Keck School Faculty

David T Woodley, MD
David T Woodley, MD
Professor of Dermatology
Dermatology
USC/Norris Cancer Center -Topping #3405 Health Sciences Campus Los Angeles
Dr. Woodley was trained in Dermatology in Chapel Hill at the University of North Carolina. He was a Research Fellow at the University of Paris/Rothschild Institute for two years and an Expert Investigator at the National Institutes of Health. He later joined the dermatology faculty at the University of North Carolina where he started the Phototherapy Unit for the treatment of psoriasis.

In 1988, he became professor and vice chair of the Department of Dermatology at Stanford University and ran the Stanford Psoriasis Center and the Immunodermatology Lab. In 1992, he was appointed the Walter J. Hamlin Professor and Chair of the Department of Dermatology at Northwestern University.

In 1999, he joined USC as professor and co-chief of the Division of Dermatology. In 2005, dermatology became an independent academic department, and Dr. Woodley was appointed professor and chair of the new department. He has published over 165 scientific papers and has had continuous NIH funding since 1982.

Gentamicin induces LAMB3 nonsense mutation readthrough and restores functional laminin 332 in junctional epidermolysis bullosa Proc Natl Acad Sci U S A. 2018 Jun 26. . View in PubMed

Improving Hairdressers' Knowledge and Self-efficacy to Detect Scalp and Neck Melanoma by Use of an Educational Video JAMA Dermatol. 2018 Feb 01; 154(2):214-216. . View in PubMed

Extracellular and Non-Chaperone Function of Heat Shock Protein-90a Is Required for Skin Wound Healing J Invest Dermatol. 2018 Feb; 138(2):423-433. . View in PubMed

Gentamicin induces LAMB3 nonsense mutation readthrough and restores functional laminin 332 in junctional epidermolysis bullosa Proc Natl Acad Sci U S A. 2018 07 10; 115(28):E6536-E6545. . View in PubMed

PRAS40 Connects Microenvironmental Stress Signaling to Exosome-Mediated Secretion Mol Cell Biol. 2017 Oct 01; 37(19). . View in PubMed

Gentamicin induces functional type VII collagen in recessive dystrophic epidermolysis bullosa patients J Clin Invest. 2017 Aug 01; 127(8):3028-3038. . View in PubMed

Distinct Fibroblasts in the Papillary and Reticular Dermis: Implications for Wound Healing Dermatol Clin. 2017 Jan; 35(1):95-100. . View in PubMed

Keratinocyte-Secreted Heat Shock Protein-90alpha: Leading Wound Reepithelialization and Closure Adv Wound Care (New Rochelle). 2016 Apr 01; 5(4):176-184. . View in PubMed

Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90a) to Survive a Hostile Hypoxic Environment Sci Rep. 2016 Feb 05; 6:20605. . View in PubMed

Dual therapeutic functions of F-5 fragment in burn wounds: preventing wound progression and promoting wound healing in pigs Mol Ther Methods Clin Dev. 2016; 3:16041. . View in PubMed

Intravenously Administered Recombinant Human Type VII Collagen Derived from Chinese Hamster Ovary Cells Reverses the Disease Phenotype in Recessive Dystrophic Epidermolysis Bullosa Mice J Invest Dermatol. 2015 Dec; 135(12):3060-3067. . View in PubMed

Reduced Toxicity Conditioning and Allogeneic Hematopoietic Progenitor Cell Transplantation for Recessive Dystrophic Epidermolysis BullosaJ Pediatr. 2015 Sep; 167(3):765-9. e1. . View in PubMed

Recessive Dystrophic Epidermolysis Bullosa: Advances in the Laboratory Leading to New Therapies J Invest Dermatol. 2015 Jul; 135(7):1705-1707. . View in PubMed

Hsp90a and Hsp90ß together operate a hypoxia and nutrient paucity stress-response mechanism during wound healing J Cell Sci. 2015 Apr 15; 128(8):1475-80. . View in PubMed

Treatment of fibroelastolytic papulosis with fractionated carbon dioxide laser J Cosmet Laser Ther. 2015 Apr; 17(2):90-2. . View in PubMed

Keratinocyte Migration and a Hypothetical New Role for Extracellular Heat Shock Protein 90 Alpha in Orchestrating Skin Wound Healing Adv Wound Care (New Rochelle). 2015 Apr 01; 4(4):203-212. . View in PubMed

Definitions and outcome measures for mucous membrane pemphigoid: recommendations of an international panel of experts J Am Acad Dermatol. 2015 Jan; 72(1):168-74. . View in PubMed

Aminoglycosides restore full-length type VII collagen by overcoming premature termination codons: therapeutic implications for dystrophic epidermolysis bullosa Mol Ther. 2014 Oct; 22(10):1741-52. . View in PubMed

Omalizumab therapy for bullous pemphigoid J Am Acad Dermatol. 2014 Sep; 71(3):468-74. . View in PubMed

From epidemiology and genetics to diagnostics, outcome measures, and novel treatments in autoimmune bullous diseases J Invest Dermatol. 2014 Sep; 134(9):2298-2300. . View in PubMed

Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification J Am Acad Dermatol. 2014 Jun; 70(6):1103-26. . View in PubMed

De novo anti-type VII collagen antibodies in patients with recessive dystrophic epidermolysis bullosa J Invest Dermatol. 2014 Apr; 134(4):1138-1140. . View in PubMed

Identification of the critical therapeutic entity in secreted Hsp90a that promotes wound healing in newly re-standardized healthy and diabetic pig models PLoS One. 2014; 9(12):e113956. . View in PubMed

Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo Mol Cell Biol. 2013 Dec; 33(24):4947-59. . View in PubMed

Intravenously injected recombinant human type VII collagen homes to skin wounds and restores skin integrity of dystrophic epidermolysis bullosa J Invest Dermatol. 2013 Jul; 133(7):1910-3. . View in PubMed

Topical application of recombinant type VII collagen incorporates into the dermal-epidermal junction and promotes wound closure Mol Ther. 2013 Jul; 21(7):1335-44. . View in PubMed

Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally Int Rev Cell Mol Biol. 2013; 303:203-35. . View in PubMed

Assessing hairdressers' knowledge of scalp and neck melanoma and their willingness to detect lesions and make referrals to dermatologists J Am Acad Dermatol. 2013 Jan; 68(1):183-5. . View in PubMed

The anti-motility signaling mechanism of TGFß3 that controls cell traffic during skin wound healing Biol Open. 2012 Dec 15; 1(12):1169-77. . View in PubMed

Successful treatment of bullous pemphigoid with omalizumab Arch Dermatol. 2012 Nov; 148(11):1241-3. . View in PubMed

Utilizing hairdressers for early detection of head and neck melanoma: an untapped resource J Am Acad Dermatol. 2012 Apr; 66(4):687-8. . View in PubMed

Definitions and outcome measures for bullous pemphigoid: recommendations by an international panel of experts J Am Acad Dermatol. 2012 Mar; 66(3):479-85. . View in PubMed

Epidermolysis bullosa acquisita: autoimmunity to anchoring fibril collagen Autoimmunity. 2012 Feb; 45(1):91-101. . View in PubMed

A potentially common peptide target in secreted heat shock protein-90a for hypoxia-inducible factor-1a-positive tumors Mol Biol Cell. 2012 Feb; 23(4):602-13. . View in PubMed

Epidermolysis bullosa acquisita Clin Dermatol. 2012 Jan-Feb; 30(1):60-9. . View in PubMed

A fragment of secreted Hsp90a carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice J Clin Invest. 2011 Nov; 121(11):4348-61. . View in PubMed

Congenital epidermolysis bullosa acquisita: vertical transfer of maternal autoantibody from mother to infant Arch Dermatol. 2011 Mar; 147(3):337-41. . View in PubMed

TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression J Cell Sci. 2011 Jan 01; 124(Pt 1):19-24. . View in PubMed

Skin blood flow in patients with stage 5 chronic kidney disease on hemodialysis J Ren Nutr. 2010 Sep; 20(5 Suppl):S89-94. . View in PubMed

Bone marrow transplantation for recessive dystrophic epidermolysis bullosa N Engl J Med. 2010 Aug 12; 363(7):629-39. . View in PubMed

Reliability and convergent validity of two outcome instruments for pemphigus J Invest Dermatol. 2009 Oct; 129(10):2404-10. . View in PubMed

Non-compensating roles between Nckalpha and Nckbeta in PDGF-BB signaling to promote human dermal fibroblast migration J Invest Dermatol. 2009 Aug; 129(8):1909-20. . View in PubMed

Potential new insight into the pathogenesis of psoriasis Arch Dermatol. 2009 Jun; 145(6):713-4. . View in PubMed

Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90alpha autocrine signaling to promote keratinocyte migration J Cell Sci. 2009 May 15; 122(Pt 10):1495-8. . View in PubMed

TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites Cell. 2009 Mar 06; 136(5):891-902. . View in PubMed

Injection of recombinant human type VII collagen corrects the disease phenotype in a murine model of dystrophic epidermolysis bullosa Mol Ther. 2009 Jan; 17(1):26-33. . View in PubMed

Familial epidermolysis bullosa acquisita Dermatol Online J. 2008 Dec 15; 14(12):2. . View in PubMed

Duplicating autoimmune bullous diseases by passively transferring autoantibodies into animals J Invest Dermatol. 2008 Oct 06; 128(E3):E25-7. . View in PubMed

Duplicating Autoimmune Bullous Diseases by Passively Transferring Autoantibodies into Animals J Invest Dermatol. 2008 Oct; 128 Suppl 3:E25-7. . View in PubMed

The role of oxygen in wound healing: a review of the literature Dermatol Surg. 2008 Sep; 34(9):1159-69. . View in PubMed

Profiling motility signal-specific genes in primary human keratinocytes J Invest Dermatol. 2008 Aug; 128(8):1981-90. . View in PubMed

Characterization of molecular mechanisms underlying mutations in dystrophic epidermolysis bullosa using site-directed mutagenesis J Biol Chem. 2008 Jun 27; 283(26):17838-45. . View in PubMed

The classification of inherited epidermolysis bullosa (EB): Report of the Third International Consensus Meeting on Diagnosis and Classification of EB J Am Acad Dermatol. 2008 Jun; 58(6):931-50. . View in PubMed

Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healing Mol Cell Biol. 2008 May; 28(10):3344-58. . View in PubMed

Hypoxia induces epidermal keratinocyte matrix metalloproteinase-9 secretion via the protein kinase C pathway J Cell Physiol. 2008 Jan; 214(1):47-55. . View in PubMed

Autoimmunity to type VII collagen: epidermolysis bullosa acquisita Curr Dir Autoimmun. 2008; 10:195-205. . View in PubMed

Autoimmunity to type VII collagen: epidermolysis bullosa acquisita Clin Rev Allergy Immunol. 2007 Oct; 33(1-2):78-84. . View in PubMed

Nckbeta adapter controls neuritogenesis by maintaining the cellular paxillin level Mol Cell Biol. 2007 Sep; 27(17):6001-11. . View in PubMed

The cartilage matrix protein subdomain of type VII collagen is pathogenic for epidermolysis bullosa acquisita Am J Pathol. 2007 Jun; 170(6):2009-18. . View in PubMed

Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing EMBO J. 2007 Mar 07; 26(5):1221-33. . View in PubMed

Intravenously injected human fibroblasts home to skin wounds, deliver type VII collagen, and promote wound healing Mol Ther. 2007 Mar; 15(3):628-35. . View in PubMed

The role of IgE anti-basement membrane zone autoantibodies in bullous pemphigoid Arch Dermatol. 2007 Feb; 143(2):249-50. . View in PubMed

Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration J Invest Dermatol. 2006 Sep; 126(9):2096-105. . View in PubMed

PKCdelta clustering at the leading edge and mediating growth factor-enhanced, but not ecm-initiated, dermal fibroblast migration J Invest Dermatol. 2006 Jun; 126(6):1233-43. . View in PubMed

Induction of epidermolysis bullosa acquisita in mice by passive transfer of autoantibodies from patients J Invest Dermatol. 2006 Jun; 126(6):1323-30. . View in PubMed

Fibroblasts as target cells for DEB gene therapy J Invest Dermatol. 2006 Apr; 126(4):708-10. . View in PubMed

A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing J Cell Biol. 2006 Mar 27; 172(7):1093-105. . View in PubMed

Pterygium inversum unguis associated with stroke J Am Acad Dermatol. 2005 Sep; 53(3):501-3. . View in PubMed

Evidence that anti-type VII collagen antibodies are pathogenic and responsible for the clinical, histological, and immunological features of epidermolysis bullosa acquisita J Invest Dermatol. 2005 May; 124(5):958-64. . View in PubMed

Wound-healing perspectives Dermatol Clin. 2005 Apr; 23(2):181-92. . View in PubMed

Widespread unilateral plaques in a 68-year-old woman after neurosurgery Arch Dermatol. 2004 Dec; 140(12):1531-6. . View in PubMed

Signals that initiate, augment, and provide directionality for human keratinocyte motility J Invest Dermatol. 2004 Oct; 123(4):622-33. . View in PubMed

Intradermal injection of lentiviral vectors corrects regenerated human dystrophic epidermolysis bullosa skin tissue in vivo Mol Ther. 2004 Aug; 10(2):318-26. . View in PubMed

Epidermolysis bullosa: then and now J Am Acad Dermatol. 2004 Jul; 51(1 Suppl):S55-7. . View in PubMed

A patient with both bullous pemphigoid and epidermolysis bullosa acquisita: an example of intermolecular epitope spreading J Am Acad Dermatol. 2004 Jul; 51(1):118-22. . View in PubMed

Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa Nat Med. 2004 Jul; 10(7):693-5. . View in PubMed

Mechanism of human dermal fibroblast migration driven by type I collagen and platelet-derived growth factor-BB Mol Biol Cell. 2004 Jan; 15(1):294-309. . View in PubMed

Normal and gene-corrected dystrophic epidermolysis bullosa fibroblasts alone can produce type VII collagen at the basement membrane zone J Invest Dermatol. 2003 Nov; 121(5):1021-8. . View in PubMed

Epidermolysis bullosa acquisita in childhood J Dermatol. 2003 Mar; 30(3):226-9. . View in PubMed

Migration of human keratinocytes in plasma and serum and wound re-epithelialisation Lancet. 2003 Feb 15; 361(9357):574-6. . View in PubMed

Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa Nat Genet. 2002 Dec; 32(4):670-5. . View in PubMed

The epidermolysis bullosa acquisita antigen (type VII collagen) is present in human colon and patients with crohn's disease have autoantibodies to type VII collagen J Invest Dermatol. 2002 Jun; 118(6):1059-64. . View in PubMed

Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen J Am Acad Dermatol. 2002 May; 46(5 Suppl):S161-4. . View in PubMed

The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators Arch Dermatol. 2002 Mar; 138(3):370-9. . View in PubMed

An important role for protein kinase C-delta in human keratinocyte migration on dermal collagen Exp Cell Res. 2002 Feb 15; 273(2):219-28. . View in PubMed

The recombinant expression of full-length type VII collagen and characterization of molecular mechanisms underlying dystrophic epidermolysis bullosa J Biol Chem. 2002 Jan 18; 277(3):2118-24. . View in PubMed

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