel treatments in autoimmune bullous diseases J Invest Dermatol. 2014 Sep; 134(9):2298-2300. . View in PubMed

De novo anti-type VII collagen antibodies in patients with recessive dystrophic epidermolysis bullosa J Invest Dermatol. 2014 Apr; 134(4):1138-1140. . View in PubMed

Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo Mol Cell Biol. 2013 Dec; 33(24):4947-59. . View in PubMed

Assessing hairdressers' knowledge of scalp and neck melanoma and their willingness to detect lesions and make referrals to dermatologists J Am Acad Dermatol. 2013 Jan; 68(1):183-5. . View in PubMed

Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally Int Rev Cell Mol Biol. 2013; 303:203-35. . View in PubMed

Definitions and outcome measures for bullous pemphigoid: recommendations by an international panel of experts J Am Acad Dermatol. 2012 Mar; 66(3):479-85. . View in PubMed

Epidermolysis bullosa acquisita: autoimmunity to anchoring fibril collagen Autoimmunity. 2012 Feb; 45(1):91-101. . View in PubMed

A potentially common peptide target in secreted heat shock protein-90a for hypoxia-inducible factor-1a-positive tumors Mol Biol Cell. 2012 Feb; 23(4):602-13. . View in PubMed

Epidermolysis bullosa acquisita Clin Dermatol. 2012 Jan-Feb; 30(1):60-9. . View in PubMed

A fragment of secreted Hsp90a carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice J Clin Invest. 2011 Nov; 121(11):4348-61. . View in PubMed

Congenital epidermolysis bullosa acquisita: vertical transfer of maternal autoantibody from mother to infant Arch Dermatol. 2011 Mar; 147(3):337-41. . View in PubMed

Bone marrow transplantation for recessive dystrophic epidermolysis bullosa N Engl J Med. 2010 Aug 12; 363(7):629-39. . View in PubMed

Familial epidermolysis bullosa acquisita Dermatol Online J. 2008 Dec 15; 14(12):2. . View in PubMed

Duplicating autoimmune bullous diseases by passively transferring autoantibodies into animals J Invest Dermatol. 2008 Oct 06; 128(E3):E25-7. . View in PubMed

Duplicating Autoimmune Bullous Diseases by Passively Transferring Autoantibodies into Animals J Invest Dermatol. 2008 Oct; 128 Suppl 3:E25-7. . View in PubMed

Characterization of molecular mechanisms underlying mutations in dystrophic epidermolysis bullosa using site-directed mutagenesis J Biol Chem. 2008 Jun 27; 283(26):17838-45. . View in PubMed

Autoimmunity to type VII collagen: epidermolysis bullosa acquisita Curr Dir Autoimmun. 2008; 10:195-205. . View in PubMed

Autoimmunity to type VII collagen: epidermolysis bullosa acquisita Clin Rev Allergy Immunol. 2007 Oct; 33(1-2):78-84. . View in PubMed

Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing EMBO J. 2007 Mar 07; 26(5):1221-33. . View in PubMed

Fibroblasts as target cells for DEB gene therapy J Invest Dermatol. 2006 Apr; 126(4):708-10. . View in PubMed

A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing J Cell Biol. 2006 Mar 27; 172(7):1093-105. . View in PubMed

Evidence that anti-type VII collagen antibodies are pathogenic and responsible for the clinical, histological, and immunological features of epidermolysis bullosa acquisita J Invest Dermatol. 2005 May; 124(5):958-64. . View in PubMed

Epidermolysis bullosa: then and now J Am Acad Dermatol. 2004 Jul; 51(1 Suppl):S55-7. . View in PubMed

A patient with both bullous pemphigoid and epidermolysis bullosa acquisita: an example of intermolecular epitope spreading J Am Acad Dermatol. 2004 Jul; 51(1):118-22. . View in PubMed

An efficient gene transduction system for studying gene function in primary human dermal fibroblasts and epidermal keratinocytes Clin Exp Dermatol. 2003 Mar; 28(2):193-9. . View in PubMed

Epidermolysis bullosa acquisita in childhood J Dermatol. 2003 Mar; 30(3):226-9. . View in PubMed

Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen J Am Acad Dermatol. 2002 May; 46(5 Suppl):S161-4. . View in PubMed

An important role for protein kinase C-delta in human keratinocyte migration on dermal collagen Exp Cell Res. 2002 Feb 15; 273(2):219-28. . View in PubMed

Epidermolysis bullosa acquisita: update and review Clin Dermatol. 2001 Nov-Dec; 19(6):712-8. . View in PubMed

Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression Mol Biol Cell. 2000 Nov; 11(11):3835-48. . View in PubMed

Autoantibodies to type VII collagen have heterogeneous subclass and light chain compositions and their complement-activating capacities do not correlate with the inflammatory clinical phenotype J Clin Immunol. 2000 Nov; 20(6):416-23. . View in PubMed

Development and characterization of a recombinant truncated type VII collagen "minigene"Implication for gene therapy of dystrophic epidermolysis bullosa. J Biol Chem. 2000 Aug 11; 275(32):24429-35. . View in PubMed

Alpha 2 beta 1 integrin mediates dermal fibroblast attachment to type VII collagen via a 158-amino-acid segment of the NC1 domain Exp Cell Res. 1999 Jun 15; 249(2):231-9. . View in PubMed

Bullous systemic lupus erythematosus with autoantibodies recognizing multiple skin basement membrane components, bullous pemphigoid antigen 1, laminin-5, laminin-6, and type VII collagen Arch Dermatol. 1999 May; 135(5):569-73. . View in PubMed

Extent of laminin-5 assembly and secretion effect junctional epidermolysis bullosa phenotype J Exp Med. 1998 Apr 20; 187(8):1273-83. . View in PubMed

Epitope spreading: lessons from autoimmune skin diseases J Invest Dermatol. 1998 Feb; 110(2):103-9. . View in PubMed

Development of an ELISA for rapid detection of anti-type VII collagen autoantibodies in epidermolysis bullosa acquisita J Invest Dermatol. 1997 Jan; 108(1):68-72. . View in PubMed

Extracellular matrix-associated serine protease inhibitors (Mr 33,000, 31,000, and 27,000) are single-gene products with differential glycosylation: cDNA cloning of the 33-kDa inhibitor reveals its identity to tissue factor pathway inhibitor-2 Arch Biochem Biophys. 1996 Nov 01; 335(1):82-92. . View in PubMed

Colchicine for epidermolysis bullosa acquisita J Am Acad Dermatol. 1996 May; 34(5 Pt 1):781-4. . View in PubMed

Enhanced modulation of keratinocyte motility by transforming growth factor-alpha (TGF-alpha) relative to epidermal growth factor (EGF) J Invest Dermatol. 1996 Apr; 106(4):590-7. . View in PubMed

Alpha 1-antitrypsin is degraded and non-functional in chronic wounds but intact and functional in acute wounds: the inhibitor protects fibronectin from degradation by chronic wound fluid enzymes J Invest Dermatol. 1995 Oct; 105(4):572-8. . View in PubMed

Canine bullous pemphigoid (BP): identification of the 180-kd canine BP antigen by circulating autoantibodies Vet Pathol. 1995 Jul; 32(4):387-93. . View in PubMed

A newly identified 105-kD lower lamina lucida autoantigen is an acidic protein distinct from the 105-kD gamma 2 chain of laminin-5 J Invest Dermatol. 1995 Jul; 105(1):75-9. . View in PubMed

A nonscarring sublamina densa bullous drug eruption J Am Acad Dermatol. 1995 Feb; 32(2 Pt 2):367-71. . View in PubMed

A novel 105-kDa lamina lucida autoantigen: association with bullous pemphigoid J Invest Dermatol. 1994 Jul; 103(1):78-83. . View in PubMed

Dibutyryl cyclic AMP modulates keratinocyte migration without alteration of integrin expression J Invest Dermatol. 1994 Jun; 102(6):891-7. . View in PubMed

Autoimmunity to anchoring fibrils Adv Dermatol. 1994; 9:61-77; discussion 78. . View in PubMed

Epidermal growth factor (EGF) promotes human keratinocyte locomotion on collagen by increasing the alpha 2 integrin subunit Exp Cell Res. 1993 Dec; 209(2):216-23. . View in PubMed

Epitope mapping of type VII collagenIdentification of discrete peptide sequences recognized by sera from patients with acquired epidermolysis bullosa. J Clin Invest. 1993 Oct; 92(4):1831-9. . View in PubMed

Constitutive synthesis of a 92-kDa keratinocyte-derived type IV collagenase is enhanced by type I collagen and decreased by type IV collagen matrices J Invest Dermatol. 1992 Dec; 99(6):836-41. . View in PubMed

Differences in direct immunofluorescence staining patterns in epidermolysis bullosa acquisita and bullous pemphigoid J Am Acad Dermatol. 1992 Nov; 27(5 Pt 1):674-8. . View in PubMed

A double-blind comparison of adhesive bandages with the use of uniform suction blister wounds Arch Dermatol. 1992 Oct; 128(10):1354-7. . View in PubMed

Congenital localized absence of the skin as a manifestation of epidermolysis bullosa Arch Dermatol. 1992 Aug; 128(8):1087-90. . View in PubMed

Collagen cross-linking in sun-exposed and unexposed sites of aged human skin J Invest Dermatol. 1991 Nov; 97(5):938-41. . View in PubMed

Epidermolysis bullosa acquisita (EBA) and esophageal webs: a new association Am J Gastroenterol. 1991 Oct; 86(10):1518-22. . View in PubMed

Autoimmunity to type VII collagen Semin Dermatol. 1991 Sep; 10(3):232-9. . View in PubMed

Collagen telopeptides (cross-linking sites) play a role in collagen gel lattice contraction J Invest Dermatol. 1991 Sep; 97(3):580-5. . View in PubMed

Epidermolysis bullosa acquisita and associated symptomatic esophageal webs Arch Dermatol. 1991 Mar; 127(3):373-7. . View in PubMed

Coexistence of pemphigus foliaceus and bullous pemphigoidDemonstration of autoantibodies that bind to both the pemphigus foliaceus antigen complex and the bullous pemphigoid antigen. Arch Dermatol. 1991 Mar; 127(3):387-90. . View in PubMed

Concomitant granuloma annulare and necrobiosis lipoidicaReport of a case and review of the literature. Dermatologica. 1991; 183(3):225-9. . View in PubMed

Acquired epidermolysis bullosaA bullous disease associated with autoimmunity to type VII (anchoring fibril) collagen. Dermatol Clin. 1990 Oct; 8(4):717-26. . View in PubMed

Characterization of "neo-dermis" formation beneath cultured human epidermal autografts transplanted on muscle fascia J Invest Dermatol. 1990 Jul; 95(1):20-6. . View in PubMed

Enhanced synthesis of collagenase by human keratinocytes cultured on type I or type IV collagen J Invest Dermatol. 1990 Mar; 94(3):341-6. . View in PubMed

Characterization of cellular elements in healed cultured keratinocyte autografts used to cover burn wounds Arch Dermatol. 1990 Feb; 126(2):175-80. . View in PubMed

Covering wounds with cultured keratinocytes JAMA. 1989 Oct 20; 262(15):2140-1. . View in PubMed

Epidermolysis bullosa acquisita in childhoodDifferentiation from hereditary epidermolysis bullosa. Arch Dermatol. 1989 Jul; 125(7):944-9. . View in PubMed

Constitutive production of procollagenase and tissue inhibitor of metalloproteinases by human keratinocytes in culture J Invest Dermatol. 1989 Feb; 92(2):156-9. . View in PubMed

Epidermolysis bullosa acquista Immunol Ser. 1989; 46:547-63. . View in PubMed

Clearing of epidermolysis bullosa acquisita with cyclosporine J Am Acad Dermatol. 1988 Nov; 19(5 Pt 2):937-42. . View in PubMed

Burn wounds resurfaced by cultured epidermal autografts show abnormal reconstitution of anchoring fibrils JAMA. 1988 May 06; 259(17):2566-71. . View in PubMed

Aging and cross-linking of skin collagen Biochem Biophys Res Commun. 1988 Apr 29; 152(2):898-903. . View in PubMed

Epidermolysis bullosa acquisita antigen is the globular carboxyl terminus of type VII procollagen J Clin Invest. 1988 Mar; 81(3):683-7. . View in PubMed

Epidermolysis bullosa acquisita antigen: relationship between the collagenase-sensitive and -insensitive domains J Invest Dermatol. 1988 Feb; 90(2):127-33. . View in PubMed

Epidermolysis bullosa acquisita antigen, a major cutaneous basement membrane component, is synthesized by human dermal fibroblasts and other cutaneous tissues J Invest Dermatol. 1986 Aug; 87(2):227-31. . View in PubMed

Epidermolysis bullosa acquisita antigen, a new major component of cutaneous basement membrane, is a glycoprotein with collagenous domains J Invest Dermatol. 1986 Jun; 86(6):668-72. . View in PubMed

Adult human keratinocytes migrating over nonviable dermal collagen produce collagenolytic enzymes that degrade type I and type IV collagen J Invest Dermatol. 1986 Apr; 86(4):418-23. . View in PubMed

Deep granuloma annulare in adults Int J Dermatol. 1986 Mar; 25(2):109-12. . View in PubMed

Epidermolysis bullosa acquisita antigen is synthesized by human keratinocytes cultured in serum-free medium Biochem Biophys Res Commun. 1985 Aug 15; 130(3):1267-72. . View in PubMed

Epidermolysis bullosa acquisita of the immunopathological type (dermolytic pemphigoid) J Invest Dermatol. 1985 Jul; 85(1 Suppl):79s-84s. . View in PubMed

Evidence that anti-basement membrane zone antibodies in bullous eruption of systemic lupus erythematosus recognize epidermolysis bullosa acquisita autoantigen J Invest Dermatol. 1985 Jun; 84(6):472-6. . View in PubMed

A mouse monoclonal antibody against a newly discovered basement membrane component, the epidermolysis bullosa acquisita antigen J Invest Dermatol. 1985 Mar; 84(3):215-7. . View in PubMed

Cutaneous wound healing: a model for cell-matrix interactions J Am Acad Dermatol. 1985 Feb; 12(2 Pt 2):420-33. . View in PubMed

Cutaneous symptoms in primary immunodeficiencies Curr Probl Dermatol. 1985; 13:50-91. . View in PubMed

Epidermolysis bullosa acquisita--a pemphigoid-like disease J Am Acad Dermatol. 1984 Nov; 11(5 Pt 1):820-32. . View in PubMed

Epidermolysis bullosa acquisita: an autoimmune disease with distinctive immunoultrastructural features Cutis. 1983 Dec; 32(6):521-7. . View in PubMed

Differential proteolytic susceptibility of laminin alpha and beta subunits Arch Biochem Biophys. 1982 Nov; 219(1):65-70. . View in PubMed

Bullous pemphigoid antigen synthesized in vitro by human epidermal cells J Invest Dermatol. 1980 Aug; 75(2):148-51. . View in PubMed

Dr. Woodley was trained in Dermatology in Chapel Hill at the University of North Carolina. He was a Research Fellow at the University of Paris/Rothschild Institute for two years and an Expert Investigator at the National Institutes of Health. He later joined the dermatology faculty at the University of North Carolina where he started the Phototherapy Unit for the treatment of psoriasis.

In 1988, he became professor and vice chair of the Department of Dermatology at Stanford University and ran the Stanford Psoriasis Center and the Immunodermatology Lab. In 1992, he was appointed the Walter J. Hamlin Professor and Chair of the Department of Dermatology at Northwestern University.

In 1999, he joined USC as professor and co-chief of the Division of Dermatology. In 2005, dermatology became an independent academic department, and Dr. Woodley was appointed professor and chair of the new department. He has published over 165 scientific papers and has had continuous NIH funding since 1982.
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