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Fumito Ito, MD, PhD

Associate Professor of Surgery and Molecular Microbiology and Immunology

Co-Leader of the Translational and Clinical Sciences Research (TACS) Program

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Publications

  • Combined PD-1 and CTLA-4 Blockade in an International Cohort of Patients with Acral Lentiginous Melanoma Br J Dermatol. 2024 Oct 23. . View in PubMed
  • Generation, Transcriptomic States, and Clinical Relevance of CX3CR1+ CD8 T Cells in Melanoma Cancer Res Commun. 2024 07 01; 4(7):1802-1814. . View in PubMed
  • Innate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors Cell Death Dis. 2024 Feb 14; 15(2):140. . View in PubMed
  • Clinical and immunological relevance of SLAMF6 expression in the tumor microenvironment of breast cancer and melanoma Sci Rep. 2024 Jan 29; 14(1):2394. . View in PubMed
  • Multi-omic profiling reveals discrepant immunogenic properties and a unique tumor microenvironment among melanoma brain metastases NPJ Precis Oncol. 2023 Nov 14; 7(1):120. . View in PubMed
  • Axillary lymph node recurrence following wire-directed sentinel lymph node dissection for breast cancer patients with biopsy-proven axillary metastases prior to neoadjuvant chemotherapy at a safety net medical center J Surg Oncol. 2023 Jul; 128(1):9-15. . View in PubMed
  • Fluctuations in Gut Microbiome Composition During Immune Checkpoint Inhibitor Therapy World J Oncol. 2023 Jun; 14(3):178-187. . View in PubMed
  • Predictive and Prognostic Implications of Circulating CX3CR1+ CD8+ T Cells in Non-Small Cell Lung Cancer Patients Treated with Chemo-Immunotherapy Cancer Res Commun. 2023 03; 3(3):510-520. . View in PubMed
  • Tcf-1 protects anti-tumor TCR-engineered CD8+ T-cells from GzmB mediated self-destruction Cancer Immunol Immunother. 2022 Dec; 71(12):2881-2898. . View in PubMed
  • Generation of cDC-like cells from human induced pluripotent stem cells via Notch signaling J Immunother Cancer. 2022 01; 10(1). . View in PubMed
  • CD40 and CD80/86 signaling in cDC1s mediate effective neoantigen vaccination and generation of antigen-specific CX3CR1+ CD8+ T cells Cancer Immunol Immunother. 2022 Jan; 71(1):137-151. . View in PubMed
  • Neoadjuvant In Situ Immunomodulation Enhances Systemic Antitumor Immunity against Highly Metastatic Tumors Cancer Res. 2021 12 15; 81(24):6183-6195. . View in PubMed
  • Immunization with short peptide particles reveals a functional CD8+ T-cell neoepitope in a murine renal carcinoma model J Immunother Cancer. 2021 12; 9(12). . View in PubMed
  • Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8+ T-Cell Responses Adv Sci (Weinh). 2021 12; 8(24):e2103023. . View in PubMed
  • Local, multimodal intralesional therapy renders distant brain metastases susceptible to PD-L1 blockade in a preclinical model of triple-negative breast cancer Sci Rep. 2021 11 09; 11(1):21992. . View in PubMed
  • Multimodal Intralesional Therapy for Reshaping the Myeloid Compartment of Tumors Resistant to Anti-PD-L1 Therapy via IRF8 Expression J Immunol. 2021 09 01; 207(5):1298-1309. . View in PubMed
  • Clinical characteristics, time course, treatment and outcomes of patients with immune checkpoint inhibitor-associated myocarditis J Immunother Cancer. 2021 06; 9(6). . View in PubMed
  • In situ delivery of iPSC-derived dendritic cells with local radiotherapy generates systemic antitumor immunity and potentiates PD-L1 blockade in preclinical poorly immunogenic tumor models J Immunother Cancer. 2021 05; 9(5). . View in PubMed
  • T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors Nat Commun. 2021 03 03; 12(1):1402. . View in PubMed
  • Defining best practices for tissue procurement in immuno-oncology clinical trials: consensus statement from the Society for Immunotherapy of Cancer Surgery Committee J Immunother Cancer. 2020 11; 8(2). . View in PubMed
  • Overcoming primary and acquired resistance to anti-PD-L1 therapy by induction and activation of tumor-residing cDC1s Nat Commun. 2020 10 27; 11(1):5415. . View in PubMed
  • A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells J Immunol. 2020 10 01; 205(7):1867-1877. . View in PubMed
  • CX3CR1-CD8+ T cells are critical in antitumor efficacy but functionally suppressed in the tumor microenvironment JCI Insight. 2020 04 23; 5(8). . View in PubMed
  • In situ thermal ablation augments antitumor efficacy of adoptive T cell therapy Int J Hyperthermia. 2019 11; 36(sup1):22-36. . View in PubMed
  • Induced Pluripotent Stem Cell-Derived T Cells for Cancer Immunotherapy Surg Oncol Clin N Am. 2019 07; 28(3):489-504. . View in PubMed
  • Low DMT1 Expression Associates With Increased Oxidative Phosphorylation and Early Recurrence in Hepatocellular Carcinoma J Surg Res. 2019 02; 234:343-352. . View in PubMed
  • Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System Cell Rep. 2018 03 20; 22(12):3175-3190. . View in PubMed
  • Emerging role of RNA binding protein UNR/CSDE1 in melanoma J Xiangya Med. 2017 May; 2. . View in PubMed
  • Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes J Vis Exp. 2016 11 11; (117). . View in PubMed
  • Adoptive Transfer of CD8+ T Cells Generated from Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along with Immunological Memory Cancer Res. 2016 06 15; 76(12):3473-83. . View in PubMed
  • Pre-resectional Radiofrequency Ablation as a Neoadjuvant in situ Tumor Vaccine J Vaccines Vaccin. 2016 Apr; 7(2). . View in PubMed
  • Reprogramming of Melanoma Tumor-Infiltrating Lymphocytes to Induced Pluripotent Stem Cells Stem Cells Int. 2016; 2016:8394960. . View in PubMed
  • Antitumor effector B cells directly kill tumor cells via the Fas/FasL pathway and are regulated by IL-10 Eur J Immunol. 2015 Apr; 45(4):999-1009. . View in PubMed
  • Immune Adjuvant Activity of Pre-Resectional Radiofrequency Ablation Protects against Local and Systemic Recurrence in Aggressive Murine Colorectal Cancer PLoS One. 2015; 10(11):e0143370. . View in PubMed
  • Cancer immunotherapy: current status and future directions Surg Oncol Clin N Am. 2013 Oct; 22(4):765-83. . View in PubMed
  • Water: a simple solution for tumor spillage Ann Surg Oncol. 2011 Aug; 18(8):2357-63. . View in PubMed
  • Hilar cholangiocarcinoma: current management Ann Surg. 2009 Aug; 250(2):210-8. . View in PubMed
  • Resection of hilar cholangiocarcinoma: concomitant liver resection decreases hepatic recurrence Ann Surg. 2008 Aug; 248(2):273-9. . View in PubMed
  • Transabdominal preperitoneal robotic inguinal hernia repair J Laparoendosc Adv Surg Tech A. 2008 Jun; 18(3):397-9. . View in PubMed
  • The utility of intraoperative bilateral internal jugular venous sampling with rapid parathyroid hormone testing Ann Surg. 2007 Jun; 245(6):959-63. . View in PubMed
  • Robotic foregut surgery Int J Med Robot. 2006 Dec; 2(4):287-92. . View in PubMed
  • Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines Cancer Res. 2004 Nov 15; 64(22):8411-9. . View in PubMed
  • Phenotypic stability of mature dendritic cells tuned by TLR or CD40 to control the efficiency of cytotoxic T cell priming Microbiol Immunol. 2004; 48(3):211-9. . View in PubMed
  • Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration Cancer Res. 2003 Dec 01; 63(23):8466-75. . View in PubMed
  • Polarization effects of 4-1BB during CD28 costimulation in generating tumor-reactive T cells for cancer immunotherapy Cancer Res. 2003 May 15; 63(10):2546-52. . View in PubMed
  • Antitumor reactivity of anti-CD3/anti-CD28 bead-activated lymphoid cells: implications for cell therapy in a murine model J Immunother. 2003 May-Jun; 26(3):222-33. . View in PubMed

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