Keck School Faculty

Frank Z Stanczyk, PhD
Frank Z Stanczyk, PhD
Research Professor of Obstetrics & Gynecology (Part-Time)
Obstetrics & Gynecology
LRB 1321 N. Mission Rd Off Campus Los Angeles
Dr. Stanczyk is the Director of the Reproductive Endocrinology Laboratory and the Co-Director of the USC Reproductive Endocrine Clinical Laboratory. A nationally recognized expert in steroid and prostaglandin biochemistry, Dr. Stanczyk is a resource to residents interested in laboratory techniques, assay methodologies, and laboratory data analyses. He oversees the Molecular Biology Core Laboratory and actively participates in resident research.

Association of Prepubertal and Adolescent Androgen Concentrations With Timing of Breast Development and Family History of Breast Cancer JAMA Netw Open. 2019 Feb 01; 2(2):e190083. . View in PubMed

Altered pharmacokinetics of combined Oral contraceptives in obesity - multi-study assessment Contraception. 2019 Jan 23. . View in PubMed

Association of urinary levels of 6-sulfatoxymelatonin (aMT6s) with prevalent and incident hypertension Chronobiol Int. 2018 Aug; 35(8):1115-1121. . View in PubMed

Association of urinary levels of 6-sulfatoxymelatonin (aMT6s) with prevalent and incident hypertension Chronobiol Int. 2018 May 11; 1-7. . View in PubMed

Associations between polymorphisms in genes related to estrogen metabolism and function and prostate cancer risk: results from the Prostate Cancer Prevention Trial Carcinogenesis. 2018 02 09; 39(2):125-133. . View in PubMed

Associations between postmenopausal endogenous sex hormones and C-reactive protein: a clearer picture with regional adiposity adjustment? Menopause. 2017 Sep; 24(9):1040-1048.. View in PubMed

Anastrozole in Pulmonary Arterial HypertensionA Randomized, Double-Blind, Placebo-controlled Trial. Am J Respir Crit Care Med. 2017 Feb 01; 195(3):360-368. . View in PubMed

Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age JAMA. 2017 10 10; 318(14):1367-1376. . View in PubMed

Anastrozole in Pulmonary Arterial HypertensionA Randomized, Double-Blind, Placebo-controlled Trial. Am J Respir Crit Care Med. 2017 02 01; 195(3):360-368. . View in PubMed

Associations of sex steroid hormones with mortality in women with breast cancer Breast Cancer Res Treat. 2016 Feb; 155(3):559-67. . View in PubMed

Antimüllerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking Fertil Steril. 2016 09 01; 106(3):723-30. . View in PubMed

Assay reproducibility of serum androgen measurements using liquid chromatography-tandem mass spectrometry J Steroid Biochem Mol Biol. 2016 Jan; 155(Pt A):56-62. . View in PubMed

Associations of Breast Cancer Risk Factors with Premenopausal Sex Hormones in Women with Very Low Breast Cancer Risk Int J Environ Res Public Health. 2016 10 31; 13(11). . View in PubMed

A Prospective Evaluation of Endogenous Sex Hormone Levels and Colorectal Cancer Risk in Postmenopausal Women J Natl Cancer Inst. 2015 Oct; 107(10). . View in PubMed

Can highly sensitive antimüllerian hormone testing predict failed response to ovarian stimulation? Fertil Steril. 2015 Sep; 104(3):643-8.. View in PubMed

Adolescent endogenous sex hormones and breast density in early adulthood Breast Cancer Res. 2015 Jun 04; 17:77. . View in PubMed

Anti-Müllerian hormone concentrations in premenopausal women and breast cancer risk Cancer Prev Res (Phila). 2015 Jun; 8(6):528-34. . View in PubMed

A prospective evaluation of C-peptide levels and colorectal adenoma incidence Cancer Epidemiol. 2015 Apr; 39(2):160-5. . View in PubMed

Association of endogenous sex hormones with adipokines and ghrelin in postmenopausal women J Clin Endocrinol Metab. 2015 Feb; 100(2):508-15. . View in PubMed

Association of estrogen measurements in serum and urine of premenopausal women Biomark Med. 2015; 9(5):417-24. . View in PubMed

Brca1 Mutations Enhance Mouse Reproductive Functions by Increasing Responsiveness to Male-Derived Scent PLoS One. 2015; 10(10):e0139013. . View in PubMed

Androgen deficiency and dry eye syndrome in the aging male Invest Ophthalmol Vis Sci. 2014 Jul 03; 55(8):5046-53. . View in PubMed

A pilot study examining short-term changes in bone mineral density among class 3 obese users of depot-medroxyprogesterone acetate Eur J Contracept Reprod Health Care. 2013 Jun; 18(3):199-205. . View in PubMed

Bile acid concentration reference ranges in a pregnant Latina population Am J Perinatol. 2013 May; 30(5):389-93. . View in PubMed

Association between sex hormones, glucose homeostasis, adipokines, and inflammatory markers and mammographic density among postmenopausal women Breast Cancer Res Treat. 2013 May; 139(1):255-65. . View in PubMed

Associations of serum sex steroid hormone and 5a-androstane-3a,17ß-diol glucuronide concentrations with prostate cancer risk among men treated with finasteride Cancer Epidemiol Biomarkers Prev. 2012 Oct; 21(10):1823-32. . View in PubMed

Androstenediol complements estrogenic bioactivity during the menopausal transition Menopause. 2012 Jun; 19(6):650-7. . View in PubMed

Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation Breast Cancer Res Treat. 2012 Apr; 132(2):653-60. . View in PubMed

A 12-month moderate-intensity exercise intervention does not alter serum prolactin concentrations Cancer Epidemiol. 2011 Dec; 35(6):569-73. . View in PubMed

Associations of pregnancy characteristics with maternal and cord steroid hormones, angiogenic factors, and insulin-like growth factor axis Cancer Causes Control. 2011 Nov; 22(11):1587-95. . View in PubMed

Can the increase in breast cancer observed in the estrogen plus progestin arm of the Women's Health Initiative trial be explained by progesterone receptor membrane component 1? Menopause. 2011 Aug; 18(8):833-4.. View in PubMed

Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease Neurobiol Aging. 2011 Apr; 32(4):604-13. . View in PubMed

Antimüllerian hormone as a predictor of natural fecundability in women aged 30-42 years Obstet Gynecol. 2011 Apr; 117(4):798-804. . View in PubMed

Associations between polymorphisms in glucuronidation and sulfation enzymes and sex steroid concentrations in premenopausal women in the United States J Steroid Biochem Mol Biol. 2011 Mar; 124(1-2):10-8. . View in PubMed

A prospective evaluation of C-reactive protein levels and colorectal adenoma development Cancer Epidemiol Biomarkers Prev. 2011 Mar; 20(3):537-44. . View in PubMed

Association of functional polymorphisms in CYP19A1 with aromatase inhibitor associated arthralgia in breast cancer survivors Breast Cancer Res. 2011 Jan 20; 13(1):R8. . View in PubMed

Anthropometric, dietary, and hormonal correlates of serum adiponectin in Asian American women Nutr Cancer. 2011; 63(4):549-57. . View in PubMed

Advantages and challenges of mass spectrometry assays for steroid hormones J Steroid Biochem Mol Biol. 2010 Aug; 121(3-5):491-5. . View in PubMed

Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women Menopause. 2010 Jul; 17(4):785-90. . View in PubMed

Androgens, growth factors, and risk of prostate cancer: the Multiethnic Cohort Prostate. 2010 Jun 01; 70(8):906-15. . View in PubMed

Adolescent diet and subsequent serum hormones, breast density, and bone mineral density in young women: results of the Dietary Intervention Study in Children follow-up study Cancer Epidemiol Biomarkers Prev. 2010 Jun; 19(6):1545-56. . View in PubMed

Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women J Clin Oncol. 2010 Mar 20; 28(9):1458-66. . View in PubMed

Antimullerian hormone and obesity: insights in oral contraceptive users Contraception. 2010 Mar; 81(3):245-8. . View in PubMed

Age-related changes in serum and brain levels of androgens in male Brown Norway rats Neuroreport. 2009 Nov 25; 20(17):1534-7. . View in PubMed

Associations between endogenous sex hormone levels and mammographic and bone densities in premenopausal women Cancer Causes Control. 2009 Sep; 20(7):1039-53. . View in PubMed

Androgen and prostate cancer: is the hypothesis dead? Cancer Epidemiol Biomarkers Prev. 2008 Oct; 17(10):2525-30.. View in PubMed

AKR1C1 and SRD5A1 messenger RNA expression at term in the human myometrium and chorioamniotic membranes Am J Perinatol. 2008 Oct; 25(9):577-82. . View in PubMed

3alpha-Hydroxysteroid dehydrogenase type III deficiency: a novel mechanism for hirsutism J Clin Endocrinol Metab. 2008 Apr; 93(4):1298-303. . View in PubMed

Associations between the CYP17, CYPIB1, COMT and SHBG polymorphisms and serum sex hormones in post-menopausal breast cancer survivors Breast Cancer Res Treat. 2007 Sep; 105(1):45-54. . View in PubMed

A pilot and feasibility study on the effects of naturopathic botanical and dietary interventions on sex steroid hormone metabolism in premenopausal women Cancer Epidemiol Biomarkers Prev. 2007 Aug; 16(8):1601-9. . View in PubMed

A longitudinal study of LH, gonadal and adrenal steroids in four intact Asian bull elephants (Elephas maximus) and one castrate African bull (Loxodonta africana) during musth and non-musth periods Gen Comp Endocrinol. 2007 May 01; 151(3):241-5. . View in PubMed

ACTH stimulation in four Asian bull elephants (Elephas maximus): an investigation of androgen sources in bull elephants Gen Comp Endocrinol. 2007 May 01; 151(3):246-51. . View in PubMed

Acute effects of metformin therapy include improvement of insulin resistance and ovarian morphology Fertil Steril. 2007 Apr; 87(4):870-5. . View in PubMed

An association between a common variant (G972R) in the IRS-1 gene and sex hormone levels in post-menopausal breast cancer survivors Breast Cancer Res Treat. 2006 Oct; 99(3):323-31. . View in PubMed

Alcohol and dietary fibre intakes affect circulating sex hormones among premenopausal women Public Health Nutr. 2006 Oct; 9(7):875-81. . View in PubMed

Associations between reproductive and menstrual factors and postmenopausal androgen concentrations J Womens Health (Larchmt). 2005 Oct; 14(8):704-12. . View in PubMed

Associations among circulating sex hormones, insulin-like growth factor, lipids, and mammographic density in postmenopausal women Cancer Epidemiol Biomarkers Prev. 2005 Jun; 14(6):1411-7. . View in PubMed

Association of genetic polymorphisms with serum estrogens measured multiple times during a 2-year period in premenopausal women Cancer Epidemiol Biomarkers Prev. 2005 Jun; 14(6):1521-7. . View in PubMed

A controlled 2-mo dietary fat reduction and soy food supplementation study in postmenopausal women Am J Clin Nutr. 2005 May; 81(5):1133-41. . View in PubMed

Bioavailability of the Yuzpe and levonorgestrel regimens of emergency contraception: vaginal vsoral administration. Contraception. 2005 Mar; 71(3):197-201. . View in PubMed

Age-related testosterone depletion and the development of Alzheimer disease JAMA. 2004 Sep 22; 292(12):1431-2. . View in PubMed

Associations between reproductive and menstrual factors and postmenopausal sex hormone concentrations Cancer Epidemiol Biomarkers Prev. 2004 Aug; 13(8):1296-301. . View in PubMed

Accelerated endometrial maturation in the luteal phase of cycles utilizing controlled ovarian hyperstimulation: impact of gonadotropin-releasing hormone agonists versus antagonists Fertil Steril. 2004 Jul; 82(1):167-71. . View in PubMed

Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women Cancer Epidemiol Biomarkers Prev. 2004 Jan; 13(1):94-101. . View in PubMed

Androgens modulate beta-amyloid levels in male rat brain J Neurochem. 2003 Nov; 87(4):1052-5. . View in PubMed

All progestins are not created equal Steroids. 2003 Nov; 68(10-13):879-90. . View in PubMed

Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women J Natl Cancer Inst. 2003 Aug 20; 95(16):1218-26. . View in PubMed

Adiposity and sex hormones in postmenopausal breast cancer survivors J Clin Oncol. 2003 May 15; 21(10):1961-6. . View in PubMed

17beta-estradiol reduces plasma Abeta40 for HRT-naïve postmenopausal women with Alzheimer disease: a preliminary study Am J Geriatr Psychiatry. 2003 Mar-Apr; 11(2):239-44. . View in PubMed

Body size and serum levels of insulin and leptin in relation to the risk of benign prostatic hyperplasia J Urol. 2002 Aug; 168(2):599-604. . View in PubMed

A randomized isoflavone intervention among premenopausal women Cancer Epidemiol Biomarkers Prev. 2002 Feb; 11(2):195-201. . View in PubMed

Altered balance between the 5 alpha-reductase and aromatase pathways of androgen metabolism during controlled ovarian hyperstimulation with human menopausal gonadotropins J Assist Reprod Genet. 2001 Oct; 18(10):527-33. . View in PubMed

Body size and prostate cancer: a population-based case-control study in China Cancer Epidemiol Biomarkers Prev. 2000 Dec; 9(12):1335-41. . View in PubMed

Apoptosis may be an early event of progestin therapy for endometrial hyperplasia Gynecol Oncol. 2000 Nov; 79(2):169-76. . View in PubMed

Associations between circulating sex steroid hormones and cognition in normal elderly women Neurology. 2000 Feb 08; 54(3):599-603. . View in PubMed

Aromatase and breast cancer susceptibility Endocr Relat Cancer. 1999 Jun; 6(2):165-73. . View in PubMed

Adrenal dynamic responses to physiologic and pharmacologic adrenocorticotropic hormone stimulation before and after ovarian steroid modulation in women with polycystic ovary syndrome Fertil Steril. 1999 Mar; 71(3):439-44. . View in PubMed

Androgen metabolism and prostate cancer: establishing a model of genetic susceptibility Cancer Res. 1998 Oct 15; 58(20):4497-504. . View in PubMed

Androgens in serum and the risk of prostate cancer: a nested case-control study from the Janus serum bank in Norway Cancer Epidemiol Biomarkers Prev. 1997 Nov; 6(11):967-9. . View in PubMed

A pilot study of urinary estrogen metabolites (16alpha-OHE1 and 2-OHE1) in postmenopausal women with and without breast cancer Environ Health Perspect. 1997 Apr; 105 Suppl 3:601-5. . View in PubMed

A prevalent missense substitution that modulates activity of prostatic steroid 5alpha-reductase Cancer Res. 1997 Mar 15; 57(6):1020-2. . View in PubMed

Androgen support of lacrimal gland function Endocrine. 1997 Feb; 6(1):39-45. . View in PubMed

5 alpha-reductase activity and prostate cancer: a case-control study using stored sera Cancer Epidemiol Biomarkers Prev. 1997 Jan; 6(1):21-4. . View in PubMed

Biologic effects of 17 alpha-dihydroequilin sulfate Fertil Steril. 1996 Nov; 66(5):748-52. . View in PubMed

A cohort study of serum testosterone and hepatocellular carcinoma in Shanghai, China Int J Cancer. 1995 Nov 15; 63(4):491-3. . View in PubMed

Altered regulation of insulin-like growth factor binding protein-1 in patients with polycystic ovary syndrome J Soc Gynecol Investig. 1995 Nov-Dec; 2(6):743-7. . View in PubMed

Alterations in the sensitivity of serum insulin-like growth factor 1 and insulin-like growth factor binding protein-3 to octreotide in polycystic ovary syndrome Fertil Steril. 1995 Apr; 63(4):742-6. . View in PubMed

A prospective randomized trial comparing finasteride to spironolactone in the treatment of hirsute women J Clin Endocrinol Metab. 1995 Jan; 80(1):233-8. . View in PubMed

Alterations in androgen conjugate levels in women and men with alopecia Fertil Steril. 1994 Oct; 62(4):744-50. . View in PubMed

A possible bimodal effect of estrogen on insulin sensitivity in postmenopausal women and the attenuating effect of added progestin Fertil Steril. 1993 Oct; 60(4):664-7. . View in PubMed

Behavioral stress responses in premenopausal and postmenopausal women and the effects of estrogen Am J Obstet Gynecol. 1992 Dec; 167(6):1831-6. . View in PubMed

A reevaluation of estrogen status in postmenopausal women who smoke Am J Obstet Gynecol. 1992 May; 166(5):1444-8. . View in PubMed

5-alpha-reductase activity and risk of prostate cancer among Japanese and US white and black males Lancet. 1992 Apr 11; 339(8798):887-9. . View in PubMed

Androstenedione is an important precursor of dihydrotestosterone in the genital skin of women and is metabolized via 5 alpha-androstanedione J Steroid Biochem Mol Biol. 1990 Sep; 37(1):129-32. . View in PubMed

Androgen sulfate and glucuronide conjugates in nonhirsute and hirsute women with polycystic ovarian syndrome Am J Obstet Gynecol. 1989 Dec; 161(6 Pt 1):1704-9. . View in PubMed

A pharmacodynamic comparison of human urinary follicle-stimulating hormone and human menopausal gonadotropin in normal women and polycystic ovary syndrome Fertil Steril. 1989 Aug; 52(2):216-20. . View in PubMed

A randomized comparison of nonoral estradiol delivery in postmenopausal women Am J Obstet Gynecol. 1988 Dec; 159(6):1540-6. . View in PubMed

Alterations in sex steroid-binding protein (SBP), corticosteroid-binding globulin (CBG), and steroid hormone concentrations during pregnancy in rhesus macaques Biol Reprod. 1986 Aug; 35(1):126-32. . View in PubMed

Adrenocorticotropin-dependent virilizing paraovarian tumors in Nelson's syndrome J Clin Endocrinol Metab. 1979 Sep; 49(3):381-6. . View in PubMed

A radioimmunoassay for norethindrone (NET): measurement of serum NET concentrations following ingestion of NET-containing oral contraceptive steroids Contraception. 1978 Dec; 18(6):615-33. . View in PubMed

Bleeding and serum d-norgestrel, estradiol and progesterone patterns in women using d-norgestrel subdermal polysiloxane capsules for contraception Contraception. 1978 Apr; 17(4):315-28. . View in PubMed

A double-antibody radioimmunoassay for serum progesterone using progesterone-3-(O-carboxymethyl) oximino-[125I]-iodo-histamine as radioligand Steroids. 1978 Mar; 31(3):393-405. . View in PubMed

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