Keck School Faculty

Deepa Bhojwani

Deepa Bhojwani

Associate Professor of Clinical Pediatrics
CHLA 4650 W. Sunset Blvd. Off Campus Los Angeles

Hispanic ethnicity and the rs4880 variant in SOD2 are associated with elevated liver enzymes and bilirubin levels in children receiving asparaginase-containing chemotherapy for acute lymphoblastic leukemia Biomed Pharmacother. 2022 Jun; 150:113000. . View in PubMed

Preinfusion factors impacting relapse immunophenotype following CD19 CAR T cells Blood Adv. 2022 Apr 28. . View in PubMed

Real-world experience in treating pediatric relapsed/refractory or therapy-related myeloid malignancies with decitabine, vorinostat, and FLAG therapy based on a phase 1 study run by the TACL consortium Pediatr Blood Cancer. 2022 10; 69(10):e29812. . View in PubMed

Decitabine and vorinostat with FLAG chemotherapy in pediatric relapsed/refractory AML: Report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium Am J Hematol. 2022 05; 97(5):613-622. . View in PubMed

Acute myeloid leukemia with t(X;6)9p11;q23);MYB-GATA1 and female sex: GATA1 insufficiency may be insufficient for pathogenesis Cancer Genet. 2022 01; 260-261:37-40. . View in PubMed

Low rate of subsequent malignant neoplasms after CD19 CAR T-cell therapy Blood Adv. 2022 09 13; 6(17):5222-5226. . View in PubMed

Phase II Trial of Inotuzumab Ozogamicin in Children and Adolescents With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia: Children's Oncology Group Protocol AALL1621 J Clin Oncol. 2022 03 20; 40(9):956-967. . View in PubMed

Blinatumomab Nonresponse and High-Disease Burden Are Associated With Inferior Outcomes After CD19-CAR for B-ALL J Clin Oncol. 2022 03 20; 40(9):932-944. . View in PubMed

Germline GATA1s-generating mutations predispose to leukemia with acquired trisomy 21 and Down syndrome-like phenotype Blood. 2022 05 26; 139(21):3159-3165. . View in PubMed

In vitro and in vivo effects of AVA4746, a novel competitive antagonist of the ligand binding of VLA-4, in B-cell acute lymphoblastic leukemia Exp Ther Med. 2022 Jan; 23(1):47. . View in PubMed

Characterization of PAX5 intragenic tandem multiplication in pediatric B-lymphoblastic leukemia by optical genome mapping Blood Adv. 2022 06 14; 6(11):3343-3346. . View in PubMed

Antibody-Drug Conjugates for the Treatment of Acute Pediatric Leukemia J Clin Med. 2021 Aug 13; 10(16). . View in PubMed

Severe toxicity free survival: physician-derived definitions of unacceptable long-term toxicities following acute lymphocytic leukaemia Lancet Haematol. 2021 Jul; 8(7):e513-e523. . View in PubMed

Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: A consecutive case series EBioMedicine. 2021 May; 67:103355. . View in PubMed

Persistent SARS-CoV-2 infection and increasing viral variants in children and young adults with impaired humoral immunity medRxiv. 2021 Mar 02. . View in PubMed

Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children-a novel health disparity Leukemia. 2021 08; 35(8):2399-2402. . View in PubMed

A multimodal genomics approach to diagnostic evaluation of pediatric hematologic malignancies Cancer Genet. 2021 06; 254-255:25-33. . View in PubMed

Fatal capillary leak syndrome in a child with acute lymphoblastic leukemia treated with moxetumomab pasudotox for pre-transplant minimal residual disease reduction Pediatr Blood Cancer. 2021 01; 68(1):e28574. . View in PubMed

Phase 1 study of bendamustine in combination with clofarabine, etoposide, and dexamethasone in pediatric patients with relapsed or refractory hematologic malignancies Cancer. 2021 06 15; 127(12):2074-2082. . View in PubMed

Managing therapy-associated neurotoxicity in children with ALL Hematology Am Soc Hematol Educ Program. 2021 12 10; 2021(1):376-383. . View in PubMed

Preclinical Evaluation of a Novel Dual Targeting PI3Kd/BRD4 Inhibitor, SF2535, in B-Cell Acute Lymphoblastic Leukemia Front Oncol. 2021; 11:766888. . View in PubMed

Severe, Fatal Methotrexate-related Neurotoxicity in 2 Adolescent Patients With ALL J Pediatr Hematol Oncol. 2020 11; 42(8):e839-e844. . View in PubMed

Ibrutinib plus CIT for R/R mature B-NHL in children (SPARKLE trial): initial safety, pharmacokinetics, and efficacy Leukemia. 2020 08; 34(8):2271-2275. . View in PubMed

Results from an international phase 2 study of the anti-CD22 immunotoxin moxetumomab pasudotox in relapsed or refractory childhood B-lineage acute lymphoblastic leukemia Pediatr Blood Cancer. 2020 05; 67(5):e28112. . View in PubMed

Intravitreal dexamethasone implant as an alternative to systemic steroids as prophylaxis for uveitic cataract surgery: a randomized trial Eye (Lond). 2020 03; 34(3):491-498. . View in PubMed

Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5394-5401. . View in PubMed

ARID5B Influences Antimetabolite Drug Sensitivity and Prognosis of Acute Lymphoblastic Leukemia Clin Cancer Res. 2020 01 01; 26(1):256-264. . View in PubMed

Safety, pharmacokinetics, and pharmacodynamics of panobinostat in children, adolescents, and young adults with relapsed acute myeloid leukemia Cancer. 2020 11 01; 126(21):4800-4805. . View in PubMed

Integrin a6 mediates the drug resistance of acute lymphoblastic B-cell leukemia Blood. 2020 07 09; 136(2):210-223. . View in PubMed

Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study Clin Cancer Res. 2020 05 15; 26(10):2297-2307. . View in PubMed

Correction: Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia Leukemia. 2019 Apr; 33(4):1061-1062. . View in PubMed

Pro Re Nata Dexamethasone Implant for Treatment-Naive Phakic Eyes with Diabetic Macular Edema: A Prospective Study Ophthalmol Retina. 2019 11; 3(11):929-937. . View in PubMed

Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia Leukemia. 2019 04; 33(4):884-892. . View in PubMed

Relapse-associated AURKB blunts the glucocorticoid sensitivity of B cell acute lymphoblastic leukemia Proc Natl Acad Sci U S A. 2019 02 19; 116(8):3052-3061. . View in PubMed

Reducing minimal residual disease with blinatumomab prior to HCT for pediatric patients with acute lymphoblastic leukemia Blood Adv. 2019 07 09; 3(13):1926-1929. . View in PubMed


Association of clinical trial enrollment and survival using contemporary therapy for pediatric acute lymphoblastic leukemia Pediatr Blood Cancer. 2018 Feb; 65(2). . View in PubMed

The Impact of Persistent Leukoencephalopathy on Brain White Matter Microstructure in Long-Term Survivors of Acute Lymphoblastic Leukemia Treated with Chemotherapy Only AJNR Am J Neuroradiol. 2018 10; 39(10):1919-1925. . View in PubMed

Myeloid lineage switch following chimeric antigen receptor T-cell therapy in a patient with TCF3-ZNF384 fusion-positive B-lymphoblastic leukemia Pediatr Blood Cancer. 2018 09; 65(9):e27265. . View in PubMed

Obesity and risk for venous thromboembolism from contemporary therapy for pediatric acute lymphoblastic leukemia Thromb Res. 2018 05; 165:44-50. . View in PubMed

Predictors of hepatotoxicity and pancreatitis in children and adolescents with acute lymphoblastic leukemia treated according to contemporary regimens Pediatr Blood Cancer. 2018 03; 65(3). . View in PubMed

Survival after blinatumomab treatment in pediatric patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia Blood Cancer J. 2018 08 22; 8(9):80. . View in PubMed

A neoplasm with FIP1L1-PDGFRA fusion presenting as pediatric T-cell lymphoblastic leukemia/lymphoma without eosinophilia Cancer Genet. 2017 Oct; 216-217:91-99. . View in PubMed

The PI3Kd Inhibitor Idelalisib Inhibits Homing in an in Vitro and in Vivo Model of B ALL Cancers (Basel). 2017 Sep 10; 9(9). . View in PubMed

Investigating the biology of relapsed acute leukemia: Proceedings of the Therapeutic Advances for Childhood Leukemia & Lymphoma (TACL) Consortium Biology Working Group Pediatr Hematol Oncol. 2017 Sep - Oct; 34(6-7):355-364. . View in PubMed

Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP Genome Res. 2017 02; 27(2):185-195. . View in PubMed

Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia Blood. 2017 10 05; 130(14):1620-1627. . View in PubMed

Intravitreal dexamethasone implant for recurrent cystoid macular edema due to Irvine-Gass syndrome: a prospective case series Eye (Lond). 2016 Dec; 30(12):1549-1557. . View in PubMed

Leukoencephalopathy and long-term neurobehavioural, neurocognitive, and brain imaging outcomes in survivors of childhood acute lymphoblastic leukaemia treated with chemotherapy: a longitudinal analysis Lancet Haematol. 2016 Oct; 3(10):e456-e466. . View in PubMed

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity Nat Genet. 2016 Apr; 48(4):367-73. . View in PubMed

The Role of Leukapheresis in the Current Management of Hyperleukocytosis in Newly Diagnosed Childhood Acute Lymphoblastic Leukemia Pediatr Blood Cancer. 2016 09; 63(9):1546-51. . View in PubMed

Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia J Clin Oncol. 2016 06 20; 34(18):2133-40. . View in PubMed

Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia J Clin Oncol. 2016 12 20; 34(36):4381-4389. . View in PubMed

In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs Mayo Clin Proc. 2015 Aug; 90(8):996-1000. . View in PubMed

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells Nat Genet. 2015 Jun; 47(6):607-14. . View in PubMed

Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective study Lancet Oncol. 2015 Apr; 16(4):465-74. . View in PubMed

The role of FDG-PET/CT in the evaluation of residual disease in paediatric non-Hodgkin lymphoma Br J Haematol. 2015 Mar; 168(6):845-53. . View in PubMed

Utility of early screening magnetic resonance imaging for extensive hip osteonecrosis in pediatric patients treated with glucocorticoids J Clin Oncol. 2015 Feb 20; 33(6):610-5. . View in PubMed

Biology of childhood acute lymphoblastic leukemia Pediatr Clin North Am. 2015 Feb; 62(1):47-60. . View in PubMed

A revised definition for cure of childhood acute lymphoblastic leukemia Leukemia. 2014 Dec; 28(12):2336-43. . View in PubMed

Severe hypertriglyceridaemia during therapy for childhood acute lymphoblastic leukaemia Eur J Cancer. 2014 Oct; 50(15):2685-94. . View in PubMed

A phase I study of EZN-3042, a novel survivin messenger ribonucleic acid (mRNA) antagonist, administered in combination with chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL): a report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium J Pediatr Hematol Oncol. 2014 Aug; 36(6):458-63. . View in PubMed

Voriconazole plasma concentrations in immunocompromised pediatric patients vary by CYP2C19 diplotypes Pharmacogenomics. 2014 Jun; 15(8):1065-78. . View in PubMed

Impact of tyrosine kinase inhibitors on minimal residual disease and outcome in childhood Philadelphia chromosome-positive acute lymphoblastic leukemia Cancer. 2014 May 15; 120(10):1514-9. . View in PubMed

Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia J Clin Oncol. 2014 Mar 20; 32(9):949-59. . View in PubMed

Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse Nat Genet. 2013 Dec; 45(12):1494-8. . View in PubMed

HMGA1 overexpression correlates with relapse in childhood B-lineage acute lymphoblastic leukemia Leuk Lymphoma. 2013 Nov; 54(11):2565-7. . View in PubMed

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia Nat Genet. 2013 Oct; 45(10):1226-1231. . View in PubMed

Results of treatment of advanced-stage lymphoblastic lymphoma at St Jude Children's Research Hospital from 1962 to 2002 Ann Oncol. 2013 Sep; 24(9):2425-9. . View in PubMed

Genetic mediators of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia J Clin Oncol. 2013 Jun 10; 31(17):2182-8. . View in PubMed

Prognostic impact of absolute lymphocyte counts at the end of remission induction in childhood acute lymphoblastic leukemia Cancer. 2013 Jun 01; 119(11):2061-6. . View in PubMed

Novel susceptibility variants at 10p1231-12. 2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. J Natl Cancer Inst. 2013 May 15; 105(10):733-42. . View in PubMed

Relapsed childhood acute lymphoblastic leukaemia Lancet Oncol. 2013 May; 14(6):e205-17. . View in PubMed

Thiopurine S-methyltransferase pharmacogenetics in childhood acute lymphoblastic leukemia Methods Mol Biol. 2013; 999:273-84. . View in PubMed

ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy Leukemia. 2012 Feb; 26(2):265-70. . View in PubMed

Endogenous knockdown of survivin improves chemotherapeutic response in ALL models Leukemia. 2012 Feb; 26(2):271-9. . View in PubMed

Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling Blood. 2012 Jan 19; 119(3):817-25. . View in PubMed

Combination chemotherapy with clofarabine, cyclophosphamide, and etoposide in children with refractory or relapsed haematological malignancies Br J Haematol. 2012 Jan; 156(2):275-9. . View in PubMed

Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies Blood. 2011 Nov 10; 118(19):5218-26. . View in PubMed

Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles Leukemia. 2011 Oct; 25(10):1555-63. . View in PubMed

Spinal epidural lipomatosis in children with hematologic malignancies Ann Hematol. 2011 Sep; 90(9):1067-74. . View in PubMed

Improved prognosis for older adolescents with acute lymphoblastic leukemia J Clin Oncol. 2011 Feb 01; 29(4):386-91. . View in PubMed

Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome Blood. 2010 Dec 02; 116(23):4874-84. . View in PubMed

Cytotoxicity of the anti-CD22 immunotoxin HA22 (CAT-8015) against paediatric acute lymphoblastic leukaemia Br J Haematol. 2010 Aug; 150(3):352-8. . View in PubMed

Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia Blood. 2010 Feb 18; 115(7):1394-405. . View in PubMed

Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia Leukemia. 2010 Feb; 24(2):371-82. . View in PubMed

High-risk childhood acute lymphoblastic leukemia Clin Lymphoma Myeloma. 2009; 9 Suppl 3:S222-30. . View in PubMed

Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia Blood. 2008 Nov 15; 112(10):4178-83. . View in PubMed

Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: A Children's Oncology Group Study [corrected] J Clin Oncol. 2008 Sep 20; 26(27):4376-84. . View in PubMed

T-cell PTLD presenting as acalculous cholecystitis Pediatr Transplant. 2008 Sep; 12(6):717-20. . View in PubMed

Intrathecal liposomal cytarabine: more friend than foe? Leuk Lymphoma. 2008 Aug; 49(8):1427-30.. View in PubMed

Potential of gene expression profiling in the management of childhood acute lymphoblastic leukemia Paediatr Drugs. 2007; 9(3):149-56. . View in PubMed

Gene expression profiling reveals intrinsic differences between T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma Pediatr Blood Cancer. 2006 Aug; 47(2):130-40. . View in PubMed

Biologic pathways associated with relapse in childhood acute lymphoblastic leukemia: a Children's Oncology Group study Blood. 2006 Jul 15; 108(2):711-7. . View in PubMed

Childhood acute lymphoblastic leukemia in the age of genomics Pediatr Blood Cancer. 2006 May 01; 46(5):570-8. . View in PubMed

Individualized therapy for childhood acute lymphoblastic leukemia Per Med. 2005 Nov; 2(4):349-361. . View in PubMed

Thrombophilia in childhood Curr Probl Pediatr Adolesc Health Care. 2004 May-Jun; 34(5):190-212. . View in PubMed

Pediatric acute lymphoblastic leukemia Hematology Am Soc Hematol Educ Program. 2003; 102-31. . View in PubMed

sc ctsi logoPowered by SC CTSI