Keck School Faculty

Douglas E. Feldman

Douglas E. Feldman

Assistant Professor of Research Pathology
Pathology
HMR 2011 Zonal Ave Health Sciences Campus Los Angeles

Bacteriophage anti-defense genes that neutralize TIR and STING immune responses bioRxiv. 2022. . View in PubMed

HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B CellsMol Cell. 2020 01 16; 77(2):384-394. e4. . View in PubMed

An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb SilencingMol Cell. 2019 06 20; 74(6):1138-1147. e6. . View in PubMed

Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease Cell Rep. 2017 Oct 10; 21(2):482-494. . View in PubMed

Reciprocal regulation by TLR4 and TGF-ß in tumor-initiating stem-like cells J Clin Invest. 2013 Jul; 123(7):2832-49. . View in PubMed

The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex PLoS One. 2013; 8(2):e57312. . View in PubMed

Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. . View in PubMed

Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):829-34. . View in PubMed

Identification of mitogen-activated protein kinase signaling pathways that confer resistance to endoplasmic reticulum stress in Saccharomyces cerevisiae Mol Cancer Res. 2005 Dec; 3(12):669-77. . View in PubMed

Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding Mol Cell. 2003 Nov; 12(5):1213-24. . View in PubMed

Functional analysis of viral counter-immune systems.
We seek to translate insights from studies on virus anti-defense systems into the design, engineering and testing of novel immunomodulators and therapeutics for the treatment of life-threatening diseases, including cancer and fibrotic liver disease.


Categories: Gene Control, Stem Cells, Cancer, Epigenetics, DNA modification, immune engineering, immunotherapy
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