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Dillon P Cogan

Assistant Professor of Pharmacology and Pharmaceutical Sciences

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Phone +1 323 442 0974
Email [email protected]
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Publications

  • Structure-based discovery and definition of RiPP recognition elements. mSystems. 2025 Dec 17; 10(12):e0125225.. View in PubMed
  • Molecular Basis for Asynchronous Chain Elongation During Rifamycin Antibiotic Biosynthesis. bioRxiv. 2025 Jul 06.. View in PubMed
  • Structural basis for intermodular communication in assembly-line polyketide biosynthesis. Nat Chem Biol. 2025 Jun; 21(6):876-882.. View in PubMed
  • Structure and Mechanisms of Assembly-Line Polyketide Synthases. Annu Rev Biochem. 2024 08; 93(1):471-498.. View in PubMed
  • Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase. Biochemistry. 2023 06 06; 62(11):1589-1593.. View in PubMed
  • In vivo visualization and molecular targeting of the cardiac conduction system. J Clin Invest. 2022 10 17; 132(20).. View in PubMed
  • Structure and mechanism for iterative amide N-methylation in the biosynthesis of channel-forming peptide cytotoxins. Proc Natl Acad Sci U S A. 2022 03 29; 119(13):e2116578119.. View in PubMed
  • Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science. 2021 Nov 05; 374(6568):729-734.. View in PubMed
  • Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation. ACS Chem Biol. 2020 10 16; 15(10):2783-2791.. View in PubMed
  • Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction. J Am Chem Soc. 2020 09 02; 142(35):14933-14939.. View in PubMed
  • Characterization of glutamyl-tRNA-dependent dehydratases using nonreactive substrate mimics. Proc Natl Acad Sci U S A. 2019 08 27; 116(35):17245-17250.. View in PubMed
  • Substrate-assisted enzymatic formation of lysinoalanine in duramycin. Nat Chem Biol. 2018 10; 14(10):928-933.. View in PubMed
  • Structural basis of transcriptional regulation by CouR, a repressor of coumarate catabolism, in Rhodopseudomonas palustris. J Biol Chem. 2018 07 27; 293(30):11727-11735.. View in PubMed
  • Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis. Proc Natl Acad Sci U S A. 2017 12 05; 114(49):12928-12933.. View in PubMed
  • Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis. ACS Chem Biol. 2017 02 17; 12(2):548-557.. View in PubMed
  • Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides. Medchemcomm. 2016 Jan 01; 7(1):28-36.. View in PubMed
  • Inhibition of the human proteasome by imidazoline scaffolds. J Med Chem. 2013 Jul 25; 56(14):5974-8.. View in PubMed

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