Keck School Faculty

Frank D. Gilliland

Frank D. Gilliland

Professor of Preventive Medicine
Environmental Health
SSB 230G 2001 N. Soto Street Health Sciences Campus Los Angeles

Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults Environ Int. 2020 Dec; 145:106091. . View in PubMed

Contribution of Tailpipe and Non-tailpipe Traffic Sources to Quasi-Ultrafine, Fine and Coarse Particulate Matter in Southern California J Air Waste Manag Assoc. 2020 Sep 29. . View in PubMed

Biomedical REAl-Time Health Evaluation (BREATHE): toward an mHealth informatics platform JAMIA Open. 2020 Jul; 3(2):190-200. . View in PubMed

Air pollution exposure is associated with the gut microbiome as revealed by shotgun metagenomic sequencing Environ Int. 2020 05; 138:105604. . View in PubMed

Asthma and its relationship to mitochondrial copy number: Results from the Asthma Translational Genomics Collaborative (ATGC) of the Trans-Omics for Precision Medicine (TOPMed) program PLoS One. 2020; 15(11):e0242364. . View in PubMed

Chemical Characterization and Seasonality of Ambient Particles (PM25) in the City Centre of Addis Ababa. Int J Environ Res Public Health. 2020 09 24; 17(19). . View in PubMed

A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity PLoS Genet. 2019 12; 15(12):e1008528. . View in PubMed

Associations of air pollution, obesity and cardiometabolic health in young adults: The Meta-AIR study Environ Int. 2019 12; 133(Pt A):105180. . View in PubMed

Cluster-based bagging of constrained mixed-effects models for high spatiotemporal resolution nitrogen oxides prediction over large regions Environ Int. 2019 07; 128:310-323. . View in PubMed

An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos J Allergy Clin Immunol. 2019 03; 143(3):957-969. . View in PubMed

Association of Changes in Air Quality With Incident Asthma in Children in California, 1993-2014 JAMA. 2019 05 21; 321(19):1906-1915. . View in PubMed

Applying Multivariate Segmentation Methods to Human Activity Recognition From Wearable Sensors' Data JMIR Mhealth Uhealth. 2019 02 07; 7(2):e11201. . View in PubMed

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes Nat Commun. 2019 02 12; 10(1):713. . View in PubMed

Dietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation Front Immunol. 2019; 10:2051. . View in PubMed

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity Hum Mol Genet. 2019 10 01; 28(19):3327-3338. . View in PubMed

Ambient and Traffic-Related Air Pollution Exposures as Novel Risk Factors for Metabolic Dysfunction and Type 2 Diabetes Curr Epidemiol Rep. 2018 Jun; 5(2):79-91. . View in PubMed

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis Nat Genet. 2018 09; 50(9):1343. . View in PubMed

Eur Respir J. 2018 09; 52(3). . View in PubMed

Effect of inhaled allergens and air pollutants on childhood rhinitis development Ann Allergy Asthma Immunol. 2018 02; 120(2):212-214. . View in PubMed

Dietary Nutrient Intake, Ethnicity, and Epigenetic Silencing of Lung Cancer Genes Detected in Sputum in New Mexican Smokers Cancer Prev Res (Phila). 2018 02; 11(2):93-102. . View in PubMed

Association of Prenatal Exposure to Ambient and Traffic-Related Air Pollution With Newborn Thyroid Function: Findings From the Children's Health Study JAMA Netw Open. 2018 09 07; 1(5):e182172. . View in PubMed

Constrained Mixed-Effect Models with Ensemble Learning for Prediction of Nitrogen Oxides Concentrations at High Spatiotemporal Resolution Environ Sci Technol. 2017 Sep 05; 51(17):9920-9929. . View in PubMed

Dietary nutrients associated with preservation of lung function in Hispanic and non-Hispanic white smokers from New Mexico Int J Chron Obstruct Pulmon Dis. 2017; 12:3171-3181. . View in PubMed

Association of Changes in Air Quality With Bronchitic Symptoms in Children in California, 1993-2012 JAMA. 2016 Apr 12; 315(14):1491-501. . View in PubMed

Ambient Air Pollutants Have Adverse Effects on Insulin and Glucose Homeostasis in Mexican Americans Diabetes Care. 2016 Apr; 39(4):547-54. . View in PubMed

Does near-roadway air pollution contribute to childhood obesity? Pediatr Obes. 2016 Feb; 11(1):1-3.. View in PubMed

Air pollution affects lung cancer survival Thorax. 2016 10; 71(10):891-8. . View in PubMed

A prospective and retrospective analysis of smoking behavior changes in ever smokers with high risk for lung cancer from New Mexico and Pennsylvania Int J Mol Epidemiol Genet. 2016; 7(2):95-104. . View in PubMed

Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes-Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies Am J Respir Crit Care Med. 2016 06 01; 193(11):1271-80. . View in PubMed

Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation J Am Heart Assoc. 2016 07 28; 5(8). . View in PubMed

Correction: Inducible Nitric Oxide Synthase Promoter Haplotypes and Residential Traffic-Related Air Pollution Jointly Influence Exhaled Nitric Oxide Level in Children PLoS One. 2016; 11(5):e0155567. . View in PubMed

Atopic allergic conditions and colorectal cancer risk in the Multiethnic Cohort Study Am J Epidemiol. 2015 Jun 01; 181(11):889-97. . View in PubMed

A longitudinal cohort study of body mass index and childhood exposure to secondhand tobacco smoke and air pollution: the Southern California Children's Health Study Environ Health Perspect. 2015 Apr; 123(4):360-6. . View in PubMed

Association of improved air quality with lung development in children N Engl J Med. 2015 Mar 05; 372(10):905-13. . View in PubMed

15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers J Natl Cancer Inst. 2015 Feb 23; 107(5). . View in PubMed

Correction: Genetic Ancestry and Asthma and Rhinitis Occurrence in Hispanic Children: Findings from the Southern California Children's Health Study PLoS One. 2015; 10(9):e0139397. . View in PubMed

Determinants of Children's Exhaled Nitric Oxide: New Insights from Quantile Regression PLoS One. 2015; 10(7):e0130505. . View in PubMed

Chronic effects of air pollution on respiratory health in Southern California children: findings from the Southern California Children's Health Study J Thorac Dis. 2015 Jan; 7(1):46-58. . View in PubMed

A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes J Allergy Clin Immunol. 2014 Nov; 134(5):1153-62. . View in PubMed

Analysis of bisphenol A diglycidyl ether (BADGE) and its hydrolytic metabolites in biological specimens by high-performance liquid chromatography and tandem mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 15; 965:33-8. . View in PubMed

Associations of children's lung function with ambient air pollution: joint effects of regional and near-roadway pollutants Thorax. 2014 Jun; 69(6):540-7. . View in PubMed

Birth weight and carotid artery intima-media thicknessJ Pediatr. 2013 May; 162(5):906-11. e1-2. . View in PubMed

A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations J Allergy Clin Immunol. 2013 Apr; 131(4):1176-84. . View in PubMed

Development of a regional-scale pollen emission and transport modeling framework for investigating the impact of climate change on allergic airway disease Biogeosciences. 2013 Mar 01; 10(3):3977-4023. . View in PubMed

Confounding and heterogeneity in genetic association studies with admixed populations Am J Epidemiol. 2013 Feb 15; 177(4):351-60. . View in PubMed

Effect of secondhand smoke on asthma control among black and Latino childrenJ Allergy Clin Immunol. 2012 Jun; 129(6):1478-83. e7. . View in PubMed

A genome-wide association meta-analysis identifies new childhood obesity loci Nat Genet. 2012 May; 44(5):526-31. . View in PubMed

DNA methylation in the arginase-nitric oxide synthase pathway is associated with exhaled nitric oxide in children with asthma Am J Respir Crit Care Med. 2011 Jul 15; 184(2):191-7. . View in PubMed

Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California Am J Epidemiol. 2011 May 01; 173(9):1039-48. . View in PubMed

Childhood obesity and proximity to urban parks and recreational resources: a longitudinal cohort study Health Place. 2011 Jan; 17(1):207-14. . View in PubMed

Childhood incident asthma and traffic-related air pollution at home and school Environ Health Perspect. 2010 Jul; 118(7):1021-6. . View in PubMed

Ambient air pollution and the progression of atherosclerosis in adults PLoS One. 2010 Feb 08; 5(2):e9096. . View in PubMed

Automobile traffic around the home and attained body mass index: a longitudinal cohort study of children aged 10-18 years Prev Med. 2010 Jan; 50 Suppl 1:S50-8. . View in PubMed

Dietary fat, tamoxifen use and circulating sex hormones in postmenopausal breast cancer survivors Nutr Cancer. 2010; 62(2):164-74. . View in PubMed

Ambient ozone modifies the effect of tumor necrosis factor G-308A on bronchitic symptoms among children with asthma Allergy. 2009 Sep; 64(9):1342-8. . View in PubMed

Breast cancer survivors who use estrogenic botanical supplements have lower serum estrogen levels than non users Breast Cancer Res Treat. 2009 Sep; 117(1):111-9. . View in PubMed

Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein J Biol Chem. 2009 Jul 17; 284(29):19650-8. . View in PubMed

Correlates of circulating C-reactive protein and serum amyloid A concentrations in breast cancer survivors Breast Cancer Res Treat. 2009 Mar; 114(1):155-67. . View in PubMed

Association between alcohol intake and serum sex hormones and peptides differs by tamoxifen use in breast cancer survivors Cancer Epidemiol Biomarkers Prev. 2008 Nov; 17(11):3224-32. . View in PubMed

Difference in airflow obstruction between Hispanic and non-Hispanic White female smokers COPD. 2008 Oct; 5(5):274-81. . View in PubMed

Association between common genetic variation in Cockayne syndrome A and B genes and nucleotide excision repair capacity among smokers Cancer Epidemiol Biomarkers Prev. 2008 Aug; 17(8):2062-9. . View in PubMed

5-year urinary and sexual outcomes after radical prostatectomy: results from the Prostate Cancer Outcomes Study J Urol. 2008 May; 179(5 Suppl):S40-4. . View in PubMed

Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation Cancer Res. 2008 Apr 15; 68(8):3049-56. . View in PubMed

Associations of FcepsilonRIbeta E237G polymorphism with wheezing in Taiwanese schoolchildren Clin Exp Allergy. 2008 Mar; 38(3):413-20. . View in PubMed

Associations between the CYP17, CYPIB1, COMT and SHBG polymorphisms and serum sex hormones in post-menopausal breast cancer survivors Breast Cancer Res Treat. 2007 Sep; 105(1):45-54. . View in PubMed

Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study Lancet. 2007 Feb 17; 369(9561):571-7. . View in PubMed

Dog ownership enhances symptomatic responses to air pollution in children with asthma Environ Health Perspect. 2006 Dec; 114(12):1910-5. . View in PubMed

An association between a common variant (G972R) in the IRS-1 gene and sex hormone levels in post-menopausal breast cancer survivors Breast Cancer Res Treat. 2006 Oct; 99(3):323-31. . View in PubMed

Associations of tumor necrosis factor G-308A with childhood asthma and wheezing Am J Respir Crit Care Med. 2006 May 01; 173(9):970-6. . View in PubMed

A testing framework for identifying susceptibility genes in the presence of epistasis Am J Hum Genet. 2006 Jan; 78(1):15-27. . View in PubMed

Birth outcomes and prenatal exposure to ozone, carbon monoxide, and particulate matter: results from the Children's Health Study Environ Health Perspect. 2005 Nov; 113(11):1638-44. . View in PubMed

Childhood asthma and exposure to traffic and nitrogen dioxide Epidemiology. 2005 Nov; 16(6):737-43. . View in PubMed

Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research Environ Health Perspect. 2005 Oct; 113(10):1447-54. . View in PubMed

5-year urinary and sexual outcomes after radical prostatectomy: results from the prostate cancer outcomes study J Urol. 2005 May; 173(5):1701-5. . View in PubMed

Changes in body fat and weight after a breast cancer diagnosis: influence of demographic, prognostic, and lifestyle factors J Clin Oncol. 2005 Feb 01; 23(4):774-82. . View in PubMed

Ambient air pollution and atherosclerosis in Los Angeles Environ Health Perspect. 2005 Feb; 113(2):201-6. . View in PubMed

Association of body composition and weight history with breast cancer prognostic markers: divergent pattern for Hispanic and non-Hispanic White women Am J Epidemiol. 2004 Dec 01; 160(11):1087-97. . View in PubMed

Cross-sectional and longitudinal comparisons of health-related quality of life between patients with prostate carcinoma and matched controls Cancer. 2004 Nov 01; 101(9):2011-9. . View in PubMed

Early-life environmental risk factors for asthma: findings from the Children's Health Study Environ Health Perspect. 2004 May; 112(6):760-5. . View in PubMed

Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study Lancet. 2004 Jan 10; 363(9403):119-25. . View in PubMed

Children's lung function and antioxidant vitamin, fruit, juice, and vegetable intake Am J Epidemiol. 2003 Sep 15; 158(6):576-84. . View in PubMed

Breathless in Los Angeles: the exhausting search for clean air Am J Public Health. 2003 Sep; 93(9):1494-9. . View in PubMed

Adiposity and sex hormones in postmenopausal breast cancer survivors J Clin Oncol. 2003 May 15; 21(10):1961-6. . View in PubMed

Associations of weight, weight change, and body mass with breast cancer risk in Hispanic and non-Hispanic white women Ann Epidemiol. 2002 Aug; 12(6):435-4. . View in PubMed

Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers Cancer Res. 2002 Apr 15; 62(8):2370-7. . View in PubMed

Asthma in exercising children exposed to ozone: a cohort study Lancet. 2002 Feb 02; 359(9304):386-91. . View in PubMed

Dietary magnesium, potassium, sodium, and children's lung function Am J Epidemiol. 2002 Jan 15; 155(2):125-31. . View in PubMed

Association between air pollution and lung function growth in southern California children Am J Respir Crit Care Med. 2000 Oct; 162(4 Pt 1):1383-90. . View in PubMed

Biologic characteristics of interval and screen-detected breast cancers J Natl Cancer Inst. 2000 May 03; 92(9):743-9. . View in PubMed

A population-based survey of prostate cancer testing in New Mexico J Community Health. 1999 Dec; 24(6):409-19. . View in PubMed

Association between outcome and telomere DNA content in prostate cancer J Urol. 1999 Nov; 162(5):1788-92. . View in PubMed

Air pollution and bronchitic symptoms in Southern California children with asthma Environ Health Perspect. 1999 Sep; 107(9):757-60. . View in PubMed

A theoretical basis for investigating ambient air pollution and children's respiratory health Environ Health Perspect. 1999 Jun; 107 Suppl 3:403-7. . View in PubMed

An epidemiologic investigation of reproductive hormones in men with occupational exposure to perfluorooctanoic acid J Occup Environ Med. 1998 Jul; 40(7):614-22. . View in PubMed

Concurrent fluorescence in situ hybridization and immunocytochemistry for the detection of chromosome aberrations in exfoliated bronchial epithelial cells Acta Cytol. 1997 Nov-Dec; 41(6):1769-73. . View in PubMed

Breast cancer survival among New Mexico Hispanic, American Indian, and non-Hispanic white women (1973-1992) Cancer Epidemiol Biomarkers Prev. 1996 Nov; 5(11):861-6. . View in PubMed

Detection of trisomy 7 in nonmalignant bronchial epithelium from lung cancer patients and individuals at risk for lung cancer Cancer Epidemiol Biomarkers Prev. 1996 Aug; 5(8):631-7. . View in PubMed

Decreasing rates of cervical cancer among American Indians and Hispanics in New Mexico (United States) Cancer Causes Control. 1996 Mar; 7(2):205-13. . View in PubMed

Contrasting trends of prostate cancer incidence and mortality in New Mexico's Hispanics, non-Hispanic whites, American Indians, and blacks Cancer. 1994 Apr 15; 73(8):2192-9. . View in PubMed

Determinants of the Spatial Distributions of Elemental Carbon and Particulate Matter in Eight Southern Californian Communities Atmos Environ (1994). 2014 Apr 01; 86:84-92. . View in PubMed

Dr. Gilliland is an established leading investigator in air pollution research, respiratory health and cancer epidemiology, and gene-environment interactions, and he has been the principal investigator for many epidemiological investigations.

Since arriving at USC in 1997, he has published more than 190 scientific papers. Dr. Gilliland is Hastings Professor of Preventive Medicine at the Keck School of Medicine of USC. After obtaining a master’s degree in physics, he received his medical degree from the University of Virginia, followed by a residency and fellowship in occupational and environmental medicine at the University of Minnesota, where he received his M.P.H. and Ph.D. in environmental epidemiology. He also obtained board certification in emergency medicine and in environmental and occupational medicine.

Prior to his appointment at USC, Dr. Gilliland was a faculty member at the University of New Mexico, focusing on occupational and environmental determinants of malignant and non-malignant respiratory disease as well as prostate and breast cancer.
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