Etan Orgel, MD

Professor of Clinical Pediatrics

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Overview

Dr. Orgel is currently an attending physician on the Medical Supportive Care/Survivorship and Supportive Care Program and the Leukemia and Lymphoma Team within the Division of pediatric Hematology, Oncology, and Blood & Marrow Transplantation at the Children’s Hospital Los Angeles (Los Angeles, CA). Dr. Orgel’s clinical specialty focuses on higher risk and rare malignant hematology, and specifically, Mixed-Phenotype Acute Leukemia (MPAL). He possesses an academic appointment as an Associate Professor of Clinical Pediatrics in the Keck School of Medicine of the University of Southern California (USC) and earned a Masters of Science in Clinical and Biomedical Investigations from the Department of Preventive Medicine at USC.

Dr. Orgel’s primary research interest lies in the field of medical supportive care or cancer control (reducing acute and late treatment-related toxicities). The goal of his translational research is to target specific toxic effects to widen therapeutic windows for common chemotherapies and/or improve the quality of life of children with cancer. Currently, Dr. Orgel’s investigator- initiated research includes two primary areas of emphasis (1) studying new agents and novel strategies to reduce hearing loss from chemotherapy (cisplatin), and (2) targeting overweight and obesity in pediatric ALL to reduce chemoresistance and improve survival.

Publications

  • Ultra-High Dose Vitamin D in Pediatric Hematopoietic Stem Cell Transplantation: A Nonrandomized Controlled TrialTransplant Cell Ther. 2021 12; 27(12):1001. e1-1001. e9. . View in PubMed
  • An Exome Capture-Based RNA-Sequencing Assay for Genome-Wide Identification and Prioritization of Clinically Important Fusions in Pediatric Tumors J Mol Diagn. 2024 Feb; 26(2):127-139. . View in PubMed
  • Lack of benefit from premedication for pegylated asparaginase during pediatric acute lymphoblastic leukemia/lymphoma therapy: A side-by-side comparison Pediatr Blood Cancer. 2024 Jan; 71(1):e30716. . View in PubMed
  • Apixaban versus no anticoagulation for the prevention of venous thromboembolism in children with newly diagnosed acute lymphoblastic leukaemia or lymphoma (PREVAPIX-ALL): a phase 3, open-label, randomised, controlled trial Lancet Haematol. 2024 Jan; 11(1):e27-e37. . View in PubMed
  • Prospective External Validation of the Esbenshade Vanderbilt Models Accurately Predicts Bloodstream Infection Risk in Febrile Non-Neutropenic Children With Cancer J Clin Oncol. 2023 Dec 07; JCO2301814. . View in PubMed
  • Dose-limiting mucositis: friend or foe? Support Care Cancer. 2023 Oct 07; 31(10):617.. View in PubMed
  • Reevaluation of sodium thiosulfate otoprotection using the consensus International Society of Paediatric Oncology Ototoxicity Scale: A report from the Children’s Oncology Group study ACCL0431 Pediatr Blood Cancer. 2023 Jul 07; e30550. . View in PubMed
  • Symptom management care pathway adaptation process and specific adaptation decisions BMC Cancer. 2023 Apr 17; 23(1):350. . View in PubMed
  • Efficacy and safety of FLAG-IDA as front-line therapy in de novo paediatric acute myeloid leukaemia population Br J Haematol. 2023 07; 202(1):e3-e6. . View in PubMed
  • Special considerations in the design and implementation of pediatric otoprotection trials J Cancer Surviv. 2023 02; 17(1):4-16. . View in PubMed
  • Intravenous N-Acetylcysteine to Prevent Cisplatin-Induced Hearing Loss in Children: A Nonrandomized Controlled Phase I Trial Clin Cancer Res. 2023 07 05; 29(13):2410-2418. . View in PubMed
  • The International Consensus Classification of acute leukemias of ambiguous lineage Blood. 2023 05 04; 141(18):2275-2277. . View in PubMed
  • From soup to nuts: Obesity impairs chemotherapy during early and late phases of acute lymphoblastic leukemia treatment Cancer. 2023 01 01; 129(1):15-17. . View in PubMed
  • Asparaginase toxicity in Hispanic adult and pediatric patients with acute lymphoblastic leukemia: current understanding Expert Opin Drug Metab Toxicol. 2023 Jan-Jun; 19(6):357-366. . View in PubMed
  • Erratum to: Cohen-Cutler S, Wong K, Mena V, et alHearing Loss Risk in Pediatric Patients Treated with Cranial Irradiation and Cisplatin-Based Chemotherapy. Int J Radiat Oncol Biol Phys 2021:110(5);1488-1495. Int J Radiat Oncol Biol Phys. 2022 Mar 01; 112(3):838-839. . View in PubMed
  • Sodium thiosulfate for prevention of cisplatin-induced hearing loss: updated survival from ACCL0431 Lancet Oncol. 2022 05; 23(5):570-572. . View in PubMed
  • Temsirolimus combined with cyclophosphamide and etoposide for pediatric patients with relapsed/refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium trial (TACL 2014-001) Haematologica. 2022 10 01; 107(10):2295-2303. . View in PubMed
  • Association of body mass index with toxicity and survival in pediatric patients treated with cisplatin-containing regimens Pediatr Hematol Oncol. 2021 Apr; 38(3):239-250. . View in PubMed
  • Levocarnitine for pegaspargase-induced hepatotoxicity in older children and young adults with acute lymphoblastic leukemia Cancer Med. 2021 11; 10(21):7551-7560. . View in PubMed
  • Effect of Body Fat on Population Pharmacokinetics of High-Dose Methotrexate in Pediatric Patients With Acute Lymphoblastic Leukemia J Clin Pharmacol. 2021 06; 61(6):755-762. . View in PubMed
  • Prevalence and risk factors for cisplatin-induced hearing loss in children, adolescents, and young adults: a multi-institutional North American cohort study Lancet Child Adolesc Health. 2021 04; 5(4):274-283. . View in PubMed
  • Adipocytes Provide Fatty Acids to Acute Lymphoblastic Leukemia Cells Front Oncol. 2021; 11:665763. . View in PubMed
  • Increased prevalence of CRLF2 rearrangements in obesity-associated acute lymphoblastic leukemia Blood. 2021 07 15; 138(2):199-202. . View in PubMed
  • Caloric and nutrient restriction to augment chemotherapy efficacy for acute lymphoblastic leukemia: the IDEAL trial Blood Adv. 2021 04 13; 5(7):1853-1861. . View in PubMed
  • Mixed Phenotype Acute Leukemia: Current Approaches to Diagnosis and Treatment Curr Oncol Rep. 2021 02 05; 23(2):22. . View in PubMed
  • Hearing Loss Risk in Pediatric Patients Treated with Cranial Irradiation and Cisplatin-Based Chemotherapy Int J Radiat Oncol Biol Phys. 2021 08 01; 110(5):1488-1495. . View in PubMed
  • Clinical features and outcomes of patients with Shwachman-Diamond syndrome and myelodysplastic syndrome or acute myeloid leukaemia: a multicentre, retrospective, cohort study Lancet Haematol. 2020 Mar; 7(3):e238-e246. . View in PubMed
  • Assessment of provider perspectives on otoprotection research for children and adolescents: A Children’s Oncology Group Cancer Control and Supportive Care Committee survey Pediatr Blood Cancer. 2020 11; 67(11):e28647. . View in PubMed
  • Significance of minimal residual disease in pediatric mixed phenotype acute leukemia: a multicenter cohort study Leukemia. 2020 07; 34(7):1741-1750. . View in PubMed
  • Levocarnitine does not impair chemotherapy cytotoxicity against acute lymphoblastic leukemia Leuk Lymphoma. 2020 02; 61(2):420-428. . View in PubMed
  • Association between Vitamin D and Risk for Early and Late Post-Transplant Complications Biol Blood Marrow Transplant. 2020 02; 26(2):343-350. . View in PubMed
  • Improving the Timeliness of Chemotherapy Administration in the Bone Marrow Transplant Unit Biol Blood Marrow Transplant. 2020 01; 26(1):150-156. . View in PubMed
  • Integrin a6 mediates the drug resistance of acute lymphoblastic B-cell leukemia Blood. 2020 07 09; 136(2):210-223. . View in PubMed
  • Preexisting or therapy-induced mutations in relapsed acute lymphoblastic leukemia? Blood. 2020 11 05; 136(19):2233-2235.. View in PubMed
  • Mixed-phenotype acute leukemia: A cohort and consensus research strategy from the Children’s Oncology Group Acute Leukemia of Ambiguous Lineage Task Force Cancer. 2020 02 01; 126(3):593-601. . View in PubMed
  • Myosteatosis in adolescents and young adults treated for acute lymphoblastic leukemia Leuk Lymphoma. 2019 12; 60(13):3146-3153. . View in PubMed
  • Recommendations for ototoxicity surveillance for childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCare Consortium Lancet Oncol. 2019 01; 20(1):e29-e41. . View in PubMed
  • Mechanisms by Which Obesity Impacts Survival from Acute Lymphoblastic Leukemia J Natl Cancer Inst Monogr. 2019 09 01; 2019(54):152-156. . View in PubMed
  • Adipocyte metabolism of the chemotherapy daunorubicin Oncoscience. 2018 May; 5(5-6):146-147. . View in PubMed
  • Association of clinical trial enrollment and survival using contemporary therapy for pediatric acute lymphoblastic leukemia Pediatr Blood Cancer. 2018 Feb; 65(2). . View in PubMed
  • The genetic basis and cell of origin of mixed phenotype acute leukaemia Nature. 2018 10; 562(7727):373-379. . View in PubMed
  • Therapy for children and adults with mixed phenotype acute leukemia: a systematic review and meta-analysis Leukemia. 2018 07; 32(7):1515-1528. . View in PubMed
  • Obesity and risk for venous thromboembolism from contemporary therapy for pediatric acute lymphoblastic leukemia Thromb Res. 2018 05; 165:44-50. . View in PubMed
  • Predictors of hepatotoxicity and pancreatitis in children and adolescents with acute lymphoblastic leukemia treated according to contemporary regimens Pediatr Blood Cancer. 2018 03; 65(3). . View in PubMed
  • Limitations of body mass index to assess body composition due to sarcopenic obesity during leukemia therapy Leuk Lymphoma. 2018 01; 59(1):138-145. . View in PubMed
  • A randomized controlled trial testing an adherence-optimized Vitamin D regimen to mitigate bone change in adolescents being treated for acute lymphoblastic leukemia Leuk Lymphoma. 2017 Oct; 58(10):2370-2378. . View in PubMed
  • TACL’ing supportive care needs in pediatric early phase clinical trials for acute leukemia: A report from the therapeutic advances in childhood leukemia & lymphoma (TACL) consortium supportive care committee Pediatr Hematol Oncol. 2017 Sep – Oct; 34(6-7):409-417. . View in PubMed
  • Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin Mol Cancer Res. 2017 12; 15(12):1704-1713. . View in PubMed
  • Clinical Significance of Isolated Myeloperoxidase Expression in Pediatric B-Lymphoblastic Leukemia Am J Clin Pathol. 2017 04 01; 147(4):374-381. . View in PubMed
  • Early injury to cortical and cancellous bone from induction chemotherapy for adolescents and young adults treated for acute lymphoblastic leukemia Bone. 2016 Apr; 85:131-7. . View in PubMed
  • Association of body mass index and survival in pediatric leukemia: a meta-analysis Am J Clin Nutr. 2016 Mar; 103(3):808-17. . View in PubMed
  • Effect of Sensorineural Hearing Loss on Neurocognitive Functioning in Pediatric Brain Tumor Survivors Pediatr Blood Cancer. 2016 Mar; 63(3):527-34. . View in PubMed
  • Treatment-related adverse events associated with a modified UK ALLR3 induction chemotherapy backbone for childhood relapsed/refractory acute lymphoblastic leukemia Pediatr Blood Cancer. 2016 11; 63(11):1943-8. . View in PubMed
  • Clinical and microbiologic outcomes of quinolone prophylaxis in children with acute myeloid leukemia Pediatr Infect Dis J. 2015 Apr; 34(4):e78-84. . View in PubMed
  • Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia Blood. 2014 Dec 18; 124(26):3932-8. . View in PubMed
  • Impact on survival and toxicity by duration of weight extremes during treatment for pediatric acute lymphoblastic leukemia: A report from the Children’s Oncology Group J Clin Oncol. 2014 May 01; 32(13):1331-7. . View in PubMed
  • Efficacy and tolerability of intravenous pentamidine isethionate for Pneumocystis jiroveci prophylaxis in a pediatric oncology population Pediatr Infect Dis J. 2014 Mar; 33(3):319-21. . View in PubMed
  • Infectious morbidity by catheter type in neutropenic children with cancer Pediatr Infect Dis J. 2014 Mar; 33(3):263-6. . View in PubMed
  • Why Healthcare Providers Should Focus on the Fertility of AYA Cancer Survivors: It’s Not Too Late! Front Oncol 2013 Oct 07; 3:248. . View in PubMed
  • Early cardiac outcomes following contemporary treatment for childhood acute myeloid leukemia: a North American perspective Pediatr Blood Cancer. 2013 Sep; 60(9):1528-33. . View in PubMed
  • The links between insulin resistance, diabetes, and cancer Curr Diab Rep. 2013 Apr; 13(2):213-22. . View in PubMed
  • Hearing loss among survivors of childhood brain tumors treated with an irradiation-sparing approach Pediatr Blood Cancer. 2012 Jun; 58(6):953-8. . View in PubMed
  • A failing medical educational model: a self-assessment by physicians at all levels of training of ability and comfort to deliver bad news J Palliat Med. 2010 Jun; 13(6):677-83. . View in PubMed