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Eunjung Lee, PhD

Associate Professor of Clinical Population and Public Health Sciences

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Phone +1 323 865 0827
Email leee@usc.edu
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Overview

My primary research interests are in understanding the environmental and lifestyle factors that influence cancer risk and cancer disparities with focus on understudied Asian American and Latinx populations.

Publications

  • Lithium deficiency and the onset of Alzheimer’s disease. Nature. 2025 Sep; 645(8081):712-721.. View in PubMed
  • The Somatic Mosaicism across Human Tissues Network. Nature. 2025 Jul; 643(8070):47-59.. View in PubMed
  • Identifying kinematic biomarkers of the dystrophic phenotype in a zebrafish model of Duchenne muscular dystrophy. Skelet Muscle. 2025 Jun 20; 15(1):17.. View in PubMed
  • Cell-type-specific patterns and consequences of somatic mutation in development and aging brain. bioRxiv. 2025 May 31.. View in PubMed
  • Clonal Hematopoiesis Mutations Increase Risk of Alzheimer’s Disease with APOE ε3/ε3 Genotype. bioRxiv. 2025 May 21.. View in PubMed
  • Inverted Alu repeats in loop-out exon skipping across hominoid evolution. bioRxiv. 2025 Mar 10.. View in PubMed
  • Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders. bioRxiv. 2025 Mar 08.. View in PubMed
  • Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy. bioRxiv. 2025 Mar 04.. View in PubMed
  • Multi-omic analysis of the ciliogenic transcription factor RFX3 reveals a role in promoting activity-dependent responses via enhancing CREB binding in human neurons. bioRxiv. 2025 Mar 01.. View in PubMed
  • Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants. Brain Commun. 2025; 7(2):fcaf113.. View in PubMed
  • Somatic mosaicism in schizophrenia brains reveals prenatal mutational processes. Science. 2024 10 11; 386(6718):217-224.. View in PubMed
  • Reproductive factors and mammographic density within the International Consortium of Mammographic Density: A cross-sectional study. Breast Cancer Res. 2024 Sep 30; 26(1):139.. View in PubMed
  • Population-based evaluation of disparities in stomach cancer by nativity among Asian and Hispanic populations in California, 2011-2015. Cancer. 2024 04 01; 130(7):1092-1100.. View in PubMed
  • Sociobiome – Individual and neighborhood socioeconomic status influence the gut microbiome in a multi-ethnic population in the US. NPJ Biofilms Microbiomes. 2024 Mar 11; 10(1):19.. View in PubMed
  • Somatic Mosaicism in PIK3CA Variant Correlates With Stereoelectroencephalography-Derived Electrophysiology. Neurol Genet. 2024 Feb; 10(1):e200117.. View in PubMed
  • A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer’s disease. Nat Commun. 2023 11 02; 14(1):7030.. View in PubMed
  • Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions. Cell Genom. 2023 Aug 09; 3(8):100356.. View in PubMed
  • A framework for individualized splice-switching oligonucleotide therapy. Nature. 2023 07; 619(7971):828-836.. View in PubMed
  • Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition. Nat Genet. 2023 Jun; 55(6):1080.. View in PubMed
  • An Approach to the Primary and Secondary Prevention of Gastric Cancer in the United States. Clin Gastroenterol Hepatol. 2022 10; 20(10):2218-2228.e2.. View in PubMed
  • The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density. Breast Cancer Res. 2022 07 14; 24(1):49.. View in PubMed
  • Endoscopy screening in high-risk populations as a strategy to improve early detection of gastric cancer in the United States. Journal of Asian Health. 2022; 9:e202201.
  • Bariatric surgery in patients with breast and endometrial cancer in California: population-based prevalence and survival. Surg Obes Relat Dis. 2022 Jan; 18(1):42-52.. View in PubMed
  • Rates and Patterns of Clonal Oncogenic Mutations in the Normal Human Brain. Cancer Discov. 2022 01; 12(1):172-185.. View in PubMed
  • Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study. Drugs Aging. 2021 09; 38(9):817-828.. View in PubMed
  • Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk. J Natl Cancer Inst. 2021 03 01; 113(3):329-337.. View in PubMed
  • A Summary of the 2020 Gastric Cancer Summit at Stanford University. Gastroenterology. 2020 10; 159(4):1221-1226.. View in PubMed
  • Hypertension, antihypertensive medications use and risk of age-related macular degeneration in California Teachers Cohort. J Hum Hypertens. 2020 09; 34(8):568-576.. View in PubMed
  • Identification and Genotyping of Transposable Element Insertions From Genome Sequencing Data. Curr Protoc Hum Genet. 2020 09; 107(1):e102.. View in PubMed
  • Parallel RNA and DNA analysis after deep sequencing (PRDD-seq) reveals cell type-specific lineage patterns in human brain. Proc Natl Acad Sci U S A. 2020 06 23; 117(25):13886-13895.. View in PubMed
  • Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition. Nat Genet. 2020 03; 52(3):306-319.. View in PubMed
  • Immigration history, lifestyle characteristics, and breast density in the Vietnamese American Women’s Health Study: a cross-sectional analysis. Cancer Causes Control. 2020 Feb; 31(2):127-138.. View in PubMed
  • Serum Levels of Commonly Detected Persistent Organic Pollutants and Per- and Polyfluoroalkyl Substances (PFASs) and Mammographic Density in Postmenopausal Women. Int J Environ Res Public Health. 2020 01 17; 17(2).. View in PubMed
  • Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. Nat Genet. 2020 01; 52(1):56-73.. View in PubMed
  • Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease. N Engl J Med. 2019 10 24; 381(17):1644-1652.. View in PubMed
  • Global impact of somatic structural variation on the DNA methylome of human cancers. Genome Biol. 2019 10 15; 20(1):209.. View in PubMed
  • Genome-wide association study of germline variants and breast cancer-specific mortality. Br J Cancer. 2019 03; 120(6):647-657.. View in PubMed
  • Shared heritability and functional enrichment across six solid cancers. Nat Commun. 2019 01 25; 10(1):431.. View in PubMed
  • Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes. Am J Hum Genet. 2019 01 03; 104(1):21-34.. View in PubMed
  • Evaluation of Medicare Claims Data as a Tool to Identify Dementia. J Alzheimers Dis. 2019; 67(2):769-778.. View in PubMed
  • Growth factor genes and change in mammographic density after stopping combined hormone therapy in the California Teachers Study. BMC Cancer. 2018 Nov 06; 18(1):1072.. View in PubMed
  • Immune signatures correlate with L1 retrotransposition in gastrointestinal cancers. Genome Res. 2018 08; 28(8):1136-1146.. View in PubMed
  • A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases. Cell Rep. 2018 07 10; 24(2):515-527.. View in PubMed
  • Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis. Breast Cancer Res. 2018 01 22; 20(1):5.. View in PubMed
  • Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Nat Genet. 2017 Dec; 49(12):1767-1778.. View in PubMed
  • A Randomized Controlled Trial of Green Tea Extract Supplementation and Mammographic Density in Postmenopausal Women at Increased Risk of Breast Cancer. Cancer Prev Res (Phila). 2017 Dec; 10(12):710-718.. View in PubMed
  • Association analysis identifies 65 new breast cancer risk loci. Nature. 2017 11 02; 551(7678):92-94.. View in PubMed
  • NGSCheckMate: software for validating sample identity in next-generation sequencing studies within and across data types. Nucleic Acids Res. 2017 Jun 20; 45(11):e103.. View in PubMed
  • Stomach Cancer Disparity among Korean Americans by Tumor Characteristics: Comparison with Non-Hispanic Whites, Japanese Americans, South Koreans, and Japanese. Cancer Epidemiol Biomarkers Prev. 2017 04; 26(4):587-596.. View in PubMed
  • Reproductive factors and the risk of triple-negative breast cancer in white women and African-American women: a pooled analysis. Breast Cancer Res. 2017 01 13; 19(1):6.. View in PubMed
  • Body size over the life-course and the risk of endometrial cancer: the California Teachers Study. Cancer Causes Control. 2016 Dec; 27(12):1419-1428.. View in PubMed
  • Traditional Breast Cancer Risk Factors in Filipina Americans Compared with Chinese and Japanese Americans in Los Angeles County. Cancer Epidemiol Biomarkers Prev. 2016 12; 25(12):1572-1586.. View in PubMed
  • Recreational physical activity and risk of triple negative breast cancer in the California Teachers Study. Breast Cancer Res. 2016 06 17; 18(1):62.. View in PubMed
  • Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry. Cancer Causes Control. 2016 May; 27(5):679-93.. View in PubMed
  • Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Nat Commun. 2016 04 27; 7:11375.. View in PubMed
  • Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Nat Genet. 2016 Apr; 48(4):374-86.. View in PubMed
  • Disparities in colorectal cancer incidence among Latino subpopulations in California defined by country of origin. Cancer Causes Control. 2016 Feb; 27(2):147-55.. View in PubMed
  • International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries. Cancer Epidemiol. 2016 Feb; 40:141-51.. View in PubMed
  • BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers. J Natl Cancer Inst. 2016 Feb; 108(2).. View in PubMed
  • Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study. BMC Cancer. 2016 Jan 12; 16:14.. View in PubMed
  • Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk. Cancer Epidemiol Biomarkers Prev. 2015 Nov; 24(11):1801-3.. View in PubMed
  • Indicators of microbial-rich environments and the development of papillary thyroid cancer in the California Teachers Study. Cancer Epidemiol. 2015 Aug; 39(4):548-53.. View in PubMed
  • Risk factors for endometrial cancer in black and white women: a pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2). Cancer Causes Control. 2015 Feb; 26(2):287-296.. View in PubMed
  • Hormone metabolism pathway genes and mammographic density change after quitting estrogen and progestin combined hormone therapy in the California Teachers Study. Breast Cancer Res. 2014 Dec 11; 16(6):477.. View in PubMed
  • Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade. Hum Mol Genet. 2014 Nov 15; 23(22):6034-46.. View in PubMed
  • Estimating risks for variants of unknown significance according to their predicted pathogenicity classes with application to BRCA1. Breast Cancer Res Treat. 2014 Feb; 144(1):171-7.. View in PubMed
  • Reproductive factors, exogenous hormones, and pancreatic cancer risk in the CTS. Am J Epidemiol. 2013 Nov 01; 178(9):1403-13.. View in PubMed
  • Hormone metabolism genes and mammographic density in Singapore Chinese women. Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):984-6.. View in PubMed
  • Genetic variation in transforming growth factor beta 1 and mammographic density in Singapore Chinese women. Cancer Res. 2013 Mar 15; 73(6):1876-82.. View in PubMed
  • Variation in inflammatory cytokine/growth-factor genes and mammographic density in premenopausal women aged 50-55. PLoS One. 2013; 8(6):e65313.. View in PubMed
  • Soy isoflavones and breast cancer. Am Soc Clin Oncol Educ Book. 2013; 102-6.. View in PubMed
  • Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2012 Jul; 21(7):1156-66.. View in PubMed
  • Variations in sex hormone metabolism genes, postmenopausal hormone therapy and risk of endometrial cancer. Int J Cancer. 2012 Apr 01; 130(7):1629-38.. View in PubMed
  • Genetic variation in peroxisome proliferator-activated receptor gamma, soy, and mammographic density in Singapore Chinese women. Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):635-44.. View in PubMed
  • Characteristics of triple-negative breast cancer in patients with a BRCA1 mutation: results from a population-based study of young women. J Clin Oncol. 2011 Nov 20; 29(33):4373-80.. View in PubMed
  • The association of polymorphisms in hormone metabolism pathway genes, menopausal hormone therapy, and breast cancer risk: a nested case-control study in the California Teachers Study cohort. Breast Cancer Res. 2011 Apr 01; 13(2):R37.. View in PubMed
  • GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy. Int J Cancer. 2011 Feb 01; 128(3):726-31.. View in PubMed
  • Menopausal hormone therapy and subsequent risk of specific invasive breast cancer subtypes in the California Teachers Study. Cancer Epidemiol Biomarkers Prev. 2010 Sep; 19(9):2366-78.. View in PubMed
  • Genetic variation in the progesterone receptor gene and risk of endometrial cancer: a haplotype-based approach. Carcinogenesis. 2010 Aug; 31(8):1392-9.. View in PubMed
  • Effect of reproductive factors and oral contraceptives on breast cancer risk in BRCA1/2 mutation carriers and noncarriers: results from a population-based study. Cancer Epidemiol Biomarkers Prev. 2008 Nov; 17(11):3170-8.. View in PubMed
  • Evaluation of unclassified variants in the breast cancer susceptibility genes BRCA1 and BRCA2 using five methods: results from a population-based study of young breast cancer patients. Breast Cancer Res. 2008; 10(1):R19.. View in PubMed
  • The role of established breast cancer susceptibility loci in mammographic density in young women. Cancer Epidemiol Biomarkers Prev. 2008 Jan; 17(1):258-60.. View in PubMed
  • GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer. Cancer Res. 2006 Aug 15; 66(16):7849-53.. View in PubMed
  • Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1alpha. Mol Pharmacol. 2001 May; 59(5):1216-24.. View in PubMed

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