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Dongshi Chen, PhD, MS

Assistant Professor of Research Medicine

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Email dongshic@usc.edu
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Overview

Dr. Chen’s current research focuses on the signal pathway of cell death and its role and functional mechanism in cigarette smoking induced lung injury and inflammation, as well as their correlation with lung diseases, such as COPD, lung cancer. His current studies engaged into the interplay of apoptosis, necroptosis, and lung inflammatory response, including activation of macrophage, neutrophil and T cells. On the other hand, he is interested in studying how elastases (ELANE, MMP12, et al) released in the inflammatory microenvironment contribute to the progression of COPD and lung cancer. The long term goal is to identify novel molecular targets and treatment strategies to improve COPD, lung cancer therapy. He is also interested in studying the role and molecular mechanisms of aging in the progression of COPD and tumorigenesis.

Publications

  • RIP3-dependent necroptosis contributes to the pathogenesis of chronic obstructive pulmonary disease. JCI Insight. 2021 06 22; 6(12).. View in PubMed
  • RNA m6 A methylation regulates sorafenib resistance in liver cancer through FOXO3-mediated autophagy. EMBO J. 2020 06 17; 39(12):e103181.. View in PubMed
  • p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice. Hepatology. 2019 05; 69(5):2164-2179.. View in PubMed
  • Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer. Oncogene. 2018 08; 37(33):4599-4610.. View in PubMed
  • PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):3930-3935.. View in PubMed
  • Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res. 2017 05 01; 77(9):2512-2521.. View in PubMed
  • BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells. Oncotarget. 2016 Jul 26; 7(30):47699-47710.. View in PubMed
  • Necroptosis: an alternative cell death program defending against cancer. Biochim Biophys Acta. 2016 Apr; 1865(2):228-36.. View in PubMed
  • Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer. Oncotarget. 2015 Jun 20; 6(17):15022-34.. View in PubMed
  • Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis. Cell Death Dis. 2015 Apr 23; 6:e1729.. View in PubMed
  • TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity. Oncotarget. 2014 Sep 30; 5(18):8107-22.. View in PubMed
  • Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis. Clin Cancer Res. 2014 Jul 01; 20(13):3472-84.. View in PubMed
  • Understanding copper sensitivity in zebrafish (Danio rerio) through the intracellular localization of copper transporters in a hepatocyte cell-line ZFL and the tissue expression profiles of copper transporters. Metallomics. 2014 May; 6(5):1057-67.. View in PubMed
  • Aurora kinase inhibition induces PUMA via NF-κB to kill colon cancer cells. Mol Cancer Ther. 2014 May; 13(5):1298-308.. View in PubMed
  • Identification of hepatic copper-binding proteins from tilapia by column chromatography with proteomic approaches. Metallomics. 2012 Aug; 4(8):820-34.. View in PubMed
  • PCR-cloning of tilapia ATP7A cDNA and its mRNA levels in tissues of tilapia following copper administrations. Aquat Toxicol. 2011 Oct; 105(3-4):717-27.. View in PubMed
  • Effects of Cu2O nanoparticle and CuCl2 on zebrafish larvae and a liver cell-line. Aquat Toxicol. 2011 Oct; 105(3-4):344-54.. View in PubMed
  • Differentially expressed proteins in zebrafish liver cells exposed to copper. Aquat Toxicol. 2011 Aug; 104(3-4):270-7.. View in PubMed
  • Changes in the protein expression profiles of the Hepa-T1 cell line when exposed to Cu2+. Aquat Toxicol. 2009 Sep 14; 94(3):163-76.. View in PubMed
  • with Proteomic Techniques in Aplysia Under the Stress Condition of Cadmium Chloride. Chemical Journal of Chinese Universities-Chinese. 2009; 30:314-319.
  • Biokinetics of cadmium and zinc in a marine bacterium: influences of metal interaction and pre-exposure. Environ Toxicol Chem. 2008 Aug; 27(8):1794-801.. View in PubMed
  • MALDI-TOF-MS reveals diagnostic biomarkers in male patients with liver cancer. International Journal of Mass Spectrometry. 2007; 261(2-3):108-114.
  • Optimized Separation and Identification of Proteome from the Baccal Ganalion of Aplysia (Notarcus leachii cirrosus Stimpson). Chemical Journal of Chinese Universities-Chinese. 2006; 27:1257-1261.
  • Polymer Characteristics of Catechin and Catechin Ge4 Measured with a Technology of Mass Spectrometry. Chinese Journal of Analytical Chemistry. 2006; 1:52-56.

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