Keck School Faculty

Deepa Bhojwani

Deepa Bhojwani

Associate Professor of Clinical Pediatrics
CHLA 4650 W. Sunset Blvd. Off Campus Los Angeles

Efficacy and safety of FLAG-IDA as front-line therapy in de novo paediatric acute myeloid leukaemia population Br J Haematol. 2023 May 02. . View in PubMed

Patients with Down syndrome can be included in early phase clinical trials- a report from the T2016-003 Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) study Leukemia. 2023 Feb 22. . View in PubMed

Artemis inhibition as a therapeutic strategy for acute lymphoblastic leukemia Front Cell Dev Biol. 2023; 11:1134121. . View in PubMed

Preinfusion factors impacting relapse immunophenotype following CD19 CAR T cells Blood Adv. 2023 02 28; 7(4):575-585. . View in PubMed

Ibrutinib plus RICE or RVICI for relapsed/refractory mature B-cell non-Hodgkin lymphoma in children and young adults: SPARKLE trial Blood Adv. 2023 02 28; 7(4):602-610. . View in PubMed

Hispanic ethnicity and the rs4880 variant in SOD2 are associated with elevated liver enzymes and bilirubin levels in children receiving asparaginase-containing chemotherapy for acute lymphoblastic leukemia Biomed Pharmacother. 2022 Jun; 150:113000. . View in PubMed

Real-world experience in treating pediatric relapsed/refractory or therapy-related myeloid malignancies with decitabine, vorinostat, and FLAG therapy based on a phase 1 study run by the TACL consortium Pediatr Blood Cancer. 2022 10; 69(10):e29812. . View in PubMed

Decitabine and vorinostat with FLAG chemotherapy in pediatric relapsed/refractory AML: Report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium Am J Hematol. 2022 05; 97(5):613-622. . View in PubMed

Acute myeloid leukemia with t(X;6)9p11;q23);MYB-GATA1 and female sex: GATA1 insufficiency may be insufficient for pathogenesis Cancer Genet. 2022 01; 260-261:37-40. . View in PubMed

Low rate of subsequent malignant neoplasms after CD19 CAR T-cell therapy Blood Adv. 2022 09 13; 6(17):5222-5226. . View in PubMed

Blinatumomab Nonresponse and High-Disease Burden Are Associated With Inferior Outcomes After CD19-CAR for B-ALL J Clin Oncol. 2022 03 20; 40(9):932-944. . View in PubMed

Characterization of PAX5 intragenic tandem multiplication in pediatric B-lymphoblastic leukemia by optical genome mapping Blood Adv. 2022 06 14; 6(11):3343-3346. . View in PubMed

In vitro and in vivo effects of AVA4746, a novel competitive antagonist of the ligand binding of VLA-4, in B-cell acute lymphoblastic leukemia Exp Ther Med. 2022 Jan; 23(1):47. . View in PubMed

Germline GATA1s-generating mutations predispose to leukemia with acquired trisomy 21 and Down syndrome-like phenotype Blood. 2022 05 26; 139(21):3159-3165. . View in PubMed

Phase II Trial of Inotuzumab Ozogamicin in Children and Adolescents With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia: Children's Oncology Group Protocol AALL1621 J Clin Oncol. 2022 03 20; 40(9):956-967. . View in PubMed

Antibody-Drug Conjugates for the Treatment of Acute Pediatric Leukemia J Clin Med. 2021 Aug 13; 10(16). . View in PubMed

Severe toxicity free survival: physician-derived definitions of unacceptable long-term toxicities following acute lymphocytic leukaemia Lancet Haematol. 2021 Jul; 8(7):e513-e523. . View in PubMed

Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: A consecutive case series EBioMedicine. 2021 May; 67:103355. . View in PubMed

Persistent SARS-CoV-2 infection and increasing viral variants in children and young adults with impaired humoral immunity medRxiv. 2021 Mar 02. . View in PubMed

Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children-a novel health disparity Leukemia. 2021 08; 35(8):2399-2402. . View in PubMed

A multimodal genomics approach to diagnostic evaluation of pediatric hematologic malignancies Cancer Genet. 2021 06; 254-255:25-33. . View in PubMed

Fatal capillary leak syndrome in a child with acute lymphoblastic leukemia treated with moxetumomab pasudotox for pre-transplant minimal residual disease reduction Pediatr Blood Cancer. 2021 01; 68(1):e28574. . View in PubMed

Managing therapy-associated neurotoxicity in children with ALL Hematology Am Soc Hematol Educ Program. 2021 12 10; 2021(1):376-383. . View in PubMed

Phase 1 study of bendamustine in combination with clofarabine, etoposide, and dexamethasone in pediatric patients with relapsed or refractory hematologic malignancies Cancer. 2021 06 15; 127(12):2074-2082. . View in PubMed

Preclinical Evaluation of a Novel Dual Targeting PI3Kd/BRD4 Inhibitor, SF2535, in B-Cell Acute Lymphoblastic Leukemia Front Oncol. 2021; 11:766888. . View in PubMed

Severe, Fatal Methotrexate-related Neurotoxicity in 2 Adolescent Patients With ALL J Pediatr Hematol Oncol. 2020 11; 42(8):e839-e844. . View in PubMed

Ibrutinib plus CIT for R/R mature B-NHL in children (SPARKLE trial): initial safety, pharmacokinetics, and efficacy Leukemia. 2020 08; 34(8):2271-2275. . View in PubMed

Results from an international phase 2 study of the anti-CD22 immunotoxin moxetumomab pasudotox in relapsed or refractory childhood B-lineage acute lymphoblastic leukemia Pediatr Blood Cancer. 2020 05; 67(5):e28112. . View in PubMed

Intravitreal dexamethasone implant as an alternative to systemic steroids as prophylaxis for uveitic cataract surgery: a randomized trial Eye (Lond). 2020 03; 34(3):491-498. . View in PubMed

Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5394-5401. . View in PubMed

ARID5B Influences Antimetabolite Drug Sensitivity and Prognosis of Acute Lymphoblastic Leukemia Clin Cancer Res. 2020 01 01; 26(1):256-264. . View in PubMed

Safety, pharmacokinetics, and pharmacodynamics of panobinostat in children, adolescents, and young adults with relapsed acute myeloid leukemia Cancer. 2020 11 01; 126(21):4800-4805. . View in PubMed

Integrin a6 mediates the drug resistance of acute lymphoblastic B-cell leukemia Blood. 2020 07 09; 136(2):210-223. . View in PubMed

Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study Clin Cancer Res. 2020 05 15; 26(10):2297-2307. . View in PubMed

Correction: Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia Leukemia. 2019 Apr; 33(4):1061-1062. . View in PubMed

Pro Re Nata Dexamethasone Implant for Treatment-Naive Phakic Eyes with Diabetic Macular Edema: A Prospective Study Ophthalmol Retina. 2019 11; 3(11):929-937. . View in PubMed

Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia Leukemia. 2019 04; 33(4):884-892. . View in PubMed

Reducing minimal residual disease with blinatumomab prior to HCT for pediatric patients with acute lymphoblastic leukemia Blood Adv. 2019 07 09; 3(13):1926-1929. . View in PubMed

Relapse-associated AURKB blunts the glucocorticoid sensitivity of B cell acute lymphoblastic leukemia Proc Natl Acad Sci U S A. 2019 02 19; 116(8):3052-3061. . View in PubMed


Association of clinical trial enrollment and survival using contemporary therapy for pediatric acute lymphoblastic leukemia Pediatr Blood Cancer. 2018 Feb; 65(2). . View in PubMed

The Impact of Persistent Leukoencephalopathy on Brain White Matter Microstructure in Long-Term Survivors of Acute Lymphoblastic Leukemia Treated with Chemotherapy Only AJNR Am J Neuroradiol. 2018 10; 39(10):1919-1925. . View in PubMed

Myeloid lineage switch following chimeric antigen receptor T-cell therapy in a patient with TCF3-ZNF384 fusion-positive B-lymphoblastic leukemia Pediatr Blood Cancer. 2018 09; 65(9):e27265. . View in PubMed

Obesity and risk for venous thromboembolism from contemporary therapy for pediatric acute lymphoblastic leukemia Thromb Res. 2018 05; 165:44-50. . View in PubMed

Predictors of hepatotoxicity and pancreatitis in children and adolescents with acute lymphoblastic leukemia treated according to contemporary regimens Pediatr Blood Cancer. 2018 03; 65(3). . View in PubMed

Survival after blinatumomab treatment in pediatric patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia Blood Cancer J. 2018 08 22; 8(9):80. . View in PubMed

A neoplasm with FIP1L1-PDGFRA fusion presenting as pediatric T-cell lymphoblastic leukemia/lymphoma without eosinophilia Cancer Genet. 2017 Oct; 216-217:91-99. . View in PubMed

The PI3Kd Inhibitor Idelalisib Inhibits Homing in an in Vitro and in Vivo Model of B ALL Cancers (Basel). 2017 Sep 10; 9(9). . View in PubMed

Investigating the biology of relapsed acute leukemia: Proceedings of the Therapeutic Advances for Childhood Leukemia & Lymphoma (TACL) Consortium Biology Working Group Pediatr Hematol Oncol. 2017 Sep - Oct; 34(6-7):355-364. . View in PubMed

Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP Genome Res. 2017 02; 27(2):185-195. . View in PubMed

Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia Blood. 2017 10 05; 130(14):1620-1627. . View in PubMed

Intravitreal dexamethasone implant for recurrent cystoid macular edema due to Irvine-Gass syndrome: a prospective case series Eye (Lond). 2016 Dec; 30(12):1549-1557. . View in PubMed

Leukoencephalopathy and long-term neurobehavioural, neurocognitive, and brain imaging outcomes in survivors of childhood acute lymphoblastic leukaemia treated with chemotherapy: a longitudinal analysis Lancet Haematol. 2016 Oct; 3(10):e456-e466. . View in PubMed

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity Nat Genet. 2016 Apr; 48(4):367-73. . View in PubMed

The Role of Leukapheresis in the Current Management of Hyperleukocytosis in Newly Diagnosed Childhood Acute Lymphoblastic Leukemia Pediatr Blood Cancer. 2016 09; 63(9):1546-51. . View in PubMed

Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia J Clin Oncol. 2016 06 20; 34(18):2133-40. . View in PubMed

Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia J Clin Oncol. 2016 12 20; 34(36):4381-4389. . View in PubMed

In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs Mayo Clin Proc. 2015 Aug; 90(8):996-1000. . View in PubMed

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells Nat Genet. 2015 Jun; 47(6):607-14. . View in PubMed

Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective study Lancet Oncol. 2015 Apr; 16(4):465-74. . View in PubMed

The role of FDG-PET/CT in the evaluation of residual disease in paediatric non-Hodgkin lymphoma Br J Haematol. 2015 Mar; 168(6):845-53. . View in PubMed

Utility of early screening magnetic resonance imaging for extensive hip osteonecrosis in pediatric patients treated with glucocorticoids J Clin Oncol. 2015 Feb 20; 33(6):610-5. . View in PubMed

Biology of childhood acute lymphoblastic leukemia Pediatr Clin North Am. 2015 Feb; 62(1):47-60. . View in PubMed

A revised definition for cure of childhood acute lymphoblastic leukemia Leukemia. 2014 Dec; 28(12):2336-43. . View in PubMed

Severe hypertriglyceridaemia during therapy for childhood acute lymphoblastic leukaemia Eur J Cancer. 2014 Oct; 50(15):2685-94. . View in PubMed

A phase I study of EZN-3042, a novel survivin messenger ribonucleic acid (mRNA) antagonist, administered in combination with chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL): a report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium J Pediatr Hematol Oncol. 2014 Aug; 36(6):458-63. . View in PubMed

Voriconazole plasma concentrations in immunocompromised pediatric patients vary by CYP2C19 diplotypes Pharmacogenomics. 2014 Jun; 15(8):1065-78. . View in PubMed

Impact of tyrosine kinase inhibitors on minimal residual disease and outcome in childhood Philadelphia chromosome-positive acute lymphoblastic leukemia Cancer. 2014 May 15; 120(10):1514-9. . View in PubMed

Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia J Clin Oncol. 2014 Mar 20; 32(9):949-59. . View in PubMed

Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse Nat Genet. 2013 Dec; 45(12):1494-8. . View in PubMed

HMGA1 overexpression correlates with relapse in childhood B-lineage acute lymphoblastic leukemia Leuk Lymphoma. 2013 Nov; 54(11):2565-7. . View in PubMed

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia Nat Genet. 2013 Oct; 45(10):1226-1231. . View in PubMed

Results of treatment of advanced-stage lymphoblastic lymphoma at St Jude Children's Research Hospital from 1962 to 2002 Ann Oncol. 2013 Sep; 24(9):2425-9. . View in PubMed

Genetic mediators of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia J Clin Oncol. 2013 Jun 10; 31(17):2182-8. . View in PubMed

Prognostic impact of absolute lymphocyte counts at the end of remission induction in childhood acute lymphoblastic leukemia Cancer. 2013 Jun 01; 119(11):2061-6. . View in PubMed

Novel susceptibility variants at 10p1231-12. 2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. J Natl Cancer Inst. 2013 May 15; 105(10):733-42. . View in PubMed

Relapsed childhood acute lymphoblastic leukaemia Lancet Oncol. 2013 May; 14(6):e205-17. . View in PubMed

Thiopurine S-methyltransferase pharmacogenetics in childhood acute lymphoblastic leukemia Methods Mol Biol. 2013; 999:273-84. . View in PubMed

ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy Leukemia. 2012 Feb; 26(2):265-70. . View in PubMed

Endogenous knockdown of survivin improves chemotherapeutic response in ALL models Leukemia. 2012 Feb; 26(2):271-9. . View in PubMed

Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling Blood. 2012 Jan 19; 119(3):817-25. . View in PubMed

Combination chemotherapy with clofarabine, cyclophosphamide, and etoposide in children with refractory or relapsed haematological malignancies Br J Haematol. 2012 Jan; 156(2):275-9. . View in PubMed

Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies Blood. 2011 Nov 10; 118(19):5218-26. . View in PubMed

Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles Leukemia. 2011 Oct; 25(10):1555-63. . View in PubMed

Spinal epidural lipomatosis in children with hematologic malignancies Ann Hematol. 2011 Sep; 90(9):1067-74. . View in PubMed

Improved prognosis for older adolescents with acute lymphoblastic leukemia J Clin Oncol. 2011 Feb 01; 29(4):386-91. . View in PubMed

Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome Blood. 2010 Dec 02; 116(23):4874-84. . View in PubMed

Cytotoxicity of the anti-CD22 immunotoxin HA22 (CAT-8015) against paediatric acute lymphoblastic leukaemia Br J Haematol. 2010 Aug; 150(3):352-8. . View in PubMed

Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia Blood. 2010 Feb 18; 115(7):1394-405. . View in PubMed

Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia Leukemia. 2010 Feb; 24(2):371-82. . View in PubMed

High-risk childhood acute lymphoblastic leukemia Clin Lymphoma Myeloma. 2009; 9 Suppl 3:S222-30. . View in PubMed

Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia Blood. 2008 Nov 15; 112(10):4178-83. . View in PubMed

Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: A Children's Oncology Group Study [corrected] J Clin Oncol. 2008 Sep 20; 26(27):4376-84. . View in PubMed

T-cell PTLD presenting as acalculous cholecystitis Pediatr Transplant. 2008 Sep; 12(6):717-20. . View in PubMed

Intrathecal liposomal cytarabine: more friend than foe? Leuk Lymphoma. 2008 Aug; 49(8):1427-30.. View in PubMed

Potential of gene expression profiling in the management of childhood acute lymphoblastic leukemia Paediatr Drugs. 2007; 9(3):149-56. . View in PubMed

Gene expression profiling reveals intrinsic differences between T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma Pediatr Blood Cancer. 2006 Aug; 47(2):130-40. . View in PubMed

Biologic pathways associated with relapse in childhood acute lymphoblastic leukemia: a Children's Oncology Group study Blood. 2006 Jul 15; 108(2):711-7. . View in PubMed

Childhood acute lymphoblastic leukemia in the age of genomics Pediatr Blood Cancer. 2006 May 01; 46(5):570-8. . View in PubMed

Individualized therapy for childhood acute lymphoblastic leukemia Per Med. 2005 Nov; 2(4):349-361. . View in PubMed

Thrombophilia in childhood Curr Probl Pediatr Adolesc Health Care. 2004 May-Jun; 34(5):190-212. . View in PubMed

Pediatric acute lymphoblastic leukemia Hematology Am Soc Hematol Educ Program. 2003; 102-31. . View in PubMed

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