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Donna Shoupe, MD

Professor of Obstetrics & Gynecology

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Phone +1 323 226 3351
Email shoupe@usc.edu
CTSI Profile

Publications

  • Sex Steroid Hormones and Subclinical Atherosclerosis Progression in Postmenopausal Women Eur J Endocrinol. 2025 Feb 21. . View in PubMed
  • Estrogen deficiency in the menopause and the role of hormone therapy: integrating the findings of basic science research with clinical trials Menopause. 2024 Oct 01; 31(10):926-939. . View in PubMed
  • A comparison of letrozole regimens for ovulation induction in women with polycystic ovary syndrome F S Rep. 2024 Jun; 5(2):170-175. . View in PubMed
  • The progestin revolution 2: progestins are now a dominant player in the tight interlink between contraceptive protection and bleeding control-plus more Contracept Reprod Med. 2023 Oct 09; 8(1):48. . View in PubMed
  • The association of hysterectomy with or without ovarian conservation with subclinical atherosclerosis progression in healthy postmenopausal women Menopause. 2023 07 01; 30(7):692-702. . View in PubMed
  • Utilizations and characteristics of ovarian conservation at hysterectomy for cervical carcinoma in situ Int J Gynaecol Obstet. 2023 May; 161(2):631-639. . View in PubMed
  • Dietary and/or physical activity interventions in women with overweight or obesity prior to fertility treatment: protocol for a systematic review and individual participant data meta-analysis BMJ Open. 2022 11 07; 12(11):e065206. . View in PubMed
  • A Revised Markov Model Evaluating Oophorectomy at the Time of Hysterectomy for Benign Indication: Age 65 Years Revisited Obstet Gynecol. 2022 09 01; 140(3):520-521. . View in PubMed
  • Substantial variability in ovarian conservation at hysterectomy for endometrial hyperplasiaAm J Obstet Gynecol. 2022 08; 227(2):255. e1-255. e18. . View in PubMed
  • Effect of menopausal hormone therapy on arterial wall echomorphology: Results from the Early versus Late Intervention Trial with Estradiol (ELITE) Maturitas. 2022 08; 162:15-22. . View in PubMed
  • Use of oral estradiol plus vaginal progesterone in healthy postmenopausal women Maturitas. 2021 Dec; 154:13-19. . View in PubMed
  • The Progestin Revolution: progestins are arising as the dominant players in the tight interlink between contraceptives and bleeding control Contracept Reprod Med. 2021 Jan 07; 6(1):3. . View in PubMed
  • Factors Associated With Serum Estradiol Levels Among Postmenopausal Women Using Hormone Therapy Obstet Gynecol. 2020 10; 136(4):675-684. . View in PubMed
  • Patterns of utilization and outcome of ovarian conservation for young women with minimal-risk endometrial cancer Gynecol Oncol. 2019 07; 154(1):45-52. . View in PubMed
  • Differential Effect of Plasma Estradiol on Subclinical Atherosclerosis Progression in Early vs Late Postmenopause J Clin Endocrinol Metab. 2019 02 01; 104(2):293-300. . View in PubMed
  • Ovarian Conservation and Overall Survival in Young Women With Early-Stage Cervical Cancer Obstet Gynecol. 2017 01; 129(1):139-151. . View in PubMed
  • Ovarian Conservation and Overall Survival in Young Women With Early-Stage Low-Grade Endometrial Cancer Obstet Gynecol. 2016 10; 128(4):761-70. . View in PubMed
  • Rationale for Developing a Specimen Bank to Study the Pathogenesis of High-Grade Serous Carcinoma: A Review of the Evidence Cancer Prev Res (Phila). 2016 Sep; 9(9):713-20. . View in PubMed
  • Cognitive effects of estradiol after menopause: A randomized trial of the timing hypothesis Neurology. 2016 Aug 16; 87(7):699-708. . View in PubMed
  • Contributing factors for menopausal symptoms after surgical staging for endometrial cancer Menopause. 2016 05; 23(5):535-43. . View in PubMed
  • Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol N Engl J Med. 2016 Mar 31; 374(13):1221-31. . View in PubMed
  • Surgical menopause and increased risk of nonalcoholic fatty liver disease in endometrial cancer Menopause. 2016 Feb; 23(2):189-96. . View in PubMed
  • The effect of home exercise on ovulation induction using clomiphene citrate in overweight underserved women with polycystic ovarian syndrome Contracept Reprod Med. 2016; 1:14. . View in PubMed
  • LARC methods: entering a new age of contraception and reproductive health Contracept Reprod Med. 2016; 1:4. . View in PubMed
  • Surgical Menopause Endocrinol Metab Clin North Am. 2015 Sep; 44(3):531-42. . View in PubMed
  • Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradiol testing the menopausal hormone timing hypothesis Menopause. 2015 Apr; 22(4):391-401. . View in PubMed
  • Effect of prior oophorectomy on changes in bone mineral density and carotid artery intima-media thickness in postmenopausal women Fertil Steril. 2014 Apr; 101(4):1117-22. . View in PubMed
  • Hormone replacement therapy: consensus and controversies Panminerva Med. 2014; 56(4):263-72. . View in PubMed
  • Cognition, mood, and physiological concentrations of sex hormones in the early and late postmenopause Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20290-5. . View in PubMed
  • Individualizing hormone-therapy according to cardiovascular risk Minerva Ginecol. 2013 Dec; 65(6):631-9. . View in PubMed
  • In reply Obstet Gynecol. 2013 Aug; 122(2 Pt 1):396. . View in PubMed
  • Effect of isoflavone soy protein supplementation on endometrial thickness, hyperplasia, and endometrial cancer risk in postmenopausal women: a randomized controlled trial Menopause. 2013 Aug; 20(8):840-4. . View in PubMed
  • Long-term mortality associated with oophorectomy compared with ovarian conservation in the nurses’ health study Obstet Gynecol. 2013 Apr; 121(4):709-716. . View in PubMed
  • Individualizing hormone-therapy according to cardiovascular risk Minerva Med. 2012 Oct; 103(5):343-52. . View in PubMed
  • Isoflavone soy protein supplementation and atherosclerosis progression in healthy postmenopausal women: a randomized controlled trial Stroke. 2011 Nov; 42(11):3168-75. . View in PubMed
  • Individualizing hormone therapy to minimize risk: accurate assessment of risks and benefits Womens Health (Lond). 2011 Jul; 7(4):475-85. . View in PubMed
  • Effect of bilateral oophorectomy on women’s long-term health Womens Health (Lond). 2009 Sep; 5(5):565-76. . View in PubMed
  • Ovarian conservation at the time of hysterectomy and long-term health outcomes in the nurses’ health study Obstet Gynecol. 2009 May; 113(5):1027-1037. . View in PubMed
  • Elective oophorectomy in the gynecological patient: when is it desirable? Curr Opin Obstet Gynecol. 2007 Aug; 19(4):350-4.. View in PubMed
  • Ovarian conservation at the time of hysterectomy for benign disease Clin Obstet Gynecol. 2007 Jun; 50(2):354-61. . View in PubMed
  • Elective oophorectomy for benign gynecological disorders Menopause. 2007 May-Jun; 14(3 Pt 2):580-5. . View in PubMed
  • Unopposed estradiol therapy in postmenopausal women: results from two randomized trials Obstet Gynecol. 2007 Mar; 109(3):581-7. . View in PubMed
  • Postmenopausal oral estrogen therapy and blood pressure in normotensive and hypertensive subjects: the Estrogen in the Prevention of Atherosclerosis Trial Menopause. 2005 Nov-Dec; 12(6):728-33. . View in PubMed
  • Ovarian conservation at the time of hysterectomy for benign disease Obstet Gynecol. 2005 Aug; 106(2):219-26. . View in PubMed
  • A short study in the treatment of hot flashes with buccal administration of 17-beta estradiol Maturitas. 2004 Oct 15; 49(2):140-7. . View in PubMed
  • Elevated subclinical atherosclerosis associated with oophorectomy is related to time since menopause rather than type of menopause Fertil Steril. 2004 Aug; 82(2):391-7. . View in PubMed
  • Hormone therapy and the progression of coronary-artery atherosclerosis in postmenopausal women N Engl J Med. 2003 Aug 07; 349(6):535-45. . View in PubMed
  • Estrogen in the prevention of atherosclerosisA randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2001 Dec 04; 135(11):939-53. . View in PubMed
  • Comparison of estrogen and androgen levels after oral estrogen replacement therapy J Reprod Med. 2001 Dec; 46(12):1052-6. . View in PubMed
  • Relief of vasomotor symptoms and vaginal atrophy with lower doses of conjugated equine estrogens and medroxyprogesterone acetate Fertil Steril. 2001 Jun; 75(6):1065-79. . View in PubMed
  • Markedly elevated levels of estrone sulfate after long-term oral, but not transdermal, administration of estradiol in postmenopausal women Menopause. 2001 May-Jun; 8(3):200-3. . View in PubMed
  • HRT dosing regimens: continuous versus cyclic-pros and cons Int J Fertil Womens Med. 2001 Jan-Feb; 46(1):7-15. . View in PubMed
  • Hysterectomy or an alternative? Hosp Pract (1995). 2000 Sep 15; 35(9):55-62; quiz 92.. View in PubMed
  • Estrogen for Alzheimer’s disease in women: randomized, double-blind, placebo-controlled trial Neurology. 2000 Jan 25; 54(2):295-301. . View in PubMed
  • Hormone replacement therapy: reassessing the risks and benefits Hosp Pract (1995). 1999 Aug 15; 34(8):97-103107-8113-4. . View in PubMed
  • Androgens and bone: clinical implications for menopausal women Am J Obstet Gynecol. 1999 Mar; 180(3 Pt 2):S329-33. . View in PubMed
  • Phase I prehysterectomy studies of the transcervical administration of quinacrine pellets Contraception. 1996 Sep; 54(3):181-6. . View in PubMed
  • Contraception in the 1990s Curr Opin Obstet Gynecol. 1996 Jun; 8(3):211-5. . View in PubMed
  • Decreased central opioid activity in premenstrual syndrome: luteinizing hormone response to naloxone J Soc Gynecol Investig. 1996 Mar-Apr; 3(2):93-8. . View in PubMed
  • A contraceptive vaginal ring releasing norethindrone acetate and ethinyl estradiol Contraception. 1994 Dec; 50(6):517-33. . View in PubMed
  • Depot leuprolide acetate with estrogen and progestin add-back for long-term treatment of premenstrual syndrome Fertil Steril. 1994 Nov; 62(5):932-7. . View in PubMed
  • Multicenter randomized comparative trial of two low-dose triphasic combined oral contraceptives containing desogestrel or norethindrone Obstet Gynecol. 1994 May; 83(5 Pt 1):679-85. . View in PubMed
  • New progestins–clinical experiences: gestodene Am J Obstet Gynecol. 1994 May; 170(5 Pt 2):1562-8. . View in PubMed
  • Changes in mammographic densities induced by a hormonal contraceptive designed to reduce breast cancer risk J Natl Cancer Inst. 1994 Mar 16; 86(6):431-6. . View in PubMed
  • Prevention of vaginal trichomoniasis by compliant use of the female condom Sex Transm Dis. 1993 May-Jun; 20(3):137-9. . View in PubMed
  • Luteal phase defects J Reprod Med. 1993 May; 38(5):348-56. . View in PubMed
  • Pilot trial of a gonadotropin hormone agonist with replacement hormones as a prototype contraceptive to prevent breast cancer Contraception. 1993 May; 47(5):427-44. . View in PubMed
  • Effects of desogestrel on carbohydrate metabolism Am J Obstet Gynecol. 1993 Mar; 168(3 Pt 2):1041-7. . View in PubMed
  • Prevention of endometrial hyperplasia in postmenopausal women with intrauterine progesterone N Engl J Med. 1991 Dec 19; 325(25):1811-2. . View in PubMed
  • Gonadotropin-releasing hormone agonist plus add-back sex steroids to reduce risk of breast cancer J Natl Cancer Inst. 1991 Dec 04; 83(23):1763. . View in PubMed
  • GnRH agonists as contraceptive agents: predicted significantly reduced risk of breast cancer Contraception. 1991 Sep; 44(3):289-310. . View in PubMed
  • Postmenopausal hormone replacement with a combination estrogen-progestin regimen for five days per week J Reprod Med. 1991 May; 36(5):351-5. . View in PubMed
  • Characteristics of ovarian follicular development in Norplant users Fertil Steril. 1991 Apr; 55(4):766-70. . View in PubMed
  • The significance of bleeding patterns in Norplant implant users Obstet Gynecol. 1991 Feb; 77(2):256-60. . View in PubMed
  • Contraceptive options for the gestational diabetic woman Int J Fertil. 1991; 36 Suppl 2:80-4; discussion 84-6. . View in PubMed
  • Effect of low-dose oral contraceptives on carbohydrate and lipid metabolism in women with recent gestational diabetes: results of a controlled, randomized, prospective study Am J Obstet Gynecol. 1990 Dec; 163(6 Pt 1):1822-7. . View in PubMed
  • Antiprogestin treatment decreases midluteal luteinizing hormone pulse amplitude and primarily exerts a pituitary inhibition Am J Obstet Gynecol. 1990 Dec; 163(6 Pt 1):1982-5. . View in PubMed
  • Long-term contraception with the levonorgestrel 20 mcg/day (LNg 20) and the copper T 380Ag intrauterine devices: a five-year randomized study Contraception. 1990 Oct; 42(4):361-78. . View in PubMed
  • Predictors of failed attempted abortion with the antiprogestin mifepristone (RU 486) Am J Obstet Gynecol. 1990 Apr; 162(4):910-5; discussion 915-7. . View in PubMed
  • Norplant: subdermal implant system for long-term contraception Am J Obstet Gynecol. 1989 May; 160(5 Pt 2):1286-92. . View in PubMed
  • Correlation of endometrial maturation with four methods of estimating day of ovulation Obstet Gynecol. 1989 Jan; 73(1):88-92. . View in PubMed
  • Response to the antiprogestagen RU 486 (mifepristone) during early pregnancy and the menstrual cycle in women J Reprod Fertil Suppl. 1989; 37:253-60. . View in PubMed
  • A randomized comparison of nonoral estradiol delivery in postmenopausal women Am J Obstet Gynecol. 1988 Dec; 159(6):1540-6. . View in PubMed
  • Early abortion with a single dose of the antiprogestin RU-486 Am J Obstet Gynecol. 1988 Jun; 158(6 Pt 1):1307-12. . View in PubMed
  • Effects of oral contraceptives on the borderline NIDD patient Int J Fertil. 1988; 33 Suppl:27-34. . View in PubMed
  • Effects of the antiprogesterone RU 486 in normal womenI. Single-dose administration in the midluteal phase. Am J Obstet Gynecol. 1987 Dec; 157(6):1415-20. . View in PubMed
  • Effects of the antiprogesterone RU 486 in normal womenII. Administration in the late follicular phase. Am J Obstet Gynecol. 1987 Dec; 157(6):1421-6. . View in PubMed
  • Metabolism and serum binding of RU 486 in women after various single doses Hum Reprod. 1987 Jul; 2(5):379-85. . View in PubMed
  • Termination of early gestation with the anti-progestin steroid RU 486: medium versus low dose Contraception. 1987 Apr; 35(4):307-21. . View in PubMed
  • Pharmacokinetics and metabolism of RU 486 J Steroid Biochem. 1987; 27(4-6):859-63. . View in PubMed
  • Quantitation of RU 486 in human plasma by HPLC and RIA after column chromatography Contraception. 1986 Dec; 34(6):613-24. . View in PubMed
  • Recovery of fertility after use of the levonorgestrel 20 mcg/d or Copper T 380 Ag intrauterine device Contraception. 1986 Sep; 34(3):261-7. . View in PubMed
  • Pregnancy termination with a high and medium dosage regimen of RU 486 Contraception. 1986 May; 33(5):455-61. . View in PubMed
  • Ovulation inhibition with nafarelin acetate nasal administration for six months Contraception. 1985 Dec; 32(6):531-51. . View in PubMed
  • Dose-related changes in LH bioactivity with intranasal GnRH agonist administration Contraception. 1985 Oct; 32(4):347-57. . View in PubMed
  • Estrogen and progestin effects on urinary calcium and calciotropic hormones in surgically-induced postmenopausal women Horm Metab Res. 1985 Jul; 17(7):370-3. . View in PubMed
  • Prolactin response after gonadotropin-releasing hormone in the polycystic ovary syndrome Fertil Steril. 1985 Apr; 43(4):549-53. . View in PubMed
  • The effects of two doses of spironolactone on serum androgens and anagen hair in hirsute women Fertil Steril. 1985 Feb; 43(2):200-5. . View in PubMed
  • The effects of estrogen and progestin on endogenous opioid activity in oophorectomized women J Clin Endocrinol Metab. 1985 Jan; 60(1):178-83. . View in PubMed
  • Priming with gonadotropin-releasing hormone restores gonadotropin secretion during first but not second trimester of pregnancy Am J Obstet Gynecol. 1984 Nov 01; 150(5 Pt 1):460-4. . View in PubMed
  • Evidence for altered catecholamine metabolism in polycystic ovary syndrome Am J Obstet Gynecol. 1984 Nov 01; 150(5 Pt 1):566-71. . View in PubMed
  • Central and peripheral metabolites of norepinephrine and dopamine in postmenopausal women Am J Obstet Gynecol. 1984 Jul 01; 149(5):548-52. . View in PubMed
  • Differences in the ratio of bioactive to immunoreactive serum luteinizing hormone during vasomotor flushes and hormonal therapy in postmenopausal women J Clin Endocrinol Metab. 1984 May; 58(5):925-9. . View in PubMed
  • The influence of androgens on insulin resistance Fertil Steril. 1984 Mar; 41(3):385-8. . View in PubMed
  • The control of bioactive luteinizing hormone secretion in women with polycystic ovary syndrome Am J Obstet Gynecol. 1984 Feb 15; 148(4):423-8. . View in PubMed
  • Insulin resistance in polycystic ovary syndrome Am J Obstet Gynecol. 1983 Nov 01; 147(5):588-92. . View in PubMed
  • Prolactin molecular heterogeneityResponse to thyrotropin-releasing hormone stimulation of concanavalin A-bound and -unbound immunoassayable prolactin during human pregnancy. Am J Obstet Gynecol. 1983 Nov 01; 147(5):482-7. . View in PubMed

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