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Donna Shoupe, MD

Professor of Obstetrics & Gynecology

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Phone +1 323 226 3351
Email shoupe@usc.edu
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Publications

  • Effect of hormone therapy on tryptophan metabolism and atherosclerosis among postmenopausal women. Climacteric. 2025 Dec; 28(6):702-708.. View in PubMed
  • Letters to the Editor. Menopause. 2025 Jul 01; 32(7):669-671.. View in PubMed
  • Sex steroid hormones and subclinical atherosclerosis progression in postmenopausal women. Eur J Endocrinol. 2025 Mar 03; 192(3):248-256.. View in PubMed
  • Estrogen deficiency in the menopause and the role of hormone therapy: integrating the findings of basic science research with clinical trials. Menopause. 2024 Oct 01; 31(10):926-939.. View in PubMed
  • A comparison of letrozole regimens for ovulation induction in women with polycystic ovary syndrome. F S Rep. 2024 Jun; 5(2):170-175.. View in PubMed
  • The progestin revolution 2: progestins are now a dominant player in the tight interlink between contraceptive protection and bleeding control-plus more. Contracept Reprod Med. 2023 Oct 09; 8(1):48.. View in PubMed
  • The association of hysterectomy with or without ovarian conservation with subclinical atherosclerosis progression in healthy postmenopausal women. Menopause. 2023 07 01; 30(7):692-702.. View in PubMed
  • Utilizations and characteristics of ovarian conservation at hysterectomy for cervical carcinoma in situ. Int J Gynaecol Obstet. 2023 May; 161(2):631-639.. View in PubMed
  • Dietary and/or physical activity interventions in women with overweight or obesity prior to fertility treatment: protocol for a systematic review and individual participant data meta-analysis. BMJ Open. 2022 11 07; 12(11):e065206.. View in PubMed
  • A Revised Markov Model Evaluating Oophorectomy at the Time of Hysterectomy for Benign Indication: Age 65 Years Revisited. Obstet Gynecol. 2022 09 01; 140(3):520-521.. View in PubMed
  • Substantial variability in ovarian conservation at hysterectomy for endometrial hyperplasia. Am J Obstet Gynecol. 2022 08; 227(2):255.e1-255.e18.. View in PubMed
  • Effect of menopausal hormone therapy on arterial wall echomorphology: Results from the Early versus Late Intervention Trial with Estradiol (ELITE). Maturitas. 2022 08; 162:15-22.. View in PubMed
  • Use of oral estradiol plus vaginal progesterone in healthy postmenopausal women. Maturitas. 2021 Dec; 154:13-19.. View in PubMed
  • The Progestin Revolution: progestins are arising as the dominant players in the tight interlink between contraceptives and bleeding control. Contracept Reprod Med. 2021 Jan 07; 6(1):3.. View in PubMed
  • Factors Associated With Serum Estradiol Levels Among Postmenopausal Women Using Hormone Therapy. Obstet Gynecol. 2020 10; 136(4):675-684.. View in PubMed
  • Patterns of utilization and outcome of ovarian conservation for young women with minimal-risk endometrial cancer. Gynecol Oncol. 2019 07; 154(1):45-52.. View in PubMed
  • Differential Effect of Plasma Estradiol on Subclinical Atherosclerosis Progression in Early vs Late Postmenopause. J Clin Endocrinol Metab. 2019 02 01; 104(2):293-300.. View in PubMed
  • Ovarian Conservation and Overall Survival in Young Women With Early-Stage Cervical Cancer. Obstet Gynecol. 2017 01; 129(1):139-151.. View in PubMed
  • Ovarian Conservation and Overall Survival in Young Women With Early-Stage Low-Grade Endometrial Cancer. Obstet Gynecol. 2016 10; 128(4):761-70.. View in PubMed
  • Rationale for Developing a Specimen Bank to Study the Pathogenesis of High-Grade Serous Carcinoma: A Review of the Evidence. Cancer Prev Res (Phila). 2016 Sep; 9(9):713-20.. View in PubMed
  • Cognitive effects of estradiol after menopause: A randomized trial of the timing hypothesis. Neurology. 2016 Aug 16; 87(7):699-708.. View in PubMed
  • Contributing factors for menopausal symptoms after surgical staging for endometrial cancer. Menopause. 2016 05; 23(5):535-43.. View in PubMed
  • Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol. N Engl J Med. 2016 Mar 31; 374(13):1221-31.. View in PubMed
  • Surgical menopause and increased risk of nonalcoholic fatty liver disease in endometrial cancer. Menopause. 2016 Feb; 23(2):189-96.. View in PubMed
  • The effect of home exercise on ovulation induction using clomiphene citrate in overweight underserved women with polycystic ovarian syndrome. Contracept Reprod Med. 2016; 1:14.. View in PubMed
  • LARC methods: entering a new age of contraception and reproductive health. Contracept Reprod Med. 2016; 1:4.. View in PubMed
  • Surgical Menopause. Endocrinol Metab Clin North Am. 2015 Sep; 44(3):531-42.. View in PubMed
  • Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradiol testing the menopausal hormone timing hypothesis. Menopause. 2015 Apr; 22(4):391-401.. View in PubMed
  • Effect of prior oophorectomy on changes in bone mineral density and carotid artery intima-media thickness in postmenopausal women. Fertil Steril. 2014 Apr; 101(4):1117-22.. View in PubMed
  • Hormone replacement therapy: consensus and controversies. Panminerva Med. 2014; 56(4):263-72.. View in PubMed
  • Cognition, mood, and physiological concentrations of sex hormones in the early and late postmenopause. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20290-5.. View in PubMed
  • Individualizing hormone-therapy according to cardiovascular risk. Minerva Ginecol. 2013 Dec; 65(6):631-9.. View in PubMed
  • In reply. Obstet Gynecol. 2013 Aug; 122(2 Pt 1):396.. View in PubMed
  • Effect of isoflavone soy protein supplementation on endometrial thickness, hyperplasia, and endometrial cancer risk in postmenopausal women: a randomized controlled trial. Menopause. 2013 Aug; 20(8):840-4.. View in PubMed
  • Long-term mortality associated with oophorectomy compared with ovarian conservation in the nurses’ health study. Obstet Gynecol. 2013 Apr; 121(4):709-716.. View in PubMed
  • Individualizing hormone-therapy according to cardiovascular risk. Minerva Med. 2012 Oct; 103(5):343-52.. View in PubMed
  • Isoflavone soy protein supplementation and atherosclerosis progression in healthy postmenopausal women: a randomized controlled trial. Stroke. 2011 Nov; 42(11):3168-75.. View in PubMed
  • Individualizing hormone therapy to minimize risk: accurate assessment of risks and benefits. Womens Health (Lond). 2011 Jul; 7(4):475-85.. View in PubMed
  • Effect of bilateral oophorectomy on women’s long-term health. Womens Health (Lond). 2009 Sep; 5(5):565-76.. View in PubMed
  • Ovarian conservation at the time of hysterectomy and long-term health outcomes in the nurses’ health study. Obstet Gynecol. 2009 May; 113(5):1027-1037.. View in PubMed
  • Elective oophorectomy in the gynecological patient: when is it desirable? Curr Opin Obstet Gynecol. 2007 Aug; 19(4):350-4.. View in PubMed
  • Ovarian conservation at the time of hysterectomy for benign disease. Clin Obstet Gynecol. 2007 Jun; 50(2):354-61.. View in PubMed
  • Elective oophorectomy for benign gynecological disorders. Menopause. 2007 May-Jun; 14(3 Pt 2):580-5.. View in PubMed
  • Unopposed estradiol therapy in postmenopausal women: results from two randomized trials. Obstet Gynecol. 2007 Mar; 109(3):581-7.. View in PubMed
  • Postmenopausal oral estrogen therapy and blood pressure in normotensive and hypertensive subjects: the Estrogen in the Prevention of Atherosclerosis Trial. Menopause. 2005 Nov-Dec; 12(6):728-33.. View in PubMed
  • Ovarian conservation at the time of hysterectomy for benign disease. Obstet Gynecol. 2005 Aug; 106(2):219-26.. View in PubMed
  • A short study in the treatment of hot flashes with buccal administration of 17-beta estradiol. Maturitas. 2004 Oct 15; 49(2):140-7.. View in PubMed
  • Elevated subclinical atherosclerosis associated with oophorectomy is related to time since menopause rather than type of menopause. Fertil Steril. 2004 Aug; 82(2):391-7.. View in PubMed
  • Hormone therapy and the progression of coronary-artery atherosclerosis in postmenopausal women. N Engl J Med. 2003 Aug 07; 349(6):535-45.. View in PubMed
  • Estrogen in the prevention of atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2001 Dec 04; 135(11):939-53.. View in PubMed
  • Comparison of estrogen and androgen levels after oral estrogen replacement therapy. J Reprod Med. 2001 Dec; 46(12):1052-6.. View in PubMed
  • Relief of vasomotor symptoms and vaginal atrophy with lower doses of conjugated equine estrogens and medroxyprogesterone acetate. Fertil Steril. 2001 Jun; 75(6):1065-79.. View in PubMed
  • Markedly elevated levels of estrone sulfate after long-term oral, but not transdermal, administration of estradiol in postmenopausal women. Menopause. 2001 May-Jun; 8(3):200-3.. View in PubMed
  • HRT dosing regimens: continuous versus cyclic-pros and cons. Int J Fertil Womens Med. 2001 Jan-Feb; 46(1):7-15.. View in PubMed
  • Hysterectomy or an alternative? Hosp Pract (1995). 2000 Sep 15; 35(9):55-62; quiz 92.. View in PubMed
  • Estrogen for Alzheimer’s disease in women: randomized, double-blind, placebo-controlled trial. Neurology. 2000 Jan 25; 54(2):295-301.. View in PubMed
  • Hormone replacement therapy: reassessing the risks and benefits. Hosp Pract (1995). 1999 Aug 15; 34(8):97-103, 107-8, 113-4.. View in PubMed
  • Androgens and bone: clinical implications for menopausal women. Am J Obstet Gynecol. 1999 Mar; 180(3 Pt 2):S329-33.. View in PubMed
  • Phase I prehysterectomy studies of the transcervical administration of quinacrine pellets. Contraception. 1996 Sep; 54(3):181-6.. View in PubMed
  • Contraception in the 1990s. Curr Opin Obstet Gynecol. 1996 Jun; 8(3):211-5.. View in PubMed
  • Decreased central opioid activity in premenstrual syndrome: luteinizing hormone response to naloxone. J Soc Gynecol Investig. 1996 Mar-Apr; 3(2):93-8.. View in PubMed
  • A contraceptive vaginal ring releasing norethindrone acetate and ethinyl estradiol. Contraception. 1994 Dec; 50(6):517-33.. View in PubMed
  • Depot leuprolide acetate with estrogen and progestin add-back for long-term treatment of premenstrual syndrome. Fertil Steril. 1994 Nov; 62(5):932-7.. View in PubMed
  • New progestins–clinical experiences: gestodene. Am J Obstet Gynecol. 1994 May; 170(5 Pt 2):1562-8.. View in PubMed
  • Multicenter randomized comparative trial of two low-dose triphasic combined oral contraceptives containing desogestrel or norethindrone. Obstet Gynecol. 1994 May; 83(5 Pt 1):679-85.. View in PubMed
  • Changes in mammographic densities induced by a hormonal contraceptive designed to reduce breast cancer risk. J Natl Cancer Inst. 1994 Mar 16; 86(6):431-6.. View in PubMed
  • Luteal phase defects. J Reprod Med. 1993 May; 38(5):348-56.. View in PubMed
  • Pilot trial of a gonadotropin hormone agonist with replacement hormones as a prototype contraceptive to prevent breast cancer. Contraception. 1993 May; 47(5):427-44.. View in PubMed
  • Prevention of vaginal trichomoniasis by compliant use of the female condom. Sex Transm Dis. 1993 May-Jun; 20(3):137-9.. View in PubMed
  • Effects of desogestrel on carbohydrate metabolism. Am J Obstet Gynecol. 1993 Mar; 168(3 Pt 2):1041-7.. View in PubMed
  • Prevention of endometrial hyperplasia in postmenopausal women with intrauterine progesterone. N Engl J Med. 1991 Dec 19; 325(25):1811-2.. View in PubMed
  • Gonadotropin-releasing hormone agonist plus add-back sex steroids to reduce risk of breast cancer. J Natl Cancer Inst. 1991 Dec 04; 83(23):1763.. View in PubMed
  • GnRH agonists as contraceptive agents: predicted significantly reduced risk of breast cancer. Contraception. 1991 Sep; 44(3):289-310.. View in PubMed
  • Postmenopausal hormone replacement with a combination estrogen-progestin regimen for five days per week. J Reprod Med. 1991 May; 36(5):351-5.. View in PubMed
  • Characteristics of ovarian follicular development in Norplant users. Fertil Steril. 1991 Apr; 55(4):766-70.. View in PubMed
  • The significance of bleeding patterns in Norplant implant users. Obstet Gynecol. 1991 Feb; 77(2):256-60.. View in PubMed
  • Contraceptive options for the gestational diabetic woman. Int J Fertil. 1991; 36 Suppl 2:80-4; discussion 84-6.. View in PubMed
  • Effect of low-dose oral contraceptives on carbohydrate and lipid metabolism in women with recent gestational diabetes: results of a controlled, randomized, prospective study. Am J Obstet Gynecol. 1990 Dec; 163(6 Pt 1):1822-7.. View in PubMed
  • Antiprogestin treatment decreases midluteal luteinizing hormone pulse amplitude and primarily exerts a pituitary inhibition. Am J Obstet Gynecol. 1990 Dec; 163(6 Pt 1):1982-5.. View in PubMed
  • Long-term contraception with the levonorgestrel 20 mcg/day (LNg 20) and the copper T 380Ag intrauterine devices: a five-year randomized study. Contraception. 1990 Oct; 42(4):361-78.. View in PubMed
  • Predictors of failed attempted abortion with the antiprogestin mifepristone (RU 486). Am J Obstet Gynecol. 1990 Apr; 162(4):910-5; discussion 915-7.. View in PubMed
  • Norplant: subdermal implant system for long-term contraception. Am J Obstet Gynecol. 1989 May; 160(5 Pt 2):1286-92.. View in PubMed
  • Correlation of endometrial maturation with four methods of estimating day of ovulation. Obstet Gynecol. 1989 Jan; 73(1):88-92.. View in PubMed
  • Response to the antiprogestagen RU 486 (mifepristone) during early pregnancy and the menstrual cycle in women. J Reprod Fertil Suppl. 1989; 37:253-60.. View in PubMed
  • A randomized comparison of nonoral estradiol delivery in postmenopausal women. Am J Obstet Gynecol. 1988 Dec; 159(6):1540-6.. View in PubMed
  • Early abortion with a single dose of the antiprogestin RU-486. Am J Obstet Gynecol. 1988 Jun; 158(6 Pt 1):1307-12.. View in PubMed
  • Effects of oral contraceptives on the borderline NIDD patient. Int J Fertil. 1988; 33 Suppl:27-34.. View in PubMed
  • Effects of the antiprogesterone RU 486 in normal women. I. Single-dose administration in the midluteal phase. Am J Obstet Gynecol. 1987 Dec; 157(6):1415-20.. View in PubMed
  • Effects of the antiprogesterone RU 486 in normal women. II. Administration in the late follicular phase. Am J Obstet Gynecol. 1987 Dec; 157(6):1421-6.. View in PubMed
  • Metabolism and serum binding of RU 486 in women after various single doses. Hum Reprod. 1987 Jul; 2(5):379-85.. View in PubMed
  • Termination of early gestation with the anti-progestin steroid RU 486: medium versus low dose. Contraception. 1987 Apr; 35(4):307-21.. View in PubMed
  • Pharmacokinetics and metabolism of RU 486. J Steroid Biochem. 1987; 27(4-6):859-63.. View in PubMed
  • Quantitation of RU 486 in human plasma by HPLC and RIA after column chromatography. Contraception. 1986 Dec; 34(6):613-24.. View in PubMed
  • Recovery of fertility after use of the levonorgestrel 20 mcg/d or Copper T 380 Ag intrauterine device. Contraception. 1986 Sep; 34(3):261-7.. View in PubMed
  • Pregnancy termination with a high and medium dosage regimen of RU 486. Contraception. 1986 May; 33(5):455-61.. View in PubMed
  • Ovulation inhibition with nafarelin acetate nasal administration for six months. Contraception. 1985 Dec; 32(6):531-51.. View in PubMed
  • Dose-related changes in LH bioactivity with intranasal GnRH agonist administration. Contraception. 1985 Oct; 32(4):347-57.. View in PubMed
  • Estrogen and progestin effects on urinary calcium and calciotropic hormones in surgically-induced postmenopausal women. Horm Metab Res. 1985 Jul; 17(7):370-3.. View in PubMed
  • Prolactin response after gonadotropin-releasing hormone in the polycystic ovary syndrome. Fertil Steril. 1985 Apr; 43(4):549-53.. View in PubMed
  • The effects of two doses of spironolactone on serum androgens and anagen hair in hirsute women. Fertil Steril. 1985 Feb; 43(2):200-5.. View in PubMed
  • The effects of estrogen and progestin on endogenous opioid activity in oophorectomized women. J Clin Endocrinol Metab. 1985 Jan; 60(1):178-83.. View in PubMed
  • Evidence for altered catecholamine metabolism in polycystic ovary syndrome. Am J Obstet Gynecol. 1984 Nov 01; 150(5 Pt 1):566-71.. View in PubMed
  • Priming with gonadotropin-releasing hormone restores gonadotropin secretion during first but not second trimester of pregnancy. Am J Obstet Gynecol. 1984 Nov 01; 150(5 Pt 1):460-4.. View in PubMed
  • Central and peripheral metabolites of norepinephrine and dopamine in postmenopausal women. Am J Obstet Gynecol. 1984 Jul 01; 149(5):548-52.. View in PubMed
  • Differences in the ratio of bioactive to immunoreactive serum luteinizing hormone during vasomotor flushes and hormonal therapy in postmenopausal women. J Clin Endocrinol Metab. 1984 May; 58(5):925-9.. View in PubMed
  • The influence of androgens on insulin resistance. Fertil Steril. 1984 Mar; 41(3):385-8.. View in PubMed
  • The control of bioactive luteinizing hormone secretion in women with polycystic ovary syndrome. Am J Obstet Gynecol. 1984 Feb 15; 148(4):423-8.. View in PubMed
  • Insulin resistance in polycystic ovary syndrome. Am J Obstet Gynecol. 1983 Nov 01; 147(5):588-92.. View in PubMed
  • Prolactin molecular heterogeneity. Response to thyrotropin-releasing hormone stimulation of concanavalin A-bound and -unbound immunoassayable prolactin during human pregnancy. Am J Obstet Gynecol. 1983 Nov 01; 147(5):482-7.. View in PubMed

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