Keck School Faculty

Frank D. Gilliland, MD, PhD
Frank D. Gilliland, MD, PhD
Professor of Preventive Medicine
Environmental Health
SSB 230G 2001 N. Soto Street Health Sciences Campus Los Angeles
Dr. Gilliland is an established leading investigator in air pollution research, respiratory health and cancer epidemiology, and gene-environment interactions, and he has been the principal investigator for many epidemiological investigations.

Since arriving at USC in 1997, he has published more than 190 scientific papers. Dr. Gilliland is Hastings Professor of Preventive Medicine at the Keck School of Medicine of USC. After obtaining a master’s degree in physics, he received his medical degree from the University of Virginia, followed by a residency and fellowship in occupational and environmental medicine at the University of Minnesota, where he received his M.P.H. and Ph.D. in environmental epidemiology. He also obtained board certification in emergency medicine and in environmental and occupational medicine.

Prior to his appointment at USC, Dr. Gilliland was a faculty member at the University of New Mexico, focusing on occupational and environmental determinants of malignant and non-malignant respiratory disease as well as prostate and breast cancer.

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes Nat Commun. 2019 Feb 12; 10(1):713. . View in PubMed

Exposure measurement error in air pollution studies: A framework for assessing shared, multiplicative measurement error in ensemble learning estimates of nitrogen oxides Environ Int. 2019 Jan 31; 125:97-106. . View in PubMed

Epigenome-wide meta-analysis of DNA methylation and childhood asthma J Allergy Clin Immunol. 2018 Dec 21. . View in PubMed

Epigenome-wide Meta-analysis of DNA Methylation and Childhood Asthma J Allergy Clin Immunol. 2018 Dec 20. . View in PubMed

Eur Respir J. 2018 Sep 12. . View in PubMed

Association of Prenatal Exposure to Ambient and Traffic-Related Air Pollution With Newborn Thyroid Function: Findings From the Children's Health Study JAMA Netw Open. 2018 Sep 07; 1(5):e182172. . View in PubMed

An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos J Allergy Clin Immunol. 2018 Sep 07. . View in PubMed

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis Nat Genet. 2018 Sep; 50(9):1343. . View in PubMed

Eur Respir J. 2018 Sep; 52(3). . View in PubMed

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis Nat Genet. 2018 Aug 16. . View in PubMed

Ambient and Traffic-Related Air Pollution Exposures as Novel Risk Factors for Metabolic Dysfunction and Type 2 Diabetes Curr Epidemiol Rep. 2018 Jun; 5(2):79-91. . View in PubMed

Dietary Nutrient Intake, Ethnicity, and Epigenetic Silencing of Lung Cancer Genes Detected in Sputum in New Mexican Smokers Cancer Prev Res (Phila). 2018 Feb; 11(2):93-102. . View in PubMed

Exposure to traffic-related air pollution and the composition of the gut microbiota in overweight and obese adolescents Environ Res. 2018 Feb; 161:472-478. . View in PubMed

Effect of inhaled allergens and air pollutants on childhood rhinitis development Ann Allergy Asthma Immunol. 2018 Feb; 120(2):212-214. . View in PubMed

Eur Respir J. 2018 09; 52(3). . View in PubMed

Exposure to traffic-related air pollution and the composition of the gut microbiota in overweight and obese adolescents Environ Res. 2018 02; 161:472-478. . View in PubMed

Effect of inhaled allergens and air pollutants on childhood rhinitis development Ann Allergy Asthma Immunol. 2018 02; 120(2):212-214. . View in PubMed

Dietary Nutrient Intake, Ethnicity, and Epigenetic Silencing of Lung Cancer Genes Detected in Sputum in New Mexican Smokers Cancer Prev Res (Phila). 2018 02; 11(2):93-102. . View in PubMed

Constrained Mixed-Effect Models with Ensemble Learning for Prediction of Nitrogen Oxides Concentrations at High Spatiotemporal Resolution Environ Sci Technol. 2017 Sep 05; 51(17):9920-9929. . View in PubMed

Effects of Childhood Asthma on the Development of Obesity among School-aged Children Am J Respir Crit Care Med. 2017 May 01; 195(9):1181-1188. . View in PubMed

Epigenetic regulation of AXL and risk of childhood asthma symptoms Clin Epigenetics. 2017; 9:121. . View in PubMed

Dietary nutrients associated with preservation of lung function in Hispanic and non-Hispanic white smokers from New Mexico Int J Chron Obstruct Pulmon Dis. 2017; 12:3171-3181. . View in PubMed

Effects of Childhood Asthma on the Development of Obesity among School-aged Children Am J Respir Crit Care Med. 2017 05 01; 195(9):1181-1188. . View in PubMed

Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation J Am Heart Assoc. 2016 Jul 28; 5(8). . View in PubMed

Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes-Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies Am J Respir Crit Care Med. 2016 Jun 01; 193(11):1271-80. . View in PubMed

Association of Changes in Air Quality With Bronchitic Symptoms in Children in California, 1993-2012 JAMA. 2016 Apr 12; 315(14):1491-501. . View in PubMed

Ambient Air Pollutants Have Adverse Effects on Insulin and Glucose Homeostasis in Mexican Americans Diabetes Care. 2016 Apr; 39(4):547-54. . View in PubMed

Air pollution affects lung cancer survival Thorax. 2016 10; 71(10):891-8. . View in PubMed

Ambient Air Pollutants Have Adverse Effects on Insulin and Glucose Homeostasis in Mexican Americans Diabetes Care. 2016 04; 39(4):547-54. . View in PubMed

A prospective and retrospective analysis of smoking behavior changes in ever smokers with high risk for lung cancer from New Mexico and Pennsylvania Int J Mol Epidemiol Genet. 2016; 7(2):95-104. . View in PubMed

Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes-Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies Am J Respir Crit Care Med. 2016 06 01; 193(11):1271-80. . View in PubMed

Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation J Am Heart Assoc. 2016 07 28; 5(8). . View in PubMed

Exhaled NO: Determinants and Clinical Application in Children With Allergic Airway Disease Allergy Asthma Immunol Res. 2016 Jan; 8(1):12-21. . View in PubMed

Correction: Inducible Nitric Oxide Synthase Promoter Haplotypes and Residential Traffic-Related Air Pollution Jointly Influence Exhaled Nitric Oxide Level in Children PLoS One. 2016; 11(5):e0155567. . View in PubMed

Atopic allergic conditions and colorectal cancer risk in the Multiethnic Cohort Study Am J Epidemiol. 2015 Jun 01; 181(11):889-97. . View in PubMed

A longitudinal cohort study of body mass index and childhood exposure to secondhand tobacco smoke and air pollution: the Southern California Children's Health Study Environ Health Perspect. 2015 Apr; 123(4):360-6. . View in PubMed

Association of improved air quality with lung development in children N Engl J Med. 2015 Mar 05; 372(10):905-13. . View in PubMed

Emissions reduction policies and recent trends in Southern California's ambient air quality J Air Waste Manag Assoc. 2015 Mar; 65(3):324-35. . View in PubMed

15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers J Natl Cancer Inst. 2015 Feb 23; 107(5). . View in PubMed

Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma Nat Commun. 2015 Jan 16; 6:5965. . View in PubMed

Chronic effects of air pollution on respiratory health in Southern California children: findings from the Southern California Children's Health Study J Thorac Dis. 2015 Jan; 7(1):46-58. . View in PubMed

Correction: Genetic Ancestry and Asthma and Rhinitis Occurrence in Hispanic Children: Findings from the Southern California Children's Health Study PLoS One. 2015; 10(9):e0139397. . View in PubMed

Determinants of Children's Exhaled Nitric Oxide: New Insights from Quantile Regression PLoS One. 2015; 10(7):e0130505. . View in PubMed

A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes J Allergy Clin Immunol. 2014 Nov; 134(5):1153-62. . View in PubMed

Analysis of bisphenol A diglycidyl ether (BADGE) and its hydrolytic metabolites in biological specimens by high-performance liquid chromatography and tandem mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 15; 965:33-8. . View in PubMed

Fraction of exhaled nitric oxide values in childhood are associated with 17q112-q12 and 17q12-q21 variants. J Allergy Clin Immunol. 2014 Jul; 134(1):46-55. . View in PubMed

Associations of children's lung function with ambient air pollution: joint effects of regional and near-roadway pollutants Thorax. 2014 Jun; 69(6):540-7. . View in PubMed

Estimation of parameters in the two-compartment model for exhaled nitric oxide PLoS One. 2014; 9(1):e85471. . View in PubMed

Environmental pollution in Mongolia: effects across the lifespan Environ Res. 2013 Jul; 124:65-6. . View in PubMed

Birth weight and carotid artery intima-media thicknessJ Pediatr. 2013 May; 162(5):906-11. e1-2. . View in PubMed

A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations J Allergy Clin Immunol. 2013 Apr; 131(4):1176-84. . View in PubMed

Development of a regional-scale pollen emission and transport modeling framework for investigating the impact of climate change on allergic airway disease Biogeosciences. 2013 Mar 01; 10(3):3977-4023. . View in PubMed

Confounding and heterogeneity in genetic association studies with admixed populations Am J Epidemiol. 2013 Feb 15; 177(4):351-60. . View in PubMed

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans J Allergy Clin Immunol. 2012 Dec; 130(6):1294-301. . View in PubMed

Effect of secondhand smoke on asthma control among black and Latino childrenJ Allergy Clin Immunol. 2012 Jun; 129(6):1478-83. e7. . View in PubMed

A genome-wide association meta-analysis identifies new childhood obesity loci Nat Genet. 2012 May; 44(5):526-31. . View in PubMed

DNA methylation in the arginase-nitric oxide synthase pathway is associated with exhaled nitric oxide in children with asthma Am J Respir Crit Care Med. 2011 Jul 15; 184(2):191-7. . View in PubMed

Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California Am J Epidemiol. 2011 May 01; 173(9):1039-48. . View in PubMed

Ethnic differences in the effect of asthma on pulmonary function in children Am J Respir Crit Care Med. 2011 Mar 01; 183(5):596-603. . View in PubMed

Childhood obesity and proximity to urban parks and recreational resources: a longitudinal cohort study Health Place. 2011 Jan; 17(1):207-14. . View in PubMed

Childhood incident asthma and traffic-related air pollution at home and school Environ Health Perspect. 2010 Jul; 118(7):1021-6. . View in PubMed

Ambient air pollution and the progression of atherosclerosis in adults PLoS One. 2010 Feb 08; 5(2):e9096. . View in PubMed

Dietary fat, tamoxifen use and circulating sex hormones in postmenopausal breast cancer survivors Nutr Cancer. 2010; 62(2):164-74. . View in PubMed

Automobile traffic around the home and attained body mass index: a longitudinal cohort study of children aged 10-18 years Prev Med. 2010 Jan; 50 Suppl 1:S50-8. . View in PubMed

Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactions Am J Epidemiol. 2009 Dec 15; 170(12):1494-501. . View in PubMed

Extended exhaled nitric oxide analysis in field surveys of schoolchildren: a pilot test Pediatr Pulmonol. 2009 Oct; 44(10):1033-42. . View in PubMed

Breast cancer survivors who use estrogenic botanical supplements have lower serum estrogen levels than non users Breast Cancer Res Treat. 2009 Sep; 117(1):111-9. . View in PubMed

Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients J Clin Oncol. 2009 Jul 20; 27(21):3437-44. . View in PubMed

Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein J Biol Chem. 2009 Jul 17; 284(29):19650-8. . View in PubMed

Exhaled nitric oxide in a population-based study of southern California schoolchildren Respir Res. 2009 Apr 21; 10:28. . View in PubMed

Correlates of circulating C-reactive protein and serum amyloid A concentrations in breast cancer survivors Breast Cancer Res Treat. 2009 Mar; 114(1):155-67. . View in PubMed

Association between alcohol intake and serum sex hormones and peptides differs by tamoxifen use in breast cancer survivors Cancer Epidemiol Biomarkers Prev. 2008 Nov; 17(11):3224-32. . View in PubMed

Difference in airflow obstruction between Hispanic and non-Hispanic White female smokers COPD. 2008 Oct; 5(5):274-81. . View in PubMed

Association between common genetic variation in Cockayne syndrome A and B genes and nucleotide excision repair capacity among smokers Cancer Epidemiol Biomarkers Prev. 2008 Aug; 17(8):2062-9. . View in PubMed

Effects of in utero and childhood tobacco smoke exposure and beta2-adrenergic receptor genotype on childhood asthma and wheezing Pediatrics. 2008 Jul; 122(1):e107-14. . View in PubMed

5-year urinary and sexual outcomes after radical prostatectomy: results from the Prostate Cancer Outcomes Study J Urol. 2008 May; 179(5 Suppl):S40-4. . View in PubMed

Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation Cancer Res. 2008 Apr 15; 68(8):3049-56. . View in PubMed

Associations between the CYP17, CYPIB1, COMT and SHBG polymorphisms and serum sex hormones in post-menopausal breast cancer survivors Breast Cancer Res Treat. 2007 Sep; 105(1):45-54. . View in PubMed

Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study Lancet. 2007 Feb 17; 369(9561):571-7. . View in PubMed

Dog ownership enhances symptomatic responses to air pollution in children with asthma Environ Health Perspect. 2006 Dec; 114(12):1910-5. . View in PubMed

An association between a common variant (G972R) in the IRS-1 gene and sex hormone levels in post-menopausal breast cancer survivors Breast Cancer Res Treat. 2006 Oct; 99(3):323-31. . View in PubMed

Associations of tumor necrosis factor G-308A with childhood asthma and wheezing Am J Respir Crit Care Med. 2006 May 01; 173(9):970-6. . View in PubMed

Endogenous and exogenous sex steroid hormones and asthma and wheeze in young women J Allergy Clin Immunol. 2006 May; 117(5):1001-7. . View in PubMed

A testing framework for identifying susceptibility genes in the presence of epistasis Am J Hum Genet. 2006 Jan; 78(1):15-27. . View in PubMed

Birth outcomes and prenatal exposure to ozone, carbon monoxide, and particulate matter: results from the Children's Health Study Environ Health Perspect. 2005 Nov; 113(11):1638-44. . View in PubMed

Childhood asthma and exposure to traffic and nitrogen dioxide Epidemiology. 2005 Nov; 16(6):737-43. . View in PubMed

Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research Environ Health Perspect. 2005 Oct; 113(10):1447-54. . View in PubMed

5-year urinary and sexual outcomes after radical prostatectomy: results from the prostate cancer outcomes study J Urol. 2005 May; 173(5):1701-5. . View in PubMed

Changes in body fat and weight after a breast cancer diagnosis: influence of demographic, prognostic, and lifestyle factors J Clin Oncol. 2005 Feb 01; 23(4):774-82. . View in PubMed

Ambient air pollution and atherosclerosis in Los Angeles Environ Health Perspect. 2005 Feb; 113(2):201-6. . View in PubMed

Cross-sectional and longitudinal comparisons of health-related quality of life between patients with prostate carcinoma and matched controls Cancer. 2004 Nov 01; 101(9):2011-9. . View in PubMed

Effects of ambient air pollutants on asthma medication use and wheezing among fourth-grade school children from 12 Southern California communities enrolled in The Children's Health Study Arch Environ Health. 2004 Oct; 59(10):505-14. . View in PubMed

Early-life environmental risk factors for asthma: findings from the Children's Health Study Environ Health Perspect. 2004 May; 112(6):760-5. . View in PubMed

Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study Lancet. 2004 Jan 10; 363(9403):119-25. . View in PubMed

Children's lung function and antioxidant vitamin, fruit, juice, and vegetable intake Am J Epidemiol. 2003 Sep 15; 158(6):576-84. . View in PubMed

Breathless in Los Angeles: the exhausting search for clean air Am J Public Health. 2003 Sep; 93(9):1494-9. . View in PubMed

Effects of misattribution in assigning cause of death on prostate cancer mortality rates Ann Epidemiol. 2003 Jul; 13(6):450-4. . View in PubMed

Environmental tobacco smoke and absenteeism related to respiratory illness in schoolchildren Am J Epidemiol. 2003 May 15; 157(10):861-9. . View in PubMed

Adiposity and sex hormones in postmenopausal breast cancer survivors J Clin Oncol. 2003 May 15; 21(10):1961-6. . View in PubMed

Effects of early onset asthma and in utero exposure to maternal smoking on childhood lung function Am J Respir Crit Care Med. 2003 Mar 15; 167(6):917-24. . View in PubMed

Family history, Hispanic ethnicity, and prostate cancer risk Ethn Dis. 2003; 13(2):233-9. . View in PubMed

Effects of ethnicity, family income, and education on dietary intake among adolescents Prev Med. 2003 Jan; 36(1):30-40. . View in PubMed

Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growth Am J Respir Crit Care Med. 2002 Sep 01; 166(5):710-6. . View in PubMed

Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children Am J Respir Crit Care Med. 2002 Aug 15; 166(4):457-63. . View in PubMed

Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children Am J Respir Crit Care Med. 2002 Aug 01; 166(3):346-51. . View in PubMed

Associations of weight, weight change, and body mass with breast cancer risk in Hispanic and non-Hispanic white women Ann Epidemiol. 2002 Aug; 12(6):435-4. . View in PubMed

Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers Cancer Res. 2002 Apr 15; 62(8):2370-7. . View in PubMed

Asthma in exercising children exposed to ozone: a cohort study Lancet. 2002 Feb 02; 359(9304):386-91. . View in PubMed

Dietary magnesium, potassium, sodium, and children's lung function Am J Epidemiol. 2002 Jan 15; 155(2):125-31. . View in PubMed

Biologic characteristics of interval and screen-detected breast cancers J Natl Cancer Inst. 2000 May 03; 92(9):743-9. . View in PubMed

Determinants of the Spatial Distributions of Elemental Carbon and Particulate Matter in Eight Southern Californian Communities Atmos Environ (1994). 2014 Apr 01; 86:84-92. . View in PubMed

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