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Donald Barkauskas, PhD

Professor of Clinical Population and Public Health Sciences

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Phone +1 323 442 1212
Email [email protected]
CTSI Profile

Publications

  • NAPRT expression and epigenetic regulation in pediatric rhabdomyosarcoma as a potential biomarker for NAMPT inhibition. bioRxiv. 2025 Jul 31.. View in PubMed
  • The impact of genetic ancestry on survival outcomes in pediatric rhabdomyosarcoma: A report from the Children’s Oncology Group. HGG Adv. 2025 Jul 10; 6(3):100466.. View in PubMed
  • Larotrectinib for Newly Diagnosed Infantile Fibrosarcoma and Other Pediatric NTRK Fusion-Positive Solid Tumors (Children’s Oncology Group ADVL1823). J Clin Oncol. 2025 Apr; 43(10):1188-1197.. View in PubMed
  • ICOS and ICOS ligand: expression patterns and outcomes in oncology patients. Ther Adv Med Oncol. 2025; 17:17588359251330514.. View in PubMed
  • Efficacy of the Allosteric MEK Inhibitor Trametinib in Relapsed and Refractory Juvenile Myelomonocytic Leukemia: a Report from the Children’s Oncology Group. Cancer Discov. 2024 Sep 04; 14(9):1590-1598.. View in PubMed
  • Embryonal sarcoma of the liver in pediatric and young adult patients: A report from Children’s Oncology Group study ARST0332. Cancer. 2024 Aug 01; 130(15):2683-2693.. View in PubMed
  • Clinical features and outcomes of young patients with low-grade non-rhabdomyosarcoma soft tissue sarcomas treated with a risk-based strategy: A report from Children’s Oncology Group study ARST0332. Pediatr Blood Cancer. 2024 Aug; 71(8):e31062.. View in PubMed
  • Durable immunity to EBV after rituximab and third-party LMP-specific T cells: a Children’s Oncology Group study. Blood Adv. 2024 03 12; 8(5):1116-1127.. View in PubMed
  • Germline Genetic Testing and Survival Outcomes Among Children With Rhabdomyosarcoma: A Report From the Children’s Oncology Group. JAMA Netw Open. 2024 03 04; 7(3):e244170.. View in PubMed
  • Osteosarcoma Explorer: A Data Commons With Clinical, Genomic, Protein, and Tissue Imaging Data for Osteosarcoma Research. JCO Clin Cancer Inform. 2023 09; 7:e2300104.. View in PubMed
  • The Role of FAS Receptor Methylation in Osteosarcoma Metastasis. Int J Mol Sci. 2023 Jul 29; 24(15).. View in PubMed
  • Germline genetic variants and pediatric rhabdomyosarcoma outcomes: a report from the Children’s Oncology Group. J Natl Cancer Inst. 2023 06 08; 115(6):733-741.. View in PubMed
  • Effect of rituximab on immune status in children with mature B-cell non-Hodgkin lymphoma: a prespecified secondary analysis of the Inter-B-NHL Ritux 2010 trial. Lancet Haematol. 2023 Jun; 10(6):e445-e457.. View in PubMed
  • Circulating Tumor DNA Is Prognostic in Intermediate-Risk Rhabdomyosarcoma: A Report From the Children’s Oncology Group. J Clin Oncol. 2023 05 01; 41(13):2382-2393.. View in PubMed
  • Crizotinib in Combination With Chemotherapy for Pediatric Patients With ALK+ Anaplastic Large-Cell Lymphoma: The Results of Children’s Oncology Group Trial ANHL12P1. J Clin Oncol. 2023 04 10; 41(11):2043-2053.. View in PubMed
  • Lymph node metastases in paediatric and young adult patients with non-rhabdomyosarcoma soft tissue sarcoma (NRSTS): Findings from Children’s Oncology Group (COG) study ARST0332. Eur J Cancer. 2023 02; 180:89-98.. View in PubMed
  • Predicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients Using Deep Learning of H&E Images: A Report from the Children’s Oncology Group. Clin Cancer Res. 2023 01 17; 29(2):364-378.. View in PubMed
  • Adverse prognostic impact of the loss of STAG2 protein expression in patients with newly diagnosed localised Ewing sarcoma: A report from the Children’s Oncology Group. Br J Cancer. 2022 12; 127(12):2220-2226.. View in PubMed
  • Integrated DNA Copy Number and Expression Profiling Identifies IGF1R as a Prognostic Biomarker in Pediatric Osteosarcoma. Int J Mol Sci. 2022 Jul 21; 23(14).. View in PubMed
  • Reply to R. Lakhotia et al. J Clin Oncol. 2022 06 20; 40(18):2064-2066.. View in PubMed
  • Deep Learning of Rhabdomyosarcoma Pathology Images for Classification and Survival Outcome Prediction. Am J Pathol. 2022 06; 192(6):917-925.. View in PubMed
  • Dose-Adjusted Etoposide, Doxorubicin, and Cyclophosphamide With Vincristine and Prednisone Plus Rituximab Therapy in Children and Adolescents With Primary Mediastinal B-Cell Lymphoma: A Multicenter Phase II Trial. J Clin Oncol. 2021 11 20; 39(33):3716-3724.. View in PubMed
  • Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium. J Clin Oncol. 2021 09 10; 39(26):2859-2871.. View in PubMed
  • Toxicity and pharmacokinetics of actinomycin-D and vincristine in children and adolescents: Children’s Oncology Group Study ADVL06B1. Cancer Chemother Pharmacol. 2021 08; 88(2):359-365.. View in PubMed
  • Brentuximab vedotin in combination with chemotherapy for pediatric patients with ALK+ ALCL: results of COG trial ANHL12P1. Blood. 2021 07 01; 137(26):3595-3603.. View in PubMed
  • Germline Cancer Predisposition Variants in Pediatric Rhabdomyosarcoma: A Report From the Children’s Oncology Group. J Natl Cancer Inst. 2021 07 01; 113(7):875-883.. View in PubMed
  • BRAF V600E/V600K Mutations versus Nonstandard Alterations: Prognostic Implications and Therapeutic Outcomes. Mol Cancer Ther. 2021 06; 20(6):1072-1079.. View in PubMed
  • STK11 alterations in the pan-cancer setting: prognostic and therapeutic implications. Eur J Cancer. 2021 05; 148:215-229.. View in PubMed
  • Deployment and Psychological Correlates of Suicide Ideation: A Prospective, Longitudinal Study of Risk and Resilience Among Combat Veterans. Mil Med. 2021 Jan 30; 186(1-2):e58-e66.. View in PubMed
  • Pathogenic Germline Variants in Cancer Susceptibility Genes in Children and Young Adults With Rhabdomyosarcoma. JCO Precis Oncol. 2021; 5.. View in PubMed
  • Prognostic and Therapeutic Utility of Variably Expressed Cell Surface Receptors in Osteosarcoma. Sarcoma. 2021; 2021:8324348.. View in PubMed
  • ADVL1522: A phase 2 study of lorvotuzumab mertansine (IMGN901) in children with relapsed or refractory wilms tumor, rhabdomyosarcoma, neuroblastoma, pleuropulmonary blastoma, malignant peripheral nerve sheath tumor, or synovial sarcoma-A Children’s Oncology Group study. Cancer. 2020 12 15; 126(24):5303-5310.. View in PubMed
  • Relationship between tumor mutational burden and maximum standardized uptake value in 2-[18F]FDG PET (positron emission tomography) scan in cancer patients. EJNMMI Res. 2020 Dec 09; 10(1):150.. View in PubMed
  • High Tumor Mutational Burden Correlates with Longer Survival in Immunotherapy-Naïve Patients with Diverse Cancers. Mol Cancer Ther. 2020 10; 19(10):2139-2145.. View in PubMed
  • Tumor mutational burden is not predictive of cytotoxic chemotherapy response. Oncoimmunology. 2020 06 24; 9(1):1781997.. View in PubMed
  • Rituximab for High-Risk, Mature B-Cell Non-Hodgkin’s Lymphoma in Children. N Engl J Med. 2020 06 04; 382(23):2207-2219.. View in PubMed
  • Relationship between protein biomarkers of chemotherapy response and microsatellite status, tumor mutational burden and PD-L1 expression in cancer patients. Int J Cancer. 2020 06 01; 146(11):3087-3097.. View in PubMed
  • Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma. JAMA Oncol. 2020 05 01; 6(5):724-734.. View in PubMed
  • Targeting fusions for improved outcomes in oncology treatment. Cancer. 2020 03 15; 126(6):1315-1321.. View in PubMed
  • Efficacy and safety of anticancer drug combinations: a meta-analysis of randomized trials with a focus on immunotherapeutics and gene-targeted compounds. Oncoimmunology. 2020; 9(1):1710052.. View in PubMed
  • A Phase II Study of Alisertib in Children with Recurrent/Refractory Solid Tumors or Leukemia: Children’s Oncology Group Phase I and Pilot Consortium (ADVL0921). Clin Cancer Res. 2019 06 01; 25(11):3229-3238.. View in PubMed
  • Correction: Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children’s Oncology Group. Br J Cancer. 2019 Apr; 120(8):869.. View in PubMed
  • Relations of combat stress and posttraumatic stress disorder to 24-h plasma and cerebrospinal fluid interleukin-6 levels and circadian rhythmicity. Psychoneuroendocrinology. 2019 02; 100:237-245.. View in PubMed
  • Effects of dexrazoxane on doxorubicin-related cardiotoxicity and second malignant neoplasms in children with osteosarcoma: a report from the Children’s Oncology Group. Cardiooncology. 2019; 5:15.. View in PubMed
  • Factors influencing survival after recurrence in osteosarcoma: A report from the Children’s Oncology Group. Pediatr Blood Cancer. 2019 01; 66(1):e27444.. View in PubMed
  • Demographic and Treatment Variables Influencing Outcome for Localized Paratesticular Rhabdomyosarcoma: Results From a Pooled Analysis of North American and European Cooperative Groups. J Clin Oncol. 2018 Oct 23; JCO2018789388.. View in PubMed
  • Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children’s Oncology Group. Br J Cancer. 2018 08; 119(5):615-621.. View in PubMed
  • Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients. Int J Cancer. 2018 04 15; 142(8):1594-1601.. View in PubMed
  • The prognostic significance of circulating serum amyloid A and CXC chemokine ligand 4 in osteosarcoma. Pediatr Blood Cancer. 2017 Dec; 64(12).. View in PubMed
  • Biomarker significance of plasma and tumor miR-21, miR-221, and miR-106a in osteosarcoma. Oncotarget. 2017 Nov 14; 8(57):96738-96752.. View in PubMed
  • Hyperprogressors after Immunotherapy: Analysis of Genomic Alterations Associated with Accelerated Growth Rate. Clin Cancer Res. 2017 Aug 01; 23(15):4242-4250.. View in PubMed
  • Osteosarcoma enters a post genomic era with in silico opportunities: Generation of the High Dimensional Database for facilitating sarcoma biology research: A report from the Children’s Oncology Group and the QuadW Foundation. PLoS One. 2017; 12(7):e0181204.. View in PubMed
  • A novel prognostic model for osteosarcoma using circulating CXCL10 and FLT3LG. Cancer. 2017 Jan 01; 123(1):144-154.. View in PubMed
  • Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children’s Oncology Group. Clin Cancer Res. 2016 07 15; 22(14):3643-50.. View in PubMed
  • p27 Is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma. Cancer Res. 2016 07 01; 76(13):4002-11.. View in PubMed
  • Prospective Associations Between Traumatic Brain Injury and Postdeployment Tinnitus in Active-Duty Marines. J Head Trauma Rehabil. 2016 Jan-Feb; 31(1):30-9.. View in PubMed
  • Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types. J Natl Cancer Inst. 2015 Dec; 107(12):djv279.. View in PubMed
  • A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma. Cancer Discov. 2015 Sep; 5(9):920-31.. View in PubMed
  • Cross-species identification of a plasma microRNA signature for detection, therapeutic monitoring, and prognosis in osteosarcoma. Cancer Med. 2015 Jul; 4(7):977-88.. View in PubMed
  • Germline TP53 variants and susceptibility to osteosarcoma. J Natl Cancer Inst. 2015 Jul; 107(7).. View in PubMed
  • Gene Expression Profiling of Ewing Sarcoma Tumors Reveals the Prognostic Importance of Tumor-Stromal Interactions: A Report from the Children’s Oncology Group. J Pathol Clin Res. 2015 Apr; 1(2):83-94.. View in PubMed
  • The Serum Immunoglobulin G Glycosylation Signature of Gastric Cancer. EuPA Open Proteom. 2015 Mar 01; 6:1-9.. View in PubMed
  • A summary of the osteosarcoma banking efforts: a report from the Children’s Oncology Group and the QuadW Foundation. Pediatr Blood Cancer. 2015 Mar; 62(3):450-5.. View in PubMed
  • Systemic levels of neuropeptide Y and dipeptidyl peptidase activity in patients with Ewing sarcoma–associations with tumor phenotype and survival. Cancer. 2015 Mar 01; 121(5):697-707.. View in PubMed
  • Predictive properties of DNA methylation patterns in primary tumor samples for osteosarcoma relapse status. Epigenetics. 2015; 10(1):31-9.. View in PubMed
  • Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. Hum Mol Genet. 2014 Dec 15; 23(24):6616-33.. View in PubMed
  • The cumulative effect of different childhood trauma types on self-reported symptoms of adult male depression and PTSD, substance abuse and health-related quality of life in a large active-duty military cohort. J Psychiatr Res. 2014 Nov; 58:46-54.. View in PubMed
  • HER-2 expression is not prognostic in osteosarcoma; a Children’s Oncology Group prospective biology study. Pediatr Blood Cancer. 2014 Sep; 61(9):1558-64.. View in PubMed
  • Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men. Psychoneuroendocrinology. 2014 Jun; 44:71-82.. View in PubMed
  • Response to “High BMI at diagnosis is associated with inferior survival in patients with osteosarcoma”. Pediatr Blood Cancer. 2014 May; 61(5):951.. View in PubMed
  • Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: a children’s oncology group study. Pediatr Blood Cancer. 2014 Apr; 61(4):749-52.. View in PubMed
  • Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk. JAMA Psychiatry. 2014 Apr; 71(4):423-31.. View in PubMed
  • Association between traumatic brain injury and risk of posttraumatic stress disorder in active-duty Marines. JAMA Psychiatry. 2014 Feb; 71(2):149-57.. View in PubMed
  • Serum glycan signatures of gastric cancer. Cancer Prev Res (Phila). 2014 Feb; 7(2):226-35.. View in PubMed
  • High-BMI at diagnosis is associated with inferior survival in patients with osteosarcoma: a report from the Children’s Oncology Group. Pediatr Blood Cancer. 2013 Dec; 60(12):2042-6.. View in PubMed
  • Characterization of cerebrospinal fluid (CSF) and plasma NPY levels in normal volunteers over a 24-h timeframe. Psychoneuroendocrinology. 2013 Oct; 38(10):2378-82.. View in PubMed
  • Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma. Neoplasia. 2013 Sep; 15(9):1049-63.. View in PubMed
  • Genome-wide association study identifies two susceptibility loci for osteosarcoma. Nat Genet. 2013 Jul; 45(7):799-803.. View in PubMed
  • Outcome for adolescent and young adult patients with osteosarcoma: a report from the Children’s Oncology Group. Cancer. 2012 Sep 15; 118(18):4597-605.. View in PubMed
  • Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children’s oncology group. J Clin Oncol. 2012 Jul 10; 30(20):2545-51.. View in PubMed
  • Poor survival for osteosarcoma of the pelvis: a report from the Children’s Oncology Group. Clin Orthop Relat Res. 2012 Jul; 470(7):2007-13.. View in PubMed
  • Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet. 2012 May 06; 44(6):651-8.. View in PubMed
  • Investigation of the insulin-like growth factor-1 signaling pathway in localized Ewing sarcoma: a report from the Children’s Oncology Group. Cancer. 2011 Nov 01; 117(21):4966-76.. View in PubMed
  • A general-purpose baseline estimation algorithm for spectroscopic data. Anal Chim Acta. 2010 Jan 11; 657(2):191-7.. View in PubMed
  • Analysis of MALDI FT-ICR mass spectrometry data: a time series approach. Anal Chim Acta. 2009 Aug 26; 648(2):207-14.. View in PubMed
  • Detecting glycan cancer biomarkers in serum samples using MALDI FT-ICR mass spectrometry data. Bioinformatics. 2009 Jan 15; 25(2):251-7.. View in PubMed

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