Keck School Faculty

Douglas E. Feldman, PhD
Douglas E. Feldman, PhD
Assistant Professor of Research Pathology
HMR 2011 Zonal Ave Health Sciences Campus Los Angeles
Our laboratory studies how conserved elements of bacterial anti-phage immunity and phage counter-restriction systems function in the context of human innate immunity and in gene control.

Categories: Gene Control, Stem Cells, Cancer, Epigenetics, DNA modification

HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B CellsMol Cell. 2020 Jan 16; 77(2):384-394. e4. . View in PubMed

An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb SilencingMol Cell. 2019 06 20; 74(6):1138-1147. e6. . View in PubMed

Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease Cell Rep. 2017 Oct 10; 21(2):482-494. . View in PubMed

The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex PLoS One. 2013; 8(2):e57312. . View in PubMed

Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):829-34. . View in PubMed

Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding Mol Cell. 2003 Nov; 12(5):1213-24. . View in PubMed

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