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Fumito Ito, MD, PhD

Professor of Surgery and Molecular Microbiology and Immunology

Co-Leader of the Translational and Clinical Sciences Research (TACS) Program

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Publications

  • Facilitators and Barriers to the Timely Diagnosis and Treatment of Melanoma in Latino Persons. JAMA Dermatol. 2025 Dec 01; 161(12):1224-1228.. View in PubMed
  • The science of tumor-infiltrating lymphocytes (TIL): perspectives from the SITC Surgery Committee. J Immunother Cancer. 2025 Nov 29; 13(11).. View in PubMed
  • Factors Associated With Residual Positive Lymph Nodes With Targeted Axillary Lymph Node Dissection for Breast Cancer and Accuracy of Clipped Node Retrieval in Non-Mapping Patients. J Surg Oncol. 2025 Oct; 132(5):853-859.. View in PubMed
  • Impact of Glucocorticoids on Immune Checkpoint Inhibitor Efficacy and Circulating Biomarkers in Non-Small Cell Lung Cancer Patients. Cancer Res Commun. 2025 Jul 01; 5(7):1082-1094.. View in PubMed
  • Comprehensive Profiling of Acral Lentiginous Melanoma Reveals Downregulated Immune Activation Compared to Cutaneous Melanoma. Pigment Cell Melanoma Res. 2025 May; 38(3):e70027.. View in PubMed
  • Divergent transcriptional states and kinetics of circulating tumor-infiltrating lymphocyte repertoires with highly homologous T-cell receptor sequences in a patient during immunotherapy. J Immunother Cancer. 2025 Jan 25; 13(1).. View in PubMed
  • Combined programmed cell death protein 1 and cytotoxic T-lymphocyte associated protein 4 blockade in an international cohort of patients with acral lentiginous melanoma. Br J Dermatol. 2025 Jan 24; 192(2):316-326.. View in PubMed
  • Generation, Transcriptomic States, and Clinical Relevance of CX3CR1+ CD8 T Cells in Melanoma. Cancer Res Commun. 2024 07 01; 4(7):1802-1814.. View in PubMed
  • Innate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors. Cell Death Dis. 2024 02 14; 15(2):140.. View in PubMed
  • Clinical and immunological relevance of SLAMF6 expression in the tumor microenvironment of breast cancer and melanoma. Sci Rep. 2024 01 29; 14(1):2394.. View in PubMed
  • Multi-omic profiling reveals discrepant immunogenic properties and a unique tumor microenvironment among melanoma brain metastases. NPJ Precis Oncol. 2023 Nov 14; 7(1):120.. View in PubMed
  • Axillary lymph node recurrence following wire-directed sentinel lymph node dissection for breast cancer patients with biopsy-proven axillary metastases prior to neoadjuvant chemotherapy at a safety net medical center. J Surg Oncol. 2023 Jul; 128(1):9-15.. View in PubMed
  • Fluctuations in Gut Microbiome Composition During Immune Checkpoint Inhibitor Therapy. World J Oncol. 2023 Jun; 14(3):178-187.. View in PubMed
  • Predictive and Prognostic Implications of Circulating CX3CR1+ CD8+ T Cells in Non-Small Cell Lung Cancer Patients Treated with Chemo-Immunotherapy. Cancer Res Commun. 2023 03; 3(3):510-520.. View in PubMed
  • Tcf-1 protects anti-tumor TCR-engineered CD8+ T-cells from GzmB mediated self-destruction. Cancer Immunol Immunother. 2022 Dec; 71(12):2881-2898.. View in PubMed
  • Generation of cDC-like cells from human induced pluripotent stem cells via Notch signaling. J Immunother Cancer. 2022 01; 10(1).. View in PubMed
  • CD40 and CD80/86 signaling in cDC1s mediate effective neoantigen vaccination and generation of antigen-specific CX3CR1+ CD8+ T cells. Cancer Immunol Immunother. 2022 Jan; 71(1):137-151.. View in PubMed
  • Neoadjuvant In Situ Immunomodulation Enhances Systemic Antitumor Immunity against Highly Metastatic Tumors. Cancer Res. 2021 12 15; 81(24):6183-6195.. View in PubMed
  • Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8+ T-Cell Responses. Adv Sci (Weinh). 2021 12; 8(24):e2103023.. View in PubMed
  • Immunization with short peptide particles reveals a functional CD8+ T-cell neoepitope in a murine renal carcinoma model. J Immunother Cancer. 2021 12; 9(12).. View in PubMed
  • Local, multimodal intralesional therapy renders distant brain metastases susceptible to PD-L1 blockade in a preclinical model of triple-negative breast cancer. Sci Rep. 2021 11 09; 11(1):21992.. View in PubMed
  • Multimodal Intralesional Therapy for Reshaping the Myeloid Compartment of Tumors Resistant to Anti-PD-L1 Therapy via IRF8 Expression. J Immunol. 2021 09 01; 207(5):1298-1309.. View in PubMed
  • Clinical characteristics, time course, treatment and outcomes of patients with immune checkpoint inhibitor-associated myocarditis. J Immunother Cancer. 2021 06; 9(6).. View in PubMed
  • In situ delivery of iPSC-derived dendritic cells with local radiotherapy generates systemic antitumor immunity and potentiates PD-L1 blockade in preclinical poorly immunogenic tumor models. J Immunother Cancer. 2021 05; 9(5).. View in PubMed
  • T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors. Nat Commun. 2021 03 03; 12(1):1402.. View in PubMed
  • Defining best practices for tissue procurement in immuno-oncology clinical trials: consensus statement from the Society for Immunotherapy of Cancer Surgery Committee. J Immunother Cancer. 2020 11; 8(2).. View in PubMed
  • Overcoming primary and acquired resistance to anti-PD-L1 therapy by induction and activation of tumor-residing cDC1s. Nat Commun. 2020 10 27; 11(1):5415.. View in PubMed
  • A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells. J Immunol. 2020 10 01; 205(7):1867-1877.. View in PubMed
  • CX3CR1-CD8+ T cells are critical in antitumor efficacy but functionally suppressed in the tumor microenvironment. JCI Insight. 2020 04 23; 5(8).. View in PubMed
  • In situ thermal ablation augments antitumor efficacy of adoptive T cell therapy. Int J Hyperthermia. 2019 11; 36(sup1):22-36.. View in PubMed
  • Induced Pluripotent Stem Cell-Derived T Cells for Cancer Immunotherapy. Surg Oncol Clin N Am. 2019 07; 28(3):489-504.. View in PubMed
  • Low DMT1 Expression Associates With Increased Oxidative Phosphorylation and Early Recurrence in Hepatocellular Carcinoma. J Surg Res. 2019 02; 234:343-352.. View in PubMed
  • Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System. Cell Rep. 2018 03 20; 22(12):3175-3190.. View in PubMed
  • Emerging role of RNA binding protein UNR/CSDE1 in melanoma. J Xiangya Med. 2017 May; 2.. View in PubMed
  • Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes. J Vis Exp. 2016 11 11; (117).. View in PubMed
  • Adoptive Transfer of CD8+ T Cells Generated from Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along with Immunological Memory. Cancer Res. 2016 06 15; 76(12):3473-83.. View in PubMed
  • Pre-resectional Radiofrequency Ablation as a Neoadjuvant in situ Tumor Vaccine. J Vaccines Vaccin. 2016 Apr; 7(2).. View in PubMed
  • Reprogramming of Melanoma Tumor-Infiltrating Lymphocytes to Induced Pluripotent Stem Cells. Stem Cells Int. 2016; 2016:8394960.. View in PubMed
  • Antitumor effector B cells directly kill tumor cells via the Fas/FasL pathway and are regulated by IL-10. Eur J Immunol. 2015 Apr; 45(4):999-1009.. View in PubMed
  • Immune Adjuvant Activity of Pre-Resectional Radiofrequency Ablation Protects against Local and Systemic Recurrence in Aggressive Murine Colorectal Cancer. PLoS One. 2015; 10(11):e0143370.. View in PubMed
  • Cancer immunotherapy: current status and future directions. Surg Oncol Clin N Am. 2013 Oct; 22(4):765-83.. View in PubMed
  • Water: a simple solution for tumor spillage. Ann Surg Oncol. 2011 Aug; 18(8):2357-63.. View in PubMed
  • Hilar cholangiocarcinoma: current management. Ann Surg. 2009 Aug; 250(2):210-8.. View in PubMed
  • Resection of hilar cholangiocarcinoma: concomitant liver resection decreases hepatic recurrence. Ann Surg. 2008 Aug; 248(2):273-9.. View in PubMed
  • Transabdominal preperitoneal robotic inguinal hernia repair. J Laparoendosc Adv Surg Tech A. 2008 Jun; 18(3):397-9.. View in PubMed
  • The utility of intraoperative bilateral internal jugular venous sampling with rapid parathyroid hormone testing. Ann Surg. 2007 Jun; 245(6):959-63.. View in PubMed
  • Robotic foregut surgery. Int J Med Robot. 2006 Dec; 2(4):287-92.. View in PubMed
  • Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines. Cancer Res. 2004 Nov 15; 64(22):8411-9.. View in PubMed
  • Phenotypic stability of mature dendritic cells tuned by TLR or CD40 to control the efficiency of cytotoxic T cell priming. Microbiol Immunol. 2004; 48(3):211-9.. View in PubMed
  • Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration. Cancer Res. 2003 Dec 01; 63(23):8466-75.. View in PubMed
  • Polarization effects of 4-1BB during CD28 costimulation in generating tumor-reactive T cells for cancer immunotherapy. Cancer Res. 2003 May 15; 63(10):2546-52.. View in PubMed
  • Antitumor reactivity of anti-CD3/anti-CD28 bead-activated lymphoid cells: implications for cell therapy in a murine model. J Immunother. 2003 May-Jun; 26(3):222-33.. View in PubMed

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