Edy Soffer, MD

Professor of Clinical Medicine

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Edy E. Soffer, MD is Director of the GI Motility program at the Division of Gastroenterology, Keck School of Medicine of USC. Dr. Soffer’s primary areas of research interest involve innovative treatments for gastroesophageal reflux disease and gastroparesis. His research has received funding from the American College of Gastroenterology, the BIRD Foundation, and several pharmaceutical companies.

Board certified in Internal Medicine with a subspecialty in gastroenterology, Dr. Soffer is a member of the American College of Gastroenterology, American Gastroenterological Association and American Motility Society. He has written articles for numerous peer-reviewed publications, including American Journal of Gastroenterology, American Journal of Physiology, Neurogastroenterology & Motility, Digestive Diseases and Sciences, and Medical Engineering and Technology.

Dr. Soffer received his medical degree from Technion School of Medicine in Haifa, Israel. He completed internships at Soroka Medical Center in Beer-Sheva, Israel and at Coney Island Hospital in New York, where he also completed a residency in internal medicine. Dr. Soffer fulfilled a fellowship in gastroenterology at the University of Tennessee Center for Health Sciences in Memphis and research fellowships at the University of Iowa Hospital/Clinic in Iowa City and at London Hospital Medical College in England.


  • Asia Pacific Digestive Week: Presidential Award, 2012
  • Editorial Board of Neurogastroenterology and Motility: Most Cited Manuscript Award, 2004


  • Electroceuticals for Neurogastroenterology and Motility Disorders Curr Gastroenterol Rep. 2023 Apr; 25(4):91-97. . View in PubMed
  • DrJeffrey L. Conklin memoriam. Neurogastroenterol Motil. 2022 Oct; 34(10):e14463. . View in PubMed
  • Sleeve Gastrectomy as a Novel Procedure for Gastroparesis Am Surg. 2021 Aug; 87(8):1287-1291. . View in PubMed
  • Pattern of methane levels with lactulose breath testing; can we shorten the test duration? JGH Open. 2021 Jul; 5(7):809-812.. View in PubMed
  • Gender-Specific Risk Factors for Reflux Esophagitis in a Predominantly Hispanic Population of a Large Safety-Net Hospital Dig Dis Sci. 2021 06; 66(6):1940-1948. . View in PubMed
  • Effect of bolus enteral tube feeding on body weight in ambulatory adults with obesity and type 2 diabetes: a feasibility pilot randomized trial Nutr Diabetes. 2020 06 17; 10(1):22. . View in PubMed
  • Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors World J Gastrointest Pharmacol Ther. 2016 Feb 06; 7(1):145-55. . View in PubMed
  • Provocative testing of the esophagus and its future Ann N Y Acad Sci. 2016 09; 1380(1):33-47. . View in PubMed
  • Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD: long-term 3-year results Surg Endosc. 2016 07; 30(7):2666-72. . View in PubMed
  • Electrical stimulation for gastroesophageal reflux disease: current state of the art Clin Exp Gastroenterol. 2016; 9:11-9. . View in PubMed
  • Novel surgical options for gastroesophageal reflux disease Expert Rev Gastroenterol Hepatol. 2015 Jul; 9(7):943-51. . View in PubMed
  • Two-year results of intermittent electrical stimulation of the lower esophageal sphincter treatment of gastroesophageal reflux disease Surgery. 2015 Mar; 157(3):556-67. . View in PubMed
  • Gastric electrical stimulation for obesity Curr Gastroenterol Rep. 2015 Jan; 17(1):424. . View in PubMed
  • Long-term results of electrical stimulation of the lower esophageal sphincter for treatment of proximal GERD Surg Endosc. 2014 Dec; 28(12):3293-301. . View in PubMed
  • American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation Am J Gastroenterol. 2014 Aug; 109 Suppl 1:S2-26; quiz S27. . View in PubMed
  • Successful gastric volvulus reduction and gastropexy using a dual endoscope technique Case Rep Med. 2014; 2014:136381. . View in PubMed
  • Recorded lower esophageal pressures as a function of electronic sleeve placement and location of gastric pressure measurement in patients with hiatal hernia J Neurogastroenterol Motil. 2013 Oct; 19(4):479-84. . View in PubMed
  • Smoothelin expression in the gastrointestinal tract: implication in colonic inertia Appl Immunohistochem Mol Morphol. 2013 Oct; 21(5):452-9. . View in PubMed
  • Long-term results of electrical stimulation of the lower esophageal sphincter for the treatment of gastroesophageal reflux disease Endoscopy. 2013 Aug; 45(8):595-604. . View in PubMed
  • Evaluation of peripapillary lymphocytosis and lymphocytic esophagitis in adult inflammatory bowel disease Gastroenterol Hepatol (N Y). 2013 Aug; 9(8):505-11. . View in PubMed
  • Correlation between serum serotonin and endoscopy inflammation scores in patients with ileal pouches J Crohns Colitis. 2013 May; 7(4):e133-42. . View in PubMed
  • Severity of dyspeptic symptoms correlates with delayed and early variables of gastric emptying Dig Dis Sci. 2013 Feb; 58(2):478-87. . View in PubMed
  • Short-term electrical stimulation of the lower esophageal sphincter increases sphincter pressure in patients with gastroesophageal reflux disease Neurogastroenterol Motil. 2012 May; 24(5):446-50e213. . View in PubMed
  • Gastric electrical stimulation for gastroparesis J Neurogastroenterol Motil. 2012 Apr; 18(2):131-7. . View in PubMed
  • Intestinal methane production in obese individuals is associated with a higher body mass index Gastroenterol Hepatol (N Y). 2012 Jan; 8(1):22-8. . View in PubMed
  • Review article: the impact of bariatric surgery on gastrointestinal motility Aliment Pharmacol Ther. 2011 Oct; 34(8):825-31. . View in PubMed
  • Efficacy of the glucagon-like peptide-1 agonist exenatide in the treatment of short bowel syndrome Neurogastroenterol Motil. 2011 Aug; 23(8):739-e328. . View in PubMed
  • Apple sauce improves detection of esophageal motor dysfunction during high-resolution manometry evaluation of dysphagia Dig Dis Sci. 2011 Jun; 56(6):1723-8. . View in PubMed
  • Evaluation of gastrointestinal transit in clinical practice: position paper of the American and European Neurogastroenterology and Motility Societies Neurogastroenterol Motil. 2011 Jan; 23(1):8-23. . View in PubMed
  • ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS World J Gastroenterol. 2010 Aug 07; 16(29):3680-6. . View in PubMed
  • Redefining the role of lymphocytes in gastroesophageal reflux disease and eosinophilic esophagitis Dis Esophagus. 2010 Jul; 23(5):368-76. . View in PubMed
  • Review article: gastric electrical stimulation for gastroparesis–physiological foundations, technical aspects and clinical implications Aliment Pharmacol Ther. 2009 Oct; 30(7):681-94. . View in PubMed
  • A high-resolution view of achalasia J Clin Gastroenterol. 2009 Aug; 43(7):644-51. . View in PubMed
  • Gastric electrical stimulation with the TANTALUS System in obese type 2 diabetes patients: effect on weight and glycemic control J Diabetes Sci Technol. 2009 Jul 01; 3(4):964-70. . View in PubMed
  • The effect of eating on lower esophageal sphincter electrical activity Am J Physiol Gastrointest Liver Physiol. 2009 Apr; 296(4):G793-7. . View in PubMed
  • Concurrent findings of achalasia and duodenal duplication in a Down syndrome patient J Formos Med Assoc. 2009 Jan; 108(1):78-81. . View in PubMed
  • Gastric electrical stimulation for gastroparesis J Am Coll Surg. 2008 Oct; 207(4):533-8. . View in PubMed
  • Effect of electrical stimulation of the LES on LES pressure in a canine model Am J Physiol Gastrointest Liver Physiol. 2008 Aug; 295(2):G389-94. . View in PubMed
  • The TANTALUS system for obesity: effect on gastric emptying of solids and ghrelin plasma levels Obes Surg. 2007 Nov; 17(11):1503-9. . View in PubMed
  • Oral pantoprazole in the form of granules or tablets are pharmacodynamically equivalent in suppressing acid output in patients with gastro-oesophageal reflux disease and a history of erosive oesophagitis Aliment Pharmacol Ther. 2007 Jul 15; 26(2):249-56. . View in PubMed
  • Laparoscopic insertion of gastric electrodes for electrical stimulation J Laparoendosc Adv Surg Tech A. 2007 Feb; 17(1):1-6. . View in PubMed
  • Neural gastrointestinal electrical stimulation enhances colonic motility in a chronic canine model of delayed colonic transit Neurogastroenterol Motil. 2006 Aug; 18(8):647-53. . View in PubMed
  • Gastric electrical stimulation significantly increases canine lower esophageal sphincter pressure Dig Dis Sci. 2005 Aug; 50(8):1481-7. . View in PubMed
  • Esophageal manometry: assessment of interpreter consistency Clin Gastroenterol Hepatol. 2005 Mar; 3(3):218-24. . View in PubMed
  • Laparoscopic revision of gastric pacing wires J Laparoendosc Adv Surg Tech A. 2004 Jun; 14(3):187-9. . View in PubMed
  • Intestinal dysmotility and its relationship to sphincter of Oddi dysfunction Curr Gastroenterol Rep. 2004 Apr; 6(2):137-9. . View in PubMed
  • Gastric electrical stimulation does not significantly affect canine gastric acid secretion and 24-hour gastric pH Dig Dis Sci. 2004 Jan; 49(1):48-53. . View in PubMed
  • Transcutaneous electrical acustimulation can reduce visceral perception in patients with the irritable bowel syndrome: a pilot study Altern Ther Health Med. 2004 Jan-Feb; 10(1):38-42. . View in PubMed
  • Hardware-software co-design of portable functional gastrointestinal stimulator system J Med Eng Technol. 2003 Jul-Aug; 27(4):164-77. . View in PubMed
  • Diabetic gastropathy: a practical approach to a vexing problem Cleve Clin J Med. 2000 Sep; 67(9):659-64. . View in PubMed
  • Colonic motor function in humans is not affected by gender Dig Dis Sci. 2000 Jul; 45(7):1281-4. . View in PubMed
  • Effect of acute hyperglycemia on jejunal compliance and peristaltic reflex in healthy humans Dig Dis Sci. 1999 Jan; 44(1):50-5. . View in PubMed
  • Prolonged ambulatory duodeno-jejunal manometry in humans: normal values and gender effect Am J Gastroenterol. 1998 Aug; 93(8):1318-23. . View in PubMed
  • Ambulatory intestinal manometry: a consensus report on its clinical role Dig Dis Sci. 1997 Dec; 42(12):2395-400. . View in PubMed
  • Small bowel manometry: short or long recording sessions? Dig Dis Sci. 1997 May; 42(5):873-7.. View in PubMed
  • Clinical value of duodenojejunal manometryIts usefulness in diagnosis and management of patients with gastrointestinal symptoms. Dig Dis Sci. 1996 May; 41(5):859-63. . View in PubMed
  • Effects of cisapride on salivary production in normal subjects Dig Dis Sci. 1996 Mar; 41(3):480-4. . View in PubMed
  • Ambulatory recording of lower esophageal sphincter pressure: adding the missing link Gastroenterology. 1995 Jan; 108(1):289-91. . View in PubMed
  • Intestinal dysmotility in patients with sphincter of Oddi dysfunctionA reason for failed response to sphincterotomy. Dig Dis Sci. 1994 Sep; 39(9):1942-6. . View in PubMed
  • Misoprostol is effective treatment for patients with severe chronic constipation Dig Dis Sci. 1994 May; 39(5):929-33. . View in PubMed
  • Morphology and pathology of radiation-induced esophagitisDouble-blind study of naproxen vs placebo for prevention of radiation injury. Dig Dis Sci. 1994 Mar; 39(3):655-60. . View in PubMed
  • Effect of graded exercise on esophageal motility and gastroesophageal reflux in nontrained subjects Dig Dis Sci. 1994 Jan; 39(1):193-8. . View in PubMed
  • Effect of misoprostol on postprandial intestinal motility and orocecal transit time in humans Dig Dis Sci. 1993 May; 38(5):851-5. . View in PubMed
  • Effect of graded exercise on esophageal motility and gastroesophageal reflux in trained athletes Dig Dis Sci. 1993 Feb; 38(2):220-4. . View in PubMed
  • Effect of meal composition and sham feeding on duodenojejunal motility in humans Dig Dis Sci. 1992 Jul; 37(7):1009-14. . View in PubMed
  • Spontaneous noncardiac chest pain: value of ambulatory esophageal pH and motility monitoring Dig Dis Sci. 1989 Nov; 34(11):1651-5. . View in PubMed
  • Effects of upper dorsal sympathectomy on esophageal motility in humans Dig Dis Sci. 1988 Feb; 33(2):157-60. . View in PubMed
  • Elevated ANA titers in patients with severely abnormal gastrointestinal motility Dig Dis Sci. 1984 Aug; 29(8):735-9. . View in PubMed